Incidental Mutation 'R6192:Patj'
| ID |
502635 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Patj
|
| Ensembl Gene |
ENSMUSG00000061859 |
| Gene Name |
PATJ, crumbs cell polarity complex component |
| Synonyms |
Cipp, Inadl |
| MMRRC Submission |
044332-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6192 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
98284022-98607840 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 98344394 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Tryptophan
at position 569
(G569W)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102649
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041284]
[ENSMUST00000107029]
[ENSMUST00000107030]
[ENSMUST00000107033]
[ENSMUST00000107034]
|
| AlphaFold |
Q63ZW7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000041284
AA Change: G573W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000049176
Gene: ENSMUSG00000061859
AA Change: G573W
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
8 |
68 |
6.53e-9 |
SMART |
|
PDZ
|
143 |
221 |
1.78e-20 |
SMART |
|
PDZ
|
256 |
328 |
1.15e-23 |
SMART |
|
PDZ
|
374 |
453 |
3.15e-21 |
SMART |
|
coiled coil region
|
486 |
513 |
N/A |
INTRINSIC |
|
PDZ
|
570 |
641 |
1.28e-12 |
SMART |
|
PDZ
|
696 |
775 |
9.5e-16 |
SMART |
|
low complexity region
|
980 |
991 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1062 |
N/A |
INTRINSIC |
|
PDZ
|
1083 |
1166 |
8.65e-19 |
SMART |
|
PDZ
|
1253 |
1328 |
6.12e-19 |
SMART |
|
low complexity region
|
1356 |
1366 |
N/A |
INTRINSIC |
|
low complexity region
|
1410 |
1428 |
N/A |
INTRINSIC |
|
PDZ
|
1480 |
1555 |
4.36e-24 |
SMART |
|
PDZ
|
1577 |
1650 |
2.49e-19 |
SMART |
|
PDZ
|
1718 |
1795 |
2.13e-18 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107029
|
| SMART Domains |
Protein: ENSMUSP00000102644
Gene: ENSMUSG00000061859
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
1 |
68 |
1e-9 |
SMART |
|
PDZ
|
123 |
202 |
4.7e-18 |
SMART |
|
low complexity region
|
407 |
418 |
N/A |
INTRINSIC |
|
low complexity region
|
481 |
489 |
N/A |
INTRINSIC |
|
PDZ
|
510 |
593 |
4.3e-21 |
SMART |
|
PDZ
|
680 |
755 |
2.9e-21 |
SMART |
|
low complexity region
|
783 |
793 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
855 |
N/A |
INTRINSIC |
|
PDZ
|
907 |
982 |
2.2e-26 |
SMART |
|
PDZ
|
1004 |
1077 |
1.2e-21 |
SMART |
|
PDZ
|
1145 |
1222 |
1e-20 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107030
|
| SMART Domains |
Protein: ENSMUSP00000102645
Gene: ENSMUSG00000061859
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
8 |
68 |
6.53e-9 |
SMART |
|
PDZ
|
143 |
221 |
1.78e-20 |
SMART |
|
PDZ
|
256 |
328 |
1.15e-23 |
SMART |
|
PDZ
|
374 |
453 |
3.15e-21 |
SMART |
|
coiled coil region
|
486 |
513 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107033
AA Change: G573W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000102648
Gene: ENSMUSG00000061859
AA Change: G573W
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
8 |
68 |
6.53e-9 |
SMART |
|
PDZ
|
143 |
221 |
1.78e-20 |
SMART |
|
PDZ
|
256 |
328 |
1.15e-23 |
SMART |
|
PDZ
|
374 |
453 |
3.15e-21 |
SMART |
|
coiled coil region
|
486 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
648 |
659 |
N/A |
INTRINSIC |
|
low complexity region
|
722 |
730 |
N/A |
INTRINSIC |
|
PDZ
|
751 |
