Incidental Mutation 'R5908:Or13n4'
ID 460784
Institutional Source Beutler Lab
Gene Symbol Or13n4
Ensembl Gene ENSMUSG00000056863
Gene Name olfactory receptor family 13 subfamily N member 4
Synonyms GA_x6K02T2PBJ9-9202245-9201289, MOR260-4, Olfr702
MMRRC Submission 044105-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R5908 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 106422696-106425950 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 106423404 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 110 (T110A)
Ref Sequence ENSEMBL: ENSMUSP00000146445 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075414] [ENSMUST00000080899] [ENSMUST00000208864] [ENSMUST00000208895] [ENSMUST00000217739] [ENSMUST00000219803]
AlphaFold Q920Z2
Predicted Effect probably benign
Transcript: ENSMUST00000075414
SMART Domains Protein: ENSMUSP00000074868
Gene: ENSMUSG00000036744

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.9e-46 PFAM
Pfam:7tm_1 41 290 2.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080899
AA Change: T110A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000079704
Gene: ENSMUSG00000056863
AA Change: T110A

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 300 2.9e-8 PFAM
Pfam:7tm_1 41 290 1.5e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208864
AA Change: T110A

PolyPhen 2 Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000208895
AA Change: T110A

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000217739
Predicted Effect probably benign
Transcript: ENSMUST00000219803
AA Change: T110A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 97.3%
  • 20x: 91.8%
Validation Efficiency 97% (69/71)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 A T 17: 46,624,730 (GRCm39) L198H probably damaging Het
Anks1 C T 17: 28,214,993 (GRCm39) T480I probably damaging Het
Arhgef18 G A 8: 3,503,165 (GRCm39) R857Q probably damaging Het
B230208B08Rik A G 4: 78,132,297 (GRCm39) noncoding transcript Het
B9d2 T A 7: 25,382,724 (GRCm39) W33R probably damaging Het
Bcl2a1c A G 9: 114,159,572 (GRCm39) T117A probably benign Het
Btbd8 T G 5: 107,655,460 (GRCm39) D574E probably damaging Het
Cabin1 A G 10: 75,557,366 (GRCm39) S1091P probably damaging Het
Clip3 C A 7: 29,996,298 (GRCm39) D64E probably damaging Het
Col6a5 C G 9: 105,740,000 (GRCm39) D2540H possibly damaging Het
Commd5 A T 15: 76,785,136 (GRCm39) M178L probably benign Het
Crtc3 T A 7: 80,245,542 (GRCm39) H361L possibly damaging Het
Dip2b T A 15: 100,049,065 (GRCm39) L153Q possibly damaging Het
Eif2s1 T A 12: 78,926,817 (GRCm39) V189D probably damaging Het
Etl4 C T 2: 20,748,718 (GRCm39) A483V probably damaging Het
Foxo3 T C 10: 42,072,583 (GRCm39) I645V probably benign Het
Gm4841 A G 18: 60,403,506 (GRCm39) S196P possibly damaging Het
Hip1 A G 5: 135,453,717 (GRCm39) probably null Het
Il36rn G T 2: 24,167,502 (GRCm39) probably benign Het
Ints2 A G 11: 86,106,371 (GRCm39) probably null Het
Khnyn A G 14: 56,124,523 (GRCm39) D259G probably benign Het
Lyst T A 13: 13,871,346 (GRCm39) Y2694* probably null Het
Map4k2 T C 19: 6,401,346 (GRCm39) probably benign Het
Marchf10 C T 11: 105,281,065 (GRCm39) V407I probably benign Het
Mast4 C A 13: 102,874,764 (GRCm39) V1367F probably damaging Het
Mrgprb3 A T 7: 48,293,366 (GRCm39) S62T probably damaging Het
Mthfd1l T C 10: 4,039,392 (GRCm39) F801S probably damaging Het
Nhsl3 A G 4: 129,115,941 (GRCm39) S908P probably damaging Het
Notch2 T C 3: 98,031,239 (GRCm39) probably benign Het
Nr2e1 T C 10: 42,448,765 (GRCm39) S158G probably benign Het
Nup214 A G 2: 31,881,353 (GRCm39) I404V probably benign Het
Pik3c2g G A 6: 139,714,436 (GRCm39) R196H Het
