Incidental Mutation 'R3404:Zfp609'
| ID |
259285 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp609
|
| Ensembl Gene |
ENSMUSG00000040524 |
| Gene Name |
zinc finger protein 609 |
| Synonyms |
|
| MMRRC Submission |
040622-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.620)
|
| Stock # |
R3404 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
65599673-65734846 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 65608454 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 1142
(M1142K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124089
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159109]
|
| AlphaFold |
Q8BZ47 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159109
AA Change: M1142K
PolyPhen 2
Score 0.684 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000124089
Gene: ENSMUSG00000040524
AA Change: M1142K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
101 |
N/A |
INTRINSIC |
|
low complexity region
|
125 |
139 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
176 |
N/A |
INTRINSIC |
|
low complexity region
|
259 |
269 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
405 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
495 |
520 |
2.14e0 |
SMART |
|
low complexity region
|
629 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
657 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
724 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1020 |
N/A |
INTRINSIC |
|
low complexity region
|
1210 |
1219 |
N/A |
INTRINSIC |
|
low complexity region
|
1257 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1329 |
1348 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159878
|
| Meta Mutation Damage Score |
0.0699 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 93.8%
|
| Validation Efficiency |
98% (41/42) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy8 |
C |
T |
15: 64,571,449 (GRCm39) |
V1065M |
probably damaging |
Het |
| Alg12 |
A |
T |
15: 88,698,782 (GRCm39) |
I181N |
probably damaging |
Het |
| Alms1 |
C |
A |
6: 85,644,945 (GRCm39) |
|
probably benign |
Het |
| Ankar |
T |
A |
1: 72,682,252 (GRCm39) |
K1220* |
probably null |
Het |
| Apc |
A |
G |
18: 34,446,655 (GRCm39) |
T1150A |
probably benign |
Het |
| Baz1a |
C |
T |
12: 54,963,774 (GRCm39) |
S770N |
probably benign |
Het |
| Bcorl1 |
T |
A |
X: 47,459,884 (GRCm39) |
M1139K |
probably benign |
Het |
| Bdkrb2 |
T |
C |
12: 105,558,755 (GRCm39) |
V332A |
possibly damaging |
Het |
| Bnc2 |
G |
T |
4: 84,464,478 (GRCm39) |
N20K |
probably damaging |
Het |
| Brip1 |
T |
A |
11: 86,034,089 (GRCm39) |
N544I |
possibly damaging |
Het |
| Cdc27 |
T |
C |
11: 104,398,026 (GRCm39) |
E778G |
probably damaging |
Het |
| Cyp2c66 |
T |
C |
19: 39,151,771 (GRCm39) |
V162A |
probably benign |
Het |
| Dnai1 |
A |
T |
4: 41,603,246 (GRCm39) |
E176D |
probably benign |
Het |
| Dnhd1 |
C |
T |
7: 105,343,968 (GRCm39) |
Q1771* |
probably null |
Het |
| Fezf1 |
A |
T |
6: 23,247,283 (GRCm39) |
V264D |
probably benign |
Het |
| Gsdma |
T |
C |
11: 98,563,964 (GRCm39) |
|
probably benign |
Het |
| Hemk1 |
G |
A |
9: 107,214,415 (GRCm39) |
Q6* |
probably null |
Het |
| Hspa13 |
C |
A |
16: 75,554,914 (GRCm39) |
E391* |
probably null |
Het |
| Ighv1-53 |
T |
A |
12: 115,122,058 (GRCm39) |
T106S |
possibly damaging |
Het |
| Immp2l |
T |
A |
12: 41,160,846 (GRCm39) |
L48* |
probably null |
Het |
| Itgam |
A |
G |
7: 127,669,875 (GRCm39) |
|
probably null |
Het |
| Ltn1 |
A |
T |
16: 87,213,103 (GRCm39) |
V486D |
probably damaging |
Het |
| Mki67 |
T |
A |
7: 135,309,204 (GRCm39) |
T416S |
probably benign |
Het |
| Mycbp2 |
C |
A |
14: 103,437,550 (GRCm39) |
C2104F |
probably damaging |
Het |
| Nlrp2 |
T |
C |
7: 5,322,286 (GRCm39) |
D49G |
probably benign |
Het |
| Orc4 |
G |
A |
2: 48,827,501 (GRCm39) |
P31S |
probably benign |
Het |
| Pcdh17 |
T |
A |
14: 84,684,062 (GRCm39) |
D176E |
probably damaging |
Het |
| Prkd1 |
C |
T |
12: 50,695,687 (GRCm39) |
A24T |
unknown |
Het |
| Pzp |
G |
A |
6: 128,490,769 (GRCm39) |
T398M |
probably damaging |
Het |
| Rbfox3 |
T |
A |
11: 118,387,283 (GRCm39) |
Q277L |
possibly damaging |
Het |
| Rnf146 |
A |
G |
10: 29,223,424 (GRCm39) |
V154A |
possibly damaging |
Het |
| Senp7 |
T |
A |
16: 56,008,640 (GRCm39) |
W1007R |
probably damaging |
Het |
| Snx31 |
C |
T |
15: 36,525,799 (GRCm39) |
C300Y |
probably benign |
Het |
| Ticrr |
G |
C |
7: 79,344,539 (GRCm39) |
S1468T |
probably benign |
Het |
| Trim33 |
A |
G |
3: 103,228,875 (GRCm39) |
E327G |
probably damaging |
Het |
| Ubap2l |
T |
C |
3: 89,946,157 (GRCm39) |
E149G |
probably damaging |
Het |
| Ube4a |
A |
G |
9: 44,840,985 (GRCm39) |
