Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03366:Vmn2r104'

420075

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

IGL03366

Quality Score

Status

Chromosome

Chromosomal Location

20249687-20268467 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20249866 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 802 (T802A)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

probably damaging
Transcript: ENSMUST00000168050
AA Change: T802A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: T802A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap2a2	T	A	7: 141,209,186 (GRCm39)	S793T	probably benign	Het
Btnl6	T	C	17: 34,727,153 (GRCm39)	D459G	probably damaging	Het
Cacna1g	C	A	11: 94,347,977 (GRCm39)	D704Y	probably damaging	Het
Cby2	A	G	14: 75,820,829 (GRCm39)	S299P	probably benign	Het
Cry2	A	G	2: 92,244,060 (GRCm39)	I371T	probably damaging	Het
Dock3	A	T	9: 106,882,632 (GRCm39)	F384I	probably benign	Het
Dpp4	T	C	2: 62,187,301 (GRCm39)		probably null	Het
Hecw1	G	T	13: 14,552,382 (GRCm39)	D72E	probably damaging	Het
Htt	T	A	5: 35,064,924 (GRCm39)	W3046R	probably damaging	Het
Hydin	A	T	8: 110,993,995 (GRCm39)	N10Y	unknown	Het
Ighv8-8	T	A	12: 115,257,760 (GRCm39)	T94S	probably benign	Het
Igkv4-58	A	G	6: 69,477,538 (GRCm39)	S20P	probably damaging	Het
Il4i1	T	C	7: 44,486,919 (GRCm39)		probably benign	Het
Kif13a	A	T	13: 46,918,099 (GRCm39)	S403T	probably benign	Het
Klhl40	T	C	9: 121,612,446 (GRCm39)	L616P	probably damaging	Het
Krt7	T	C	15: 101,325,491 (GRCm39)	L440P	possibly damaging	Het
Lpin1	A	G	12: 16,594,678 (GRCm39)	L755P	probably damaging	Het
Magee2	C	A	X: 103,899,134 (GRCm39)	E506*	probably null	Het
Mast3	G	A	8: 71,234,207 (GRCm39)	R143*	probably null	Het
Med12	T	A	X: 100,321,695 (GRCm39)	H459Q	probably benign	Het
Mmp3	T	C	9: 7,450,149 (GRCm39)	S294P	probably benign	Het
Muc6	T	C	7: 141,234,349 (GRCm39)	Y714C	probably damaging	Het
Myh2	T	C	11: 67,074,349 (GRCm39)	L662S	probably damaging	Het
Notch4	G	T	17: 34,791,542 (GRCm39)	C567F	probably damaging	Het
Nprl3	A	G	11: 32,200,256 (GRCm39)	I20T	probably damaging	Het
Or10ag2	A	T	2: 87,248,587 (GRCm39)	D65V	possibly damaging	Het
Pcdhb19	A	G	18: 37,631,665 (GRCm39)	T487A	possibly damaging	Het
Phlpp2	A	G	8: 110,667,467 (GRCm39)	E1332G	probably benign	Het
Pick1	T	C	15: 79,125,481 (GRCm39)	S113P	probably damaging	Het
Ptpru	T	C	4: 131,507,178 (GRCm39)	E1023G	probably damaging	Het
Rspry1	A	C	8: 95,376,962 (GRCm39)	I382L	probably benign	Het
Sf3b3	A	C	8: 111,566,586 (GRCm39)	V248G	probably damaging	Het
Smg5	T	A	3: 88,253,759 (GRCm39)	Y126*	probably null	Het
Spin1	T	C	13: 51,281,973 (GRCm39)	V22A	probably benign	Het
Stab1	C	T	14: 30,872,220 (GRCm39)	R1189Q	possibly damaging	Het
Sytl5	A	G	X: 9,829,939 (GRCm39)	D538G	probably damaging	Het
Taar7e	T	A	10: 23,913,813 (GRCm39)	M101K	probably damaging	Het
Taf4	A	G	2: 179,576,847 (GRCm39)	V578A	probably damaging	Het
Tmem266	G	T	9: 55,344,517 (GRCm39)	C383F	probably benign	Het
Trim34a	T	C	7: 103,910,140 (GRCm39)		probably null	Het
Vmn2r32	A	C	7: 7,467,029 (GRCm39)	I833S	probably damaging	Het
Vmn2r85	T	C	10: 130,262,328 (GRCm39)	D137G	probably benign	Het
Vps13c	C	T	9: 67,853,308 (GRCm39)	S2467L	probably benign	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20,258,501 (GRCm39)	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20,268,358 (GRCm39)	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20,263,055 (GRCm39)	missense	probably benign	0.17
IGL01527:Vmn2r104	APN	17	20,263,158 (GRCm39)	missense	possibly damaging	0.82
IGL01773:Vmn2r104	APN	17	20,260,930 (GRCm39)	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20,250,187 (GRCm39)	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20,262,056 (GRCm39)	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20,263,118 (GRCm39)	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20,263,048 (GRCm39)	missense	probably benign	0.34
IGL03260:Vmn2r104	APN	17	20,263,083 (GRCm39)	missense	probably benign	0.05
R0091:Vmn2r104	UTSW	17	20,262,075 (GRCm39)	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20,250,069 (GRCm39)	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20,249,889 (GRCm39)	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20,268,264 (GRCm39)	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20,263,166 (GRCm39)	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20,262,987 (GRCm39)	missense	probably benign
R1575:Vmn2r104	UTSW	17	20,262,477 (GRCm39)	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20,262,497 (GRCm39)	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20,261,031 (GRCm39)	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20,262,313 (GRCm39)	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20,268,455 (GRCm39)	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20,249,818 (GRCm39)	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20,250,183 (GRCm39)	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20,250,147 (GRCm39)	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20,262,503 (GRCm39)	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20,268,443 (GRCm39)	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20,261,030 (GRCm39)	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20,250,288 (GRCm39)	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20,258,528 (GRCm39)	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20,262,146 (GRCm39)	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20,250,163 (GRCm39)	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20,250,450 (GRCm39)	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20,250,343 (GRCm39)	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20,260,981 (GRCm39)	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20,250,372 (GRCm39)	missense	probably benign	0.02
R5795:Vmn2r104	UTSW	17	20,250,544 (GRCm39)	missense	possibly damaging	0.89
R5970:Vmn2r104	UTSW	17	20,249,733 (GRCm39)	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20,261,970 (GRCm39)	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20,249,747 (GRCm39)	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20,258,573 (GRCm39)	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20,261,909 (GRCm39)	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20,250,507 (GRCm39)	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20,261,829 (GRCm39)	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20,249,848 (GRCm39)	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20,262,487 (GRCm39)	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20,250,358 (GRCm39)	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20,261,088 (GRCm39)	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20,249,737 (GRCm39)	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20,249,791 (GRCm39)	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20,261,971 (GRCm39)	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8031:Vmn2r104	UTSW	17	20,263,048 (GRCm39)	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20,250,483 (GRCm39)	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20,250,465 (GRCm39)	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20,261,040 (GRCm39)	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20,262,110 (GRCm39)	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8900:Vmn2r104	UTSW	17	20,261,924 (GRCm39)	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20,249,968 (GRCm39)	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20,262,097 (GRCm39)	missense	probably damaging	0.99
R9282:Vmn2r104	UTSW	17	20,261,098 (GRCm39)	missense	probably damaging	1.00
R9303:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20,268,433 (GRCm39)	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20,250,250 (GRCm39)	missense	probably damaging	0.99
R9785:Vmn2r104	UTSW	17	20,268,409 (GRCm39)	missense	probably benign
RF007:Vmn2r104	UTSW	17	20,268,302 (GRCm39)	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20,250,051 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02