Pik3r3 A T 4: 116,129,955 (GRCm39) D213V probably benign Het
Pip5k1b A T 19: 24,374,501 (GRCm39) S27T possibly damaging Het
Pkp1 G A 1: 135,846,621 (GRCm39) Q44* probably null Het
Pnma8b C T 7: 16,680,968 (GRCm39) R651C unknown Het
Pnpt1 T A 11: 29,080,887 (GRCm39) S44T probably benign Het
Polb A T 8: 23,132,319 (GRCm39) probably null Het
Pom121l2 A G 13: 22,165,984 (GRCm39) N85S probably damaging Het
Prim1 A G 10: 127,853,893 (GRCm39) K104E probably damaging Het
Prl8a1 T A 13: 27,758,040 (GRCm39) Y223F probably benign Het
Rbak T G 5: 143,159,391 (GRCm39) H554P probably damaging Het
Serpina3c T C 12: 104,117,970 (GRCm39) R123G probably benign Het
Sh3bp4 T G 1: 89,073,605 (GRCm39) S818A probably damaging Het
Sh3rf3 C G 10: 58,885,270 (GRCm39) H384Q probably benign Het
Slc9a8 C T 2: 167,293,090 (GRCm39) probably benign Het
Sptbn4 T C 7: 27,103,678 (GRCm39) E1181G probably benign Het
Taf2 G A 15: 54,935,402 (GRCm39) probably benign Het
Taf7l2 A T 10: 115,949,133 (GRCm39) I131N probably benign Het
Tbc1d9 A T 8: 83,976,174 (GRCm39) M578L probably benign Het
Tinagl1 G T 4: 130,066,763 (GRCm39) Y111* probably null Het
Tor2a T C 2: 32,651,697 (GRCm39) L304P probably damaging Het
Trp53bp1 A G 2: 121,067,304 (GRCm39) V474A probably benign Het
Trrap C A 5: 144,723,518 (GRCm39) A325E probably damaging Het
Ube4a A G 9: 44,859,322 (GRCm39) probably null Het
Use1 G C 8: 71,822,257 (GRCm39) K239N probably damaging Het
Vps9d1 G T 8: 123,973,563 (GRCm39) Q407K probably benign Het
Zfp36l1 A T 12: 80,156,449 (GRCm39) S311T possibly damaging Het
Zfp729b T C 13: 67,739,374 (GRCm39) K964E probably benign Het
Zfp974 T A 7: 27,610,382 (GRCm39) M448L probably benign Het
Zfyve28 A T 5: 34,374,214 (GRCm39) V600E possibly damaging Het
Other mutations in Or13n4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01549:Or13n4 APN 7 106,423,236 (GRCm39) missense probably benign 0.01
IGL02120:Or13n4 APN 7 106,422,905 (GRCm39) missense possibly damaging 0.94
R0025:Or13n4 UTSW 7 106,422,963 (GRCm39) missense possibly damaging 0.74
R1213:Or13n4 UTSW 7 106,423,404 (GRCm39) missense possibly damaging 0.48
R1830:Or13n4 UTSW 7 106,423,317 (GRCm39) missense probably benign 0.00
R2216:Or13n4 UTSW 7 106,423,205 (GRCm39) missense probably damaging 0.99
R2571:Or13n4 UTSW 7 106,422,933 (GRCm39) missense probably benign 0.09
R2876:Or13n4 UTSW 7 106,423,664 (GRCm39) missense probably benign 0.07
R2920:Or13n4 UTSW 7 106,423,571 (GRCm39) missense probably benign 0.11
R4082:Or13n4 UTSW 7 106,423,245 (GRCm39) missense possibly damaging 0.78
R4130:Or13n4 UTSW 7 106,422,792 (GRCm39) missense probably benign 0.01
R4750:Or13n4 UTSW 7 106,423,514 (GRCm39) missense probably damaging 0.98
R5007:Or13n4 UTSW 7 106,423,364 (GRCm39) missense probably damaging 1.00
R5117:Or13n4 UTSW 7 106,422,869 (GRCm39) missense probably damaging 0.99
R6824:Or13n4 UTSW 7 106,423,664 (GRCm39) missense probably benign 0.00
R7193:Or13n4 UTSW 7 106,423,798 (GRCm39) start gained probably benign
R7254:Or13n4 UTSW 7 106,422,777 (GRCm39) makesense probably null
R7827:Or13n4 UTSW 7 106,422,932 (GRCm39) missense probably benign 0.01
R8309:Or13n4 UTSW 7 106,423,620 (GRCm39) missense probably benign 0.00
R8410:Or13n4 UTSW 7 106,423,745 (GRCm39) start gained probably benign
R9353:Or13n4 UTSW 7 106,423,062 (GRCm39) missense probably benign 0.00
R9386:Or13n4 UTSW 7 106,423,707 (GRCm39) missense probably benign
R9562:Or13n4 UTSW 7 106,423,020 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAAGCCAGCTTTAGGAGGG -3'
(R):5'- TCGACTTCATACACCCATGTAC -3'

Sequencing Primer
(F):5'- CCAGCTTTAGGAGGGCAGGG -3'
(R):5'- ACCCATGTACTTTTTCCTCAAAAAC -3'
Posted On 2017-02-28