Incidental Mutation 'R4758:Kcnt2'
| ID |
358283 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kcnt2
|
| Ensembl Gene |
ENSMUSG00000052726 |
| Gene Name |
potassium channel, subfamily T, member 2 |
| Synonyms |
E330038N15Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R4758 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
140173896-140539805 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 140446635 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 677
(Y677H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112887
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119786]
[ENSMUST00000120709]
[ENSMUST00000120796]
|
| AlphaFold |
D3Z649 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000119786
AA Change: Y627H
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000113535
Gene: ENSMUSG00000052726
AA Change: Y627H
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.6e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
476 |
2.3e-16 |
PFAM |
|
low complexity region
|
598 |
613 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
699 |
714 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120709
AA Change: Y677H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000112887
Gene: ENSMUSG00000052726
AA Change: Y677H
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.7e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
764 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120796
AA Change: Y677H
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000113333
Gene: ENSMUSG00000052726
AA Change: Y677H
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.8e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145077
|
| SMART Domains |
Protein: ENSMUSP00000123677
Gene: ENSMUSG00000052726
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:BK_channel_a
|
1 |
88 |
1.2e-23 |
PFAM |
|
low complexity region
|
209 |
224 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
243 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000193606
AA Change: Y37H
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele are viable with normal pain and itch responses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad9 |
T |
A |
3: 36,127,754 (GRCm39) |
Y119N |
probably damaging |
Het |
| Actn2 |
T |
A |
13: 12,303,472 (GRCm39) |
K443* |
probably null |
Het |
| Adgrb2 |
A |
G |
4: 129,903,143 (GRCm39) |
N581S |
probably damaging |
Het |
| Afg2a |
T |
A |
3: 37,487,385 (GRCm39) |
S416T |
probably benign |
Het |
| Alb |
A |
T |
5: 90,616,452 (GRCm39) |
H319L |
probably benign |
Het |
| Aox1 |
A |
G |
1: 58,371,741 (GRCm39) |
I802V |
probably benign |
Het |
| Arhgap45 |
G |
A |
10: 79,866,127 (GRCm39) |
G995E |
probably benign |
Het |
| Capn12 |
A |
C |
7: 28,592,148 (GRCm39) |
T689P |
possibly damaging |
Het |
| Cars1 |
T |
C |
7: 143,125,304 (GRCm39) |
S312G |
probably benign |
Het |
| Cast |
T |
A |
13: 74,887,999 (GRCm39) |
D216V |
possibly damaging |
Het |
| Ccdc13 |
C |
T |
9: 121,662,800 (GRCm39) |
E72K |
possibly damaging |
Het |
| Cd300lg |
G |
T |
11: 101,944,417 (GRCm39) |
|
probably null |
Het |
| Cep41 |
A |
G |
6: 30,671,368 (GRCm39) |
|
probably benign |
Het |
| Chrna3 |
A |
G |
9: 54,929,560 (GRCm39) |
Y93H |
probably damaging |
Het |
| Cic |
A |
G |
7: 24,991,636 (GRCm39) |
R1309G |
possibly damaging |
Het |
| Clcnkb |
A |
G |
4: 141,135,160 (GRCm39) |
V526A |
probably benign |
Het |
| Clec4a1 |
G |
T |
6: 122,910,825 (GRCm39) |
V227F |
probably damaging |
Het |
| Cpa5 |
C |
A |
6: 30,615,159 (GRCm39) |
H99N |
possibly damaging |
Het |
| Crem |
C |
A |
18: 3,327,527 (GRCm39) |
C4F |
probably damaging |
Het |
| Cybb |
C |
G |
X: 9,316,989 (GRCm39) |
D246H |
probably benign |
Het |
| Decr2 |
C |
A |
17: 26,307,914 (GRCm39) |
E46D |
probably damaging |
Het |
| Dlg1 |
G |
A |
16: 31,610,570 (GRCm39) |
V284I |
possibly damaging |
Het |
| Dnah3 |
T |
C |
7: 119,678,629 (GRCm39) |
E360G |
probably benign |
Het |
| Dnajc1 |
A |
T |
2: 18,313,757 (GRCm39) |
Y121* |
probably null |
Het |
| Dnajc13 |
A |
G |
9: 104,049,773 (GRCm39) |
F1783L |
probably damaging |
Het |
| Eps8l2 |
T |
A |
7: 140,940,286 (GRCm39) |
D505E |
probably damaging |
Het |
| Eral1 |
G |
A |
11: 77,966,425 (GRCm39) |
T251I |
probably benign |
Het |
| Eya3 |
T |
C |
4: 132,422,196 (GRCm39) |
|
probably null |
Het |
| Fam120a |
G |
A |
13: 49,034,333 (GRCm39) |
T1093I |
probably benign |
Het |
| Fbn2 |
C |
T |
18: 58,159,458 (GRCm39) |
A2424T |
probably benign |
Het |
| Git2 |
G |
A |
