Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02593:Vmn2r7'

299784

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r7

Ensembl Gene

ENSMUSG00000116028

Gene Name

vomeronasal 2, receptor 7

Synonyms

4933425M15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

IGL02593

Quality Score

Status

Chromosome

Chromosomal Location

64598081-64627023 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 64600443 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 485 (C485Y)

Ref Sequence

ENSEMBL: ENSMUSP00000131220 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000161972] [ENSMUST00000168072]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000161972
AA Change: C576Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124192
Gene: ENSMUSG00000062200
AA Change: C576Y

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	90	507	3.8e-77	PFAM
Pfam:NCD3G	549	602	3.4e-17	PFAM
Pfam:7tm_3	635	869	1.1e-47	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000168072
AA Change: C485Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131220
Gene: ENSMUSG00000116028
AA Change: C485Y

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	5.1e-72	PFAM
Pfam:Peripla_BP_6	63	245	6.1e-10	PFAM
Pfam:NCD3G	458	511	1.8e-17	PFAM
Pfam:7tm_3	542	779	4.3e-76	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177146

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahsg	G	T	16: 22,711,078 (GRCm39)		probably null	Het
Bbs4	C	T	9: 59,235,880 (GRCm39)	D232N	probably damaging	Het
Cdh23	A	T	10: 60,301,774 (GRCm39)		probably benign	Het
Cntn5	T	C	9: 9,833,504 (GRCm39)	N554S	probably damaging	Het
Fn1	T	C	1: 71,641,591 (GRCm39)	I1652V	probably benign	Het
Golga4	T	C	9: 118,384,634 (GRCm39)		probably benign	Het
Idh3a	T	A	9: 54,503,477 (GRCm39)		probably benign	Het
Jph2	T	C	2: 163,239,166 (GRCm39)	Y94C	probably damaging	Het
Lnx2	A	G	5: 146,969,825 (GRCm39)	S238P	possibly damaging	Het
Loxhd1	A	G	18: 77,498,235 (GRCm39)	I56V	possibly damaging	Het
Myo9b	A	C	8: 71,743,417 (GRCm39)	E159D	probably damaging	Het
Nkiras1	A	G	14: 18,278,475 (GRCm38)	N63S	possibly damaging	Het
Nnmt	A	G	9: 48,516,103 (GRCm39)		probably null	Het
Or13a22	G	A	7: 140,073,244 (GRCm39)	R231H	probably benign	Het
P2ry10	T	C	X: 106,146,302 (GRCm39)	I79T	possibly damaging	Het
Padi2	A	G	4: 140,677,153 (GRCm39)	H647R	probably damaging	Het
Pate10	T	A	9: 35,653,438 (GRCm39)	C81S	possibly damaging	Het
Ptchd4	A	G	17: 42,628,037 (GRCm39)	D166G	probably benign	Het
Scml2	T	C	X: 159,970,305 (GRCm39)	V125A	probably benign	Het
Senp2	A	G	16: 21,863,021 (GRCm39)	D556G	probably damaging	Het
Serpina3a	G	T	12: 104,084,691 (GRCm39)	V29L	probably benign	Het
Sgcz	A	T	8: 37,990,432 (GRCm39)	I307N	probably damaging	Het
Slc25a13	C	T	6: 6,042,265 (GRCm39)	V638I	probably benign	Het
Snx7	G	A	3: 117,633,609 (GRCm39)	L84F	probably damaging	Het
Ticrr	A	G	7: 79,345,214 (GRCm39)	D1693G	probably damaging	Het
Tm9sf5	G	A	X: 56,467,320 (GRCm39)	D245N	probably benign	Het
Vmn2r-ps129	C	T	17: 23,211,770 (GRCm39)		noncoding transcript	Het
Zfyve9	A	G	4: 108,539,420 (GRCm39)	V951A	possibly damaging	Het

