Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02512:Or10ag58'

296575

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10ag58

Ensembl Gene

ENSMUSG00000050772

Gene Name

olfactory receptor family 10 subfamily AG member 58

Synonyms

GA_x6K02T2Q125-48936945-48937901, Olfr1124, GA_x6K02T2Q125-48935224-48935664, Olfr1125, MOR264-24, MOR264-3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL02512

Quality Score

Status

Chromosome

Chromosomal Location

87264833-87265789 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 87265402 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Methionine at position 190 (I190M)

Ref Sequence

ENSEMBL: ENSMUSP00000150244 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062494] [ENSMUST00000215909]

AlphaFold

A2AT86

Predicted Effect

possibly damaging
Transcript: ENSMUST00000062494
AA Change: I190M

PolyPhen 2 Score 0.592 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000062513
Gene: ENSMUSG00000050772
AA Change: I190M

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	314	4.2e-52	PFAM
Pfam:7tm_1	47	296	2.4e-21	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215909
AA Change: I190M

PolyPhen 2 Score 0.592 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alg10b	C	A	15: 90,111,752 (GRCm39)	H199N	probably benign	Het
Ankrd13a	T	A	5: 114,924,827 (GRCm39)	M104K	probably benign	Het
Ankrd37	A	G	8: 46,452,325 (GRCm39)	L48P	probably damaging	Het
Ankzf1	T	A	1: 75,169,222 (GRCm39)	L43M	probably damaging	Het
Ano10	A	C	9: 122,101,540 (GRCm39)	V77G	possibly damaging	Het
Arg2	G	A	12: 79,194,517 (GRCm39)	V114I	probably benign	Het
Asah1	A	C	8: 41,813,344 (GRCm39)		probably benign	Het
Clpx	A	C	9: 65,217,533 (GRCm39)	I34L	probably benign	Het
Cnga2	G	A	X: 71,052,531 (GRCm39)	V469I	probably damaging	Het
Dock9	A	T	14: 121,856,950 (GRCm39)		probably benign	Het
Eaf1	A	G	14: 31,219,743 (GRCm39)	T61A	possibly damaging	Het
Exoc3l	T	A	8: 106,017,115 (GRCm39)	D624V	probably damaging	Het
Fancd2	A	G	6: 113,547,904 (GRCm39)	D927G	probably damaging	Het
Fbn1	A	T	2: 125,180,380 (GRCm39)	Y1801N	probably damaging	Het
Garnl3	A	G	2: 32,921,150 (GRCm39)	Y292H	probably damaging	Het
Gpr174	A	T	X: 106,336,577 (GRCm39)	K130*	probably null	Het
Greb1	C	T	12: 16,742,713 (GRCm39)	V1379I	possibly damaging	Het
Grik2	A	T	10: 49,232,008 (GRCm39)	D507E	probably benign	Het
Gsn	A	T	2: 35,173,962 (GRCm39)	K24*	probably null	Het
Ift80	A	G	3: 68,835,058 (GRCm39)		probably null	Het
Inpp5j	T	A	11: 3,449,661 (GRCm39)	Y707F	probably damaging	Het
Ints13	A	T	6: 146,477,855 (GRCm39)	D31E	probably damaging	Het
Kcnh1	T	C	1: 192,187,689 (GRCm39)	F717L	possibly damaging	Het
Klhdc8a	T	C	1: 132,230,895 (GRCm39)		probably null	Het
Klkb1	G	A	8: 45,729,277 (GRCm39)		probably benign	Het
Krt16	A	T	11: 100,137,162 (GRCm39)		probably benign	Het
Msh6	T	C	17: 88,292,160 (GRCm39)	V305A	probably benign	Het
Myo6	T	A	9: 80,199,801 (GRCm39)		probably null	Het
Nampt	T	A	12: 32,880,268 (GRCm39)	Y54N	possibly damaging	Het
Neurog2	G	T	3: 127,427,504 (GRCm39)	E43*	probably null	Het
Obscn	C	T	11: 58,919,343 (GRCm39)	R6887H	probably damaging	Het
Or5ac25	T	C	16: 59,182,171 (GRCm39)	N137D	possibly damaging	Het
Or6c203	A	G	10: 129,010,119 (GRCm39)	I257T	possibly damaging	Het
Pdss1	A	G	2: 22,802,658 (GRCm39)	I166V	probably damaging	Het
Phaf1	G	A	8: 105,961,110 (GRCm39)		probably benign	Het
Ptpn21	T	C	12: 98,645,651 (GRCm39)	T1096A	probably benign	Het
Reln	A	G	5: 22,245,425 (GRCm39)	Y728H	probably benign	Het
Sec31a	T	C	5: 100,555,052 (GRCm39)	D56G	probably damaging	Het
Shroom1	T	A	11: 53,357,386 (GRCm39)	V683E	probably damaging	Het
Slc5a11	A	G	7: 122,864,478 (GRCm39)	D358G	probably damaging	Het
Slfn3	T	A	11: 83,103,851 (GRCm39)	S241T	possibly damaging	Het
Slitrk3	G	A	3: 72,957,735 (GRCm39)	P346S	probably benign	Het
Specc1	T	A	11: 62,009,215 (GRCm39)	S324T	probably damaging	Het
Sptlc3	T	C	2: 139,389,123 (GRCm39)	Y168H	probably damaging	Het
St3gal6	C	T	16: 58,293,822 (GRCm39)	E236K	probably benign	Het
Tet2	A	T	3: 133,175,069 (GRCm39)	M1426K	probably benign	Het
Tinag	A	T	9: 76,939,069 (GRCm39)		probably benign	Het
Tjp1	A	G	7: 64,993,415 (GRCm39)	S53P	probably damaging	Het
Uimc1	T	C	13: 55,188,431 (GRCm39)	T543A	possibly damaging	Het
Wdfy4	A	G	14: 32,764,448 (GRCm39)	W2147R	probably benign	Het
Zmym1	C	T	4: 126,942,465 (GRCm39)	C641Y	probably damaging	Het

