Mutagenetix > Incidental Mutation

Incidental Mutation 'R5547:Oog3'

436338

Institutional Source

Beutler Lab

Gene Symbol

Oog3

Ensembl Gene

ENSMUSG00000050810

Gene Name

oogenesin 3

Synonyms

MMRRC Submission

043105-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

R5547 (G1)

Quality Score

121

Status

Not validated

Chromosome

Chromosomal Location

143884126-143889221 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 143884598 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 446 (L446Q)

Ref Sequence

ENSEMBL: ENSMUSP00000059834 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050933]

AlphaFold

Q3UWY1

Predicted Effect

probably benign
Transcript: ENSMUST00000050933
AA Change: L446Q

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000059834
Gene: ENSMUSG00000050810
AA Change: L446Q

Domain	Start	End	E-Value	Type
low complexity region	13	26	N/A	INTRINSIC
low complexity region	31	42	N/A	INTRINSIC
SCOP:d1a4ya_	226	428	7e-5	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh7a1	A	G	18: 56,661,356 (GRCm39)	S492P	probably damaging	Het
Arfgef1	A	T	1: 10,231,201 (GRCm39)	D1133E	probably damaging	Het
Avpi1	T	C	19: 42,113,382 (GRCm39)	K25R	probably damaging	Het
Bank1	T	C	3: 135,772,110 (GRCm39)	S708G	probably damaging	Het
C1qtnf2	A	G	11: 43,381,794 (GRCm39)	E202G	probably damaging	Het
C6	T	A	15: 4,837,970 (GRCm39)	V860E	probably benign	Het
Cbr1	T	A	16: 93,406,698 (GRCm39)	V138E	probably damaging	Het
Cdip1	A	G	16: 4,587,988 (GRCm39)	S2P	probably damaging	Het
Cep126	T	C	9: 8,100,428 (GRCm39)	N702S	probably damaging	Het
Chek1	T	C	9: 36,623,400 (GRCm39)	I381V	probably benign	Het
Clock	G	A	5: 76,378,185 (GRCm39)	P572S	probably benign	Het
Cryz	C	T	3: 154,317,194 (GRCm39)	R138*	probably null	Het
Ctsll3	T	A	13: 60,948,551 (GRCm39)	M103L	probably benign	Het
Daxx	TGATGATGACGATGATGACGATGATGA	TGATGATGACGATGATGA	17: 34,131,615 (GRCm39)		probably benign	Het
Daxx	CGATGATGATGA	CGA	17: 34,131,633 (GRCm39)		probably benign	Het
Dsg1a	T	G	18: 20,469,097 (GRCm39)		probably null	Het
Eya4	T	C	10: 22,985,753 (GRCm39)	E583G	possibly damaging	Het
Flt1	T	A	5: 147,591,948 (GRCm39)	S505C	probably damaging	Het
Gpr161	C	A	1: 165,133,982 (GRCm39)	F81L	possibly damaging	Het
H2-T15	G	A	17: 36,368,796 (GRCm39)	H95Y	possibly damaging	Het
Hmcn1	A	G	1: 150,613,257 (GRCm39)	V1390A	possibly damaging	Het
Ifi44l	C	T	3: 151,467,142 (GRCm39)	V63I	unknown	Het
Klhl3	C	T	13: 58,250,243 (GRCm39)		probably null	Het
Lekr1	T	A	3: 65,576,601 (GRCm39)		probably null	Het
Lhx5	A	G	5: 120,572,675 (GRCm39)	Q98R	probably benign	Het
Nuggc	A	G	14: 65,879,330 (GRCm39)	K681E	possibly damaging	Het
Numa1	G	T	7: 101,663,137 (GRCm39)	A735S	probably damaging	Het
Or5ac19	G	A	16: 59,089,479 (GRCm39)	L184F	probably benign	Het
Otogl	C	T	10: 107,617,909 (GRCm39)	E1735K	possibly damaging	Het
Pcsk5	T	C	19: 17,729,488 (GRCm39)	D119G	probably benign	Het
Pgpep1	T	C	8: 71,105,069 (GRCm39)	K64E	probably benign	Het
Prr19	A	C	7: 25,003,388 (GRCm39)	D334A	probably damaging	Het
Ptprh	G	T	7: 4,557,221 (GRCm39)	S691*	probably null	Het
Recql4	G	A	15: 76,589,994 (GRCm39)	R684*	probably null	Het
Rnf112	C	T	11: 61,341,854 (GRCm39)	V317I	possibly damaging	Het
Rnf40	T	C	7: 127,188,302 (GRCm39)		probably null	Het
Secisbp2l	C	T	2: 125,582,657 (GRCm39)	G933D	possibly damaging	Het
Spag17	T	C	3: 99,963,468 (GRCm39)	V1062A	probably benign	Het
Tbc1d1	A	G	5: 64,481,887 (GRCm39)	D696G	possibly damaging	Het
Tdo2	T	C	3: 81,866,247 (GRCm39)	R339G	probably damaging	Het
Tmem245	C	T	4: 56,910,156 (GRCm39)		probably null	Het
Trim24	A	G	6: 37,942,485 (GRCm39)	E965G	probably damaging	Het
Trmt112	T	C	19: 6,888,156 (GRCm39)	S103P	probably damaging	Het
Trpv6	A	T	6: 41,613,088 (GRCm39)	V26D	possibly damaging	Het
Zfp850	A	G	7: 27,688,844 (GRCm39)	C455R	probably damaging	Het
Zfp946	T	C	17: 22,673,873 (GRCm39)	I209T	probably benign	Het
Zfp957	T	C	14: 79,451,406 (GRCm39)	N131S	probably benign	Het

