Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03344:Zmym6'

417378

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zmym6

Ensembl Gene

ENSMUSG00000042408

Gene Name

zinc finger, MYM-type 6

Synonyms

9330177P20Rik, Zfp258, D4Wsu24e

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03344

Quality Score

Status

Chromosome

Chromosomal Location

126971176-127018165 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 127014314 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 624 (T624A)

Ref Sequence

ENSEMBL: ENSMUSP00000045366 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046751] [ENSMUST00000094713] [ENSMUST00000106097]

AlphaFold

Q8BS54

Predicted Effect

probably damaging
Transcript: ENSMUST00000046751
AA Change: T624A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000045366
Gene: ENSMUSG00000042408
AA Change: T624A

Domain	Start	End	E-Value	Type
Blast:TRASH	77	113	1e-12	BLAST
TRASH	123	163	1.18e-1	SMART
TRASH	197	231	5.47e3	SMART
TRASH	241	277	4.01e1	SMART
TRASH	349	385	2.46e1	SMART
TRASH	391	426	3.32e2	SMART
TRASH	434	472	2.91e-1	SMART
TRASH	478	513	9.99e0	SMART
low complexity region	602	612	N/A	INTRINSIC
low complexity region	642	656	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000094713
AA Change: T532A

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000092303
Gene: ENSMUSG00000042408
AA Change: T532A

Domain	Start	End	E-Value	Type
Blast:TRASH	77	113	1e-12	BLAST
TRASH	123	163	1.18e-1	SMART
TRASH	197	231	5.47e3	SMART
TRASH	262	293	6.03e2	SMART
TRASH	299	334	3.32e2	SMART
TRASH	342	380	2.91e-1	SMART
TRASH	386	421	9.99e0	SMART
low complexity region	510	520	N/A	INTRINSIC
low complexity region	550	564	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000106097

SMART Domains

Protein: ENSMUSP00000101703
Gene: ENSMUSG00000070737

Domain	Start	End	E-Value	Type
Pfam:DoxX_2	27	111	8.1e-12	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700011L22Rik	A	T	8: 79,975,005 (GRCm39)	I26N	probably damaging	Het
Atxn7l1	A	G	12: 33,376,065 (GRCm39)	N47D	probably damaging	Het
Cer1	A	T	4: 82,803,062 (GRCm39)	W87R	probably damaging	Het
Chrna2	A	G	14: 66,388,415 (GRCm39)	K477E	probably damaging	Het
Chtf8	G	A	8: 107,612,904 (GRCm39)	P12S	probably damaging	Het
Cplane1	C	A	15: 8,216,942 (GRCm39)	P720Q	possibly damaging	Het
Deaf1	A	T	7: 140,877,461 (GRCm39)	H555Q	probably benign	Het
Dop1a	T	G	9: 86,418,197 (GRCm39)	I1975M	probably damaging	Het
Ecpas	A	C	4: 58,828,538 (GRCm39)	V965G	probably damaging	Het
Fsd2	C	A	7: 81,209,657 (GRCm39)	V62L	probably benign	Het
Fxyd6	T	G	9: 45,303,548 (GRCm39)	L81R	probably benign	Het
Htt	T	A	5: 35,064,810 (GRCm39)	S3008T	probably benign	Het
Htt	T	A	5: 35,037,172 (GRCm39)	S2086T	probably benign	Het
Mybbp1a	G	T	11: 72,336,028 (GRCm39)	R447L	probably damaging	Het
Nup210	A	G	6: 90,998,411 (GRCm39)	V792A	possibly damaging	Het
Odad2	C	A	18: 7,129,434 (GRCm39)	G915*	probably null	Het
Odr4	T	C	1: 150,239,295 (GRCm39)	E386G	probably damaging	Het
Or1e32	T	A	11: 73,705,003 (GRCm39)	I302L	probably benign	Het
Or1j14	T	C	2: 36,418,140 (GRCm39)	S239P	probably damaging	Het
Prokr1	T	C	6: 87,565,482 (GRCm39)	D121G	possibly damaging	Het
Puf60	A	G	15: 75,942,229 (GRCm39)	V548A	possibly damaging	Het
Serpina3c	T	C	12: 104,113,523 (GRCm39)	I408V	probably benign	Het
Ska2	A	G	11: 87,000,139 (GRCm39)		probably benign	Het
Slc4a9	T	A	18: 36,668,654 (GRCm39)	Y745N	probably damaging	Het
Spart	T	C	3: 55,029,106 (GRCm39)	M299T	probably benign	Het
Speer4f1	A	G	5: 17,685,332 (GRCm39)	E209G	possibly damaging	Het
Tmem202	T	C	9: 59,426,351 (GRCm39)	T272A	possibly damaging	Het
Vegfc	T	A	8: 54,610,186 (GRCm39)	I114N	possibly damaging	Het
Vmn1r61	T	A	7: 5,613,493 (GRCm39)	T274S	possibly damaging	Het
Zfpm2	A	G	15: 40,966,170 (GRCm39)	N753S	probably benign	Het