5: 114,868,412 (GRCm39) |
T256M |
probably damaging |
Het |
| Gm9805 |
A |
T |
17: 22,689,871 (GRCm38) |
Y34F |
probably benign |
Het |
| Itgb7 |
T |
G |
15: 102,124,642 (GRCm39) |
T792P |
probably benign |
Het |
| Jakmip1 |
T |
A |
5: 37,285,966 (GRCm39) |
I665N |
probably damaging |
Het |
| Klhdc4 |
G |
A |
8: 122,524,783 (GRCm39) |
P382S |
probably benign |
Het |
| Knl1 |
TCC |
TC |
2: 118,902,213 (GRCm39) |
|
probably null |
Het |
| Lamb3 |
T |
A |
1: 193,022,269 (GRCm39) |
M1039K |
possibly damaging |
Het |
| Lipm |
A |
T |
19: 34,078,570 (GRCm39) |
M1L |
possibly damaging |
Het |
| Lrrc37 |
A |
G |
11: 103,505,290 (GRCm39) |
V2226A |
possibly damaging |
Het |
| Magi3 |
T |
A |
3: 103,922,637 (GRCm39) |
D1360V |
probably benign |
Het |
| Mier2 |
C |
A |
10: 79,386,182 (GRCm39) |
C23F |
probably damaging |
Het |
| Myo1h |
C |
T |
5: 114,487,643 (GRCm39) |
R616C |
probably damaging |
Het |
| Nars2 |
A |
G |
7: 96,622,735 (GRCm39) |
D187G |
probably damaging |
Het |
| Nbea |
T |
C |
3: 55,912,824 (GRCm39) |
M988V |
probably benign |
Het |
| Nlrc5 |
C |
A |
8: 95,238,956 (GRCm39) |
Q1465K |
possibly damaging |
Het |
| Nlrp4e |
T |
C |
7: 23,020,043 (GRCm39) |
F177L |
probably benign |
Het |
| Oas1a |
A |
G |
5: 121,045,401 (GRCm39) |
F47L |
probably damaging |
Het |
| Oas1f |
A |
G |
5: 120,985,545 (GRCm39) |
E30G |
probably damaging |
Het |
| Obscn |
A |
T |
11: 58,894,189 (GRCm39) |
M6689K |
unknown |
Het |
| Obscn |
A |
T |
11: 59,026,743 (GRCm39) |
D153E |
probably damaging |
Het |
| Or52s6 |
A |
C |
7: 103,092,076 (GRCm39) |
C85G |
probably damaging |
Het |
| Osmr |
A |
T |
15: 6,882,036 (GRCm39) |
I36K |
probably benign |
Het |
| Pcf11 |
A |
T |
7: 92,310,383 (GRCm39) |
F535Y |
probably damaging |
Het |
| Pde2a |
C |
T |
7: 101,160,706 (GRCm39) |
R886C |
probably damaging |
Het |
| Pik3ca |
T |
A |
3: 32,492,127 (GRCm39) |
C242S |
probably benign |
Het |
| Pikfyve |
T |
A |
1: 65,311,674 (GRCm39) |
D1925E |
possibly damaging |
Het |
| Plekhm2 |
A |
T |
4: 141,369,316 (GRCm39) |
Y123N |
possibly damaging |
Het |
| Pomt2 |
A |
T |
12: 87,169,652 (GRCm39) |
V406D |
probably damaging |
Het |
| Ppfia2 |
G |
C |
10: 106,597,978 (GRCm39) |
L180F |
probably damaging |
Het |
| Prdm10 |
A |
T |
9: 31,273,708 (GRCm39) |
T985S |
probably benign |
Het |
| Proc |
T |
A |
18: 32,256,863 (GRCm39) |
Y268F |
probably damaging |
Het |
| Prrc1 |
C |
T |
18: 57,517,320 (GRCm39) |
T365M |
probably damaging |
Het |
| Rasa1 |
A |
T |
13: 85,382,567 (GRCm39) |
D446E |
probably benign |
Het |
| Ribc2 |
T |
A |
15: 85,025,867 (GRCm39) |
L281Q |
probably damaging |
Het |
| Runx1t1 |
A |
G |
4: 13,865,907 (GRCm39) |
D385G |
probably damaging |
Het |
| Sdk2 |
A |
G |
11: 113,717,880 (GRCm39) |
S1495P |
possibly damaging |
Het |
| Slc15a3 |
G |
T |
19: 10,831,726 (GRCm39) |
|
probably null |
Het |
| Slc43a3 |
A |
G |
2: 84,774,869 (GRCm39) |
N149S |
probably damaging |
Het |
| Specc1l |
A |
G |
10: 75,082,182 (GRCm39) |
Q543R |
probably damaging |
Het |
| Spef1 |
T |
C |
2: 131,014,661 (GRCm39) |
|
probably null |
Het |
| Spns1 |
A |
T |
7: 125,969,966 (GRCm39) |
F478Y |
probably damaging |
Het |
| Srebf2 |
T |
C |
15: 82,080,370 (GRCm39) |
V821A |
probably benign |
Het |
| Stac3 |
A |
G |
10: 127,339,214 (GRCm39) |
M108V |
possibly damaging |
Het |
| Stradb |
A |
G |
1: 59,027,730 (GRCm39) |
T87A |
probably benign |
Het |
| Stxbp5l |
A |
T |
16: 36,954,592 (GRCm39) |
M906K |
probably benign |
Het |
| Tex14 |
T |
C |
11: 87,405,311 (GRCm39) |
V741A |
probably benign |
Het |
| Thoc2l |
A |
C |
5: 104,668,265 (GRCm39) |
E929A |
possibly damaging |
Het |
| Tpo |
C |
A |
12: 30,125,870 (GRCm39) |
G830C |
probably damaging |
Het |
| Unc79 |
T |
A |
12: 103,128,080 (GRCm39) |
C2308* |
probably null |
Het |
| Vmn1r205 |
T |
C |
13: 22,777,016 (GRCm39) |
T29A |
possibly damaging |
Het |
| Vmn1r69 |
G |
A |
7: 10,314,473 (GRCm39) |
T7I |
probably benign |
Het |
| Vmn2r27 |
T |
G |
6: 124,208,596 (GRCm39) |
T50P |
possibly damaging |
Het |
| Wdr83 |
A |
G |
8: 85,801,867 (GRCm39) |
Y302H |
probably benign |
Het |
| Xirp2 |
A |
T |
2: 67,346,879 (GRCm39) |
E3040V |
probably damaging |
Het |
| Zfp629 |
C |
A |
7: 127,209,758 (GRCm39) |
G684W |
probably damaging |
Het |
|
| Other mutations in Kcnt2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00561:Kcnt2
|
APN |
1 |
140,450,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00673:Kcnt2
|
APN |
1 |
140,523,789 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL00806:Kcnt2
