Incidental Mutation 'R2474:Zfp941'
| ID |
476564 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp941
|
| Ensembl Gene |
ENSMUSG00000060314 |
| Gene Name |
zinc finger protein 941 |
| Synonyms |
BC066028 |
| MMRRC Submission |
040405-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
R2474 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
140387362-140402091 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 140391384 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 658
(H658Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101667
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080651]
[ENSMUST00000106052]
[ENSMUST00000150053]
|
| AlphaFold |
Q3URY5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000080651
|
| SMART Domains |
Protein: ENSMUSP00000079482
Gene: ENSMUSG00000060314
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
65 |
3.88e-21 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
451 |
471 |
1.16e1 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
528 |
550 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
612 |
634 |
3.69e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106052
AA Change: H658Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101667
Gene: ENSMUSG00000060314
AA Change: H658Q
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
65 |
3.88e-21 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.26e-2 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
1.12e-3 |
SMART |
|
ZnF_C2H2
|
451 |
471 |
1.16e1 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
528 |
550 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
6.42e-4 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
612 |
634 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
640 |
662 |
2.99e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150053
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 94.9%
|
| Validation Efficiency |
100% (32/32) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrl4 |
A |
G |
3: 151,248,361 (GRCm39) |
T678A |
probably benign |
Het |
| Asb7 |
A |
T |
7: 66,328,901 (GRCm39) |
N46K |
probably damaging |
Het |
| Atxn7l2 |
A |
C |
3: 108,111,293 (GRCm39) |
S414R |
probably damaging |
Het |
| Bckdk |
C |
A |
7: 127,504,590 (GRCm39) |
R105S |
probably damaging |
Het |
| Cxcl13 |
C |
T |
5: 96,107,816 (GRCm39) |
Q91* |
probably null |
Het |
| Dchs1 |
T |
C |
7: 105,404,281 (GRCm39) |
N2754D |
probably benign |
Het |
| Dchs1 |
A |
T |
7: 105,422,045 (GRCm39) |
V125E |
probably damaging |
Het |
| Enpep |
G |
C |
3: 129,077,807 (GRCm39) |
S603R |
possibly damaging |
Het |
| Greb1 |
T |
C |
12: 16,764,954 (GRCm39) |
N393S |
possibly damaging |
Het |
| Hfm1 |
A |
T |
5: 107,020,282 (GRCm39) |
V1048D |
possibly damaging |
Het |
| Ilvbl |
T |
C |
10: 78,412,558 (GRCm39) |
V93A |
probably damaging |
Het |
| Itpkb |
A |
G |
1: 180,161,716 (GRCm39) |
D614G |
probably damaging |
Het |
| Klk14 |
G |
A |
7: 43,341,501 (GRCm39) |
C51Y |
probably damaging |
Het |
| Lgi3 |
G |
A |
14: 70,770,689 (GRCm39) |
|
probably null |
Het |
| Mpeg1 |
G |
A |
19: 12,439,613 (GRCm39) |
C357Y |
probably damaging |
Het |
| Nedd1 |
A |
G |
10: 92,555,465 (GRCm39) |
F7L |
probably damaging |
Het |
| Or8g26 |
A |
G |
9: 39,095,846 (GRCm39) |
D121G |
probably damaging |
Het |
| Or8k35 |
C |
A |
2: 86,424,957 (GRCm39) |
V72F |
probably benign |
Het |
| Parp8 |
A |
T |
13: 117,029,577 (GRCm39) |
C510S |
possibly damaging |
Het |
| Phb1 |
T |
C |
11: 95,562,248 (GRCm39) |
F42L |
possibly damaging |
Het |
| Pik3r1 |
A |
T |
13: 101,839,284 (GRCm39) |
Y189* |
probably null |
Het |
| Rps5 |
T |
A |
7: 12,660,488 (GRCm39) |
|
probably null |
Het |
| Secisbp2l |
C |
T |
2: 125,582,657 (GRCm39) |
G933D |
possibly damaging |
Het |
| Senp3 |
T |
A |
11: 69,564,923 (GRCm39) |
N516Y |
probably damaging |
Het |
| Tfap2b |
A |
T |
1: 19,284,599 (GRCm39) |
H169L |
possibly damaging |
Het |
| Tmem260 |
A |
G |
14: 48,733,781 (GRCm39) |
D226G |
probably null |
Het |
| Ttc6 |
G |
T |
12: 57,622,713 (GRCm39) |
R37S |
probably benign |
Het |
| Vmn2r84 |
A |
T |
10: 130,222,392 (GRCm39) |
D609E |
possibly damaging |
Het |
| Vmn2r99 |
A |
T |
17: 19,598,891 (GRCm39) |
M192L |
probably benign |
Het |
| Zfp746 |
T |
C |
6: 48,041,703 (GRCm39) |
D341G |
probably damaging |
Het |
| Zw10 |
T |
A |
9: 48,978,105 (GRCm39) |
I351N |
probably damaging |
Het |
|
| Other mutations in Zfp941 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01393:Zfp941
|
APN |
7 |
140,391,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Zfp941
|
APN |
7 |
140,392,612 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL03202:Zfp941
|
APN |
7 |
140,392,966 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0025:Zfp941
|
UTSW |
7 |
140,393,185 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0025:Zfp941
|
UTSW |
7 |
140,393,185 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0226:Zfp941
|
UTSW |
7 |
140,393,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0945:Zfp941
|
UTSW |
7 |
140,391,577 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1455:Zfp941
|
UTSW |
7 |
140,392,687 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1581:Zfp941
|
UTSW |
7 |
140,392,033 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4052:Zfp941
|
UTSW |
7 |
140,392,340 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4576:Zfp941
|
UTSW |
7 |
140,391,503 (GRCm39) |
nonsense |
probably null |
|
|
R4604:Zfp941
|
UTSW |
7 |
140,392,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5170:Zfp941
|
UTSW |
7 |
140,392,870 (GRCm39) |
unclassified |
probably benign |
|
|
R5311:Zfp941
|
UTSW |
7 |
140,391,872 (GRCm39) |
nonsense |
probably null |
|
|
R5505:Zfp941
|
UTSW |
7 |
140,391,830 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5549:Zfp941
|
UTSW |
7 |
140,388,021 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5566:Zfp941
|
UTSW |
7 |
140,392,679 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5723:Zfp941
|
UTSW |
7 |
140,392,763 (GRCm39) |
unclassified |
probably benign |
|
|
R5736:Zfp941
|
UTSW |
7 |
140,392,973 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5861:Zfp941
|
UTSW |
7 |
140,392,052 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Zfp941
|
UTSW |
7 |
140,392,158 (GRCm39) |
nonsense |
probably null |
|
|
R6058:Zfp941
|
UTSW |
7 |
140,392,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6226:Zfp941
|
UTSW |
7 |
140,392,398 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6488:Zfp941
|
UTSW |
7 |
140,392,663 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6824:Zfp941
|
UTSW |
7 |
140,392,612 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7356:Zfp941
|
UTSW |
7 |
140,392,028 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7554:Zfp941
|
UTSW |
7 |
140,391,970 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Z1177:Zfp941
|
UTSW |
7 |
140,392,099 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
| Predicted Primers |
|
| Posted On |
2017-05-11 |
Incidental Mutation