Incidental Mutation 'R4019:Ifitm3'
ID 312684
Institutional Source Beutler Lab
Gene Symbol Ifitm3
Ensembl Gene ENSMUSG00000025492
Gene Name interferon induced transmembrane protein 3
Synonyms Fgls, 1110004C05Rik, IP15, mil-1, fragilis
MMRRC Submission 040953-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4019 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 140589503-140590657 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 140589772 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 94 (T94A)
Ref Sequence ENSEMBL: ENSMUSP00000026565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026565]
AlphaFold Q9CQW9
Predicted Effect possibly damaging
Transcript: ENSMUST00000026565
AA Change: T94A

PolyPhen 2 Score 0.710 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000026565
Gene: ENSMUSG00000025492
AA Change: T94A

DomainStartEndE-ValueType
Pfam:CD225 47 130 7.6e-33 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
PHENOTYPE: Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acy1 T C 9: 106,313,978 (GRCm39) T61A possibly damaging Het
Ap4e1 C T 2: 126,903,846 (GRCm39) S916F probably benign Het
Brpf1 G A 6: 113,287,243 (GRCm39) R157Q probably damaging Het
Canx A T 11: 50,190,072 (GRCm39) S429T probably damaging Het
Casz1 C T 4: 149,017,335 (GRCm39) P208L probably benign Het
Ctnnd1 C T 2: 84,450,302 (GRCm39) R306H probably damaging Het
Dip2c T C 13: 9,664,401 (GRCm39) V909A probably damaging Het
Epg5 C A 18: 78,073,665 (GRCm39) Q2511K probably damaging Het
Ghitm G A 14: 36,852,651 (GRCm39) A143V probably damaging Het
Gramd2b T C 18: 56,612,026 (GRCm39) probably null Het
Ift81 G A 5: 122,731,192 (GRCm39) T321M probably benign Het
Ikbkb C T 8: 23,161,728 (GRCm39) V387I probably benign Het
Lct T C 1: 128,231,963 (GRCm39) M629V probably damaging Het
Lpar5 A G 6: 125,058,638 (GRCm39) N120D probably damaging Het
Lrrc37 A G 11: 103,506,119 (GRCm39) S1950P probably benign Het
Lrrtm2 T C 18: 35,345,923 (GRCm39) I460V possibly damaging Het
Naip5 T C 13: 100,359,883 (GRCm39) E451G probably benign Het
Naip5 T C 13: 100,359,902 (GRCm39) I445V probably benign Het
Nbas A G 12: 13,532,520 (GRCm39) R1743G probably damaging Het
Nherf4 A T 9: 44,162,117 (GRCm39) probably null Het
Notch1 T C 2: 26,371,154 (GRCm39) T311A probably benign Het
Oplah A G 15: 76,181,476 (GRCm39) Y1155H probably damaging Het
Or4c15 A G 2: 88,760,080 (GRCm39) I193T probably benign Het
Or52k2 T C 7: 102,253,849 (GRCm39) F96S probably damaging Het
Pcnx1 C T 12: 81,965,018 (GRCm39) T395I probably damaging Het
Pdgfb A C 15: 79,885,923 (GRCm39) V108G probably damaging Het
Prpf40b T C 15: 99,214,357 (GRCm39) S846P probably benign Het
Ptprc T A 1: 138,006,254 (GRCm39) H752L probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Scn3a A G 2: 65,356,295 (GRCm39) probably benign Het
Sco1 T G 11: 66,954,846 (GRCm39) S284A probably benign Het
Slc25a10 T A 11: 120,388,265 (GRCm39) M227K probably damaging Het
Sox8 A G 17: 25,789,271 (GRCm39) Y76H probably damaging Het
Spdya A C 17: 71,863,309 (GRCm39) K19N possibly damaging Het
Syngap1 C T 17: 27,171,315 (GRCm39) probably benign Het
Sytl3 T C 17: 7,003,892 (GRCm39) S326P probably damaging Het
Tbl3 A G 17: 24,923,695 (GRCm39) V239A probably damaging Het
Tenm2 T C 11: 35,937,901 (GRCm39) I1592V probably benign Het
Vmn2r109 T A 17: 20,774,074 (GRCm39) D427V probably benign Het
Vmn2r115 A G 17: 23,579,017 (GRCm39) K830R probably damaging Het
Vmn2r45 A T 7: 8,474,580 (GRCm39) L816* probably null Het
Zfp335 C T 2: 164,743,380 (GRCm39) R536H probably damaging Het
Zfp777 T A 6: 48,019,046 (GRCm39) Q296L probably damaging Het
Other mutations in Ifitm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02039:Ifitm3 APN 7 140,590,563 (GRCm39) utr 5 prime probably benign
IGL02478:Ifitm3 APN 7 140,589,787 (GRCm39) missense possibly damaging 0.68
IGL02889:Ifitm3 APN 7 140,589,792 (GRCm39) missense probably damaging 1.00
I0000:Ifitm3 UTSW 7 140,590,441 (GRCm39) missense possibly damaging 0.85
R1069:Ifitm3 UTSW 7 140,589,813 (GRCm39) splice site probably benign
R4991:Ifitm3 UTSW 7 140,590,372 (GRCm39) missense probably damaging 1.00
R5288:Ifitm3 UTSW 7 140,590,554 (GRCm39) missense probably benign 0.00
R5385:Ifitm3 UTSW 7 140,590,554 (GRCm39) missense probably benign 0.00
R5386:Ifitm3 UTSW 7 140,590,554 (GRCm39) missense probably benign 0.00
R5543:Ifitm3 UTSW 7 140,589,730 (GRCm39) missense unknown
R7071:Ifitm3 UTSW 7 140,590,437 (GRCm39) missense probably benign 0.03
R7602:Ifitm3 UTSW 7 140,590,372 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCACTTCAGGACCGGAAG -3'
(R):5'- CCTGTGTGGAAAATGTTCAGG -3'

Sequencing Primer
(F):5'- CGGAAGTCGGAATCCTCTATTAAGTG -3'
(R):5'- TTCATGGGGAACAATAGCCTAC -3'
Posted On 2015-04-30