Other mutations in Vmn2r7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00961:Vmn2r7	APN	3	64,623,234 (GRCm39)	missense	possibly damaging	0.60
IGL01762:Vmn2r7	APN	3	64,598,856 (GRCm39)	missense	probably benign	0.39
IGL01903:Vmn2r7	APN	3	64,626,864 (GRCm39)	missense	probably benign	0.00
IGL02263:Vmn2r7	APN	3	64,598,868 (GRCm39)	missense	probably damaging	1.00
IGL02458:Vmn2r7	APN	3	64,600,446 (GRCm39)	missense	probably damaging	0.97
IGL02797:Vmn2r7	APN	3	64,598,666 (GRCm39)	missense	possibly damaging	0.80
IGL03047:Vmn2r7	UTSW	3	64,614,639 (GRCm39)	missense	possibly damaging	0.81
PIT4504001:Vmn2r7	UTSW	3	64,623,397 (GRCm39)	missense	probably benign	0.01
R0193:Vmn2r7	UTSW	3	64,598,460 (GRCm39)	missense	probably damaging	1.00
R0329:Vmn2r7	UTSW	3	64,598,439 (GRCm39)	missense	probably damaging	1.00
R0609:Vmn2r7	UTSW	3	64,623,900 (GRCm39)	missense	probably benign	0.44
R0735:Vmn2r7	UTSW	3	64,623,788 (GRCm39)	missense	probably benign	0.02
R0941:Vmn2r7	UTSW	3	64,624,000 (GRCm39)	missense	probably benign
R1065:Vmn2r7	UTSW	3	64,614,559 (GRCm39)	missense	possibly damaging	0.82
R1378:Vmn2r7	UTSW	3	64,599,025 (GRCm39)	missense	possibly damaging	0.59
R1445:Vmn2r7	UTSW	3	64,632,223 (GRCm39)	missense	probably benign	0.01
R1506:Vmn2r7	UTSW	3	64,614,500 (GRCm39)	missense	probably benign
R1509:Vmn2r7	UTSW	3	64,623,881 (GRCm39)	nonsense	probably null
R1519:Vmn2r7	UTSW	3	64,623,876 (GRCm39)	missense	possibly damaging	0.95
R1706:Vmn2r7	UTSW	3	64,598,880 (GRCm39)	missense	possibly damaging	0.79
R2113:Vmn2r7	UTSW	3	64,599,025 (GRCm39)	missense	possibly damaging	0.59
R3725:Vmn2r7	UTSW	3	64,632,412 (GRCm39)	missense	possibly damaging	0.65
R3874:Vmn2r7	UTSW	3	64,627,032 (GRCm39)	missense	possibly damaging	0.69
R3902:Vmn2r7	UTSW	3	64,626,937 (GRCm39)	missense	possibly damaging	0.46
R4084:Vmn2r7	UTSW	3	64,600,414 (GRCm39)	missense	probably benign	0.08
R4117:Vmn2r7	UTSW	3	64,623,138 (GRCm39)	intron	probably benign
R4333:Vmn2r7	UTSW	3	64,598,199 (GRCm39)	missense	probably damaging	1.00
R4551:Vmn2r7	UTSW	3	64,598,110 (GRCm39)	missense	possibly damaging	0.86
R4643:Vmn2r7	UTSW	3	64,623,825 (GRCm39)	missense	probably damaging	1.00
R4654:Vmn2r7	UTSW	3	64,626,864 (GRCm39)	missense	probably benign	0.00
R5091:Vmn2r7	UTSW	3	64,598,205 (GRCm39)	missense	possibly damaging	0.63
R5109:Vmn2r7	UTSW	3	64,598,088 (GRCm39)	missense	probably null	0.84
R5372:Vmn2r7	UTSW	3	64,623,745 (GRCm39)	missense	probably damaging	1.00
R5415:Vmn2r7	UTSW	3	64,623,658 (GRCm39)	missense	probably benign	0.07
R5740:Vmn2r7	UTSW	3	64,614,654 (GRCm39)	missense	probably benign
R5977:Vmn2r7	UTSW	3	64,623,464 (GRCm39)	nonsense	probably null
R6019:Vmn2r7	UTSW	3	64,623,643 (GRCm39)	missense	probably damaging	1.00
R6058:Vmn2r7	UTSW	3	64,632,436 (GRCm39)	missense	probably benign	0.00
R6139:Vmn2r7	UTSW	3	64,623,339 (GRCm39)	missense	probably damaging	1.00
R6696:Vmn2r7	UTSW	3	64,614,495 (GRCm39)	missense	probably benign	0.01
R6887:Vmn2r7	UTSW	3	64,598,248 (GRCm39)	missense	probably damaging	1.00
R6918:Vmn2r7	UTSW	3	64,598,760 (GRCm39)	missense	probably benign	0.03
R6949:Vmn2r7	UTSW	3	64,598,542 (GRCm39)	missense	probably damaging	0.99
R6980:Vmn2r7	UTSW	3	64,623,987 (GRCm39)	missense	possibly damaging	0.67
R7196:Vmn2r7	UTSW	3	64,623,198 (GRCm39)	missense	probably benign	0.00
R7286:Vmn2r7	UTSW	3	64,598,301 (GRCm39)	missense	probably benign	0.00
R7455:Vmn2r7	UTSW	3	64,624,014 (GRCm39)	missense	probably benign
R7557:Vmn2r7	UTSW	3	64,632,394 (GRCm39)	missense	probably benign
R7864:Vmn2r7	UTSW	3	64,598,947 (GRCm39)	missense	probably benign	0.10
R8046:Vmn2r7	UTSW	3	64,614,479 (GRCm39)	missense	probably damaging	1.00
R8068:Vmn2r7	UTSW	3	64,623,507 (GRCm39)	missense	probably benign	0.01
R8252:Vmn2r7	UTSW	3	64,600,527 (GRCm39)	missense	probably benign	0.00
R8814:Vmn2r7	UTSW	3	64,623,984 (GRCm39)	missense	probably benign	0.14
R9497:Vmn2r7	UTSW	3	64,614,474 (GRCm39)	missense	probably benign	0.04
R9722:Vmn2r7	UTSW	3	64,598,407 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16