Incidental Mutation 'R5015:Kif26b'
ID 385477
Institutional Source Beutler Lab
Gene Symbol Kif26b
Ensembl Gene ENSMUSG00000026494
Gene Name kinesin family member 26B
Synonyms D230039L06Rik, N-11 kinesin
MMRRC Submission 042606-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5015 (G1)
Quality Score 155
Status Not validated
Chromosome 1
Chromosomal Location 178356690-178766765 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 178755895 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 2003 (R2003L)
Ref Sequence ENSEMBL: ENSMUSP00000124462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160789] [ENSMUST00000161017]
AlphaFold Q7TNC6
Predicted Effect probably damaging
Transcript: ENSMUST00000160789
AA Change: R1556L

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000124608
Gene: ENSMUSG00000026494
AA Change: R1556L

DomainStartEndE-ValueType
KISc 1 362 2.48e-42 SMART
low complexity region 363 375 N/A INTRINSIC
low complexity region 402 416 N/A INTRINSIC
low complexity region 460 466 N/A INTRINSIC
low complexity region 560 600 N/A INTRINSIC
low complexity region 652 662 N/A INTRINSIC
low complexity region 822 841 N/A INTRINSIC
low complexity region 1038 1048 N/A INTRINSIC
low complexity region 1294 1322 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000161017
AA Change: R2003L

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000124462
Gene: ENSMUSG00000026494
AA Change: R2003L

DomainStartEndE-ValueType
low complexity region 58 123 N/A INTRINSIC
low complexity region 144 155 N/A INTRINSIC
low complexity region 220 228 N/A INTRINSIC
Blast:KISc 365 446 4e-8 BLAST
KISc 448 809 2.48e-42 SMART
low complexity region 810 822 N/A INTRINSIC
low complexity region 849 863 N/A INTRINSIC
low complexity region 907 913 N/A INTRINSIC
low complexity region 1007 1047 N/A INTRINSIC
low complexity region 1099 1109 N/A INTRINSIC
low complexity region 1269 1288 N/A INTRINSIC
low complexity region 1485 1495 N/A INTRINSIC
low complexity region 1741 1769 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 91.3%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality with impaired kidney development due to loss of cortical nephrogenic zone mesenchyme and failure of ureteric buds to invade and branch into the mesenchyme. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 T A 8: 41,207,671 (GRCm39) F312L probably benign Het
Adprm A G 11: 66,932,856 (GRCm39) F18L possibly damaging Het
Ampd1 T G 3: 103,006,981 (GRCm39) N735K possibly damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp1a4 T C 1: 172,081,649 (GRCm39) M168V probably damaging Het
Bcl6 G A 16: 23,793,600 (GRCm39) H116Y probably damaging Het
Bmpr2 T A 1: 59,890,383 (GRCm39) N338K probably damaging Het
Bms1 A T 6: 118,381,224 (GRCm39) Y697* probably null Het
Ccdc33 A C 9: 58,025,918 (GRCm39) F37C probably damaging Het
Ccdc60 T A 5: 116,426,507 (GRCm39) Q30L probably benign Het
Cndp1 C A 18: 84,650,036 (GRCm39) R219L probably damaging Het
Cstdc4 T C 16: 36,006,837 (GRCm39) probably null Het
Daam2 C A 17: 49,783,550 (GRCm39) D627Y probably damaging Het
Dffb T C 4: 154,057,416 (GRCm39) D87G possibly damaging Het
Dnah2 T G 11: 69,388,708 (GRCm39) T892P possibly damaging Het
Dqx1 A G 6: 83,043,092 (GRCm39) T610A probably benign Het
Dspp A T 5: 104,324,926 (GRCm39) I430L possibly damaging Het
Dytn T A 1: 63,672,854 (GRCm39) K516N probably benign Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fmnl2 T A 2: 52,993,773 (GRCm39) N389K possibly damaging Het
Fn1 G A 1: 71,665,336 (GRCm39) T927I probably damaging Het
Foxn1 T C 11: 78,261,989 (GRCm39) K127E probably damaging Het
