Incidental Mutation 'IGL01736:Ints4'
ID 105695
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ints4
Ensembl Gene ENSMUSG00000025133
Gene Name integrator complex subunit 4
Synonyms 2610034N24Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.960) question?
Stock # IGL01736
Quality Score
Status
Chromosome 7
Chromosomal Location 97130163-97190602 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 97175849 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 647 (L647F)
Ref Sequence ENSEMBL: ENSMUSP00000026126 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026126]
AlphaFold Q8CIM8
Predicted Effect probably benign
Transcript: ENSMUST00000026126
AA Change: L647F

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000026126
Gene: ENSMUSG00000025133
AA Change: L647F

DomainStartEndE-ValueType
Pfam:HEAT_2 153 258 9.8e-9 PFAM
Pfam:Cohesin_HEAT 179 219 7.7e-6 PFAM
low complexity region 518 527 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083426
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205387
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb A G 5: 114,326,503 (GRCm39) T290A possibly damaging Het
Apip G A 2: 102,917,486 (GRCm39) V62M probably damaging Het
Appbp2 T C 11: 85,105,143 (GRCm39) K141R possibly damaging Het
Arhgef18 T A 8: 3,501,624 (GRCm39) probably benign Het
B3galt2 A G 1: 143,522,583 (GRCm39) T240A probably benign Het
Bivm A T 1: 44,180,973 (GRCm39) N385I probably damaging Het
Brd4 A T 17: 32,417,649 (GRCm39) probably benign Het
Cage1 T C 13: 38,206,789 (GRCm39) D352G possibly damaging Het
Ceacam10 A G 7: 24,480,535 (GRCm39) Y102C probably damaging Het
Diaph3 T C 14: 87,156,282 (GRCm39) D677G probably benign Het
Dis3l T C 9: 64,226,536 (GRCm39) probably null Het
Dnah6 C T 6: 73,165,360 (GRCm39) V582M probably benign Het
Fndc3b A G 3: 27,521,552 (GRCm39) L541P probably damaging Het
Folh1 T C 7: 86,391,444 (GRCm39) T384A possibly damaging Het
Gdpd3 T C 7: 126,365,695 (GRCm39) L18P probably damaging Het
Grxcr2 T A 18: 42,132,047 (GRCm39) K7N probably damaging Het
Gulo A G 14: 66,234,325 (GRCm39) F246L probably benign Het
Inpp4b A T 8: 82,723,968 (GRCm39) D500V probably benign Het
Kif17 T A 4: 138,013,876 (GRCm39) L264Q possibly damaging Het
Kif21a T C 15: 90,843,948 (GRCm39) N1104S possibly damaging Het
Ly6e T G 15: 74,830,546 (GRCm39) L132R probably benign Het
Mis18bp1 T A 12: 65,185,452 (GRCm39) H905L probably damaging Het
Nr2f2 A G 7: 70,004,446 (GRCm39) S269P probably damaging Het
Or2b2b C A 13: 21,858,787 (GRCm39) C109F probably benign Het
Or2o1 G A 11: 49,051,354 (GRCm39) C171Y probably damaging Het
Or5d46 T A 2: 88,170,771 (GRCm39) N287K probably damaging Het
Pde8b T C 13: 95,166,910 (GRCm39) I757V probably damaging Het
Psg23 A T 7: 18,346,122 (GRCm39) I191N possibly damaging Het
Slc12a4 A T 8: 106,672,475 (GRCm39) probably null Het
Snph A T 2: 151,436,093 (GRCm39) Y209* probably null Het
Tnfaip3 T C 10: 18,882,649 (GRCm39) H256R probably damaging Het
Tnip3 T A 6: 65,573,107 (GRCm39) probably benign Het
Ttc3 T A 16: 94,243,386 (GRCm39) F1130Y probably damaging Het
Twnk T G 19: 44,998,627 (GRCm39) V515G probably damaging Het
Usp24 T A 4: 106,280,658 (GRCm39) I2324K probably benign Het
Vwa7 T C 17: 35,238,827 (GRCm39) F305S probably damaging Het
Ythdc2 A T 18: 44,983,735 (GRCm39) Q567L probably damaging Het