Other mutations in Zmym6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00430:Zmym6	APN	4	126,995,742 (GRCm39)	nonsense	probably null
IGL00486:Zmym6	APN	4	127,017,978 (GRCm39)	utr 5 prime	probably benign
IGL01017:Zmym6	APN	4	126,982,152 (GRCm39)	missense	probably benign	0.00
IGL01385:Zmym6	APN	4	127,017,899 (GRCm39)	missense	probably benign	0.02
IGL01577:Zmym6	APN	4	126,999,223 (GRCm39)	missense	probably damaging	1.00
IGL01654:Zmym6	APN	4	127,017,519 (GRCm39)	missense	probably damaging	1.00
IGL01736:Zmym6	APN	4	127,002,437 (GRCm39)	missense	probably damaging	1.00
IGL01824:Zmym6	APN	4	127,002,499 (GRCm39)	missense	probably damaging	0.99
IGL01916:Zmym6	APN	4	127,017,549 (GRCm39)	missense	probably damaging	0.98
IGL01985:Zmym6	APN	4	126,994,541 (GRCm39)	missense	probably damaging	1.00
IGL02056:Zmym6	APN	4	126,997,207 (GRCm39)	missense	probably damaging	1.00
IGL02477:Zmym6	APN	4	126,972,295 (GRCm39)	nonsense	probably null
IGL02754:Zmym6	APN	4	127,003,764 (GRCm39)	splice site	probably benign
IGL03412:Zmym6	APN	4	126,986,731 (GRCm39)	missense	probably damaging	1.00
R0335:Zmym6	UTSW	4	127,016,601 (GRCm39)	missense	probably damaging	1.00
R0448:Zmym6	UTSW	4	127,002,487 (GRCm39)	missense	probably benign	0.01
R0463:Zmym6	UTSW	4	127,016,565 (GRCm39)	missense	probably damaging	0.98
R0538:Zmym6	UTSW	4	127,017,162 (GRCm39)	missense	probably benign	0.21
R0789:Zmym6	UTSW	4	127,016,615 (GRCm39)	missense	possibly damaging	0.52
R0798:Zmym6	UTSW	4	126,997,316 (GRCm39)	missense	probably benign	0.00
R1311:Zmym6	UTSW	4	127,017,151 (GRCm39)	missense	probably damaging	1.00
R1351:Zmym6	UTSW	4	127,016,798 (GRCm39)	missense	probably benign	0.00
R1429:Zmym6	UTSW	4	127,017,672 (GRCm39)	missense	probably damaging	1.00
R1636:Zmym6	UTSW	4	127,017,560 (GRCm39)	missense	probably damaging	0.99
R1666:Zmym6	UTSW	4	127,016,652 (GRCm39)	missense	probably damaging	0.98
R1919:Zmym6	UTSW	4	126,997,207 (GRCm39)	missense	probably damaging	1.00
R2058:Zmym6	UTSW	4	126,982,208 (GRCm39)	nonsense	probably null
R3957:Zmym6	UTSW	4	127,017,089 (GRCm39)	missense	possibly damaging	0.68
R3978:Zmym6	UTSW	4	127,017,348 (GRCm39)	missense	possibly damaging	0.71
R4417:Zmym6	UTSW	4	126,986,781 (GRCm39)	missense	probably damaging	1.00
R4801:Zmym6	UTSW	4	127,017,009 (GRCm39)	missense	probably benign	0.19
R4802:Zmym6	UTSW	4	127,017,009 (GRCm39)	missense	probably benign	0.19
R5052:Zmym6	UTSW	4	127,017,767 (GRCm39)	missense	possibly damaging	0.92
R5105:Zmym6	UTSW	4	127,017,551 (GRCm39)	missense	probably benign	0.33
R5217:Zmym6	UTSW	4	126,999,167 (GRCm39)	missense	possibly damaging	0.76
R5682:Zmym6	UTSW	4	126,998,200 (GRCm39)	missense	probably damaging	1.00
R5841:Zmym6	UTSW	4	126,994,463 (GRCm39)	missense	possibly damaging	0.71
R5991:Zmym6	UTSW	4	127,002,266 (GRCm39)	splice site	probably null
R6478:Zmym6	UTSW	4	127,017,176 (GRCm39)	missense	possibly damaging	0.86
R7014:Zmym6	UTSW	4	127,017,337 (GRCm39)	nonsense	probably null
R7287:Zmym6	UTSW	4	127,016,775 (GRCm39)	missense	possibly damaging	0.50
R7290:Zmym6	UTSW	4	127,017,294 (GRCm39)	missense	possibly damaging	0.73
R7371:Zmym6	UTSW	4	126,998,106 (GRCm39)	missense	probably damaging	1.00
R7967:Zmym6	UTSW	4	127,016,453 (GRCm39)	missense	probably benign	0.03
R8237:Zmym6	UTSW	4	127,016,544 (GRCm39)	missense	probably damaging	0.99
R8306:Zmym6	UTSW	4	127,016,355 (GRCm39)	missense	probably damaging	1.00
R8312:Zmym6	UTSW	4	127,017,627 (GRCm39)	missense	probably damaging	1.00
R9090:Zmym6	UTSW	4	127,017,854 (GRCm39)	missense	probably damaging	0.99
R9216:Zmym6	UTSW	4	127,002,500 (GRCm39)	missense	probably benign	0.00
R9271:Zmym6	UTSW	4	127,017,854 (GRCm39)	missense	probably damaging	0.99
R9695:Zmym6	UTSW	4	127,016,340 (GRCm39)	missense	probably benign
X0025:Zmym6	UTSW	4	127,016,143 (GRCm39)	missense	possibly damaging	0.60
X0067:Zmym6	UTSW	4	126,998,107 (GRCm39)	missense	probably damaging	1.00
Z1177:Zmym6	UTSW	4	127,017,590 (GRCm39)	missense	not run

Posted On

2016-08-02