Fpr-rs6 A G 17: 20,402,608 (GRCm39) F251S probably damaging Het
Frrs1 A G 3: 116,672,088 (GRCm39) D62G probably damaging Het
Fut10 T A 8: 31,726,148 (GRCm39) V301D probably damaging Het
Gk5 A G 9: 96,059,470 (GRCm39) probably null Het
Glipr1l1 T A 10: 111,914,279 (GRCm39) N213K probably benign Het
Gm1110 A G 9: 26,793,162 (GRCm39) F538S probably benign Het
Gm7347 T A 5: 26,262,366 (GRCm39) T52S probably benign Het
Gsap T C 5: 21,427,406 (GRCm39) I178T probably damaging Het
H1f9 C A 11: 94,858,928 (GRCm39) N74K probably damaging Het
Hcn1 A T 13: 117,739,556 (GRCm39) Q106L unknown Het
Isg20l2 G T 3: 87,839,288 (GRCm39) L166F possibly damaging Het
Kcnq3 T A 15: 65,876,612 (GRCm39) E510D probably damaging Het
Kiss1r T C 10: 79,754,641 (GRCm39) V45A probably damaging Het
Krt14 G A 11: 100,098,032 (GRCm39) R84* probably null Het
Mbd5 T C 2: 49,148,208 (GRCm39) M806T possibly damaging Het
Mdga1 A T 17: 30,058,847 (GRCm39) I13N possibly damaging Het
Mfsd4b5 T C 10: 39,850,758 (GRCm39) K73E probably benign Het
Mterf2 C T 10: 84,955,596 (GRCm39) G343R probably benign Het
Mto1 T A 9: 78,368,903 (GRCm39) F522I probably benign Het
Myo18b T C 5: 112,937,923 (GRCm39) E1734G probably damaging Het
Myoz1 T C 14: 20,703,787 (GRCm39) T53A probably benign Het
Naxd T C 8: 11,563,032 (GRCm39) L324P probably damaging Het
Nos1 T A 5: 118,005,334 (GRCm39) V18D probably damaging Het
Nova1 T C 12: 46,863,738 (GRCm39) T71A unknown Het
Or10v5 T C 19: 11,805,482 (GRCm39) R303G probably benign Het
Or10z1 A G 1: 174,078,448 (GRCm39) L15S possibly damaging Het
Or1e29 C G 11: 73,668,007 (GRCm39) V49L probably benign Het
Or2j6 T C 7: 139,980,083 (GRCm39) D292G probably damaging Het
Or52b1 A G 7: 104,978,811 (GRCm39) V196A possibly damaging Het
Otof T A 5: 30,540,238 (GRCm39) Y981F probably damaging Het
Peg10 C CTCA 6: 4,756,453 (GRCm39) probably benign Het
Pex1 A G 5: 3,670,597 (GRCm39) K7E probably damaging Het
Pi4ka A G 16: 17,120,946 (GRCm39) S73P possibly damaging Het
Plxnb1 T A 9: 108,929,498 (GRCm39) I118N possibly damaging Het
Prcc T C 3: 87,779,560 (GRCm39) D158G probably damaging Het
Ptpn7 C A 1: 135,066,877 (GRCm39) R245S possibly damaging Het
Ptpre C T 7: 135,270,861 (GRCm39) H346Y probably benign Het
Pwp2 A G 10: 78,018,527 (GRCm39) C86R probably benign Het
Rfng T G 11: 120,673,876 (GRCm39) D178A probably damaging Het
Rhpn1 T C 15: 75,580,090 (GRCm39) I51T probably damaging Het
Rnasel G T 1: 153,629,843 (GRCm39) E120* probably null Het
Sall2 T G 14: 52,553,112 (GRCm39) S26R possibly damaging Het
Scn10a A G 9: 119,451,987 (GRCm39) V1312A possibly damaging Het
Sdk2 C A 11: 113,684,587 (GRCm39) R1958L probably damaging Het
Septin4 C T 11: 87,458,043 (GRCm39) S139F possibly damaging Het
Slc52a2 T A 15: 76,424,751 (GRCm39) C330S probably damaging Het
Smarca2 T A 19: 26,668,788 (GRCm39) I987N possibly damaging Het
Srrt A T 5: 137,294,271 (GRCm39) Y486N probably damaging Het
Stat5b A T 11: 100,695,831 (GRCm39) N50K possibly damaging Het
Strip2 T A 6: 29,931,265 (GRCm39) D405E probably benign Het
Tcstv6 T A 13: 120,298,474 (GRCm39) probably null Het
Tnc A T 4: 63,924,739 (GRCm39) D986E probably damaging Het
Tph2 T C 10: 114,915,621 (GRCm39) N473S probably benign Het
Tpp1 C T 7: 105,401,232 (GRCm39) probably benign Het
Trpm3 T C 19: 22,689,076 (GRCm39) Y2H probably damaging Het
Ttc21a A T 9: 119,795,195 (GRCm39) E1072V probably damaging Het
Zfat T C 15: 68,050,762 (GRCm39) D753G probably damaging Het
Zmym2 T A 14: 57,159,051 (GRCm39) S609T probably damaging Het
Other mutations in Kif26b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Kif26b APN 1 178,743,213 (GRCm39) missense probably damaging 1.00
