Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00954:Vmn2r24'

27670

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r24

Ensembl Gene

ENSMUSG00000072780

Gene Name

vomeronasal 2, receptor 24

Synonyms

EG243628

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL00954

Quality Score

Status

Chromosome

Chromosomal Location

123755930-123793239 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 123792596 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 641 (C641Y)

Ref Sequence

ENSEMBL: ENSMUSP00000074602 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075095]

AlphaFold

D3YUI0

Predicted Effect

probably damaging
Transcript: ENSMUST00000075095
AA Change: C641Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: C641Y

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	1.6e-32	PFAM
Pfam:NCD3G	518	571	1.1e-22	PFAM
Pfam:7tm_3	602	839	1.1e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim3	C	T	18: 61,972,756 (GRCm39)		probably benign	Het
Alox5	A	T	6: 116,431,260 (GRCm39)	V56D	probably damaging	Het
Atp1a2	A	G	1: 172,118,201 (GRCm39)	S158P	probably damaging	Het
B3glct	T	A	5: 149,619,902 (GRCm39)	M19K	probably benign	Het
BC049715	A	T	6: 136,817,093 (GRCm39)	E111V	possibly damaging	Het
Casp8ap2	C	A	4: 32,645,403 (GRCm39)	T1492K	probably damaging	Het
Cfap221	T	C	1: 119,861,939 (GRCm39)	E612G	probably damaging	Het
Cttnbp2	C	A	6: 18,381,061 (GRCm39)	K868N	possibly damaging	Het
Dpy19l2	T	A	9: 24,494,114 (GRCm39)	N672I	probably damaging	Het
Ei24	A	T	9: 36,701,166 (GRCm39)	I51N	probably damaging	Het
Gdi2	T	C	13: 3,606,467 (GRCm39)	V181A	probably benign	Het
Ggt1	G	A	10: 75,420,697 (GRCm39)	R354Q	probably benign	Het
Hao1	A	G	2: 134,340,181 (GRCm39)	I370T	possibly damaging	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Jag2	G	T	12: 112,884,026 (GRCm39)	S184R	possibly damaging	Het
Kctd16	A	G	18: 40,391,853 (GRCm39)	D147G	probably benign	Het
Kiss1r	T	C	10: 79,757,834 (GRCm39)	L396P	probably damaging	Het
Krt86	C	T	15: 101,371,741 (GRCm39)	H104Y	probably benign	Het
Lrrc66	G	T	5: 73,765,741 (GRCm39)	T434K	possibly damaging	Het
Macroh2a1	A	G	13: 56,222,132 (GRCm39)	S340P	possibly damaging	Het
Mcm5	A	T	8: 75,836,740 (GRCm39)	N64Y	possibly damaging	Het
Mroh2b	A	T	15: 4,932,536 (GRCm39)	Y54F	probably damaging	Het
Or10al6	T	A	17: 38,083,505 (GRCm39)	N329K	probably benign	Het
Or7g18	T	A	9: 18,787,369 (GRCm39)	S249T	probably benign	Het
Osgep	T	A	14: 51,153,619 (GRCm39)	I320F	probably benign	Het
Pcdh18	T	A	3: 49,710,838 (GRCm39)	D159V	probably damaging	Het
Phf20l1	G	A	15: 66,513,757 (GRCm39)	V978I	probably damaging	Het
Phospho1	T	A	11: 95,721,909 (GRCm39)	V193E	probably damaging	Het
Pip4k2b	T	C	11: 97,635,331 (GRCm39)	K34E	probably damaging	Het
Plb1	T	C	5: 32,455,858 (GRCm39)		probably benign	Het
Safb2	A	G	17: 56,885,639 (GRCm39)		probably null	Het
Sgsh	T	A	11: 119,237,311 (GRCm39)	E434D	probably benign	Het
Tkt	C	T	14: 30,291,052 (GRCm39)	H355Y	probably damaging	Het
Tmem128	A	G	5: 38,419,389 (GRCm39)	N47S	probably damaging	Het
Tmem232	A	G	17: 65,807,148 (GRCm39)	I15T	probably damaging	Het
Tns1	A	C	1: 73,964,128 (GRCm39)	V1501G	probably damaging	Het
Vmn2r77	A	G	7: 86,449,975 (GRCm39)	T74A	probably benign	Het
Zfp820	T	C	17: 22,038,860 (GRCm39)	Y156C	probably damaging	Het

