Incidental Mutation 'IGL02517:Vmn2r45'
| ID |
296807 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r45
|
| Ensembl Gene |
ENSMUSG00000090662 |
| Gene Name |
vomeronasal 2, receptor 45 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
IGL02517
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
8474468-8491958 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 8486185 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 368
(K368*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129466
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164845]
|
| AlphaFold |
L7N2B5 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000164845
AA Change: K368*
|
| SMART Domains |
Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: K368*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
154 |
469 |
4.5e-26 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
6.4e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.1e-54 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acnat2 |
T |
G |
4: 49,380,647 (GRCm39) |
M244L |
possibly damaging |
Het |
| Acnat2 |
A |
T |
4: 49,380,639 (GRCm39) |
C228* |
probably null |
Het |
| Adam24 |
T |
C |
8: 41,133,218 (GRCm39) |
S229P |
probably damaging |
Het |
| Alpk3 |
T |
C |
7: 80,727,643 (GRCm39) |
S258P |
probably benign |
Het |
| Atad2b |
A |
G |
12: 5,068,037 (GRCm39) |
T1012A |
probably benign |
Het |
| Bltp1 |
A |
G |
3: 37,013,017 (GRCm39) |
E1899G |
probably damaging |
Het |
| C4b |
A |
T |
17: 34,953,382 (GRCm39) |
S1034T |
probably benign |
Het |
| Cd300ld2 |
T |
A |
11: 114,901,249 (GRCm39) |
H277L |
possibly damaging |
Het |
| Chrna4 |
C |
T |
2: 180,670,926 (GRCm39) |
V277I |
probably benign |
Het |
| Col3a1 |
A |
G |
1: 45,364,963 (GRCm39) |
|
probably null |
Het |
| Dpep2 |
C |
T |
8: 106,715,388 (GRCm39) |
V369M |
probably damaging |
Het |
| Eml2 |
T |
A |
7: 18,940,055 (GRCm39) |
N815K |
probably damaging |
Het |
| Enpp3 |
A |
G |
10: 24,685,746 (GRCm39) |
|
probably benign |
Het |
| Git1 |
T |
C |
11: 77,390,413 (GRCm39) |
V86A |
probably benign |
Het |
| Hivep2 |
C |
T |
10: 14,006,926 (GRCm39) |
P1175S |
probably benign |
Het |
| Hydin |
T |
C |
8: 111,293,604 (GRCm39) |
I3517T |
probably benign |
Het |
| Ift172 |
T |
A |
5: 31,410,992 (GRCm39) |
|
probably null |
Het |
| Jmy |
A |
G |
13: 93,589,316 (GRCm39) |
I647T |
probably benign |
Het |
| Kifap3 |
T |
A |
1: 163,653,440 (GRCm39) |
|
probably benign |
Het |
| Lama3 |
G |
A |
18: 12,670,915 (GRCm39) |
|
probably null |
Het |
| Lipa |
A |
C |
19: 34,471,522 (GRCm39) |
I351S |
possibly damaging |
Het |
| Ltbp2 |
G |
T |
12: 84,832,091 (GRCm39) |
A1631D |
probably benign |
Het |
| Masp2 |
A |
G |
4: 148,698,477 (GRCm39) |
I519M |
probably damaging |
Het |
| Mfsd6 |
A |
G |
1: 52,702,436 (GRCm39) |
|
probably benign |
Het |
| Numa1 |
T |
G |
7: 101,661,216 (GRCm39) |
D1846E |
probably benign |
Het |
| Oog3 |
A |
T |
4: 143,885,920 (GRCm39) |
I226K |
probably damaging |
Het |
| Or11h6 |
A |
G |
14: 50,880,658 (GRCm39) |
T301A |
probably benign |
Het |
| Or5an6 |
A |
T |
19: 12,372,265 (GRCm39) |
I213F |
probably benign |
Het |
| Or8b3b |
T |
C |
9: 38,584,209 (GRCm39) |
Y177C |
probably damaging |
Het |
| Or8g53 |
T |
G |
9: 39,683,800 (GRCm39) |
T99P |
probably damaging |
Het |
| Or9s13 |
A |
T |
1: 92,548,183 (GRCm39) |
Y185F |
probably benign |
Het |
| Pkdcc |
T |
C |
17: 83,531,295 (GRCm39) |
S435P |
probably damaging |
Het |
| Ppm1g |
A |
G |
5: 31,365,425 (GRCm39) |
Y70H |
probably damaging |
Het |
| Prcc |
C |
T |
3: 87,776,984 (GRCm39) |
S330N |
probably damaging |
Het |
| Ror2 |
A |
T |
13: 53,272,876 (GRCm39) |
L251Q |
probably damaging |
Het |
| Scn11a |
