Incidental Mutation 'IGL02673:Or1n1'
ID 302989
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1n1
Ensembl Gene ENSMUSG00000075383
Gene Name olfactory receptor family 1 subfamily N member 1
Synonyms Olfr351, MOR127-2, GA_x6K02T2NLDC-33554926-33553994
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # IGL02673
Quality Score
Status
Chromosome 2
Chromosomal Location 36749426-36750358 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 36750188 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 57 (M57I)
Ref Sequence ENSEMBL: ENSMUSP00000150346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100150] [ENSMUST00000213676] [ENSMUST00000215137]
AlphaFold Q8VGK1
Predicted Effect probably benign
Transcript: ENSMUST00000100150
AA Change: M57I

PolyPhen 2 Score 0.250 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000097727
Gene: ENSMUSG00000075383
AA Change: M57I

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.7e-56 PFAM
Pfam:7tm_1 39 288 5.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213676
AA Change: M57I

PolyPhen 2 Score 0.250 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000215137
AA Change: M57I

PolyPhen 2 Score 0.250 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930012K11Rik T A 14: 70,395,056 (GRCm39) T33S probably benign Het
Abca4 T C 3: 121,897,150 (GRCm39) Y610H probably damaging Het
Agl A T 3: 116,575,248 (GRCm39) C630S probably benign Het
Alkbh6 G T 7: 30,013,536 (GRCm39) G202C probably damaging Het
Ascc3 A T 10: 50,536,769 (GRCm39) M701L probably benign Het
Bpgm T A 6: 34,464,769 (GRCm39) L162Q probably damaging Het
Ccdc150 A G 1: 54,368,149 (GRCm39) T592A probably benign Het
Chpf2 G A 5: 24,796,302 (GRCm39) R416Q probably benign Het
Col14a1 G A 15: 55,282,178 (GRCm39) G813E unknown Het
Col18a1 C T 10: 76,894,997 (GRCm39) G983D probably damaging Het
Col5a1 C T 2: 27,864,727 (GRCm39) A737V unknown Het
Cyp2a22 T G 7: 26,637,525 (GRCm39) K157Q probably benign Het
Dhx57 A G 17: 80,574,974 (GRCm39) V668A probably damaging Het
Eps8l1 T A 7: 4,481,731 (GRCm39) V743E probably damaging Het
Fnbp4 C T 2: 90,593,816 (GRCm39) T557M probably benign Het
Fzd5 C T 1: 64,774,265 (GRCm39) E499K possibly damaging Het
Gm57858 A C 3: 36,100,848 (GRCm39) probably benign Het
Il1r2 A G 1: 40,154,323 (GRCm39) Y230C probably damaging Het
Insrr A C 3: 87,720,368 (GRCm39) E1002A possibly damaging Het
Kdm4a C T 4: 118,025,769 (GRCm39) D146N probably benign Het
Kidins220 G A 12: 25,044,991 (GRCm39) V262M probably damaging Het
Kif26b C T 1: 178,649,170 (GRCm39) P430L probably damaging Het
Mamdc4 T C 2: 25,460,066 (GRCm39) S62G probably benign Het
Mcu C A 10: 59,303,466 (GRCm39) V124F probably damaging Het
Mlf1 A G 3: 67,301,280 (GRCm39) M98V probably benign Het
Mogs T C 6: 83,095,199 (GRCm39) V672A probably damaging Het
Ntrk3 T C 7: 77,900,512 (GRCm39) D609G probably damaging Het
Pdlim5 T A 3: 142,058,548 (GRCm39) E65D probably damaging Het
Peg3 T C 7: 6,713,413 (GRCm39) N603S probably damaging Het
Pkd1 A G 17: 24,790,257 (GRCm39) Y980C probably benign Het
Rack1 A G 11: 48,691,357 (GRCm39) T23A probably benign Het
Rad50 A T 11: 53,579,067 (GRCm39) I497K probably benign Het
Sin3a C A 9: 57,014,725 (GRCm39) Q649K probably damaging Het
Sirt6 A G 10: 81,461,671 (GRCm39) F46L probably damaging Het
Slc40a1 A T 1: 45,957,576 (GRCm39) I136N possibly damaging Het
Sspo G A 6: 48,452,794 (GRCm39) R2834H probably damaging Het
Sspo G T 6: 48,475,709 (GRCm39) probably null Het
Sycp2 T A 2: 178,036,004 (GRCm39) T228S possibly damaging Het
Uhrf2 T A 19: 30,070,207 (GRCm39) N785K probably damaging Het
Vmn2r58 T A 7: 41,514,082 (GRCm39) Y187F possibly damaging Het
Vmn2r80 A G 10: 79,005,318 (GRCm39) I318M probably benign Het
Vps13c T C 9: 67,785,380 (GRCm39) L249P probably damaging Het
Zw10 T A 9: 48,988,893 (GRCm39) probably null Het
Other mutations in Or1n1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01962:Or1n1 APN 2 36,749,787 (GRCm39) missense probably benign 0.04
IGL02481:Or1n1 APN 2 36,749,830 (GRCm39) missense probably damaging 0.96
IGL02754:Or1n1 APN 2 36,750,232 (GRCm39) missense probably damaging 1.00
P0041:Or1n1 UTSW 2 36,749,473 (GRCm39) missense probably damaging 1.00
R1392:Or1n1 UTSW 2 36,750,187 (GRCm39) missense probably damaging 1.00
R1392:Or1n1 UTSW 2 36,750,187 (GRCm39) missense probably damaging 1.00
R2271:Or1n1 UTSW 2 36,749,637 (GRCm39) missense probably damaging 1.00
R2274:Or1n1 UTSW 2 36,750,113 (GRCm39) missense probably damaging 0.99
R3053:Or1n1 UTSW 2 36,749,959 (GRCm39) missense probably benign 0.06
R4712:Or1n1 UTSW 2 36,750,381 (GRCm39) splice site probably null
R5001:Or1n1 UTSW 2 36,750,082 (GRCm39) missense probably benign 0.00
R5364:Or1n1 UTSW 2 36,750,006 (GRCm39) missense probably damaging 1.00
R5502:Or1n1 UTSW 2 36,750,282 (GRCm39) missense probably damaging 0.98
R6048:Or1n1 UTSW 2 36,749,853 (GRCm39) missense probably benign 0.00
R6401:Or1n1 UTSW 2 36,750,177 (GRCm39) nonsense probably null
R7353:Or1n1 UTSW 2 36,749,680 (GRCm39) nonsense probably null
R7798:Or1n1 UTSW 2 36,750,348 (GRCm39) missense probably benign 0.01
R7934:Or1n1 UTSW 2 36,750,228 (GRCm39) missense possibly damaging 0.73
R8725:Or1n1 UTSW 2 36,749,610 (GRCm39) missense probably damaging 1.00
R8842:Or1n1 UTSW 2 36,749,539 (GRCm39) missense probably benign 0.04
Posted On 2015-04-16