Other mutations in Vmn2r24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01382:Vmn2r24	APN	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
IGL01592:Vmn2r24	APN	6	123,764,445 (GRCm39)	missense	probably benign	0.30
IGL01754:Vmn2r24	APN	6	123,781,120 (GRCm39)	missense	probably damaging	1.00
IGL01939:Vmn2r24	APN	6	123,764,404 (GRCm39)	missense	probably benign
IGL02140:Vmn2r24	APN	6	123,757,631 (GRCm39)	missense	probably damaging	0.98
IGL02272:Vmn2r24	APN	6	123,763,843 (GRCm39)	missense	possibly damaging	0.94
IGL02568:Vmn2r24	APN	6	123,792,812 (GRCm39)	missense	probably benign	0.36
IGL02748:Vmn2r24	APN	6	123,793,057 (GRCm39)	missense	possibly damaging	0.90
IGL03022:Vmn2r24	APN	6	123,755,967 (GRCm39)	missense	probably damaging	0.99
IGL03343:Vmn2r24	APN	6	123,793,070 (GRCm39)	missense	probably damaging	1.00
R0357:Vmn2r24	UTSW	6	123,792,369 (GRCm39)	frame shift	probably null
R0453:Vmn2r24	UTSW	6	123,757,350 (GRCm39)	critical splice acceptor site	probably null
R0538:Vmn2r24	UTSW	6	123,793,012 (GRCm39)	missense	probably benign	0.32
R0607:Vmn2r24	UTSW	6	123,763,893 (GRCm39)	missense	probably benign
R1381:Vmn2r24	UTSW	6	123,763,692 (GRCm39)	missense	probably damaging	1.00
R1589:Vmn2r24	UTSW	6	123,783,479 (GRCm39)	splice site	probably benign
R1848:Vmn2r24	UTSW	6	123,793,183 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r24	UTSW	6	123,793,019 (GRCm39)	missense	probably damaging	1.00
R2077:Vmn2r24	UTSW	6	123,792,358 (GRCm39)	missense	probably damaging	1.00
R2122:Vmn2r24	UTSW	6	123,792,353 (GRCm39)	missense	possibly damaging	0.81
R2145:Vmn2r24	UTSW	6	123,755,972 (GRCm39)	missense	probably benign
R2483:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R2512:Vmn2r24	UTSW	6	123,763,985 (GRCm39)	missense	probably benign	0.01
R3001:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3002:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3236:Vmn2r24	UTSW	6	123,755,984 (GRCm39)	nonsense	probably null
R3623:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3624:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3835:Vmn2r24	UTSW	6	123,764,412 (GRCm39)	missense	probably benign	0.33
R4074:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4075:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4812:Vmn2r24	UTSW	6	123,756,144 (GRCm39)	missense	probably benign	0.00
R4825:Vmn2r24	UTSW	6	123,792,739 (GRCm39)	missense	probably benign	0.02
R5351:Vmn2r24	UTSW	6	123,793,223 (GRCm39)	missense	possibly damaging	0.80
R5665:Vmn2r24	UTSW	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
R5790:Vmn2r24	UTSW	6	123,792,499 (GRCm39)	missense	probably benign
R5808:Vmn2r24	UTSW	6	123,792,597 (GRCm39)	nonsense	probably null
R5879:Vmn2r24	UTSW	6	123,764,226 (GRCm39)	missense	possibly damaging	0.89
R5923:Vmn2r24	UTSW	6	123,792,751 (GRCm39)	missense	probably damaging	0.96
R5969:Vmn2r24	UTSW	6	123,755,981 (GRCm39)	missense	probably benign	0.00
R6050:Vmn2r24	UTSW	6	123,792,691 (GRCm39)	missense	probably damaging	1.00
R6171:Vmn2r24	UTSW	6	123,764,205 (GRCm39)	missense	probably damaging	0.98
R6174:Vmn2r24	UTSW	6	123,793,236 (GRCm39)	missense	probably benign	0.00
R6356:Vmn2r24	UTSW	6	123,783,368 (GRCm39)	missense	possibly damaging	0.93
R6562:Vmn2r24	UTSW	6	123,757,386 (GRCm39)	missense	probably benign	0.01
R6563:Vmn2r24	UTSW	6	123,781,137 (GRCm39)	missense	possibly damaging	0.86
R6584:Vmn2r24	UTSW	6	123,792,764 (GRCm39)	missense	possibly damaging	0.53
R6630:Vmn2r24	UTSW	6	123,763,981 (GRCm39)	missense	probably benign	0.00
R6803:Vmn2r24	UTSW	6	123,755,960 (GRCm39)	missense	possibly damaging	0.64
R6864:Vmn2r24	UTSW	6	123,756,117 (GRCm39)	missense	possibly damaging	0.89
R7252:Vmn2r24	UTSW	6	123,764,191 (GRCm39)	missense	possibly damaging	0.90
R7369:Vmn2r24	UTSW	6	123,792,638 (GRCm39)	missense	probably damaging	0.99
R7646:Vmn2r24	UTSW	6	123,793,169 (GRCm39)	missense	probably benign	0.20
R7799:Vmn2r24	UTSW	6	123,757,422 (GRCm39)	missense	probably benign	0.00
R7803:Vmn2r24	UTSW	6	123,757,438 (GRCm39)	missense	probably benign	0.00
R7959:Vmn2r24	UTSW	6	123,755,949 (GRCm39)	missense	possibly damaging	0.86
R8215:Vmn2r24	UTSW	6	123,756,077 (GRCm39)	missense	probably benign	0.10
R8796:Vmn2r24	UTSW	6	123,757,500 (GRCm39)	missense	probably benign
R9172:Vmn2r24	UTSW	6	123,783,432 (GRCm39)	missense	probably damaging	1.00
R9300:Vmn2r24	UTSW	6	123,793,030 (GRCm39)	missense	possibly damaging	0.46
R9369:Vmn2r24	UTSW	6	123,792,357 (GRCm39)	missense	probably damaging	1.00
R9375:Vmn2r24	UTSW	6	123,792,542 (GRCm39)	missense	probably damaging	1.00
R9523:Vmn2r24	UTSW	6	123,763,950 (GRCm39)	missense	possibly damaging	0.89
R9546:Vmn2r24	UTSW	6	123,764,266 (GRCm39)	missense	probably damaging	0.98
RF006:Vmn2r24	UTSW	6	123,783,378 (GRCm39)	missense	probably damaging	1.00
RF016:Vmn2r24	UTSW	6	123,781,174 (GRCm39)	missense	probably benign	0.04
X0023:Vmn2r24	UTSW	6	123,764,359 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r24	UTSW	6	123,781,155 (GRCm39)	missense	probably benign	0.00
Z1177:Vmn2r24	UTSW	6	123,763,719 (GRCm39)	missense	probably benign	0.00

Posted On

2013-04-17