Incidental Mutation 'R5055:Prdm16'
| ID |
459850 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Prdm16
|
| Ensembl Gene |
ENSMUSG00000039410 |
| Gene Name |
PR domain containing 16 |
| Synonyms |
line 27, Mel1, 5730557K01Rik, csp1 |
| MMRRC Submission |
042645-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.700)
|
| Stock # |
R5055 (G1)
|
| Quality Score |
168 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
154400582-154721330 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 154419719 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 897
(M897V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101262
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030902]
[ENSMUST00000070313]
[ENSMUST00000097759]
[ENSMUST00000105636]
[ENSMUST00000105637]
[ENSMUST00000105638]
[ENSMUST00000181143]
|
| AlphaFold |
A2A935 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000030902
AA Change: M898V
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000030902
Gene: ENSMUSG00000039410
AA Change: M898V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
217 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
230 |
250 |
2.82e1 |
SMART |
|
low complexity region
|
260 |
274 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
282 |
304 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
338 |
361 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
424 |
451 |
9.96e0 |
SMART |
|
low complexity region
|
496 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
520 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
641 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
951 |
973 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
979 |
1002 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1008 |
1030 |
7.26e-3 |
SMART |
|
low complexity region
|
1116 |
1132 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070313
AA Change: M900V
PolyPhen 2
Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000064546
Gene: ENSMUSG00000039410
AA Change: M900V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
218 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
231 |
251 |
2.82e1 |
SMART |
|
low complexity region
|
261 |
275 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
283 |
305 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
311 |
333 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
339 |
362 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
368 |
390 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
396 |
418 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
425 |
452 |
9.96e0 |
SMART |
|
low complexity region
|
497 |
518 |
N/A |
INTRINSIC |
|
low complexity region
|
521 |
541 |
N/A |
INTRINSIC |
|
low complexity region
|
611 |
642 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
953 |
975 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
981 |
1004 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1010 |
1032 |
7.26e-3 |
SMART |
|
low complexity region
|
1118 |
1134 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097759
AA Change: M899V
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000095365
Gene: ENSMUSG00000039410
AA Change: M899V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
217 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
230 |
250 |
2.82e1 |
SMART |
|
low complexity region
|
260 |
274 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
282 |
304 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
338 |
361 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
424 |
451 |
9.96e0 |
SMART |
|
low complexity region
|
496 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
520 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
641 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
952 |
974 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
980 |
1003 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1009 |
1031 |
7.26e-3 |
SMART |
|
low complexity region
|
1117 |
1133 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105636
AA Change: M899V
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000101261
Gene: ENSMUSG00000039410
AA Change: M899V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
218 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
231 |
251 |
2.82e1 |
SMART |
|
low complexity region
|
261 |
275 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
283 |
305 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
311 |
333 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
339 |
362 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
368 |
390 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
396 |
418 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
