Incidental Mutation 'R5204:Igkv4-80'
ID |
398336 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Igkv4-80
|
Ensembl Gene |
ENSMUSG00000076540 |
Gene Name |
immunoglobulin kappa variable 4-80 |
Synonyms |
Gm16729 |
MMRRC Submission |
042779-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.115)
|
Stock # |
R5204 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
6 |
Chromosomal Location |
68993542-68994064 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 68993649 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Alanine
at position 81
(S81A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000100142
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000103341]
|
AlphaFold |
A0A075B5L7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000103341
AA Change: S81A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000100142 Gene: ENSMUSG00000076540 AA Change: S81A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
IGv
|
40 |
111 |
1.7e-19 |
SMART |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 95.0%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aarsd1 |
A |
T |
11: 101,297,752 (GRCm39) |
L532Q |
probably damaging |
Het |
Abt1 |
G |
A |
13: 23,606,838 (GRCm39) |
R88C |
probably damaging |
Het |
Aopep |
G |
A |
13: 63,180,904 (GRCm39) |
V289I |
probably benign |
Het |
Arhgef7 |
T |
A |
8: 11,850,775 (GRCm39) |
L129* |
probably null |
Het |
Arid1b |
T |
C |
17: 5,393,316 (GRCm39) |
V2282A |
probably damaging |
Het |
Bivm |
G |
C |
1: 44,177,738 (GRCm39) |
G346A |
probably damaging |
Het |
Cav1 |
T |
C |
6: 17,339,254 (GRCm39) |
L102P |
probably damaging |
Het |
Ccdc57 |
A |
G |
11: 120,776,888 (GRCm39) |
V504A |
possibly damaging |
Het |
Cd7 |
A |
T |
11: 120,928,860 (GRCm39) |
|
probably null |
Het |
Cdh3 |
T |
C |
8: 107,270,871 (GRCm39) |
V508A |
probably benign |
Het |
Chrd |
A |
T |
16: 20,554,822 (GRCm39) |
I413F |
probably benign |
Het |
Clec4b1 |
T |
A |
6: 123,048,494 (GRCm39) |
*210R |
probably null |
Het |
Clock |
A |
T |
5: 76,391,017 (GRCm39) |
|
probably null |
Het |
Col4a2 |
T |
A |
8: 11,448,651 (GRCm39) |
|
probably null |
Het |
Gpx7 |
T |
C |
4: 108,260,512 (GRCm39) |
T95A |
probably benign |
Het |
Hivep3 |
T |
A |
4: 119,961,053 (GRCm39) |
|
probably null |
Het |
Hrc |
A |
G |
7: 44,985,128 (GRCm39) |
Y93C |
possibly damaging |
Het |
Klhl5 |
G |
T |
5: 65,288,781 (GRCm39) |
L14F |
possibly damaging |
Het |
Mcm6 |
A |
G |
1: 128,261,375 (GRCm39) |
L743P |
probably benign |
Het |
Nrxn1 |
A |
T |
17: 90,469,792 (GRCm39) |
F57Y |
probably damaging |
Het |
Or51af1 |
C |
T |
7: 103,141,747 (GRCm39) |
V113M |
probably damaging |
Het |
Otx1 |
C |
A |
11: 21,947,037 (GRCm39) |
A91S |
probably damaging |
Het |
Pcdh20 |
G |
T |
14: 88,706,351 (GRCm39) |
D316E |
probably damaging |
Het |
Pcdhb12 |
T |
A |
18: 37,569,142 (GRCm39) |
V96E |
probably damaging |
Het |
Pi4ka |
A |
T |
16: 17,176,909 (GRCm39) |
L346M |
possibly damaging |
Het |
Pkhd1l1 |
A |
C |
15: 44,410,437 (GRCm39) |
N2648T |
possibly damaging |
Het |
Rufy1 |
C |
T |
11: 50,297,261 (GRCm39) |
R397Q |
probably damaging |
Het |
Sema5a |
G |
T |
15: 32,686,793 (GRCm39) |
M968I |
probably benign |
Het |
Slc33a1 |
A |
G |
3: 63,871,167 (GRCm39) |
Y149H |
probably damaging |
Het |
Tln2 |
T |
A |
9: 67,261,764 (GRCm39) |
R658S |
probably benign |
Het |
Tmem30c |
T |
C |
16: 57,090,385 (GRCm39) |
N274S |
possibly damaging |
Het |
Tor3a |
A |
G |
1: 156,483,270 (GRCm39) |
L384P |
probably damaging |
Het |
Trpm3 |
T |
A |
19: 22,425,705 (GRCm39) |
L20* |
probably null |
Het |
Ttn |
T |
A |
2: 76,560,556 (GRCm39) |
I20955F |
probably damaging |
Het |
Usp15 |
A |
T |
10: 122,949,545 (GRCm39) |
S908R |
probably benign |
Het |
Zfp866 |
A |
G |
8: 70,218,690 (GRCm39) |
L310P |
probably damaging |
Het |
|
Other mutations in Igkv4-80 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02452:Igkv4-80
|
APN |
6 |
68,993,816 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02630:Igkv4-80
|
APN |
6 |
68,993,680 (GRCm39) |
nonsense |
probably null |
|
IGL02711:Igkv4-80
|
APN |
6 |
68,993,801 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02934:Igkv4-80
|
APN |
6 |
68,993,840 (GRCm39) |
missense |
probably benign |
0.32 |
R4584:Igkv4-80
|
UTSW |
6 |
68,993,720 (GRCm39) |
missense |
probably damaging |
1.00 |
R4873:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R4875:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R4925:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R4934:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R4991:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R4992:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5020:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5061:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5063:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5097:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5164:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5165:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5169:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5170:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5171:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5172:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5203:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5205:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5257:Igkv4-80
|
UTSW |
6 |
68,993,811 (GRCm39) |
missense |
probably benign |
0.01 |
R5258:Igkv4-80
|
UTSW |
6 |
68,993,811 (GRCm39) |
missense |
probably benign |
0.01 |
R5380:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5381:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5382:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5383:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5415:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R5416:Igkv4-80
|
UTSW |
6 |
68,993,649 (GRCm39) |
missense |
probably benign |
|
R6778:Igkv4-80
|
UTSW |
6 |
68,993,545 (GRCm39) |
nonsense |
probably null |
|
R7385:Igkv4-80
|
UTSW |
6 |
68,993,699 (GRCm39) |
missense |
probably damaging |
1.00 |
R7507:Igkv4-80
|
UTSW |
6 |
68,993,677 (GRCm39) |
missense |
probably benign |
0.02 |
R7994:Igkv4-80
|
UTSW |
6 |
68,993,621 (GRCm39) |
missense |
probably benign |
0.04 |
R9323:Igkv4-80
|
UTSW |
6 |
68,993,751 (GRCm39) |
missense |
probably damaging |
1.00 |
R9439:Igkv4-80
|
UTSW |
6 |
68,993,793 (GRCm39) |
missense |
probably benign |
0.00 |
R9484:Igkv4-80
|
UTSW |
6 |
68,993,766 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
|
Posted On |
2016-07-06 |