IGL00425:Kif26b APN 1 178,743,866 (GRCm39) missense probably damaging 0.96
IGL00952:Kif26b APN 1 178,759,770 (GRCm39) missense probably damaging 1.00
IGL01100:Kif26b APN 1 178,744,809 (GRCm39) missense probably benign
IGL01347:Kif26b APN 1 178,698,240 (GRCm39) missense probably damaging 1.00
IGL01543:Kif26b APN 1 178,506,526 (GRCm39) missense probably benign 0.41
IGL01938:Kif26b APN 1 178,743,603 (GRCm39) missense probably damaging 0.99
IGL02100:Kif26b APN 1 178,743,512 (GRCm39) missense probably damaging 0.99
IGL02262:Kif26b APN 1 178,743,633 (GRCm39) missense probably benign 0.05
IGL02576:Kif26b APN 1 178,743,912 (GRCm39) missense probably benign
IGL02673:Kif26b APN 1 178,649,170 (GRCm39) missense probably damaging 1.00
IGL03078:Kif26b APN 1 178,698,291 (GRCm39) missense probably damaging 1.00
IGL03155:Kif26b APN 1 178,701,693 (GRCm39) missense probably damaging 1.00
IGL03157:Kif26b APN 1 178,743,930 (GRCm39) missense probably damaging 1.00
IGL03162:Kif26b APN 1 178,744,497 (GRCm39) missense probably benign
IGL03220:Kif26b APN 1 178,692,434 (GRCm39) missense probably damaging 1.00
IGL03299:Kif26b APN 1 178,649,125 (GRCm39) missense probably benign 0.09
IGL03368:Kif26b APN 1 178,743,773 (GRCm39) missense probably damaging 1.00
IGL03370:Kif26b APN 1 178,742,946 (GRCm39) missense probably benign 0.39
PIT4449001:Kif26b UTSW 1 178,745,651 (GRCm39) missense probably damaging 1.00
R0142:Kif26b UTSW 1 178,742,954 (GRCm39) missense probably damaging 1.00
R0621:Kif26b UTSW 1 178,743,218 (GRCm39) missense probably benign 0.02
R0987:Kif26b UTSW 1 178,649,185 (GRCm39) missense probably damaging 1.00
R1107:Kif26b UTSW 1 178,745,238 (GRCm39) missense probably benign 0.03
R1367:Kif26b UTSW 1 178,744,028 (GRCm39) missense probably damaging 1.00
R1386:Kif26b UTSW 1 178,743,209 (GRCm39) missense probably benign
R1619:Kif26b UTSW 1 178,744,043 (GRCm39) missense probably benign 0.00
R1664:Kif26b UTSW 1 178,759,704 (GRCm39) missense probably damaging 1.00
R2240:Kif26b UTSW 1 178,543,488 (GRCm39) missense probably benign 0.00
R2264:Kif26b UTSW 1 178,756,407 (GRCm39) critical splice acceptor site probably null
R2443:Kif26b UTSW 1 178,742,579 (GRCm39) missense probably damaging 0.99
R3023:Kif26b UTSW 1 178,692,433 (GRCm39) missense probably damaging 0.99
R3744:Kif26b UTSW 1 178,506,595 (GRCm39) missense probably benign 0.00
R3831:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3832:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3833:Kif26b UTSW 1 178,744,181 (GRCm39) frame shift probably null
R3843:Kif26b UTSW 1 178,755,742 (GRCm39) missense probably damaging 1.00
R4108:Kif26b UTSW 1 178,744,530 (GRCm39) missense possibly damaging 0.88
R4181:Kif26b UTSW 1 178,742,991 (GRCm39) missense probably damaging 0.98
R4551:Kif26b UTSW 1 178,711,600 (GRCm39) missense probably damaging 1.00
R4552:Kif26b UTSW 1 178,711,600 (GRCm39) missense probably damaging 1.00
R4597:Kif26b UTSW 1 178,744,358 (GRCm39) missense probably damaging 1.00
R4599:Kif26b UTSW 1 178,358,024 (GRCm39) missense unknown
R4610:Kif26b UTSW 1 178,506,920 (GRCm39) missense probably damaging 1.00
R4746:Kif26b UTSW 1 178,701,546 (GRCm39) nonsense probably null
R4873:Kif26b UTSW 1 178,742,892 (GRCm39) missense probably benign 0.38
R4875:Kif26b UTSW 1 178,742,892 (GRCm39) missense probably benign 0.38
R5060:Kif26b UTSW 1 178,358,195 (GRCm39) missense unknown
R5301:Kif26b UTSW 1 178,358,233 (GRCm39) missense unknown
R5368:Kif26b UTSW 1 178,743,449 (GRCm39) missense probably damaging 1.00
R5387:Kif26b UTSW 1 178,742,441 (GRCm39) missense probably benign 0.01
