Incidental Mutation 'R4019:Or4c15'
ID 312673
Institutional Source Beutler Lab
Gene Symbol Or4c15
Ensembl Gene ENSMUSG00000075112
Gene Name olfactory receptor family 4 subfamily C member 15
Synonyms MOR233-16P, MOR233-21, GA_x6K02T2Q125-50409367-50408432, Olfr1211
MMRRC Submission 040953-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R4019 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 88759722-88764870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88760080 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 193 (I193T)
Ref Sequence ENSEMBL: ENSMUSP00000150571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099808] [ENSMUST00000213412] [ENSMUST00000215205]
AlphaFold Q7TR09
Predicted Effect probably benign
Transcript: ENSMUST00000099808
AA Change: I193T

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000097396
Gene: ENSMUSG00000075112
AA Change: I193T

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 9.5e-49 PFAM
Pfam:7tm_1 39 286 2.5e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141958
Predicted Effect probably benign
Transcript: ENSMUST00000213412
AA Change: I193T

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000215205
AA Change: I193T

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acy1 T C 9: 106,313,978 (GRCm39) T61A possibly damaging Het
Ap4e1 C T 2: 126,903,846 (GRCm39) S916F probably benign Het
Brpf1 G A 6: 113,287,243 (GRCm39) R157Q probably damaging Het
Canx A T 11: 50,190,072 (GRCm39) S429T probably damaging Het
Casz1 C T 4: 149,017,335 (GRCm39) P208L probably benign Het
Ctnnd1 C T 2: 84,450,302 (GRCm39) R306H probably damaging Het
Dip2c T C 13: 9,664,401 (GRCm39) V909A probably damaging Het
Epg5 C A 18: 78,073,665 (GRCm39) Q2511K probably damaging Het
Ghitm G A 14: 36,852,651 (GRCm39) A143V probably damaging Het
Gramd2b T C 18: 56,612,026 (GRCm39) probably null Het
Ifitm3 T C 7: 140,589,772 (GRCm39) T94A possibly damaging Het
Ift81 G A 5: 122,731,192 (GRCm39) T321M probably benign Het
Ikbkb C T 8: 23,161,728 (GRCm39) V387I probably benign Het
Lct T C 1: 128,231,963 (GRCm39) M629V probably damaging Het
Lpar5 A G 6: 125,058,638 (GRCm39) N120D probably damaging Het
Lrrc37 A G 11: 103,506,119 (GRCm39) S1950P probably benign Het
Lrrtm2 T C 18: 35,345,923 (GRCm39) I460V possibly damaging Het
Naip5 T C 13: 100,359,883 (GRCm39) E451G probably benign Het
Naip5 T C 13: 100,359,902 (GRCm39) I445V probably benign Het
Nbas A G 12: 13,532,520 (GRCm39) R1743G probably damaging Het
Nherf4 A T 9: 44,162,117 (GRCm39) probably null Het
Notch1 T C 2: 26,371,154 (GRCm39) T311A probably benign Het
Oplah A G 15: 76,181,476 (GRCm39) Y1155H probably damaging Het
Or52k2 T C 7: 102,253,849 (GRCm39) F96S probably damaging Het
Pcnx1 C T 12: 81,965,018 (GRCm39) T395I probably damaging Het
Pdgfb A C 15: 79,885,923 (GRCm39) V108G probably damaging Het
Prpf40b T C 15: 99,214,357 (GRCm39) S846P probably benign Het
Ptprc T A 1: 138,006,254 (GRCm39) H752L probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Scn3a A G 2: 65,356,295 (GRCm39) probably benign Het
Sco1 T G 11: 66,954,846 (GRCm39) S284A probably benign Het
Slc25a10 T A 11: 120,388,265 (GRCm39) M227K probably damaging Het
Sox8 A G 17: 25,789,271 (GRCm39) Y76H probably damaging Het
Spdya A C 17: 71,863,309 (GRCm39) K19N possibly damaging Het
Syngap1 C T 17: 27,171,315 (GRCm39) probably benign Het
Sytl3 T C 17: 7,003,892 (GRCm39) S326P probably damaging Het
Tbl3 A G 17: 24,923,695 (GRCm39) V239A probably damaging Het
Tenm2 T C 11: 35,937,901 (GRCm39) I1592V probably benign Het
Vmn2r109 T A 17: 20,774,074 (GRCm39) D427V probably benign Het
Vmn2r115 A G 17: 23,579,017 (GRCm39) K830R probably damaging Het
Vmn2r45 A T 7: 8,474,580 (GRCm39) L816* probably null Het
Zfp335 C T 2: 164,743,380 (GRCm39) R536H probably damaging Het
Zfp777 T A 6: 48,019,046 (GRCm39) Q296L probably damaging Het
Other mutations in Or4c15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02724:Or4c15 APN 2 88,759,792 (GRCm39) missense probably damaging 1.00
IGL02936:Or4c15 APN 2 88,760,128 (GRCm39) missense probably benign 0.01
IGL02960:Or4c15 APN 2 88,760,128 (GRCm39) missense possibly damaging 0.80
IGL02989:Or4c15 APN 2 88,760,048 (GRCm39) missense possibly damaging 0.72
R0193:Or4c15 UTSW 2 88,760,627 (GRCm39) missense probably benign 0.01
R0413:Or4c15 UTSW 2 88,759,906 (GRCm39) missense probably benign 0.16
R1644:Or4c15 UTSW 2 88,759,731 (GRCm39) missense probably benign 0.01
R3715:Or4c15 UTSW 2 88,759,757 (GRCm39) missense probably benign 0.07
R4722:Or4c15 UTSW 2 88,760,324 (GRCm39) missense possibly damaging 0.91
R4751:Or4c15 UTSW 2 88,760,258 (GRCm39) missense probably damaging 1.00
R4859:Or4c15 UTSW 2 88,760,627 (GRCm39) missense probably benign 0.01
R5053:Or4c15 UTSW 2 88,760,597 (GRCm39) missense probably benign 0.02
R6148:Or4c15 UTSW 2 88,760,597 (GRCm39) missense probably benign 0.00
R7064:Or4c15 UTSW 2 88,759,853 (GRCm39) missense probably benign 0.00
R7527:Or4c15 UTSW 2 88,760,434 (GRCm39) missense probably benign 0.00
R7584:Or4c15 UTSW 2 88,760,149 (GRCm39) missense probably damaging 1.00
R7989:Or4c15 UTSW 2 88,759,858 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCGCCACCATTTTATCAAAGGAG -3'
(R):5'- ATGAACTGGAGGCTCTGTGG -3'

Sequencing Primer
(F):5'- CACCATTTTATCAAAGGAGAAAGCAG -3'
(R):5'- TGGCACACTTATGGGGATAGC -3'
Posted On 2015-04-30