Incidental Mutation 'R3875:Drd5'
ID 276782
Institutional Source Beutler Lab
Gene Symbol Drd5
Ensembl Gene ENSMUSG00000039358
Gene Name dopamine receptor D5
Synonyms DRD1b, Drd-5, Drd1b, D5R, Gpcr1
MMRRC Submission 068967-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R3875 (G1)
Quality Score 215
Status Validated
Chromosome 5
Chromosomal Location 38476742-38479868 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 38477157 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 50 (V50G)
Ref Sequence ENSEMBL: ENSMUSP00000039691 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041646]
AlphaFold Q8BLD9
Predicted Effect possibly damaging
Transcript: ENSMUST00000041646
AA Change: V50G

PolyPhen 2 Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000039691
Gene: ENSMUSG00000039358
AA Change: V50G

DomainStartEndE-ValueType
low complexity region 26 37 N/A INTRINSIC
Pfam:7TM_GPCR_Srx 47 177 5.5e-7 PFAM
Pfam:7TM_GPCR_Srsx 49 179 1e-7 PFAM
Pfam:7tm_1 55 354 1.5e-74 PFAM
Pfam:7TM_GPCR_Srsx 210 368 2.4e-6 PFAM
low complexity region 419 430 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181240
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice develop hypertension and exhibit elevated blood pressure caused by increased sympathetic tone. Mice homozygous for another knock-out allele exhibit increased methamphetamine-induced ambulatory activity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik T C 2: 152,276,000 (GRCm39) S72P probably benign Het
Abca5 T A 11: 110,201,059 (GRCm39) Y447F probably damaging Het
Adgrg2 A G X: 159,261,992 (GRCm39) S337G probably benign Het
Akap12 G A 10: 4,307,590 (GRCm39) V1467I probably benign Het
Baz2a T A 10: 127,959,979 (GRCm39) M1419K probably damaging Het
Cacna1g G A 11: 94,328,749 (GRCm39) T1033I probably damaging Het
Car12 C A 9: 66,624,834 (GRCm39) probably benign Het
Cpne1 G A 2: 155,918,202 (GRCm39) H352Y probably damaging Het
D630039A03Rik T A 4: 57,910,606 (GRCm39) T69S probably benign Het
Dhodh T C 8: 110,321,592 (GRCm39) D310G probably null Het
Dnah2 A G 11: 69,320,174 (GRCm39) I3965T probably damaging Het
Dst C A 1: 34,210,328 (GRCm39) H934Q probably damaging Het
Eif1ad10 T C 12: 88,216,476 (GRCm39) D132G unknown Het
Far2 G A 6: 148,052,089 (GRCm39) E123K probably benign Het
Fbxo43 A T 15: 36,162,249 (GRCm39) F319L probably benign Het
Flii T C 11: 60,611,318 (GRCm39) S418G probably benign Het
Glyctk T A 9: 106,034,820 (GRCm39) Y82F probably damaging Het
Gm11353 G T 13: 26,676,651 (GRCm39) noncoding transcript Het
Gm6505 T A 3: 28,819,286 (GRCm39) noncoding transcript Het
Gpr151 A G 18: 42,711,661 (GRCm39) V339A probably benign Het
H2-T22 T C 17: 36,351,195 (GRCm39) I296V probably benign Het
Igfn1 T C 1: 135,882,352 (GRCm39) N2831S probably damaging Het
Igkv13-85 A G 6: 68,907,484 (GRCm39) V39A probably damaging Het
Irx5 A G 8: 93,086,793 (GRCm39) T242A probably benign Het
Krt26 T C 11: 99,225,570 (GRCm39) K304E probably damaging Het
Mcoln1 A G 8: 3,558,355 (GRCm39) D203G probably benign Het
Mlph T C 1: 90,855,844 (GRCm39) C57R probably damaging Het
Myh13 C A 11: 67,249,020 (GRCm39) H1275Q probably benign Het
Nbeal1 T A 1: 60,233,758 (GRCm39) probably benign Het
Orc5 T A 5: 22,742,564 (GRCm39) M115L probably benign Het
Pcdha6 T A 18: 37,101,119 (GRCm39) I104N probably damaging Het
Plcb4 T C 2: 135,844,552 (GRCm39) S157P probably damaging Het
