Incidental Mutation 'R5055:Fcamr'
ID 390743
Institutional Source Beutler Lab
Gene Symbol Fcamr
Ensembl Gene ENSMUSG00000026415
Gene Name Fc receptor, IgA, IgM, high affinity
Synonyms
MMRRC Submission 042645-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R5055 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 130728639-130742477 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 130739174 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 158 (C158Y)
Ref Sequence ENSEMBL: ENSMUSP00000108096 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027670] [ENSMUST00000112477]
AlphaFold Q2TB54
Predicted Effect probably damaging
Transcript: ENSMUST00000027670
AA Change: C102Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027670
Gene: ENSMUSG00000026415
AA Change: C102Y

DomainStartEndE-ValueType
signal peptide 1 36 N/A INTRINSIC
IG 87 191 1.19e-5 SMART
low complexity region 208 220 N/A INTRINSIC
low complexity region 241 253 N/A INTRINSIC
transmembrane domain 456 475 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112477
AA Change: C158Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000108096
Gene: ENSMUSG00000026415
AA Change: C158Y

DomainStartEndE-ValueType
low complexity region 80 87 N/A INTRINSIC
IG 143 247 1.19e-5 SMART
low complexity region 264 276 N/A INTRINSIC
low complexity region 297 309 N/A INTRINSIC
transmembrane domain 512 531 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122968
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125056
Meta Mutation Damage Score 0.3858 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 92.9%
Validation Efficiency 98% (84/86)
MGI Phenotype PHENOTYPE: Homozygous null mice have enhanced germinal center formation, affinity maturation and memory induction of IgG3 producing B cells after immunization with T cell-independent antigens. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam19 G A 11: 46,013,996 (GRCm39) V329I probably damaging Het
Adgrl3 C A 5: 81,794,398 (GRCm39) A541E possibly damaging Het
Agbl1 A T 7: 76,063,325 (GRCm39) I263F probably damaging Het
Ash1l T C 3: 88,930,519 (GRCm39) probably null Het
Bccip A G 7: 133,316,652 (GRCm39) T91A probably benign Het
Bnc1 A T 7: 81,624,163 (GRCm39) F355I probably damaging Het
Bpifa2 A T 2: 153,855,630 (GRCm39) D185V probably damaging Het
Capn8 T A 1: 182,399,526 (GRCm39) V89D probably damaging Het
Cfap46 A T 7: 139,241,106 (GRCm39) M421K probably damaging Het
Chd2 A T 7: 73,130,256 (GRCm39) L800M probably damaging Het
Chd4 A G 6: 125,077,949 (GRCm39) D137G possibly damaging Het
Crtap A G 9: 114,219,208 (GRCm39) Y154H probably benign Het
Ctdp1 T A 18: 80,499,303 (GRCm39) Q213L probably damaging Het
Cts6 T C 13: 61,344,164 (GRCm39) Y296C probably damaging Het
Daxx G T 17: 34,131,134 (GRCm39) V354F probably benign Het
Dnah2 A G 11: 69,411,599 (GRCm39) I341T possibly damaging Het
Epha2 A G 4: 141,036,380 (GRCm39) D272G probably benign Het
Etfa A G 9: 55,407,417 (GRCm39) V24A probably damaging Het
Fbxl7 C A 15: 26,553,022 (GRCm39) G82W probably damaging Het
Fyb1 A C 15: 6,614,630 (GRCm39) probably benign Het
Gars1 G A 6: 55,045,077 (GRCm39) R454H probably damaging Het
Ghsr T C 3: 27,426,421 (GRCm39) V159A probably benign Het
Glp1r A T 17: 31,137,861 (GRCm39) Q97H probably benign Het
Gm27047 T C 6: 130,606,909 (GRCm39) noncoding transcript Het
Igkv3-3 A C 6: 70,664,223 (GRCm39) I22L probably benign Het
Inpp5b G T 4: 124,636,824 (GRCm39) probably null Het
Ipo9 C A 1: 135,330,097 (GRCm39) E448* probably null Het
Itgb2l A T 16: 96,229,003 (GRCm39) I400N probably damaging Het
Kat6b T A 14: 21,567,062 (GRCm39) H40Q probably damaging Het
Kcna7 G A 7: 45,056,015 (GRCm39) R77H probably damaging Het
Kcnq2 G T 2: 180,728,554 (GRCm39) probably benign Het
Klf7 T C 1: 64,118,439 (GRCm39) T53A probably benign Het
Kmt2a A G 9: 44,729,649 (GRCm39) probably benign Het
Lrp10 C T 14: 54,705,802 (GRCm39) R331C probably benign Het
Map4k5 A T 12: 69,878,332 (GRCm39) D289E probably benign Het
Mfsd4b2 A T 10: 39,799,773 (GRCm39) M43K possibly damaging Het
Msr1 T G 8: 40,076,997 (GRCm39) R138S possibly damaging Het
Myh7b G C 2: 155,474,293 (GRCm39) R1669S possibly damaging Het
Myh9 G A 15: 77,648,723 (GRCm39) A1711V probably benign Het
Myo18b A G 5: 113,023,083 (GRCm39) probably benign Het
