Incidental Mutation 'R1266:Zfp455'
| ID |
151174 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp455
|
| Ensembl Gene |
ENSMUSG00000051037 |
| Gene Name |
zinc finger protein 455 |
| Synonyms |
Rslcan-10, 3732412P20Rik |
| MMRRC Submission |
039333-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.356)
|
| Stock # |
R1266 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
67342570-67357362 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 67355028 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 99
(R99*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112546
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000117110]
[ENSMUST00000120861]
|
| AlphaFold |
Q7M6X9 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000117110
AA Change: R34*
|
| SMART Domains |
Protein: ENSMUSP00000113356
Gene: ENSMUSG00000051037
AA Change: R34*
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
44 |
66 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
72 |
94 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
100 |
122 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
128 |
150 |
6.23e-2 |
SMART |
|
ZnF_C2H2
|
184 |
206 |
1.01e-1 |
SMART |
|
ZnF_C2H2
|
212 |
234 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
240 |
262 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
268 |
290 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
296 |
318 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
324 |
346 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
352 |
374 |
7.9e-4 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000120861
AA Change: R99*
|
| SMART Domains |
Protein: ENSMUSP00000112546
Gene: ENSMUSG00000051037
AA Change: R99*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
65 |
1.92e-34 |
SMART |
|
ZnF_C2H2
|
109 |
131 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
137 |
159 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
165 |
187 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
193 |
215 |
6.23e-2 |
SMART |
|
ZnF_C2H2
|
249 |
271 |
1.01e-1 |
SMART |
|
ZnF_C2H2
|
277 |
299 |
3.11e-2 |
SMART |
|
ZnF_C2H2
|
305 |
327 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
333 |
355 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
361 |
383 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
389 |
411 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
417 |
439 |
7.9e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.0%
- 10x: 95.3%
- 20x: 89.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 18 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Apob |
C |
A |
12: 8,056,093 (GRCm39) |
T1492N |
probably benign |
Het |
| Brix1 |
T |
C |
15: 10,478,847 (GRCm39) |
T191A |
probably damaging |
Het |
| C1qc |
A |
G |
4: 136,617,668 (GRCm39) |
S143P |
possibly damaging |
Het |
| Crim1 |
GGCTGCTGCTGCTGCTG |
GGCTGCTGCTGCTG |
17: 78,508,262 (GRCm39) |
|
probably benign |
Het |
| Defa22 |
G |
T |
8: 21,652,384 (GRCm39) |
V17F |
probably damaging |
Het |
| Fer1l4 |
T |
A |
2: 155,888,169 (GRCm39) |
T439S |
possibly damaging |
Het |
| Flt3 |
A |
G |
5: 147,293,670 (GRCm39) |
S469P |
probably benign |
Het |
| Krtap19-9b |
A |
T |
16: 88,728,940 (GRCm39) |
S54T |
unknown |
Het |
| Ncor1 |
T |
C |
11: 62,224,866 (GRCm39) |
D798G |
probably damaging |
Het |
| Oosp1 |
T |
C |
19: 11,645,163 (GRCm39) |
H167R |
possibly damaging |
Het |
| Or5d16 |
A |
T |
2: 87,773,877 (GRCm39) |
L32M |
probably benign |
Het |
| Poln |
A |
T |
5: 34,290,453 (GRCm39) |
|
probably null |
Het |
| Primpol |
A |
T |
8: 47,046,734 (GRCm39) |
N187K |
probably damaging |
Het |
| Prr12 |
A |
G |
7: 44,699,677 (GRCm39) |
|
probably benign |
Het |
| Setd1b |
A |
G |
5: 123,285,904 (GRCm39) |
T317A |
unknown |
Het |
| Sgo2b |
G |
A |
8: 64,381,455 (GRCm39) |
T459M |
probably benign |
Het |
| Trappc9 |
G |
A |
15: 72,897,816 (GRCm39) |
R377W |
probably damaging |
Het |
| Vmn2r115 |
ATCTTCT |
ATCT |
17: 23,578,962 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Zfp455 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00743:Zfp455
|
APN |
13 |
67,355,962 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL03111:Zfp455
|
APN |
13 |
67,356,063 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03210:Zfp455
|
APN |
13 |
67,355,113 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03371:Zfp455
|
APN |
13 |
67,355,066 (GRCm39) |
nonsense |
probably null |
|
|
PIT4504001:Zfp455
|
UTSW |
13 |
67,346,685 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0245:Zfp455
|
UTSW |
13 |
67,355,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0277:Zfp455
|
UTSW |
13 |
67,346,728 (GRCm39) |
splice site |
probably null |
|
|
R1141:Zfp455
|
UTSW |
13 |
67,346,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1657:Zfp455
|
UTSW |
13 |
67,346,703 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1749:Zfp455
|
UTSW |
13 |
67,355,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1757:Zfp455
|
UTSW |
13 |
67,355,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Zfp455
|
UTSW |
13 |
67,355,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1867:Zfp455
|
UTSW |
13 |
67,355,509 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4411:Zfp455
|
UTSW |
13 |
67,355,389 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6060:Zfp455
|
UTSW |
13 |
67,355,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6544:Zfp455
|
UTSW |
13 |
67,355,121 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7132:Zfp455
|
UTSW |
13 |
67,347,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7524:Zfp455
|
UTSW |
13 |
67,355,688 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7966:Zfp455
|
UTSW |
13 |
67,347,302 (GRCm39) |
missense |
probably benign |
|
|
R8848:Zfp455
|
UTSW |
13 |
67,356,089 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8994:Zfp455
|
UTSW |
13 |
67,355,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Zfp455
|
UTSW |
13 |
67,355,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCATTGTGTCCACCGACTGTATTTGT -3'
(R):5'- TGTTGCTTAAGGAATGAGGGAAAGCC -3'
Sequencing Primer
(F):5'- GAATTTTCCTCAGTGCCTACAGG -3'
(R):5'- ttgccacattcttcacacttg -3'
|
| Posted On |
2014-01-29 |
Incidental Mutation