A |
G |
9: 119,621,464 (GRCm39) |
L651P |
probably damaging |
Het |
| Skint6 |
A |
T |
4: 112,805,737 (GRCm39) |
|
probably benign |
Het |
| Slc23a4 |
A |
G |
6: 34,931,917 (GRCm39) |
F186L |
probably benign |
Het |
| Slc30a8 |
A |
T |
15: 52,198,530 (GRCm39) |
D325V |
probably benign |
Het |
| Son |
C |
T |
16: 91,452,099 (GRCm39) |
T282M |
possibly damaging |
Het |
| Tas2r118 |
A |
T |
6: 23,969,891 (GRCm39) |
F57I |
probably damaging |
Het |
| Tcf7l1 |
A |
G |
6: 72,606,966 (GRCm39) |
S447P |
probably benign |
Het |
| Thsd1 |
T |
A |
8: 22,733,454 (GRCm39) |
V167E |
probably damaging |
Het |
| Tle3 |
T |
C |
9: 61,322,063 (GRCm39) |
V696A |
probably damaging |
Het |
| Tmem67 |
A |
T |
4: 12,069,463 (GRCm39) |
I405K |
possibly damaging |
Het |
| Tmem71 |
A |
C |
15: 66,413,466 (GRCm39) |
V202G |
probably benign |
Het |
| Trim6 |
T |
C |
7: 103,881,564 (GRCm39) |
|
probably benign |
Het |
| Trip12 |
A |
G |
1: 84,721,535 (GRCm39) |
|
probably benign |
Het |
| Ubr1 |
A |
C |
2: 120,694,854 (GRCm39) |
C1693G |
possibly damaging |
Het |
| Ush2a |
G |
A |
1: 188,648,195 (GRCm39) |
R4600H |
probably damaging |
Het |
| Vil1 |
A |
G |
1: 74,465,851 (GRCm39) |
I547M |
probably benign |
Het |
| Vmn1r219 |
A |
T |
13: 23,347,266 (GRCm39) |
I152L |
probably benign |
Het |
| Vmn1r26 |
A |
G |
6: 57,986,127 (GRCm39) |
F21L |
possibly damaging |
Het |
| Vmn2r68 |
C |
T |
7: 84,871,153 (GRCm39) |
W710* |
probably null |
Het |
| Zfp808 |
T |
A |
13: 62,321,032 (GRCm39) |
*754R |
probably null |
Het |
| Zyg11b |
C |
T |
4: 108,123,515 (GRCm39) |
E151K |
probably damaging |
Het |
|
| Other mutations in Vmn2r45 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01287:Vmn2r45
|
APN |
7 |
8,488,622 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01322:Vmn2r45
|
APN |
7 |
8,484,332 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01402:Vmn2r45
|
APN |
7 |
8,484,467 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01404:Vmn2r45
|
APN |
7 |
8,484,467 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01529:Vmn2r45
|
APN |
7 |
8,486,493 (GRCm39) |
missense |
probably benign |
|
|
IGL01596:Vmn2r45
|
APN |
7 |
8,486,272 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01646:Vmn2r45
|
APN |
7 |
8,486,337 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01819:Vmn2r45
|
APN |
7 |
8,488,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02096:Vmn2r45
|
APN |
7 |
8,484,443 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02130:Vmn2r45
|
APN |
7 |
8,486,556 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL02409:Vmn2r45
|
APN |
7 |
8,488,727 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02633:Vmn2r45
|
APN |
7 |
8,488,728 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02940:Vmn2r45
|
APN |
7 |
8,475,369 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03281:Vmn2r45
|
APN |
7 |
8,486,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03358:Vmn2r45
|
APN |
7 |
8,474,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Vmn2r45
|
UTSW |
7 |
8,486,513 (GRCm39) |
missense |
probably benign |
|
|
BB014:Vmn2r45
|
UTSW |
7 |
8,486,513 (GRCm39) |
missense |
probably benign |
|
|
R0382:Vmn2r45
|
UTSW |
7 |
8,486,098 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0532:Vmn2r45
|
UTSW |
7 |
8,474,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0932:Vmn2r45
|
UTSW |
7 |
8,478,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1125:Vmn2r45
|
UTSW |
7 |
8,488,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1580:Vmn2r45
|
UTSW |
7 |
8,474,746 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1817:Vmn2r45
|
UTSW |
7 |
8,475,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r45
