Incidental Mutation 'IGL01860:Zfp609'
| ID |
178273 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp609
|
| Ensembl Gene |
ENSMUSG00000040524 |
| Gene Name |
zinc finger protein 609 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.620)
|
| Stock # |
IGL01860
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
65599673-65734846 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 65610116 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 949
(E949G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124089
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159109]
|
| AlphaFold |
Q8BZ47 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159109
AA Change: E949G
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000124089
Gene: ENSMUSG00000040524
AA Change: E949G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
101 |
N/A |
INTRINSIC |
|
low complexity region
|
125 |
139 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
176 |
N/A |
INTRINSIC |
|
low complexity region
|
259 |
269 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
405 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
495 |
520 |
2.14e0 |
SMART |
|
low complexity region
|
629 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
657 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
724 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1020 |
N/A |
INTRINSIC |
|
low complexity region
|
1210 |
1219 |
N/A |
INTRINSIC |
|
low complexity region
|
1257 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1329 |
1348 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159878
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 48 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700034J05Rik |
T |
A |
6: 146,853,914 (GRCm39) |
N248Y |
possibly damaging |
Het |
| Adamts13 |
G |
A |
2: 26,868,023 (GRCm39) |
V128M |
probably damaging |
Het |
| Agl |
A |
T |
3: 116,566,175 (GRCm39) |
|
probably benign |
Het |
| Arfgef1 |
A |
T |
1: 10,224,621 (GRCm39) |
M1405K |
probably damaging |
Het |
| Atp6v1a |
G |
T |
16: 43,920,319 (GRCm39) |
L426M |
probably damaging |
Het |
| Calhm6 |
A |
G |
10: 34,002,561 (GRCm39) |
V174A |
probably damaging |
Het |
| Cdc123 |
A |
G |
2: 5,808,752 (GRCm39) |
|
probably benign |
Het |
| Cept1 |
A |
G |
3: 106,438,444 (GRCm39) |
|
probably benign |
Het |
| Cipc |
T |
A |
12: 87,007,047 (GRCm39) |
D60E |
probably damaging |
Het |
| Efcab3 |
T |
C |
11: 104,581,747 (GRCm39) |
S30P |
probably benign |
Het |
| Exosc3 |
A |
G |
4: 45,319,659 (GRCm39) |
I121T |
probably benign |
Het |
| Fbln5 |
A |
G |
12: 101,776,128 (GRCm39) |
Y89H |
probably damaging |
Het |
| Fhod3 |
T |
C |
18: 25,030,738 (GRCm39) |
F128L |
probably damaging |
Het |
| Fhod3 |
T |
A |
18: 25,037,005 (GRCm39) |
I154N |
probably damaging |
Het |
| Fpgt |
T |
C |
3: 154,792,483 (GRCm39) |
T515A |
probably benign |
Het |
| Gas2l2 |
G |
A |
11: 83,312,906 (GRCm39) |
T802I |
probably benign |
Het |
| Gm10710 |
T |
A |
3: 83,035,156 (GRCm39) |
|
probably benign |
Het |
| Hdac4 |
A |
G |
1: 91,861,417 (GRCm39) |
M1051T |
probably benign |
Het |
| Heatr5b |
A |
G |
17: 79,115,909 (GRCm39) |
V849A |
probably damaging |
Het |
| Helb |
T |
C |
10: 119,938,738 (GRCm39) |
I579V |
probably damaging |
Het |
| Hspa1l |
A |
G |
17: 35,197,787 (GRCm39) |
I609V |
probably benign |
Het |
| Itgam |
C |
A |
7: 127,670,115 (GRCm39) |
Q136K |
probably benign |
Het |
| Kcnc1 |
T |
C |
7: 46,077,554 (GRCm39) |
L452P |
probably damaging |
Het |
| Ltbp4 |
T |
A |
7: 27,019,071 (GRCm39) |
T1083S |
probably damaging |
Het |
| Mki67 |
T |
C |
7: 135,300,686 (GRCm39) |
I1449M |
probably damaging |
Het |
| Nalf1 |
A |
T |
8: 9,257,831 (GRCm39) |
V439E |
probably damaging |
Het |
| P2rx5 |
T |
A |
11: 73,056,385 (GRCm39) |
V103E |
probably damaging |
Het |
| Pals1 |
T |
C |
12: 78,877,681 (GRCm39) |
V531A |
possibly damaging |
Het |
| Pappa |
A |
G |
4: 65,123,329 (GRCm39) |
D888G |
possibly damaging |
Het |
| Pcdhb21 |
G |
T |
18: 37,647,958 (GRCm39) |
M362I |
probably benign |
Het |
| Pde1a |
A |
G |
2: 79,705,628 (GRCm39) |
S333P |
probably damaging |
Het |
| Ppm1j |
A |
G |
3: 104,691,408 (GRCm39) |
T299A |
probably damaging |
Het |
| Pramel46 |
G |
A |
5: 95,418,510 (GRCm39) |
T162I |
probably benign |
Het |
| Ptdss2 |
A |
G |
7: 140,732,749 (GRCm39) |
E168G |
probably damaging |
Het |
| Rspry1 |
A |
G |
8: 95,376,444 (GRCm39) |
N322S |
probably benign |
Het |
| Slc7a9 |
T |
A |
7: 35,156,485 (GRCm39) |
V309E |
probably damaging |
Het |
| Slco6c1 |
A |
G |
1: 97,003,548 (GRCm39) |
|
probably benign |
Het |
| Tas2r120 |
T |
A |
6: 132,634,227 (GRCm39) |
M103K |
probably damaging |
Het |
| Tbxas1 |
T |
A |
6: 38,925,561 (GRCm39) |
F59I |
probably damaging |
Het |
| Tfpi |
A |
G |
2: 84,274,378 (GRCm39) |
S203P |
probably benign |
Het |