S979P |
probably damaging |
Het |
| Uvssa |
G |
T |
5: 33,547,162 (GRCm39) |
G243C |
probably damaging |
Het |
| Vps13b |
T |
C |
15: 35,926,200 (GRCm39) |
S3834P |
probably damaging |
Het |
| Zfp729b |
T |
G |
13: 67,739,283 (GRCm39) |
H994P |
probably damaging |
Het |
|
| Other mutations in Zfp609 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00956:Zfp609
|
APN |
9 |
65,610,045 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01688:Zfp609
|
APN |
9 |
65,611,307 (GRCm39) |
missense |
probably benign |
|
|
IGL01718:Zfp609
|
APN |
9 |
65,609,682 (GRCm39) |
nonsense |
probably null |
|
|
IGL01860:Zfp609
|
APN |
9 |
65,610,116 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02441:Zfp609
|
APN |
9 |
65,610,611 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02490:Zfp609
|
APN |
9 |
65,611,250 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02614:Zfp609
|
APN |
9 |
65,610,072 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02794:Zfp609
|
APN |
9 |
65,611,602 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02959:Zfp609
|
APN |
9 |
65,610,675 (GRCm39) |
missense |
probably benign |
|
|
IGL02967:Zfp609
|
APN |
9 |
65,604,901 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL03036:Zfp609
|
APN |
9 |
65,609,927 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL03182:Zfp609
|
APN |
9 |
65,608,287 (GRCm39) |
missense |
probably benign |
0.02 |
|
H8441:Zfp609
|
UTSW |
9 |
65,702,169 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0304:Zfp609
|
UTSW |
9 |
65,608,470 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0487:Zfp609
|
UTSW |
9 |
65,609,916 (GRCm39) |
missense |
unknown |
|
|
R0505:Zfp609
|
UTSW |
9 |
65,610,744 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0684:Zfp609
|
UTSW |
9 |
65,638,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1480:Zfp609
|
UTSW |
9 |
65,610,593 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1507:Zfp609
|
UTSW |
9 |
65,702,059 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1579:Zfp609
|
UTSW |
9 |
65,611,754 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1655:Zfp609
|
UTSW |
9 |
65,610,836 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1692:Zfp609
|
UTSW |
9 |
65,702,593 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Zfp609
|
UTSW |
9 |
65,638,282 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1735:Zfp609
|
UTSW |
9 |
65,610,374 (GRCm39) |
nonsense |
probably null |
|
|
R1883:Zfp609
|
UTSW |
9 |
65,702,040 (GRCm39) |
missense |
probably benign |
|
|
R1970:Zfp609
|
UTSW |
9 |
65,702,559 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2059:Zfp609
|
UTSW |
9 |
65,611,716 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2302:Zfp609
|
UTSW |
9 |
65,702,179 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3405:Zfp609
|
UTSW |
9 |
65,608,454 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4514:Zfp609
|
UTSW |
9 |
65,610,977 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4533:Zfp609
|
UTSW |
9 |
65,610,890 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5043:Zfp609
|
UTSW |
9 |
65,608,109 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5499:Zfp609
|
UTSW |
9 |
65,610,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7081:Zfp609
|
UTSW |
9 |
65,609,723 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7514:Zfp609
|
UTSW |
9 |
65,613,418 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7677:Zfp609
|
UTSW |
9 |
65,604,456 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7684:Zfp609
|
UTSW |
9 |
65,638,362 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8229:Zfp609
|
UTSW |
9 |
65,610,782 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8266:Zfp609
|
UTSW |
9 |
65,610,996 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8278:Zfp609
|
UTSW |
9 |
65,604,804 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8934:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8938:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8940:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8986:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9267:Zfp609
|
UTSW |
9 |
65,608,328 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9456:Zfp609
|
UTSW |
9 |
65,611,125 (GRCm39) |
missense |
|
|
|
R9561:Zfp609
|
UTSW |
9 |
65,604,512 (GRCm39) |
nonsense |
probably null |
|
|
X0028:Zfp609
|
UTSW |
9 |
65,604,362 (GRCm39) |
small deletion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGGCACATGGACACTTGG -3'
(R):5'- ACTGATGGTGTCACTGTTTCTC -3'
Sequencing Primer
(F):5'- AGGCGGGATTCCTCAGATG -3'
(R):5'- CATGACAGGGTCTCGCTATG -3'
|
| Posted On |
2015-01-23 |
Incidental Mutation