834 |
8.65e-19 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107034
AA Change: G569W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000102649
Gene: ENSMUSG00000061859
AA Change: G569W
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
8 |
68 |
6.53e-9 |
SMART |
|
PDZ
|
143 |
221 |
1.78e-20 |
SMART |
|
PDZ
|
256 |
328 |
1.15e-23 |
SMART |
|
PDZ
|
374 |
453 |
3.15e-21 |
SMART |
|
coiled coil region
|
486 |
513 |
N/A |
INTRINSIC |
|
PDZ
|
566 |
637 |
1.28e-12 |
SMART |
|
PDZ
|
692 |
771 |
9.5e-16 |
SMART |
|
low complexity region
|
976 |
987 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1058 |
N/A |
INTRINSIC |
|
PDZ
|
1079 |
1162 |
8.65e-19 |
SMART |
|
PDZ
|
1249 |
1324 |
6.12e-19 |
SMART |
|
low complexity region
|
1352 |
1362 |
N/A |
INTRINSIC |
|
low complexity region
|
1382 |
1400 |
N/A |
INTRINSIC |
|
PDZ
|
1452 |
1499 |
7.78e0 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000142103
AA Change: G51W
|
| SMART Domains |
Protein: ENSMUSP00000116021
Gene: ENSMUSG00000061859
AA Change: G51W
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
49 |
120 |
1.28e-12 |
SMART |
|
PDZ
|
175 |
254 |
9.5e-16 |
SMART |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
100% (75/75) |
| MGI Phenotype |
FUNCTION: This gene encodes a multivalent PDZ domain protein, which is expressed exclusively in brain and kidney. This protein selectively interacts with inward rectifier K+ (Kir) family members, N-methyl-D-aspartate receptor subunits, neurexins and neuroligins, as well as cell surface molecules enriched in synaptic membranes. Thus, this protein may serve as a scaffold that brings structurally diverse but functionally connected proteins into close proximity at the synapse. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(5) : Gene trapped(5) |
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts9 |
T |
C |
6: 92,774,002 (GRCm39) |
E1137G |
probably damaging |
Het |
| Adcy9 |
T |
C |
16: 4,105,818 (GRCm39) |
I1099V |
probably benign |
Het |
| Angptl4 |
A |
T |
17: 33,996,015 (GRCm39) |
N320K |
probably benign |
Het |
| Atp6v0a2 |
G |
A |
5: 124,767,268 (GRCm39) |
M10I |
probably benign |
Het |
| Bltp1 |
C |
T |
3: 37,042,318 (GRCm39) |
T2768I |
probably benign |
Het |
| Cbfa2t3 |
A |
G |
8: 123,361,135 (GRCm39) |
S395P |
probably benign |
Het |
| Cenpe |
C |
T |
3: 134,954,291 (GRCm39) |
T1716I |
possibly damaging |
Het |
| Chsy1 |
T |
C |
7: 65,820,625 (GRCm39) |
Y287H |
probably benign |
Het |
| Col4a4 |
G |
T |
1: 82,462,151 (GRCm39) |
P1075T |
probably damaging |
Het |
| Cryab |
T |
A |
9: 50,665,813 (GRCm39) |
M68K |
probably damaging |
Het |
| Cybrd1 |
T |
A |
2: 70,967,858 (GRCm39) |
L143Q |
probably null |
Het |
| Dcaf7 |
T |
C |
11: 105,942,584 (GRCm39) |
V177A |
probably damaging |
Het |
| Dclk2 |
T |
C |
3: 86,722,457 (GRCm39) |
Y392C |
probably damaging |
Het |
| Ddx20 |
T |
C |
3: 105,586,036 (GRCm39) |
T770A |
probably benign |
Het |
| Dennd1b |
T |
A |
1: 139,095,456 (GRCm39) |
D501E |
probably benign |
Het |
| Dgkh |
A |
T |
14: 78,865,504 (GRCm39) |
Y26* |
probably null |
Het |
| Dnajc2 |
A |
G |
5: 21,973,646 (GRCm39) |
V196A |
probably damaging |
Het |
| Etl4 |
A |
G |
2: 20,806,362 (GRCm39) |
K827E |
probably damaging |
Het |
| Fam8a1 |
C |
T |
13: 46,823,099 (GRCm39) |
P13L |
probably damaging |