|
APN |
1 |
140,450,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01135:Kcnt2
|
APN |
1 |
140,282,293 (GRCm39) |
critical splice donor site |
probably null |
0.00 |
|
IGL01412:Kcnt2
|
APN |
1 |
140,498,155 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01777:Kcnt2
|
APN |
1 |
140,523,736 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01780:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02134:Kcnt2
|
APN |
1 |
140,304,121 (GRCm39) |
missense |
probably benign |
|
|
IGL02350:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02357:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02481:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02483:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02866:Kcnt2
|
APN |
1 |
140,352,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02891:Kcnt2
|
APN |
1 |
140,502,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03007:Kcnt2
|
APN |
1 |
140,282,245 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03024:Kcnt2
|
APN |
1 |
140,498,193 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03231:Kcnt2
|
APN |
1 |
140,461,740 (GRCm39) |
intron |
probably benign |
|
|
BB002:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
BB012:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R0230:Kcnt2
|
UTSW |
1 |
140,174,083 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0367:Kcnt2
|
UTSW |
1 |
140,278,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Kcnt2
|
UTSW |
1 |
140,437,218 (GRCm39) |
nonsense |
probably null |
|
|
R0543:Kcnt2
|
UTSW |
1 |
140,537,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0849:Kcnt2
|
UTSW |
1 |
140,435,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1123:Kcnt2
|
UTSW |
1 |
140,501,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1156:Kcnt2
|
UTSW |
1 |
140,356,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1425:Kcnt2
|
UTSW |
1 |
140,310,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1530:Kcnt2
|
UTSW |
1 |
140,411,970 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Kcnt2
|
UTSW |
1 |
140,359,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1728:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1739:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1762:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1783:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1785:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1862:Kcnt2
|
UTSW |
1 |
140,353,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1887:Kcnt2
|
UTSW |
1 |
140,511,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1889:Kcnt2
|
UTSW |
1 |
140,512,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Kcnt2
|
UTSW |
1 |
140,353,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2005:Kcnt2
|
UTSW |
1 |
140,480,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2044:Kcnt2
|
UTSW |
1 |
140,302,892 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2115:Kcnt2
|
UTSW |
1 |
140,480,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2135:Kcnt2
|
UTSW |
1 |
140,356,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Kcnt2
|
UTSW |
1 |
140,437,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2212:Kcnt2
|
UTSW |
1 |
140,458,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2267:Kcnt2
|
UTSW |
1 |
140,501,421 (GRCm39) |
splice site |
probably null |
|
|
R2442:Kcnt2
|
UTSW |
1 |
140,304,091 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R3121:Kcnt2
|
UTSW |
1 |
140,356,622 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3176:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3276:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3704:Kcnt2
|
UTSW |
1 |
140,461,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Kcnt2
|
UTSW |
1 |
140,512,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Kcnt2
|
UTSW |
1 |
140,537,368 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4201:Kcnt2
|
UTSW |
1 |
140,353,070 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4501:Kcnt2
|
UTSW |
1 |
140,480,718 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4502:Kcnt2
|
UTSW |
1 |
140,435,485 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4632:Kcnt2
|
UTSW |
1 |
140,450,886 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4790:Kcnt2
|
UTSW |
1 |
140,282,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4892:Kcnt2
|
UTSW |
1 |
140,440,763 (GRCm39) |
nonsense |
probably null |
|
|
R4973:Kcnt2
|
UTSW |
1 |
140,537,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5154:Kcnt2