Zbtb11 T A 16: 55,818,523 (GRCm39) I649K probably damaging Het
Zbtb49 T C 5: 38,358,204 (GRCm39) Y683C probably damaging Het
Zfhx4 A T 3: 5,309,152 (GRCm39) M793L possibly damaging Het
Zmym6 T G 4: 127,002,437 (GRCm39) I556R probably damaging Het
Zswim8 C T 14: 20,764,780 (GRCm39) P717S probably benign Het
Other mutations in Ints4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00765:Ints4 APN 7 97,184,412 (GRCm39) missense probably damaging 1.00
IGL01862:Ints4 APN 7 97,190,360 (GRCm39) missense probably damaging 1.00
IGL02277:Ints4 APN 7 97,136,665 (GRCm39) missense probably damaging 1.00
IGL02396:Ints4 APN 7 97,187,107 (GRCm39) missense possibly damaging 0.64
IGL02661:Ints4 APN 7 97,144,912 (GRCm39) missense probably benign
IGL02750:Ints4 APN 7 97,166,964 (GRCm39) critical splice donor site probably null
IGL03108:Ints4 APN 7 97,140,137 (GRCm39) critical splice acceptor site probably null
R0332:Ints4 UTSW 7 97,166,925 (GRCm39) missense probably damaging 1.00
R0449:Ints4 UTSW 7 97,178,430 (GRCm39) missense probably damaging 0.97
R1065:Ints4 UTSW 7 97,157,099 (GRCm39) critical splice donor site probably null
R1722:Ints4 UTSW 7 97,162,786 (GRCm39) missense probably benign 0.24
R2060:Ints4 UTSW 7 97,150,970 (GRCm39) missense possibly damaging 0.93
R2211:Ints4 UTSW 7 97,158,957 (GRCm39) missense possibly damaging 0.63
R3731:Ints4 UTSW 7 97,155,308 (GRCm39) missense probably benign 0.18
R3881:Ints4 UTSW 7 97,165,464 (GRCm39) missense possibly damaging 0.94
R4089:Ints4 UTSW 7 97,178,462 (GRCm39) nonsense probably null
R4192:Ints4 UTSW 7 97,156,940 (GRCm39) missense probably damaging 1.00
R4479:Ints4 UTSW 7 97,134,178 (GRCm39) missense probably damaging 1.00
R4980:Ints4 UTSW 7 97,151,057 (GRCm39) critical splice donor site probably null
R5029:Ints4 UTSW 7 97,158,981 (GRCm39) missense probably benign 0.06
R5306:Ints4 UTSW 7 97,158,885 (GRCm39) missense probably damaging 1.00
R6160:Ints4 UTSW 7 97,158,790 (GRCm39) splice site probably null
R6317:Ints4 UTSW 7 97,178,425 (GRCm39) nonsense probably null
R6961:Ints4 UTSW 7 97,190,397 (GRCm39) makesense probably null
R7026:Ints4 UTSW 7 97,168,361 (GRCm39) missense possibly damaging 0.50
R7156:Ints4 UTSW 7 97,184,493 (GRCm39) critical splice donor site probably null
R7205:Ints4 UTSW 7 97,184,433 (GRCm39) nonsense probably null
R7234:Ints4 UTSW 7 97,179,507 (GRCm39) missense probably benign 0.00
R7418:Ints4 UTSW 7 97,140,179 (GRCm39) missense probably benign 0.03
R7423:Ints4 UTSW 7 97,156,926 (GRCm39) missense probably damaging 1.00
R7462:Ints4 UTSW 7 97,155,335 (GRCm39) missense probably benign 0.11
R7658:Ints4 UTSW 7 97,178,460 (GRCm39) missense possibly damaging 0.90
R7947:Ints4 UTSW 7 97,148,792 (GRCm39) missense probably benign
R8114:Ints4 UTSW 7 97,165,732 (GRCm39) splice site probably null
R8426:Ints4 UTSW 7 97,150,239 (GRCm39) nonsense probably null
R8765:Ints4 UTSW 7 97,151,016 (GRCm39) missense possibly damaging 0.70
R8777:Ints4 UTSW 7 97,134,227 (GRCm39) missense probably damaging 1.00
R8777-TAIL:Ints4 UTSW 7 97,134,227 (GRCm39) missense probably damaging 1.00
R8944:Ints4 UTSW 7 97,183,593 (GRCm39) missense probably benign
R9001:Ints4 UTSW 7 97,190,276 (GRCm39) missense possibly damaging 0.51
R9057:Ints4 UTSW 7 97,158,987 (GRCm39) missense possibly damaging 0.90
R9315:Ints4 UTSW 7 97,156,840 (GRCm39) intron probably benign
Posted On 2014-01-21