Incidental Mutation 'IGL03344:Odr4'
ID |
417372 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Odr4
|
Ensembl Gene |
ENSMUSG00000006010 |
Gene Name |
odr4 GPCR localization factor homolog |
Synonyms |
BC003331, 1810053E15Rik |
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.746)
|
Stock # |
IGL03344
|
Quality Score |
|
Status
|
|
Chromosome |
1 |
Chromosomal Location |
150237056-150268831 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 150239295 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 386
(E386G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000095152
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006167]
[ENSMUST00000094477]
[ENSMUST00000097546]
[ENSMUST00000097547]
[ENSMUST00000111913]
|
AlphaFold |
Q4PJX1 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000006167
AA Change: E386G
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000006167 Gene: ENSMUSG00000006010 AA Change: E386G
Domain | Start | End | E-Value | Type |
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000094477
|
SMART Domains |
Protein: ENSMUSP00000092050 Gene: ENSMUSG00000006010
Domain | Start | End | E-Value | Type |
Pfam:ODR4-like
|
28 |
383 |
2.8e-120 |
PFAM |
transmembrane domain
|
424 |
446 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000097546
AA Change: E386G
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000095152 Gene: ENSMUSG00000006010 AA Change: E386G
Domain | Start | End | E-Value | Type |
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000097547
AA Change: E376G
PolyPhen 2
Score 0.884 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000095153 Gene: ENSMUSG00000006010 AA Change: E376G
Domain | Start | End | E-Value | Type |
Pfam:ODR4-like
|
28 |
209 |
1.2e-57 |
PFAM |
Pfam:ODR4-like
|
206 |
354 |
3.1e-43 |
PFAM |
transmembrane domain
|
392 |
414 |
N/A |
INTRINSIC |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000111913
AA Change: E408G
PolyPhen 2
Score 0.488 (Sensitivity: 0.88; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000107544 Gene: ENSMUSG00000006010 AA Change: E408G
Domain | Start | End | E-Value | Type |
Pfam:ODR4-like
|
28 |
386 |
7.1e-113 |
PFAM |
transmembrane domain
|
424 |
446 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 30 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700011L22Rik |
A |
T |
8: 79,975,005 (GRCm39) |
I26N |
probably damaging |
Het |
Atxn7l1 |
A |
G |
12: 33,376,065 (GRCm39) |
N47D |
probably damaging |
Het |
Cer1 |
A |
T |
4: 82,803,062 (GRCm39) |
W87R |
probably damaging |
Het |
Chrna2 |
A |
G |
14: 66,388,415 (GRCm39) |
K477E |
probably damaging |
Het |
Chtf8 |
G |
A |
8: 107,612,904 (GRCm39) |
P12S |
probably damaging |
Het |
Cplane1 |
C |
A |
15: 8,216,942 (GRCm39) |
P720Q |
possibly damaging |
Het |
Deaf1 |
A |
T |
7: 140,877,461 (GRCm39) |
H555Q |
probably benign |
Het |
Dop1a |
T |
G |
9: 86,418,197 (GRCm39) |
I1975M |
probably damaging |
Het |
Ecpas |
A |
C |
4: 58,828,538 (GRCm39) |
V965G |
probably damaging |
Het |
Fsd2 |
C |
A |
7: 81,209,657 (GRCm39) |
V62L |
probably benign |
Het |
Fxyd6 |
T |
G |
9: 45,303,548 (GRCm39) |
L81R |
probably benign |
Het |
Htt |
T |
A |
5: 35,064,810 (GRCm39) |
S3008T |
probably benign |
Het |
Htt |
T |
A |
5: 35,037,172 (GRCm39) |
S2086T |
probably benign |
Het |
Mybbp1a |
G |
T |
11: 72,336,028 (GRCm39) |
R447L |
probably damaging |
Het |
Nup210 |
A |
G |
6: 90,998,411 (GRCm39) |
V792A |
possibly damaging |
Het |
Odad2 |
C |
A |
18: 7,129,434 (GRCm39) |
G915* |
probably null |
Het |
Or1e32 |
T |
A |
11: 73,705,003 (GRCm39) |
I302L |
probably benign |
Het |
Or1j14 |
T |
C |
2: 36,418,140 (GRCm39) |
S239P |
probably damaging |
Het |
Prokr1 |
T |
C |
6: 87,565,482 (GRCm39) |
D121G |
possibly damaging |
Het |
Puf60 |
A |
G |
15: 75,942,229 (GRCm39) |
V548A |
possibly damaging |
Het |
Serpina3c |
T |
C |
12: 104,113,523 (GRCm39) |
I408V |
probably benign |
Het |
Ska2 |
A |
G |
11: 87,000,139 (GRCm39) |
|
probably benign |
Het |
Slc4a9 |
T |
A |
18: 36,668,654 (GRCm39) |
Y745N |
probably damaging |
Het |
Spart |
T |
C |
3: 55,029,106 (GRCm39) |
M299T |
probably benign |
Het |
Speer4f1 |
A |
G |
5: 17,685,332 (GRCm39) |
E209G |
possibly damaging |
Het |
Tmem202 |
T |
C |
9: 59,426,351 (GRCm39) |
T272A |
possibly damaging |
Het |
Vegfc |
T |
A |
8: 54,610,186 (GRCm39) |
I114N |
possibly damaging |
Het |
Vmn1r61 |
T |
A |
7: 5,613,493 (GRCm39) |
T274S |
possibly damaging |
Het |
Zfpm2 |
A |
G |
15: 40,966,170 (GRCm39) |
N753S |
probably benign |
Het |
Zmym6 |
A |
G |
4: 127,014,314 (GRCm39) |
T624A |
probably damaging |
Het |
|
Other mutations in Odr4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01876:Odr4
|
APN |
1 |
150,258,089 (GRCm39) |
missense |
probably benign |
0.10 |
IGL02189:Odr4
|
APN |
1 |
150,247,784 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL02257:Odr4
|
APN |
1 |
150,262,155 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02485:Odr4
|
APN |
1 |
150,239,240 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02585:Odr4
|
APN |
1 |
150,239,272 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02712:Odr4
|
APN |
1 |
150,262,107 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02902:Odr4
|
APN |
1 |
150,260,179 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03014:Odr4
|
APN |
1 |
150,258,804 (GRCm39) |
splice site |
probably benign |
|
IGL03124:Odr4
|
APN |
1 |
150,262,176 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03181:Odr4
|
APN |
1 |
150,239,290 (GRCm39) |
missense |
probably benign |
0.06 |
R1170:Odr4
|
UTSW |
1 |
150,262,142 (GRCm39) |
missense |
probably benign |
0.00 |
R1796:Odr4
|
UTSW |
1 |
150,251,305 (GRCm39) |
missense |
probably benign |
|
R1902:Odr4
|
UTSW |
1 |
150,264,360 (GRCm39) |
splice site |
probably null |
|
R2149:Odr4
|
UTSW |
1 |
150,264,310 (GRCm39) |
missense |
probably benign |
0.05 |
R2155:Odr4
|
UTSW |
1 |
150,258,086 (GRCm39) |
missense |
possibly damaging |
0.68 |
R2375:Odr4
|
UTSW |
1 |
150,265,985 (GRCm39) |
critical splice donor site |
probably null |
|
R3786:Odr4
|
UTSW |
1 |
150,260,282 (GRCm39) |
missense |
probably benign |
0.21 |
R3948:Odr4
|
UTSW |
1 |
150,264,308 (GRCm39) |
nonsense |
probably null |
|
R4589:Odr4
|
UTSW |
1 |
150,260,238 (GRCm39) |
missense |
probably benign |
0.11 |
R4590:Odr4
|
UTSW |
1 |
150,262,103 (GRCm39) |
splice site |
probably null |
|
R4815:Odr4
|
UTSW |
1 |
150,250,597 (GRCm39) |
missense |
probably damaging |
0.99 |
R5196:Odr4
|
UTSW |
1 |
150,258,140 (GRCm39) |
missense |
probably damaging |
1.00 |
R5437:Odr4
|
UTSW |
1 |
150,239,269 (GRCm39) |
missense |
probably benign |
0.01 |
R5549:Odr4
|
UTSW |
1 |
150,247,909 (GRCm39) |
missense |
possibly damaging |
0.86 |
R5677:Odr4
|
UTSW |
1 |
150,250,588 (GRCm39) |
missense |
probably damaging |
1.00 |
R5896:Odr4
|
UTSW |
1 |
150,256,111 (GRCm39) |
missense |
probably benign |
0.10 |
R6472:Odr4
|
UTSW |
1 |
150,257,273 (GRCm39) |
missense |
probably benign |
0.15 |
R7108:Odr4
|
UTSW |
1 |
150,258,041 (GRCm39) |
missense |
probably benign |
0.01 |
R7402:Odr4
|
UTSW |
1 |
150,262,107 (GRCm39) |
critical splice donor site |
probably null |
|
R7662:Odr4
|
UTSW |
1 |
150,258,045 (GRCm39) |
missense |
probably benign |
|
R7767:Odr4
|
UTSW |
1 |
150,247,788 (GRCm39) |
missense |
probably benign |
0.00 |
R7810:Odr4
|
UTSW |
1 |
150,268,659 (GRCm39) |
utr 5 prime |
probably benign |
|
R7916:Odr4
|
UTSW |
1 |
150,260,249 (GRCm39) |
missense |
probably benign |
0.01 |
R8114:Odr4
|
UTSW |
1 |
150,264,308 (GRCm39) |
nonsense |
probably null |
|
R8120:Odr4
|
UTSW |
1 |
150,260,177 (GRCm39) |
splice site |
probably null |
|
R8435:Odr4
|
UTSW |
1 |
150,258,020 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9397:Odr4
|
UTSW |
1 |
150,238,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2016-08-02 |