|
UTSW |
1 |
140,278,994 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5296:Kcnt2
|
UTSW |
1 |
140,537,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5353:Kcnt2
|
UTSW |
1 |
140,354,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Kcnt2
|
UTSW |
1 |
140,502,481 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5806:Kcnt2
|
UTSW |
1 |
140,437,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5887:Kcnt2
|
UTSW |
1 |
140,353,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Kcnt2
|
UTSW |
1 |
140,461,666 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5961:Kcnt2
|
UTSW |
1 |
140,435,440 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6123:Kcnt2
|
UTSW |
1 |
140,290,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6225:Kcnt2
|
UTSW |
1 |
140,354,661 (GRCm39) |
nonsense |
probably null |
|
|
R6248:Kcnt2
|
UTSW |
1 |
140,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6351:Kcnt2
|
UTSW |
1 |
140,302,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6380:Kcnt2
|
UTSW |
1 |
140,437,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6532:Kcnt2
|
UTSW |
1 |
140,511,844 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6693:Kcnt2
|
UTSW |
1 |
140,278,965 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6817:Kcnt2
|
UTSW |
1 |
140,173,931 (GRCm39) |
unclassified |
probably benign |
|
|
R6856:Kcnt2
|
UTSW |
1 |
140,523,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6944:Kcnt2
|
UTSW |
1 |
140,511,803 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6971:Kcnt2
|
UTSW |
1 |
140,440,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7052:Kcnt2
|
UTSW |
1 |
140,310,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7138:Kcnt2
|
UTSW |
1 |
140,523,778 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7261:Kcnt2
|
UTSW |
1 |
140,282,255 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7474:Kcnt2
|
UTSW |
1 |
140,498,216 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7524:Kcnt2
|
UTSW |
1 |
140,511,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7541:Kcnt2
|
UTSW |
1 |
140,304,122 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7558:Kcnt2
|
UTSW |
1 |
140,450,928 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7651:Kcnt2
|
UTSW |
1 |
140,498,199 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7730:Kcnt2
|
UTSW |
1 |
140,446,686 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7875:Kcnt2
|
UTSW |
1 |
140,501,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7883:Kcnt2
|
UTSW |
1 |
140,450,888 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7925:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R8040:Kcnt2
|
UTSW |
1 |
140,377,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8041:Kcnt2
|
UTSW |
1 |
140,537,398 (GRCm39) |
missense |
probably benign |
|
|
R8171:Kcnt2
|
UTSW |
1 |
140,437,203 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8268:Kcnt2
|
UTSW |
1 |
140,450,954 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8905:Kcnt2
|
UTSW |
1 |
140,435,467 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8927:Kcnt2
|
UTSW |
1 |
140,356,535 (GRCm39) |
splice site |
probably null |
|
|
R8988:Kcnt2
|
UTSW |
1 |
140,356,587 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9020:Kcnt2
|
UTSW |
1 |
140,512,049 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9109:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9167:Kcnt2
|
UTSW |
1 |
140,506,200 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9232:Kcnt2
|
UTSW |
1 |
140,411,931 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9297:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9298:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9318:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9404:Kcnt2
|
UTSW |
1 |
140,353,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Kcnt2
|
UTSW |
1 |
140,440,729 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
Z1088:Kcnt2
|
UTSW |
1 |
140,511,896 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Kcnt2
|
UTSW |
1 |
140,501,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Kcnt2
|
UTSW |
1 |
140,304,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Kcnt2
|
UTSW |
1 |
140,537,386 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCATGCAGAACTGAAAGCTC -3'
(R):5'- AGAGTCTTGTGCCTGTCGTC -3'
Sequencing Primer
(F):5'- GCAGGTCATAATACATTGCAATCTG -3'
(R):5'- CCTAACTGACTGGTTAACATAACTGG -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation