Incidental Mutation 'R2190:Ntsr2'
ID 238050
Institutional Source Beutler Lab
Gene Symbol Ntsr2
Ensembl Gene ENSMUSG00000020591
Gene Name neurotensin receptor 2
Synonyms NTRL, NT2R
MMRRC Submission 040192-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R2190 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 16703477-16710223 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 16704018 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 173 (I173N)
Ref Sequence ENSEMBL: ENSMUSP00000152290 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111064] [ENSMUST00000220892] [ENSMUST00000221049] [ENSMUST00000221596]
AlphaFold P70310
Predicted Effect probably damaging
Transcript: ENSMUST00000111064
AA Change: I173N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000106693
Gene: ENSMUSG00000020591
AA Change: I173N

DomainStartEndE-ValueType
Pfam:7tm_1 49 358 4.2e-41 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000220892
AA Change: I173N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000221049
AA Change: I87N

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000221596
AA Change: I173N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222957
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice exhibit abnormal thermal nociception. Mice homozygous for different knock-out allele exhibit increased prepulse inhibition and decreased accoustic startle response. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars1 A T 8: 111,766,785 (GRCm39) T56S probably damaging Het
Acbd6 A T 1: 155,500,652 (GRCm39) H204L probably damaging Het
Acnat2 T A 4: 49,383,551 (GRCm39) M1L probably benign Het
Adgrg5 A T 8: 95,660,579 (GRCm39) I73F probably damaging Het
Ankrd52 A G 10: 128,219,487 (GRCm39) T474A probably benign Het
Arid3a A G 10: 79,782,365 (GRCm39) D252G possibly damaging Het
Aspg G T 12: 112,091,322 (GRCm39) E501D probably damaging Het
Bicral A G 17: 47,136,049 (GRCm39) I387T probably damaging Het
Bub1 T C 2: 127,652,645 (GRCm39) N574S probably benign Het
Casr G A 16: 36,315,778 (GRCm39) T764M probably damaging Het
Ccdc60 A G 5: 116,295,639 (GRCm39) S259P probably damaging Het
Ccne2 A T 4: 11,197,241 (GRCm39) N181I probably benign Het
Chd4 A G 6: 125,091,260 (GRCm39) D89G probably benign Het
Col25a1 C T 3: 130,378,364 (GRCm39) P606S probably damaging Het
Dcc A G 18: 71,680,491 (GRCm39) S582P possibly damaging Het
Dlg4 A G 11: 69,933,430 (GRCm39) D619G probably damaging Het
Elavl2 C T 4: 91,152,331 (GRCm39) V129I probably benign Het
Epha3 A G 16: 63,366,552 (GRCm39) I965T probably benign Het
Fbxw16 G A 9: 109,265,739 (GRCm39) S360L probably damaging Het
Fgf14 T C 14: 124,221,330 (GRCm39) Y158C probably damaging Het
Gm44511 A G 6: 128,803,163 (GRCm39) I16T possibly damaging Het
Has2 C A 15: 56,531,183 (GRCm39) V511F probably benign Het
Heatr5b G A 17: 79,109,185 (GRCm39) R1025C probably damaging Het
Hsd17b12 T C 2: 93,864,408 (GRCm39) Y233C probably benign Het
Il36rn A T 2: 24,170,831 (GRCm39) I43F probably damaging Het
Inpp5b T A 4: 124,678,988 (GRCm39) I465N probably damaging Het
Irak2 T A 6: 113,663,904 (GRCm39) N423K probably damaging Het
Itga2 C A 13: 115,007,141 (GRCm39) V396L probably benign Het
Itprid1 A G 6: 55,874,685 (GRCm39) T212A possibly damaging Het
Lipo2 A T 19: 33,725,969 (GRCm39) N94K probably damaging Het
Lrrc37a T C 11: 103,390,869 (GRCm39) T1519A possibly damaging Het
Macf1 A G 4: 123,353,005 (GRCm39) V1558A probably benign Het