Other mutations in Oog3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02413:Oog3	APN	4	143,884,721 (GRCm39)	missense	probably benign	0.00
IGL02517:Oog3	APN	4	143,885,920 (GRCm39)	missense	probably damaging	1.00
IGL02635:Oog3	APN	4	143,884,715 (GRCm39)	missense	probably damaging	1.00
R0016:Oog3	UTSW	4	143,884,641 (GRCm39)	missense	probably damaging	1.00
R0016:Oog3	UTSW	4	143,884,641 (GRCm39)	missense	probably damaging	1.00
R0269:Oog3	UTSW	4	143,886,784 (GRCm39)	missense	probably benign	0.10
R0617:Oog3	UTSW	4	143,886,784 (GRCm39)	missense	probably benign	0.10
R1147:Oog3	UTSW	4	143,884,982 (GRCm39)	missense	possibly damaging	0.81
R1147:Oog3	UTSW	4	143,884,982 (GRCm39)	missense	possibly damaging	0.81
R1562:Oog3	UTSW	4	143,889,169 (GRCm39)	missense	probably damaging	0.98
R1669:Oog3	UTSW	4	143,885,008 (GRCm39)	missense	probably benign	0.06
R1766:Oog3	UTSW	4	143,885,692 (GRCm39)	missense	possibly damaging	0.49
R2002:Oog3	UTSW	4	143,884,675 (GRCm39)	missense	possibly damaging	0.96
R2109:Oog3	UTSW	4	143,886,082 (GRCm39)	missense	probably damaging	1.00
R2394:Oog3	UTSW	4	143,885,884 (GRCm39)	missense	probably benign	0.00
R4615:Oog3	UTSW	4	143,884,899 (GRCm39)	missense	probably benign	0.00
R4632:Oog3	UTSW	4	143,884,698 (GRCm39)	missense	probably benign	0.00
R4816:Oog3	UTSW	4	143,885,731 (GRCm39)	missense	probably damaging	1.00
R5459:Oog3	UTSW	4	143,885,815 (GRCm39)	missense	probably benign
R6811:Oog3	UTSW	4	143,886,152 (GRCm39)	missense	probably benign	0.00
R6931:Oog3	UTSW	4	143,885,923 (GRCm39)	missense	probably benign	0.00
R7052:Oog3	UTSW	4	143,887,027 (GRCm39)	missense	probably damaging	1.00
R7194:Oog3	UTSW	4	143,889,169 (GRCm39)	missense	probably damaging	0.98
R7312:Oog3	UTSW	4	143,886,801 (GRCm39)	missense	probably benign	0.08
R7486:Oog3	UTSW	4	143,884,742 (GRCm39)	missense	probably benign	0.16
R7622:Oog3	UTSW	4	143,884,889 (GRCm39)	missense	probably benign	0.00
R8782:Oog3	UTSW	4	143,885,962 (GRCm39)	missense	probably benign	0.01
R8790:Oog3	UTSW	4	143,885,710 (GRCm39)	missense	possibly damaging	0.59
R8794:Oog3	UTSW	4	143,884,556 (GRCm39)	missense	probably benign	0.01
R9586:Oog3	UTSW	4	143,884,966 (GRCm39)	nonsense	probably null
R9652:Oog3	UTSW	4	143,884,489 (GRCm39)	missense	probably benign	0.01
R9653:Oog3	UTSW	4	143,884,489 (GRCm39)	missense	probably benign	0.01
Z1088:Oog3	UTSW	4	143,886,206 (GRCm39)	missense	probably benign	0.04
Z1088:Oog3	UTSW	4	143,884,877 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CATCGATCCCCAATACTAAGCTTGC -3'
(R):5'- TCAATTCAATGCCCTGCTGC -3'

Sequencing Primer
(F):5'- TCTGTTCCACAATCAACCTTACAGGG -3'
(R):5'- GCTGCCTGCCCTAAGTCAATG -3'

Posted On

2016-10-24