Nampt A T 12: 32,883,120 (GRCm39) N102Y possibly damaging Het
Nell2 T C 15: 95,371,460 (GRCm39) I92V probably benign Het
Nes A G 3: 87,884,521 (GRCm39) N883D probably benign Het
Neurl3 T A 1: 36,312,463 (GRCm39) probably benign Het
Ocln T A 13: 100,675,930 (GRCm39) T188S probably benign Het
Or2ag20 T A 7: 106,464,937 (GRCm39) M250K probably damaging Het
Or5m10 T C 2: 85,717,585 (GRCm39) F147S probably benign Het
Parp14 T A 16: 35,664,733 (GRCm39) Q1305L probably benign Het
Pde3a C T 6: 141,433,682 (GRCm39) Q855* probably null Het
Pde4b T C 4: 102,052,311 (GRCm39) probably benign Het
Pdk2 T C 11: 94,930,242 (GRCm39) M65V probably benign Het
Phf21a T C 2: 92,182,201 (GRCm39) S377P probably damaging Het
Plcb2 T A 2: 118,548,703 (GRCm39) T408S probably benign Het
Ppp1r12b G T 1: 134,883,471 (GRCm39) A17E probably benign Het
Ppp6r2 A G 15: 89,167,152 (GRCm39) D789G probably benign Het
Prdm16 T C 4: 154,419,719 (GRCm39) M897V possibly damaging Het
Prss57 A G 10: 79,620,178 (GRCm39) probably null Het
Psd G T 19: 46,310,907 (GRCm39) L381I probably benign Het
Ptprq A T 10: 107,370,540 (GRCm39) D2050E probably benign Het
Rfc1 G T 5: 65,423,505 (GRCm39) N1034K probably damaging Het
Ryr3 C T 2: 112,661,504 (GRCm39) G1829S probably benign Het
Scaper T C 9: 55,767,003 (GRCm39) probably null Het
Scn5a A G 9: 119,351,632 (GRCm39) I783T probably damaging Het
Slc28a1 A G 7: 80,818,796 (GRCm39) N583S possibly damaging Het
Slc35e3 C T 10: 117,580,884 (GRCm39) G140D probably damaging Het
Slc6a9 G A 4: 117,725,347 (GRCm39) probably null Het
Sptlc1 A G 13: 53,496,218 (GRCm39) S376P probably benign Het
Sspo G A 6: 48,441,729 (GRCm39) C1913Y probably damaging Het
Taar7b A T 10: 23,876,845 (GRCm39) I337F possibly damaging Het
Tdpoz2 T A 3: 93,559,235 (GRCm39) I246F probably damaging Het
Trpa1 C T 1: 14,946,183 (GRCm39) V983M probably damaging Het
Trpm5 A T 7: 142,626,521 (GRCm39) M1112K probably benign Het
Tsbp1 G A 17: 34,667,770 (GRCm39) C154Y possibly damaging Het
Uso1 A T 5: 92,340,594 (GRCm39) K670I probably benign Het
Washc4 A G 10: 83,392,771 (GRCm39) D257G probably damaging Het
Wdr41 T A 13: 95,151,725 (GRCm39) probably null Het
Zbtb17 A G 4: 141,193,860 (GRCm39) Q668R possibly damaging Het
Other mutations in Fcamr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00840:Fcamr APN 1 130,740,951 (GRCm39) missense probably benign 0.01
IGL02880:Fcamr APN 1 130,741,071 (GRCm39) missense probably benign 0.00
IGL03199:Fcamr APN 1 130,740,655 (GRCm39) missense probably damaging 1.00
IGL03392:Fcamr APN 1 130,728,685 (GRCm39) utr 5 prime probably benign
IGL03398:Fcamr APN 1 130,730,985 (GRCm39) missense probably damaging 0.97
R1101:Fcamr UTSW 1 130,742,223 (GRCm39) splice site probably null
R1312:Fcamr UTSW 1 130,739,224 (GRCm39) missense probably damaging 1.00
R1351:Fcamr UTSW 1 130,740,757 (GRCm39) missense possibly damaging 0.83
R1387:Fcamr UTSW 1 130,732,379 (GRCm39) missense possibly damaging 0.85
R1475:Fcamr UTSW 1 130,742,221 (GRCm39) splice site probably null
R1728:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1728:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1728:Fcamr UTSW 1 130,732,306 (GRCm39) missense probably benign 0.06
R1728:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1728:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1728:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1728:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1728:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1728:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1729:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1729:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1729:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1729:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1729:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1729:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1729:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1729:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1730:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1730:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1730:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1730:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1730:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1730:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1730:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1739:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1739:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1739:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1739:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1739:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1739:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1739:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1739:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1762:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1762:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1762:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1762:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1762:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1762:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1762:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1762:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1783:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1783:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1783:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1783:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1783:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1783:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1783:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1783:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1784:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1784:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1784:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1784:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1784:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1784:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1784:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1784:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1785:Fcamr UTSW 1 130,740,546 (GRCm39) missense probably benign 0.02
R1785:Fcamr UTSW 1 130,740,475 (GRCm39) missense probably benign 0.00
R1785:Fcamr UTSW 1 130,740,429 (GRCm39) missense probably benign
R1785:Fcamr UTSW 1 130,740,366 (GRCm39) missense probably benign 0.38
R1785:Fcamr UTSW 1 130,739,317 (GRCm39) missense probably benign
R1785:Fcamr UTSW 1 130,732,364 (GRCm39) missense probably benign 0.00
R1785:Fcamr UTSW 1 130,732,306 (GRCm39) missense probably benign 0.06
R1785:Fcamr UTSW 1 130,742,334 (GRCm39) missense probably benign
R1785:Fcamr UTSW 1 130,740,553 (GRCm39) missense probably benign 0.41
R1793:Fcamr UTSW 1 130,739,284 (GRCm39) missense probably benign 0.03
R2085:Fcamr UTSW 1 130,739,335 (GRCm39) missense probably damaging 1.00
R3937:Fcamr UTSW 1 130,732,313 (GRCm39) missense probably damaging 0.97
R4529:Fcamr UTSW 1 130,732,313 (GRCm39) missense probably damaging 0.99
R4624:Fcamr UTSW 1 130,730,999 (GRCm39) missense probably damaging 0.99
R4822:Fcamr UTSW 1 130,740,423 (GRCm39) missense possibly damaging 0.82
R5514:Fcamr UTSW 1 130,741,793 (GRCm39) missense probably damaging 1.00
R5807:Fcamr UTSW 1 130,739,263 (GRCm39) missense probably damaging 1.00
R6077:Fcamr UTSW 1 130,740,663 (GRCm39) missense probably damaging 1.00
R6200:Fcamr UTSW 1 130,730,927 (GRCm39) missense probably benign 0.16
R6653:Fcamr UTSW 1 130,740,939 (GRCm39) missense possibly damaging 0.89
R7081:Fcamr UTSW 1 130,740,949 (GRCm39) missense probably damaging 1.00
R7362:Fcamr UTSW 1 130,741,760 (GRCm39) missense possibly damaging 0.52
R7828:Fcamr UTSW 1 130,739,443 (GRCm39) missense probably damaging 1.00
R7861:Fcamr UTSW 1 130,742,375 (GRCm39) missense probably benign
R8188:Fcamr UTSW 1 130,730,665 (GRCm39) splice site probably null
R8869:Fcamr UTSW 1 130,739,335 (GRCm39) missense probably damaging 1.00
R8907:Fcamr UTSW 1 130,740,328 (GRCm39) missense probably damaging 1.00
R9568:Fcamr UTSW 1 130,732,356 (GRCm39) missense probably damaging 0.99
X0012:Fcamr UTSW 1 130,740,471 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- CAGTTCTACAGGCCACCTTC -3'
(R):5'- GTTTCGGTCTCCTATGCCACAG -3'

Sequencing Primer
(F):5'- CCCAGCTGCATTTTCTGACAAGTG -3'
(R):5'- TATGCCACAGCGGTAAAGTC -3'
Posted On 2016-06-06