Incidental Mutation 'R2410:Rab14'
ID 249940
Institutional Source Beutler Lab
Gene Symbol Rab14
Ensembl Gene ENSMUSG00000026878
Gene Name RAB14, member RAS oncogene family
Synonyms 2810475J17Rik, 0610030G24Rik, D030017L14Rik, A830021G03Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.913) question?
Stock # R2410 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 35070217-35091132 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 35076762 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000155278 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028238] [ENSMUST00000113025] [ENSMUST00000230751]
AlphaFold Q91V41
Predicted Effect probably null
Transcript: ENSMUST00000028238
SMART Domains Protein: ENSMUSP00000028238
Gene: ENSMUSG00000026878

DomainStartEndE-ValueType
RAB 12 175 1.4e-109 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000113025
SMART Domains Protein: ENSMUSP00000108648
Gene: ENSMUSG00000026878

DomainStartEndE-ValueType
RAB 12 151 5.28e-78 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137709
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142015
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148543
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155359
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155483
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202602
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201694
Predicted Effect probably null
Transcript: ENSMUST00000230751
Predicted Effect probably null
Transcript: ENSMUST00000230657
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik G T 11: 109,684,980 (GRCm39) C172* probably null Het
Adgrf5 C A 17: 43,766,157 (GRCm39) N1326K probably benign Het
Ciita A G 16: 10,328,568 (GRCm39) E284G probably damaging Het
Ctbp2 T C 7: 132,616,083 (GRCm39) Y284C probably benign Het
Dnah11 T C 12: 117,991,262 (GRCm39) D2368G probably damaging Het
Enpp3 C T 10: 24,650,716 (GRCm39) V807I probably benign Het
Erich3 A G 3: 154,439,240 (GRCm39) D491G probably damaging Het
Ero1a C T 14: 45,542,723 (GRCm39) V101I possibly damaging Het
Fbxl7 A G 15: 26,895,111 (GRCm39) Y9H possibly damaging Het
Fzd2 A G 11: 102,496,453 (GRCm39) Y299C possibly damaging Het
Lamc1 G A 1: 153,123,141 (GRCm39) T683M possibly damaging Het
Lrrc39 C T 3: 116,374,899 (GRCm39) P327S probably benign Het
Marf1 A T 16: 13,933,691 (GRCm39) F1566I probably benign Het
Me2 A T 18: 73,924,183 (GRCm39) M343K probably damaging Het
Mlxip T A 5: 123,581,132 (GRCm39) W260R probably damaging Het
Mrps17 T C 5: 129,795,047 (GRCm39) V64A probably damaging Het
Or4c118 A T 2: 88,974,899 (GRCm39) I156N possibly damaging Het
Phldb3 C T 7: 24,323,719 (GRCm39) S450L probably benign Het
Pi4k2a A G 19: 42,093,316 (GRCm39) E219G possibly damaging Het
Polr1a T C 6: 71,951,866 (GRCm39) S1478P probably benign Het
Rnf43 T C 11: 87,623,085 (GRCm39) Y729H possibly damaging Het
Sgms1 G A 19: 32,137,072 (GRCm39) R165* probably null Het
Sorbs1 T A 19: 40,361,959 (GRCm39) I142F probably damaging Het
Tmem255b A G 8: 13,491,278 (GRCm39) I66V probably benign Het
Vmn2r9 T C 5: 108,996,123 (GRCm39) D175G probably damaging Het
Zfp954 A T 7: 7,120,808 (GRCm39) I74N probably benign Het
Other mutations in Rab14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Rab14 APN 2 35,073,398 (GRCm39) splice site probably benign
R1676:Rab14 UTSW 2 35,076,735 (GRCm39) missense possibly damaging 0.47
R4832:Rab14 UTSW 2 35,079,978 (GRCm39) missense probably damaging 1.00
R5537:Rab14 UTSW 2 35,082,649 (GRCm39) missense possibly damaging 0.61
R7061:Rab14 UTSW 2 35,073,429 (GRCm39) nonsense probably null
R7701:Rab14 UTSW 2 35,073,427 (GRCm39) missense
R9779:Rab14 UTSW 2 35,080,047 (GRCm39) missense
Z1176:Rab14 UTSW 2 35,076,719 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AGGGAATGGTCTCTTAATCTTAGCAC -3'
(R):5'- TGGAGTAGCCATCTCATCAAAG -3'

Sequencing Primer
(F):5'- TCTCTTAATCTTAGCACCCAAATAAC -3'
(R):5'- TGAGACTGTTGTACAAGCCATG -3'
Posted On 2014-11-12