Incidental Mutation 'R5245:Pim3'
ID 401126
Institutional Source Beutler Lab
Gene Symbol Pim3
Ensembl Gene ENSMUSG00000035828
Gene Name proviral integration site 3
Synonyms Kid1, KID-1/kinase induced by depolarization
MMRRC Submission 042816-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5245 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 88746397-88749929 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88747404 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 90 (E90G)
Ref Sequence ENSEMBL: ENSMUSP00000044603 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042818]
AlphaFold P58750
Predicted Effect possibly damaging
Transcript: ENSMUST00000042818
AA Change: E90G

PolyPhen 2 Score 0.880 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000044603
Gene: ENSMUSG00000035828
AA Change: E90G

DomainStartEndE-ValueType
S_TKc 40 293 9.25e-69 SMART
low complexity region 312 325 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229969
Meta Mutation Damage Score 0.7929 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.3%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygous null mice are healthy and fertile and do not display any gross abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd17b T A 19: 21,661,624 (GRCm39) Y270* probably null Het
Akap9 A T 5: 4,026,209 (GRCm39) Q59L probably damaging Het
Aloxe3 A T 11: 69,020,502 (GRCm39) Q182L probably benign Het
Arhgef5 G T 6: 43,242,614 (GRCm39) probably benign Het
Bcas3 T A 11: 85,449,912 (GRCm39) N663K probably damaging Het
Cimap3 T C 3: 105,921,770 (GRCm39) H51R possibly damaging Het
Cntfr A T 4: 41,670,879 (GRCm39) W95R possibly damaging Het
Dcun1d4 A G 5: 73,714,657 (GRCm39) T275A probably benign Het
Eps8l1 A G 7: 4,473,873 (GRCm39) R227G probably damaging Het
Ets2 G A 16: 95,513,304 (GRCm39) W160* probably null Het
Flt4 AC ACC 11: 49,541,861 (GRCm39) probably null Het
Fsip2 A G 2: 82,823,505 (GRCm39) M6413V probably benign Het
Gm14401 C T 2: 176,778,471 (GRCm39) P186S probably damaging Het
Hrc G A 7: 44,984,855 (GRCm39) G2D probably damaging Het
Kcnq3 A G 15: 65,903,284 (GRCm39) V142A possibly damaging Het
Lama3 G A 18: 12,552,950 (GRCm39) C454Y probably damaging Het
Lrrk2 A G 15: 91,680,292 (GRCm39) T2068A probably damaging Het
Mab21l2 T C 3: 86,454,799 (GRCm39) E67G possibly damaging Het
Map3k5 G A 10: 20,016,437 (GRCm39) V1343I probably benign Het
Mcm4 T A 16: 15,448,289 (GRCm39) T423S probably benign Het
Mmp16 A G 4: 18,054,596 (GRCm39) probably benign Het
Nat3 C T 8: 68,000,832 (GRCm39) T237I probably benign Het
Nol4 A T 18: 22,828,179 (GRCm39) *484R probably null Het
Nsmf A G 2: 24,946,119 (GRCm39) E202G probably damaging Het
Olfml2b T C 1: 170,496,443 (GRCm39) V358A probably benign Het
Or2v2 T A 11: 49,004,116 (GRCm39) I146F probably benign Het
Or4b1d T A 2: 89,968,606 (GRCm39) K292N probably damaging Het
Osbpl1a T C 18: 12,891,910 (GRCm39) E466G probably damaging Het
Recql5 T C 11: 115,784,385 (GRCm39) E905G probably damaging Het
Rnf31 T G 14: 55,839,163 (GRCm39) L925R probably damaging Het
Secisbp2l A G 2: 125,589,511 (GRCm39) V679A probably damaging Het
Setdb2 T A 14: 59,663,943 (GRCm39) E68V probably null Het
Shtn1 T A 19: 59,020,652 (GRCm39) N190I possibly damaging Het
Slc25a25 G A 2: 32,311,340 (GRCm39) Q14* probably null Het
Snrnp27 A G 6: 86,659,941 (GRCm39) S18P unknown Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Het
Tbx5 T C 5: 120,021,230 (GRCm39) V412A possibly damaging Het
Tcea3 A G 4: 135,991,813 (GRCm39) T166A probably benign Het
Tdrp A T 8: 14,024,479 (GRCm39) probably benign Het
Tent5a G T 9: 85,208,401 (GRCm39) Q160K possibly damaging Het
Tmem132e T C 11: 82,333,464 (GRCm39) V624A probably damaging Het
Tnnt1 T C 7: 4,513,066 (GRCm39) D72G probably damaging Het
Trim80 C A 11: 115,332,398 (GRCm39) H197N probably damaging Het
Zfp322a A T 13: 23,541,156 (GRCm39) C195* probably null Het
Zfp335 A G 2: 164,736,678 (GRCm39) S986P probably benign Het
Other mutations in Pim3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02363:Pim3 APN 15 88,747,116 (GRCm39) missense probably benign 0.34
IGL02423:Pim3 APN 15 88,747,734 (GRCm39) missense probably benign 0.23
R2219:Pim3 UTSW 15 88,747,115 (GRCm39) missense possibly damaging 0.92
R2264:Pim3 UTSW 15 88,748,793 (GRCm39) missense probably damaging 1.00
R5086:Pim3 UTSW 15 88,748,606 (GRCm39) missense probably damaging 1.00
R5486:Pim3 UTSW 15 88,747,425 (GRCm39) missense possibly damaging 0.71
R6759:Pim3 UTSW 15 88,747,296 (GRCm39) critical splice donor site probably null
Z1177:Pim3 UTSW 15 88,748,644 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- CTTCGAGAAGGTGTACCAGG -3'
(R):5'- TGCACGACCCCACAATTGTG -3'

Sequencing Primer
(F):5'- AGGTGTACCAGGTGGGC -3'
(R):5'- GCACCTGCGCGAAGAAG -3'
Posted On 2016-07-06