Mocos C A 18: 24,797,114 (GRCm39) H91Q probably benign Het
Myh14 G A 7: 44,310,487 (GRCm39) T132I probably damaging Het
Nlrp2 A T 7: 5,322,237 (GRCm39) D803E possibly damaging Het
Or14c43 A G 7: 86,115,573 (GRCm39) Y318C possibly damaging Het
Or5b105 T G 19: 13,079,857 (GRCm39) K270N probably damaging Het
Pitx3 T C 19: 46,125,486 (GRCm39) Y86C probably damaging Het
Pkp1 T C 1: 135,807,709 (GRCm39) S520G probably benign Het
Pygo1 C T 9: 72,852,529 (GRCm39) Q239* probably null Het
Rab13 A G 3: 90,130,851 (GRCm39) E68G probably damaging Het
Rfx7 A G 9: 72,525,201 (GRCm39) E797G probably benign Het
Slc5a1 T C 5: 33,261,937 (GRCm39) probably null Het
Slco1c1 A G 6: 141,508,893 (GRCm39) T518A probably benign Het
Spint1 A G 2: 119,068,661 (GRCm39) I132V probably benign Het
Stard9 T A 2: 120,544,601 (GRCm39) I4514N probably benign Het
Tenm3 T G 8: 48,848,579 (GRCm39) S87R probably damaging Het
Thap4 G T 1: 93,678,381 (GRCm39) P135Q probably damaging Het
Tmed9 A G 13: 55,741,156 (GRCm39) E57G probably benign Het
Tnrc18 C T 5: 142,761,644 (GRCm39) V594I unknown Het
Trmt1 A T 8: 85,416,470 (GRCm39) K64* probably null Het
Usf2 A G 7: 30,654,606 (GRCm39) V198A probably damaging Het
Usp14 A T 18: 10,007,835 (GRCm39) C168S probably damaging Het
Vav3 C A 3: 109,470,130 (GRCm39) T525K probably damaging Het
Vmn1r52 A G 6: 90,156,151 (GRCm39) I152V probably benign Het
Vmn2r81 A G 10: 79,104,085 (GRCm39) D236G possibly damaging Het
Wdr19 G A 5: 65,401,509 (GRCm39) V975I possibly damaging Het
Other mutations in Ntsr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00482:Ntsr2 APN 12 16,709,849 (GRCm39) missense probably damaging 0.97
IGL01973:Ntsr2 APN 12 16,706,775 (GRCm39) missense probably benign 0.01
IGL02202:Ntsr2 APN 12 16,703,661 (GRCm39) missense probably damaging 0.99
IGL02493:Ntsr2 APN 12 16,708,390 (GRCm39) missense possibly damaging 0.90
IGL02837:Ntsr2 UTSW 12 16,703,876 (GRCm39) missense probably damaging 0.99
R0066:Ntsr2 UTSW 12 16,704,120 (GRCm39) missense probably benign 0.09
R0066:Ntsr2 UTSW 12 16,704,120 (GRCm39) missense probably benign 0.09
R0381:Ntsr2 UTSW 12 16,709,719 (GRCm39) nonsense probably null
R0437:Ntsr2 UTSW 12 16,703,696 (GRCm39) missense probably damaging 1.00
R0666:Ntsr2 UTSW 12 16,703,981 (GRCm39) missense probably benign 0.28
R0751:Ntsr2 UTSW 12 16,704,031 (GRCm39) missense probably damaging 1.00
R1919:Ntsr2 UTSW 12 16,704,111 (GRCm39) missense probably damaging 0.96
R5323:Ntsr2 UTSW 12 16,709,934 (GRCm39) missense probably benign 0.00
R5358:Ntsr2 UTSW 12 16,704,083 (GRCm39) missense probably damaging 1.00
R6282:Ntsr2 UTSW 12 16,708,426 (GRCm39) missense probably damaging 1.00
R6358:Ntsr2 UTSW 12 16,706,769 (GRCm39) missense probably benign 0.29
R6523:Ntsr2 UTSW 12 16,706,697 (GRCm39) missense probably benign 0.05
R6837:Ntsr2 UTSW 12 16,709,710 (GRCm39) missense probably benign 0.04
R8396:Ntsr2 UTSW 12 16,706,821 (GRCm39) missense probably damaging 1.00
R8418:Ntsr2 UTSW 12 16,706,662 (GRCm39) missense possibly damaging 0.83
R8784:Ntsr2 UTSW 12 16,706,852 (GRCm39) missense probably damaging 0.99
RF017:Ntsr2 UTSW 12 16,709,766 (GRCm39) missense probably damaging 0.99
X0064:Ntsr2 UTSW 12 16,706,758 (GRCm39) missense probably damaging 1.00
Z1177:Ntsr2 UTSW 12 16,703,663 (GRCm39) missense possibly damaging 0.84
Predicted Primers PCR Primer
(F):5'- TCGTGGCTATTACTTCGTGC -3'
(R):5'- CCCTGGAGGAGTTGCTTTAG -3'

Sequencing Primer
(F):5'- GGCTATTACTTCGTGCGTGAG -3'
(R):5'- ACTACCCCAGTGTGTGTGTG -3'
Posted On 2014-10-02