R5589:Kif26b UTSW 1 178,743,864 (GRCm39) missense probably benign 0.05
R6150:Kif26b UTSW 1 178,743,111 (GRCm39) missense probably damaging 1.00
R6259:Kif26b UTSW 1 178,744,970 (GRCm39) missense probably damaging 0.97
R6355:Kif26b UTSW 1 178,743,743 (GRCm39) missense probably damaging 1.00
R6408:Kif26b UTSW 1 178,745,133 (GRCm39) missense probably damaging 1.00
R6488:Kif26b UTSW 1 178,357,138 (GRCm39) missense unknown
R6546:Kif26b UTSW 1 178,755,871 (GRCm39) missense probably damaging 1.00
R6702:Kif26b UTSW 1 178,744,852 (GRCm39) missense possibly damaging 0.90
R6886:Kif26b UTSW 1 178,701,703 (GRCm39) missense probably damaging 1.00
R6953:Kif26b UTSW 1 178,701,637 (GRCm39) missense possibly damaging 0.89
R7262:Kif26b UTSW 1 178,745,219 (GRCm39) missense possibly damaging 0.84
R7291:Kif26b UTSW 1 178,506,611 (GRCm39) missense possibly damaging 0.86
R7346:Kif26b UTSW 1 178,358,306 (GRCm39) missense probably damaging 1.00
R7383:Kif26b UTSW 1 178,358,275 (GRCm39) missense probably damaging 1.00
R7448:Kif26b UTSW 1 178,742,339 (GRCm39) missense probably damaging 1.00
R7506:Kif26b UTSW 1 178,357,064 (GRCm39) start gained probably benign
R7562:Kif26b UTSW 1 178,742,541 (GRCm39) missense probably damaging 1.00
R7583:Kif26b UTSW 1 178,358,010 (GRCm39) nonsense probably null
R7585:Kif26b UTSW 1 178,744,061 (GRCm39) missense probably benign 0.01
R7644:Kif26b UTSW 1 178,506,839 (GRCm39) missense probably benign 0.04
R7759:Kif26b UTSW 1 178,506,509 (GRCm39) missense probably damaging 1.00
R7775:Kif26b UTSW 1 178,692,441 (GRCm39) missense probably benign 0.15
R7954:Kif26b UTSW 1 178,696,944 (GRCm39) missense probably damaging 0.99
R7960:Kif26b UTSW 1 178,506,484 (GRCm39) missense probably damaging 1.00
R8012:Kif26b UTSW 1 178,743,815 (GRCm39) missense probably benign 0.20
R8152:Kif26b UTSW 1 178,506,794 (GRCm39) missense possibly damaging 0.46
R8320:Kif26b UTSW 1 178,711,641 (GRCm39) critical splice donor site probably null
R8360:Kif26b UTSW 1 178,743,938 (GRCm39) missense probably benign 0.18
R8428:Kif26b UTSW 1 178,744,923 (GRCm39) missense probably benign 0.09
R8670:Kif26b UTSW 1 178,741,349 (GRCm39) missense probably damaging 1.00
R8737:Kif26b UTSW 1 178,692,430 (GRCm39) missense probably damaging 0.99
R8788:Kif26b UTSW 1 178,357,090 (GRCm39) start gained probably benign
R8854:Kif26b UTSW 1 178,743,948 (GRCm39) missense possibly damaging 0.93
R8870:Kif26b UTSW 1 178,692,594 (GRCm39) missense probably damaging 1.00
R8963:Kif26b UTSW 1 178,743,714 (GRCm39) missense probably benign 0.00
R9232:Kif26b UTSW 1 178,742,511 (GRCm39) missense probably damaging 1.00
R9297:Kif26b UTSW 1 178,543,374 (GRCm39) nonsense probably null
R9338:Kif26b UTSW 1 178,744,058 (GRCm39) missense probably damaging 1.00
R9572:Kif26b UTSW 1 178,745,042 (GRCm39) missense probably benign
R9580:Kif26b UTSW 1 178,506,643 (GRCm39) nonsense probably null
R9694:Kif26b UTSW 1 178,743,815 (GRCm39) missense probably benign 0.20
X0021:Kif26b UTSW 1 178,755,724 (GRCm39) missense probably damaging 1.00
X0024:Kif26b UTSW 1 178,506,647 (GRCm39) missense probably benign 0.14
X0025:Kif26b UTSW 1 178,742,948 (GRCm39) missense possibly damaging 0.70
X0025:Kif26b UTSW 1 178,742,831 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,742,970 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,649,115 (GRCm39) nonsense probably null
Z1177:Kif26b UTSW 1 178,649,113 (GRCm39) missense probably benign 0.11
Predicted Primers PCR Primer
(F):5'- CTCACATTCAAGTTCGCCAGC -3'
(R):5'- CAGGATCTACCAAAGTCTGTGG -3'

Sequencing Primer
(F):5'- CTCTTTGTATTAGGTTCCCAGAGACG -3'
(R):5'- TACCAAAGTCTGTGGCTGGGAC -3'
Posted On 2016-05-10