| Tram2 |
T |
C |
1: 21,074,083 (GRCm39) |
N285S |
possibly damaging |
Het |
| Trio |
T |
A |
15: 27,846,896 (GRCm39) |
D980V |
probably damaging |
Het |
| Trpv5 |
T |
A |
6: 41,637,229 (GRCm39) |
H419L |
probably damaging |
Het |
| Usp28 |
C |
T |
9: 48,943,543 (GRCm39) |
R361* |
probably null |
Het |
| Vmn1r6 |
T |
A |
6: 56,979,674 (GRCm39) |
L112* |
probably null |
Het |
| Vmn2r12 |
A |
T |
5: 109,240,025 (GRCm39) |
N179K |
probably benign |
Het |
| Vmn2r82 |
G |
T |
10: 79,214,691 (GRCm39) |
A225S |
probably benign |
Het |
| Zcchc4 |
A |
G |
5: 52,965,698 (GRCm39) |
Y334C |
probably damaging |
Het |
|
| Other mutations in Zfp609 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00956:Zfp609
|
APN |
9 |
65,610,045 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01688:Zfp609
|
APN |
9 |
65,611,307 (GRCm39) |
missense |
probably benign |
|
|
IGL01718:Zfp609
|
APN |
9 |
65,609,682 (GRCm39) |
nonsense |
probably null |
|
|
IGL02441:Zfp609
|
APN |
9 |
65,610,611 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02490:Zfp609
|
APN |
9 |
65,611,250 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02614:Zfp609
|
APN |
9 |
65,610,072 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02794:Zfp609
|
APN |
9 |
65,611,602 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02959:Zfp609
|
APN |
9 |
65,610,675 (GRCm39) |
missense |
probably benign |
|
|
IGL02967:Zfp609
|
APN |
9 |
65,604,901 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL03036:Zfp609
|
APN |
9 |
65,609,927 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03182:Zfp609
|
APN |
9 |
65,608,287 (GRCm39) |
missense |
probably benign |
0.02 |
|
H8441:Zfp609
|
UTSW |
9 |
65,702,169 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0304:Zfp609
|
UTSW |
9 |
65,608,470 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0487:Zfp609
|
UTSW |
9 |
65,609,916 (GRCm39) |
missense |
unknown |
|
|
R0505:Zfp609
|
UTSW |
9 |
65,610,744 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0684:Zfp609
|
UTSW |
9 |
65,638,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1480:Zfp609
|
UTSW |
9 |
65,610,593 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1507:Zfp609
|
UTSW |
9 |
65,702,059 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1579:Zfp609
|
UTSW |
9 |
65,611,754 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1655:Zfp609
|
UTSW |
9 |
65,610,836 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1692:Zfp609
|
UTSW |
9 |
65,702,593 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Zfp609
|
UTSW |
9 |
65,638,282 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1735:Zfp609
|
UTSW |
9 |
65,610,374 (GRCm39) |
nonsense |
probably null |
|
|
R1883:Zfp609
|
UTSW |
9 |
65,702,040 (GRCm39) |
missense |
probably benign |
|
|
R1970:Zfp609
|
UTSW |
9 |
65,702,559 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2059:Zfp609
|
UTSW |
9 |
65,611,716 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2302:Zfp609
|
UTSW |
9 |
65,702,179 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3404:Zfp609
|
UTSW |
9 |
65,608,454 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3405:Zfp609
|
UTSW |
9 |
65,608,454 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4514:Zfp609
|
UTSW |
9 |
65,610,977 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4533:Zfp609
|
UTSW |
9 |
65,610,890 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5043:Zfp609
|
UTSW |
9 |
65,608,109 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5499:Zfp609
|
UTSW |
9 |
65,610,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7081:Zfp609
|
UTSW |
9 |
65,609,723 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7514:Zfp609
|
UTSW |
9 |
65,613,418 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7677:Zfp609
|
UTSW |
9 |
65,604,456 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7684:Zfp609
|
UTSW |
9 |
65,638,362 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8229:Zfp609
|
UTSW |
9 |
65,610,782 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8266:Zfp609
|
UTSW |
9 |
65,610,996 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8278:Zfp609
|
UTSW |
9 |
65,604,804 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8934:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8938:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8940:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8986:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9267:Zfp609
|
UTSW |
9 |
65,608,328 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9456:Zfp609
|
UTSW |
9 |
65,611,125 (GRCm39) |
missense |
|
|
|
R9561:Zfp609
|
UTSW |
9 |
65,604,512 (GRCm39) |
nonsense |
probably null |
|
|
X0028:Zfp609
|
UTSW |
9 |
65,604,362 (GRCm39) |
small deletion |
probably benign |
|
|
| Posted On |
2014-05-07 |
Incidental Mutation