Other mutations in Or10ag58

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00162:Or10ag58	APN	2	87,265,407 (GRCm39)	missense	probably benign	0.00
IGL01655:Or10ag58	APN	2	87,265,229 (GRCm39)	missense	probably damaging	1.00
IGL01878:Or10ag58	APN	2	87,265,314 (GRCm39)	missense	possibly damaging	0.55
IGL02265:Or10ag58	APN	2	87,265,688 (GRCm39)	missense	probably benign	0.00
IGL02379:Or10ag58	APN	2	87,265,668 (GRCm39)	missense	probably benign	0.07
IGL02578:Or10ag58	APN	2	87,265,401 (GRCm39)	missense	probably damaging	0.96
R0617:Or10ag58	UTSW	2	87,265,005 (GRCm39)	missense	probably damaging	1.00
R1376:Or10ag58	UTSW	2	87,264,903 (GRCm39)	missense	possibly damaging	0.62
R1376:Or10ag58	UTSW	2	87,264,903 (GRCm39)	missense	possibly damaging	0.62
R4993:Or10ag58	UTSW	2	87,265,496 (GRCm39)	missense	probably benign	0.00
R5045:Or10ag58	UTSW	2	87,265,490 (GRCm39)	missense	probably damaging	1.00
R6119:Or10ag58	UTSW	2	87,265,733 (GRCm39)	nonsense	probably null
R6146:Or10ag58	UTSW	2	87,265,662 (GRCm39)	missense	possibly damaging	0.78
R6699:Or10ag58	UTSW	2	87,265,160 (GRCm39)	missense	probably benign
R6883:Or10ag58	UTSW	2	87,265,623 (GRCm39)	missense	probably damaging	0.99
R6966:Or10ag58	UTSW	2	87,265,623 (GRCm39)	missense	probably damaging	0.98
R7383:Or10ag58	UTSW	2	87,265,721 (GRCm39)	missense	possibly damaging	0.91
R8069:Or10ag58	UTSW	2	87,265,364 (GRCm39)	missense	possibly damaging	0.89
R9294:Or10ag58	UTSW	2	87,265,010 (GRCm39)	missense	probably benign	0.24
R9325:Or10ag58	UTSW	2	87,265,290 (GRCm39)	missense	possibly damaging	0.67
Z1088:Or10ag58	UTSW	2	87,265,503 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16