425 |
452 |
9.96e0 |
SMART |
|
low complexity region
|
497 |
518 |
N/A |
INTRINSIC |
|
low complexity region
|
521 |
541 |
N/A |
INTRINSIC |
|
low complexity region
|
611 |
642 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
952 |
974 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
980 |
1003 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1009 |
1031 |
7.26e-3 |
SMART |
|
low complexity region
|
1117 |
1133 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105637
AA Change: M897V
PolyPhen 2
Score 0.476 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000101262
Gene: ENSMUSG00000039410
AA Change: M897V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
216 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
229 |
249 |
2.82e1 |
SMART |
|
low complexity region
|
259 |
273 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
281 |
303 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
309 |
331 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
337 |
360 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
366 |
388 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
394 |
416 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
423 |
450 |
9.96e0 |
SMART |
|
low complexity region
|
495 |
516 |
N/A |
INTRINSIC |
|
low complexity region
|
519 |
539 |
N/A |
INTRINSIC |
|
low complexity region
|
609 |
640 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
950 |
972 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
978 |
1001 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1007 |
1029 |
7.26e-3 |
SMART |
|
low complexity region
|
1115 |
1131 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000105638
AA Change: M899V
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000101263
Gene: ENSMUSG00000039410
AA Change: M899V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
44 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
74 |
83 |
N/A |
INTRINSIC |
|
SET
|
84 |
217 |
8.75e-5 |
SMART |
|
ZnF_C2H2
|
230 |
250 |
2.82e1 |
SMART |
|
low complexity region
|
260 |
274 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
282 |
304 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
338 |
361 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
424 |
451 |
9.96e0 |
SMART |
|
low complexity region
|
496 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
520 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
641 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
952 |
974 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
980 |
1003 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
1009 |
1031 |
7.26e-3 |
SMART |
|
low complexity region
|
1117 |
1133 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141164
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145217
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156069
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000181143
|
| SMART Domains |
Protein: ENSMUSP00000138001
Gene: ENSMUSG00000097871
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
17 |
30 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0930 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 92.9%
|
| Validation Efficiency |
98% (84/86) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutant mice exhibit a cleft secondary palate, whitening of brown adipose tissue in older or fed a high-fat diet, and impaired adaptive thermogenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam19 |
G |
A |
11: 46,013,996 (GRCm39) |
V329I |
probably damaging |
Het |
| Adgrl3 |
C |
A |
5: 81,794,398 (GRCm39) |
A541E |
possibly damaging |
Het |
| Agbl1 |
A |
T |
7: 76,063,325 (GRCm39) |
I263F |
probably damaging |
Het |
| Ash1l |
T |
C |
3: 88,930,519 (GRCm39) |
|
probably null |
Het |
| Bccip |
A |
G |
7: 133,316,652 (GRCm39) |
T91A |
probably benign |
Het |
| Bnc1 |
A |
T |
7: 81,624,163 (GRCm39) |
F355I |
probably damaging |
Het |
| Bpifa2 |
A |
T |
2: 153,855,630 (GRCm39) |
D185V |
probably damaging |
Het |
| Capn8 |
T |
A |
1: 182,399,526 (GRCm39) |
V89D |
probably damaging |
Het |
| Cfap46 |
A |
T |
7: 139,241,106 (GRCm39) |
M421K |
probably damaging |
Het |
| Chd2 |
A |
T |
7: 73,130,256 (GRCm39) |
L800M |
probably damaging |
Het |
| Chd4 |
A |
G |
6: 125,077,949 (GRCm39) |
D137G |
possibly damaging |
Het |
| Crtap |
A |
G |
9: 114,219,208 (GRCm39) |
Y154H |
probably benign |
Het |
| Ctdp1 |
T |
A |
18: 80,499,303 (GRCm39) |
Q213L |
probably damaging |
Het |
| Cts6 |
T |
C |
13: 61,344,164 (GRCm39) |
Y296C |
probably damaging |
Het |
| Daxx |
G |
T |
17: 34,131,134 (GRCm39) |
V354F |
probably benign |
Het |
| Dnah2 |
A |
G |
11: 69,411,599 (GRCm39) |
I341T |
possibly damaging |
Het |
| Epha2 |
A |
G |