|
UTSW |
7 |
8,475,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Vmn2r45
|
UTSW |
7 |
8,475,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2284:Vmn2r45
|
UTSW |
7 |
8,488,765 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4019:Vmn2r45
|
UTSW |
7 |
8,474,580 (GRCm39) |
nonsense |
probably null |
|
|
R4227:Vmn2r45
|
UTSW |
7 |
8,486,277 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4381:Vmn2r45
|
UTSW |
7 |
8,474,912 (GRCm39) |
nonsense |
probably null |
|
|
R4618:Vmn2r45
|
UTSW |
7 |
8,486,436 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4624:Vmn2r45
|
UTSW |
7 |
8,484,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Vmn2r45
|
UTSW |
7 |
8,486,535 (GRCm39) |
nonsense |
probably null |
|
|
R4735:Vmn2r45
|
UTSW |
7 |
8,486,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4868:Vmn2r45
|
UTSW |
7 |
8,484,480 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4983:Vmn2r45
|
UTSW |
7 |
8,486,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5246:Vmn2r45
|
UTSW |
7 |
8,486,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5430:Vmn2r45
|
UTSW |
7 |
8,486,333 (GRCm39) |
nonsense |
probably null |
|
|
R5504:Vmn2r45
|
UTSW |
7 |
8,486,176 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5511:Vmn2r45
|
UTSW |
7 |
8,474,832 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5745:Vmn2r45
|
UTSW |
7 |
8,486,074 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5814:Vmn2r45
|
UTSW |
7 |
8,474,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6223:Vmn2r45
|
UTSW |
7 |
8,486,301 (GRCm39) |
missense |
probably benign |
|
|
R6267:Vmn2r45
|
UTSW |
7 |
8,475,207 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6623:Vmn2r45
|
UTSW |
7 |
8,474,500 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6999:Vmn2r45
|
UTSW |
7 |
8,486,219 (GRCm39) |
missense |
probably benign |
|
|
R7242:Vmn2r45
|
UTSW |
7 |
8,488,612 (GRCm39) |
nonsense |
probably null |
|
|
R7491:Vmn2r45
|
UTSW |
7 |
8,484,342 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7620:Vmn2r45
|
UTSW |
7 |
8,486,222 (GRCm39) |
nonsense |
probably null |
|
|
R7719:Vmn2r45
|
UTSW |
7 |
8,486,460 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7720:Vmn2r45
|
UTSW |
7 |
8,486,460 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7853:Vmn2r45
|
UTSW |
7 |
8,485,987 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7873:Vmn2r45
|
UTSW |
7 |
8,486,074 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7882:Vmn2r45
|
UTSW |
7 |
8,486,409 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7927:Vmn2r45
|
UTSW |
7 |
8,486,513 (GRCm39) |
missense |
probably benign |
|
|
R8684:Vmn2r45
|
UTSW |
7 |
8,486,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8780:Vmn2r45
|
UTSW |
7 |
8,484,371 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8811:Vmn2r45
|
UTSW |
7 |
8,474,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8893:Vmn2r45
|
UTSW |
7 |
8,488,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9043:Vmn2r45
|
UTSW |
7 |
8,474,904 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9208:Vmn2r45
|
UTSW |
7 |
8,486,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9327:Vmn2r45
|
UTSW |
7 |
8,474,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9586:Vmn2r45
|
UTSW |
7 |
8,486,050 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9599:Vmn2r45
|
UTSW |
7 |
8,478,457 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
U24488:Vmn2r45
|
UTSW |
7 |
8,475,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r45
|
UTSW |
7 |
8,474,484 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Posted On |
2015-04-16 |
Incidental Mutation