Incidental Mutation 'IGL02578:Or10ag58'
ID 299247
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ag58
Ensembl Gene ENSMUSG00000050772
Gene Name olfactory receptor family 10 subfamily AG member 58
Synonyms GA_x6K02T2Q125-48936945-48937901, Olfr1124, GA_x6K02T2Q125-48935224-48935664, Olfr1125, MOR264-24, MOR264-3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # IGL02578
Quality Score
Status
Chromosome 2
Chromosomal Location 87264833-87265789 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87265401 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 190 (I190K)
Ref Sequence ENSEMBL: ENSMUSP00000150244 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062494] [ENSMUST00000215909]
AlphaFold A2AT86
Predicted Effect probably damaging
Transcript: ENSMUST00000062494
AA Change: I190K

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000062513
Gene: ENSMUSG00000050772
AA Change: I190K

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 4.2e-52 PFAM
Pfam:7tm_1 47 296 2.4e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215909
AA Change: I190K

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 G A 7: 120,023,179 (GRCm39) probably null Het
Ago1 T A 4: 126,333,324 (GRCm39) D545V probably benign Het
Arid2 T C 15: 96,270,116 (GRCm39) S1410P probably benign Het
Cbfa2t3 T A 8: 123,360,187 (GRCm39) D488V possibly damaging Het
Cdx2 T C 5: 147,240,094 (GRCm39) D194G probably damaging Het
Cyp4a32 A G 4: 115,466,939 (GRCm39) Q208R possibly damaging Het
Degs1 A C 1: 182,106,592 (GRCm39) Y222* probably null Het
Dnah7a T A 1: 53,472,074 (GRCm39) E3564D probably benign Het
Dsg4 A T 18: 20,604,250 (GRCm39) I906F possibly damaging Het
Elovl3 A G 19: 46,123,132 (GRCm39) H236R possibly damaging Het
Foxp2 A G 6: 15,376,814 (GRCm39) probably benign Het
Gm9892 A T 8: 52,649,328 (GRCm39) noncoding transcript Het
Herc2 A G 7: 55,756,283 (GRCm39) probably null Het
Hhat A G 1: 192,376,221 (GRCm39) V304A probably damaging Het
Il16 C T 7: 83,327,194 (GRCm39) probably null Het
Kansl1l G A 1: 66,840,848 (GRCm39) Q151* probably null Het
Kmt2c G T 5: 25,571,198 (GRCm39) probably benign Het
Krt39 T C 11: 99,412,032 (GRCm39) N18S probably benign Het
Lcor G T 19: 41,547,589 (GRCm39) G391V probably damaging Het
Mical2 A T 7: 111,950,580 (GRCm39) T845S probably benign Het
Mon1b G T 8: 114,365,455 (GRCm39) R261L possibly damaging Het
Mphosph8 C T 14: 56,911,667 (GRCm39) A230V probably benign Het
Myh2 T A 11: 67,077,517 (GRCm39) M884K probably benign Het
Nlrp3 T C 11: 59,439,227 (GRCm39) L268P probably damaging Het
Ntng1 T A 3: 110,042,710 (GRCm39) T39S probably benign Het
Or1j14 A C 2: 36,418,156 (GRCm39) H244P probably damaging Het
Or5al7 A T 2: 85,993,073 (GRCm39) Y73* probably null Het
Pde4b T A 4: 102,112,494 (GRCm39) M26K possibly damaging Het
Polh G A 17: 46,505,218 (GRCm39) Q133* probably null Het
Postn A T 3: 54,284,625 (GRCm39) N647I possibly damaging Het
Scimp T A 11: 70,682,387 (GRCm39) I110F possibly damaging Het
Sell A G 1: 163,893,165 (GRCm39) D127G probably damaging Het
Serpinb12 G A 1: 106,883,220 (GRCm39) probably null Het
She A G 3: 89,739,373 (GRCm39) E188G probably damaging Het
Shisal2a C T 4: 108,225,225 (GRCm39) M112I probably benign Het
Slc22a1 T C 17: 12,886,126 (GRCm39) Y169C probably damaging Het
Slco2a1 C T 9: 102,923,957 (GRCm39) T57I probably damaging Het
Sox2 A T 3: 34,704,745 (GRCm39) M61L probably benign Het
Sra1 G A 18: 36,803,150 (GRCm39) Q32* probably null Het
Syne2 T A 12: 76,069,053 (GRCm39) S4340T possibly damaging Het
Ucn A C 5: 31,295,738 (GRCm39) W43G possibly damaging Het
Xdh C T 17: 74,213,241 (GRCm39) M836I probably damaging Het
Xirp2 T A 2: 67,341,591 (GRCm39) D1277E probably damaging Het
Other mutations in Or10ag58
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Or10ag58 APN 2 87,265,407 (GRCm39) missense probably benign 0.00
IGL01655:Or10ag58 APN 2 87,265,229 (GRCm39) missense probably damaging 1.00
IGL01878:Or10ag58 APN 2 87,265,314 (GRCm39) missense possibly damaging 0.55
IGL02265:Or10ag58 APN 2 87,265,688 (GRCm39) missense probably benign 0.00
IGL02379:Or10ag58 APN 2 87,265,668 (GRCm39) missense probably benign 0.07
IGL02512:Or10ag58 APN 2 87,265,402 (GRCm39) missense possibly damaging 0.59
R0617:Or10ag58 UTSW 2 87,265,005 (GRCm39) missense probably damaging 1.00
R1376:Or10ag58 UTSW 2 87,264,903 (GRCm39) missense possibly damaging 0.62
R1376:Or10ag58 UTSW 2 87,264,903 (GRCm39) missense possibly damaging 0.62
R4993:Or10ag58 UTSW 2 87,265,496 (GRCm39) missense probably benign 0.00
R5045:Or10ag58 UTSW 2 87,265,490 (GRCm39) missense probably damaging 1.00
R6119:Or10ag58 UTSW 2 87,265,733 (GRCm39) nonsense probably null
R6146:Or10ag58 UTSW 2 87,265,662 (GRCm39) missense possibly damaging 0.78
R6699:Or10ag58 UTSW 2 87,265,160 (GRCm39) missense probably benign
R6883:Or10ag58 UTSW 2 87,265,623 (GRCm39) missense probably damaging 0.99
R6966:Or10ag58 UTSW 2 87,265,623 (GRCm39) missense probably damaging 0.98
R7383:Or10ag58 UTSW 2 87,265,721 (GRCm39) missense possibly damaging 0.91
R8069:Or10ag58 UTSW 2 87,265,364 (GRCm39) missense possibly damaging 0.89
R9294:Or10ag58 UTSW 2 87,265,010 (GRCm39) missense probably benign 0.24
R9325:Or10ag58 UTSW 2 87,265,290 (GRCm39) missense possibly damaging 0.67
Z1088:Or10ag58 UTSW 2 87,265,503 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16