4: 141,036,380 (GRCm39) |
D272G |
probably benign |
Het |
| Etfa |
A |
G |
9: 55,407,417 (GRCm39) |
V24A |
probably damaging |
Het |
| Fbxl7 |
C |
A |
15: 26,553,022 (GRCm39) |
G82W |
probably damaging |
Het |
| Fcamr |
G |
A |
1: 130,739,174 (GRCm39) |
C158Y |
probably damaging |
Het |
| Fyb1 |
A |
C |
15: 6,614,630 (GRCm39) |
|
probably benign |
Het |
| Gars1 |
G |
A |
6: 55,045,077 (GRCm39) |
R454H |
probably damaging |
Het |
| Ghsr |
T |
C |
3: 27,426,421 (GRCm39) |
V159A |
probably benign |
Het |
| Glp1r |
A |
T |
17: 31,137,861 (GRCm39) |
Q97H |
probably benign |
Het |
| Gm27047 |
T |
C |
6: 130,606,909 (GRCm39) |
|
noncoding transcript |
Het |
| Igkv3-3 |
A |
C |
6: 70,664,223 (GRCm39) |
I22L |
probably benign |
Het |
| Inpp5b |
G |
T |
4: 124,636,824 (GRCm39) |
|
probably null |
Het |
| Ipo9 |
C |
A |
1: 135,330,097 (GRCm39) |
E448* |
probably null |
Het |
| Itgb2l |
A |
T |
16: 96,229,003 (GRCm39) |
I400N |
probably damaging |
Het |
| Kat6b |
T |
A |
14: 21,567,062 (GRCm39) |
H40Q |
probably damaging |
Het |
| Kcna7 |
G |
A |
7: 45,056,015 (GRCm39) |
R77H |
probably damaging |
Het |
| Kcnq2 |
G |
T |
2: 180,728,554 (GRCm39) |
|
probably benign |
Het |
| Klf7 |
T |
C |
1: 64,118,439 (GRCm39) |
T53A |
probably benign |
Het |
| Kmt2a |
A |
G |
9: 44,729,649 (GRCm39) |
|
probably benign |
Het |
| Lrp10 |
C |
T |
14: 54,705,802 (GRCm39) |
R331C |
probably benign |
Het |
| Map4k5 |
A |
T |
12: 69,878,332 (GRCm39) |
D289E |
probably benign |
Het |
| Mfsd4b2 |
A |
T |
10: 39,799,773 (GRCm39) |
M43K |
possibly damaging |
Het |
| Msr1 |
T |
G |
8: 40,076,997 (GRCm39) |
R138S |
possibly damaging |
Het |
| Myh7b |
G |
C |
2: 155,474,293 (GRCm39) |
R1669S |
possibly damaging |
Het |
| Myh9 |
G |
A |
15: 77,648,723 (GRCm39) |
A1711V |
probably benign |
Het |
| Myo18b |
A |
G |
5: 113,023,083 (GRCm39) |
|
probably benign |
Het |
| Nampt |
A |
T |
12: 32,883,120 (GRCm39) |
N102Y |
possibly damaging |
Het |
| Nell2 |
T |
C |
15: 95,371,460 (GRCm39) |
I92V |
probably benign |
Het |
| Nes |
A |
G |
3: 87,884,521 (GRCm39) |
N883D |
probably benign |
Het |
| Neurl3 |
T |
A |
1: 36,312,463 (GRCm39) |
|
probably benign |
Het |
| Ocln |
T |
A |
13: 100,675,930 (GRCm39) |
T188S |
probably benign |
Het |
| Or2ag20 |
T |
A |
7: 106,464,937 (GRCm39) |
M250K |
probably damaging |
Het |
| Or5m10 |
T |
C |
2: 85,717,585 (GRCm39) |
F147S |
probably benign |
Het |
| Parp14 |
T |
A |
16: 35,664,733 (GRCm39) |
Q1305L |
probably benign |
Het |
| Pde3a |
C |
T |
6: 141,433,682 (GRCm39) |
Q855* |
probably null |
Het |
| Pde4b |
T |
C |
4: 102,052,311 (GRCm39) |
|
probably benign |
Het |
| Pdk2 |
T |
C |
11: 94,930,242 (GRCm39) |
M65V |
probably benign |
Het |
| Phf21a |
T |
C |
2: 92,182,201 (GRCm39) |
S377P |
probably damaging |
Het |
| Plcb2 |
T |
A |
2: 118,548,703 (GRCm39) |
T408S |
probably benign |
Het |
| Ppp1r12b |
G |
T |
1: 134,883,471 (GRCm39) |
A17E |
probably benign |
Het |
| Ppp6r2 |
A |
G |
15: 89,167,152 (GRCm39) |
D789G |
probably benign |
Het |
| Prss57 |
A |
G |
10: 79,620,178 (GRCm39) |
|
probably null |
Het |
| Psd |
G |
T |
19: 46,310,907 (GRCm39) |
L381I |
probably benign |
Het |
| Ptprq |
A |
T |
10: 107,370,540 (GRCm39) |
D2050E |
probably benign |
Het |
| Rfc1 |
G |
T |
5: 65,423,505 (GRCm39) |
N1034K |
probably damaging |
Het |
| Ryr3 |
C |
T |
2: 112,661,504 (GRCm39) |
G1829S |
probably benign |
Het |
| Scaper |
T |
C |
9: 55,767,003 (GRCm39) |
|
probably null |
Het |
| Scn5a |
A |
G |
9: 119,351,632 (GRCm39) |
I783T |
probably damaging |
Het |
| Slc28a1 |
A |
G |
7: 80,818,796 (GRCm39) |
N583S |
possibly damaging |
Het |
| Slc35e3 |
C |
T |
10: 117,580,884 (GRCm39) |
G140D |
probably damaging |
Het |
| Slc6a9 |
G |
A |
4: 117,725,347 (GRCm39) |
|
probably null |
Het |
| Sptlc1 |
A |
G |
13: 53,496,218 (GRCm39) |
S376P |
probably benign |
Het |
| Sspo |
G |
A |
6: 48,441,729 (GRCm39) |
C1913Y |
probably damaging |
Het |
| Taar7b |
A |
T |
10: 23,876,845 (GRCm39) |
I337F |
possibly damaging |
Het |
| Tdpoz2 |
T |
A |
3: 93,559,235 (GRCm39) |
I246F |
probably damaging |
Het |
| Trpa1 |
C |
T |
1: 14,946,183 (GRCm39) |
V983M |
probably damaging |
Het |
| Trpm5 |
A |
T |
7: 142,626,521 (GRCm39) |
M1112K |
probably benign |
Het |
| Tsbp1 |
G |
A |
17: 34,667,770 (GRCm39) |
C154Y |
possibly damaging |
Het |
| Uso1 |
A |
T |
5: 92,340,594 (GRCm39) |
K670I |
probably benign |
Het |
| Washc4 |
A |
G |
10: 83,392,771 (GRCm39) |
D257G |
probably damaging |
Het |
| Wdr41 |
T |
A |
13: 95,151,725 (GRCm39) |
|
probably null |
Het |
| Zbtb17 |
A |
G |
4: 141,193,860 (GRCm39) |
Q668R |
possibly damaging |
Het |
|
| Other mutations in Prdm16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00987:Prdm16
|
APN |
4 |