Polq A G 16: 36,894,389 (GRCm39) D1787G probably damaging Het
Prkar2b T G 12: 32,015,122 (GRCm39) I142L probably benign Het
Ptprq A G 10: 107,520,965 (GRCm39) S736P possibly damaging Het
Qrich2 A T 11: 116,336,477 (GRCm39) V2046D probably damaging Het
Rad21 A T 15: 51,833,361 (GRCm39) F373I probably damaging Het
Rcvrn A G 11: 67,590,880 (GRCm39) I155V probably benign Het
Rsrc2 C T 5: 123,874,691 (GRCm39) probably benign Het
Sgsh A G 11: 119,241,773 (GRCm39) L111P probably damaging Het
Ssc5d A T 7: 4,930,261 (GRCm39) D114V probably damaging Het
St6gal2 C A 17: 55,789,698 (GRCm39) P244Q probably benign Het
Tarbp1 A G 8: 127,165,538 (GRCm39) probably benign Het
Tmem221 T C 8: 72,008,399 (GRCm39) probably null Het
Trh A T 6: 92,220,679 (GRCm39) V61E possibly damaging Het
Trim32 A T 4: 65,531,703 (GRCm39) I87F possibly damaging Het
Tti2 A G 8: 31,641,175 (GRCm39) K100E probably benign Het
Usp34 C T 11: 23,439,033 (GRCm39) P3532S possibly damaging Het
Vps13d A G 4: 144,917,114 (GRCm39) Y17H probably damaging Het
Zfp106 T C 2: 120,365,094 (GRCm39) K438E probably benign Het
Zfp60 T C 7: 27,449,006 (GRCm39) I558T probably damaging Het
Zzef1 A C 11: 72,779,866 (GRCm39) I1880L probably benign Het
Other mutations in Drd5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03153:Drd5 APN 5 38,477,124 (GRCm39) missense probably benign 0.25
PIT4305001:Drd5 UTSW 5 38,477,927 (GRCm39) missense probably damaging 1.00
R0051:Drd5 UTSW 5 38,477,957 (GRCm39) missense probably benign 0.39
R0051:Drd5 UTSW 5 38,477,957 (GRCm39) missense probably benign 0.39
R0571:Drd5 UTSW 5 38,477,270 (GRCm39) missense probably damaging 1.00
R1507:Drd5 UTSW 5 38,478,065 (GRCm39) missense probably damaging 1.00
R1663:Drd5 UTSW 5 38,478,198 (GRCm39) missense probably benign 0.02
R1777:Drd5 UTSW 5 38,477,504 (GRCm39) missense probably damaging 1.00
R1932:Drd5 UTSW 5 38,477,319 (GRCm39) missense probably benign 0.14
R1986:Drd5 UTSW 5 38,477,456 (GRCm39) missense probably damaging 0.99
R2047:Drd5 UTSW 5 38,477,679 (GRCm39) missense probably damaging 1.00
R5033:Drd5 UTSW 5 38,477,544 (GRCm39) missense probably damaging 1.00
R5201:Drd5 UTSW 5 38,477,366 (GRCm39) missense probably damaging 0.96
R5255:Drd5 UTSW 5 38,477,310 (GRCm39) missense probably damaging 1.00
R5393:Drd5 UTSW 5 38,478,248 (GRCm39) missense probably benign
R5639:Drd5 UTSW 5 38,477,178 (GRCm39) missense possibly damaging 0.81
R7241:Drd5 UTSW 5 38,477,879 (GRCm39) missense probably damaging 1.00
R7520:Drd5 UTSW 5 38,478,195 (GRCm39) missense probably benign 0.00
R7739:Drd5 UTSW 5 38,477,421 (GRCm39) missense probably damaging 1.00
R8300:Drd5 UTSW 5 38,477,672 (GRCm39) missense probably damaging 0.99
R8746:Drd5 UTSW 5 38,477,433 (GRCm39) missense probably benign 0.04
R8829:Drd5 UTSW 5 38,477,078 (GRCm39) missense probably benign 0.08
R8832:Drd5 UTSW 5 38,477,078 (GRCm39) missense probably benign 0.08
R8870:Drd5 UTSW 5 38,477,747 (GRCm39) missense possibly damaging 0.76
R9600:Drd5 UTSW 5 38,478,174 (GRCm39) missense possibly damaging 0.79
R9705:Drd5 UTSW 5 38,478,027 (GRCm39) missense probably damaging 1.00
R9717:Drd5 UTSW 5 38,478,090 (GRCm39) missense probably damaging 1.00
Z1177:Drd5 UTSW 5 38,477,729 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- AAGGATCCCAAGCAGTGCAG -3'
(R):5'- TGTCGCAGAATGCCCCAAAG -3'

Sequencing Primer
(F):5'- AAGTTGGGATCGCACGC -3'
(R):5'- CAATGCCACGAAGAGGT -3'
Posted On 2015-04-06