154,426,426 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01517:Prdm16
|
APN |
4 |
154,412,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01810:Prdm16
|
APN |
4 |
154,432,384 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02260:Prdm16
|
APN |
4 |
154,412,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02623:Prdm16
|
APN |
4 |
154,425,334 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02744:Prdm16
|
APN |
4 |
154,429,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0126:Prdm16
|
UTSW |
4 |
154,413,295 (GRCm39) |
splice site |
probably benign |
|
|
R0345:Prdm16
|
UTSW |
4 |
154,425,568 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0365:Prdm16
|
UTSW |
4 |
154,426,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0440:Prdm16
|
UTSW |
4 |
154,561,084 (GRCm39) |
splice site |
probably benign |
|
|
R0899:Prdm16
|
UTSW |
4 |
154,613,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1127:Prdm16
|
UTSW |
4 |
154,613,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1546:Prdm16
|
UTSW |
4 |
154,613,117 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1803:Prdm16
|
UTSW |
4 |
154,419,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2117:Prdm16
|
UTSW |
4 |
154,432,382 (GRCm39) |
missense |
probably null |
0.99 |
|
R3814:Prdm16
|
UTSW |
4 |
154,412,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4348:Prdm16
|
UTSW |
4 |
154,561,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4458:Prdm16
|
UTSW |
4 |
154,406,765 (GRCm39) |
missense |
probably benign |
|
|
R4557:Prdm16
|
UTSW |
4 |
154,613,284 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4581:Prdm16
|
UTSW |
4 |
154,407,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4584:Prdm16
|
UTSW |
4 |
154,422,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4627:Prdm16
|
UTSW |
4 |
154,451,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4926:Prdm16
|
UTSW |
4 |
154,426,009 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5152:Prdm16
|
UTSW |
4 |
154,430,559 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5257:Prdm16
|
UTSW |
4 |
154,451,671 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5258:Prdm16
|
UTSW |
4 |
154,451,671 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5368:Prdm16
|
UTSW |
4 |
154,429,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5464:Prdm16
|
UTSW |
4 |
154,430,601 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5640:Prdm16
|
UTSW |
4 |
154,426,367 (GRCm39) |
missense |
probably benign |
|
|
R5744:Prdm16
|
UTSW |
4 |
154,613,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5892:Prdm16
|
UTSW |
4 |
154,407,716 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5938:Prdm16
|
UTSW |
4 |
154,432,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6380:Prdm16
|
UTSW |
4 |
154,425,824 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6784:Prdm16
|
UTSW |
4 |
154,407,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7097:Prdm16
|
UTSW |
4 |
154,429,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7181:Prdm16
|
UTSW |
4 |
154,613,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7197:Prdm16
|
UTSW |
4 |
154,425,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7273:Prdm16
|
UTSW |
4 |
154,429,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7379:Prdm16
|
UTSW |
4 |
154,613,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7641:Prdm16
|
UTSW |
4 |
154,429,901 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7704:Prdm16
|
UTSW |
4 |
154,425,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7751:Prdm16
|
UTSW |
4 |
154,412,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8048:Prdm16
|
UTSW |
4 |
154,405,339 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8225:Prdm16
|
UTSW |
4 |
154,439,702 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8503:Prdm16
|
UTSW |
4 |
154,426,009 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8683:Prdm16
|
UTSW |
4 |
154,613,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8880:Prdm16
|
UTSW |
4 |
154,613,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9257:Prdm16
|
UTSW |
4 |
154,422,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9259:Prdm16
|
UTSW |
4 |
154,430,525 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
RF008:Prdm16
|
UTSW |
4 |
154,426,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0010:Prdm16
|
UTSW |
4 |
154,407,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Prdm16
|
UTSW |
4 |
154,426,243 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGTTTCACCTGCACGTGTATC -3'
(R):5'- CTGCATAGCCTGGGGTTTTAAC -3'
Sequencing Primer
(F):5'- ACCTGCACGTGTATCTCTCC -3'
(R):5'- AGATGACCCTGGATTATAGTCCC -3'
|
| Posted On |
2017-02-27 |
Incidental Mutation