Het |
| Gfra3 |
T |
C |
18: 34,837,582 (GRCm39) |
S139G |
possibly damaging |
Het |
| Ggnbp1 |
G |
A |
17: 27,248,847 (GRCm39) |
V139I |
possibly damaging |
Het |
| Gja1 |
T |
A |
10: 56,264,330 (GRCm39) |
Y230N |
probably damaging |
Het |
| Gldc |
A |
G |
19: 30,111,172 (GRCm39) |
S535P |
probably damaging |
Het |
| Gm45871 |
A |
G |
18: 90,610,357 (GRCm39) |
T532A |
probably benign |
Het |
| Gm5431 |
T |
A |
11: 48,785,220 (GRCm39) |
D107V |
probably benign |
Het |
| Herc2 |
C |
T |
7: 55,857,510 (GRCm39) |
T4031M |
probably damaging |
Het |
| Iffo2 |
G |
A |
4: 139,333,769 (GRCm39) |
A282T |
probably damaging |
Het |
| Ifi44 |
T |
G |
3: 151,451,276 (GRCm39) |
|
probably null |
Het |
| Igkv4-53 |
C |
T |
6: 69,625,915 (GRCm39) |
R62H |
possibly damaging |
Het |
| Lrp11 |
A |
C |
10: 7,474,454 (GRCm39) |
|
probably null |
Het |
| Lrp4 |
A |
G |
2: 91,338,833 (GRCm39) |
T1755A |
probably benign |
Het |
| Mcm3ap |
A |
T |
10: 76,336,934 (GRCm39) |
K1316M |
probably damaging |
Het |
| Mctp1 |
T |
G |
13: 76,971,082 (GRCm39) |
|
probably null |
Het |
| Mroh5 |
A |
T |
15: 73,662,630 (GRCm39) |
I396N |
probably damaging |
Het |
| Mrps5 |
T |
A |
2: 127,443,305 (GRCm39) |
H294Q |
probably damaging |
Het |
| Muc16 |
A |
T |
9: 18,569,985 (GRCm39) |
S845T |
unknown |
Het |
| Mycbpap |
A |
T |
11: 94,398,557 (GRCm39) |
V474E |
probably damaging |
Het |
| Mzt2 |
G |
C |
16: 15,666,551 (GRCm39) |
S122W |
probably benign |
Het |
| Neb |
T |
C |
2: 52,146,802 (GRCm39) |
I2821V |
probably benign |
Het |
| Ngef |
A |
T |
1: 87,415,622 (GRCm39) |
D347E |
probably damaging |
Het |
| Nlrp14 |
T |
C |
7: 106,781,646 (GRCm39) |
V281A |
probably benign |
Het |
| Obscn |
A |
T |
11: 58,888,864 (GRCm39) |
Y7597N |
unknown |
Het |
| Or4k47 |
T |
C |
2: 111,451,520 (GRCm39) |
R300G |
possibly damaging |
Het |
| Pdzrn4 |
A |
T |
15: 92,655,562 (GRCm39) |
E485V |
probably damaging |
Het |
| Phf2 |
T |
A |
13: 48,973,583 (GRCm39) |
T361S |
unknown |
Het |
| Pik3r6 |
A |
G |
11: 68,434,455 (GRCm39) |
E552G |
probably damaging |
Het |
| Pitx2 |
A |
G |
3: 129,009,521 (GRCm39) |
T147A |
probably benign |
Het |
| Pkmyt1 |
G |
A |
17: 23,953,167 (GRCm39) |
G241D |
probably damaging |
Het |
| Pola2 |
A |
T |
19: 6,003,802 (GRCm39) |
V191D |
possibly damaging |
Het |
| Ralgapb |
T |
A |
2: 158,291,367 (GRCm39) |
|
probably null |
Het |
| Rapgef4 |
T |
C |
2: 71,811,661 (GRCm39) |
S11P |
probably benign |
Het |
| Rnf10 |
G |
A |
5: 115,395,136 (GRCm39) |
R151C |
probably damaging |
Het |
| Rpl34 |
G |
A |
3: 130,522,716 (GRCm39) |
P50L |
probably benign |
Het |
| Rptn |
C |
G |
3: 93,305,437 (GRCm39) |
H923Q |
possibly damaging |
Het |
| Sbno2 |
A |
T |
10: 79,895,850 (GRCm39) |
L977Q |
probably damaging |
Het |
| Sec14l3 |
G |
A |
11: 4,025,566 (GRCm39) |
|
probably null |
Het |
| Serping1 |
A |
T |
2: 84,600,612 (GRCm39) |
N243K |
possibly damaging |
Het |
| Slco2b1 |
T |
A |
7: 99,334,779 (GRCm39) |
I231F |
probably damaging |
Het |
| Spag8 |
A |
G |
4: 43,652,458 (GRCm39) |
F294S |
probably damaging |
Het |
| Speer4f1 |
G |
A |
5: 17,684,493 (GRCm39) |
A174T |
probably damaging |
Het |
| Spred3 |
T |
C |
7: 28,862,402 (GRCm39) |
D147G |
probably benign |
Het |
| Stard9 |
A |
G |
2: 120,527,241 (GRCm39) |
D1166G |
probably damaging |
Het |
| Svep1 |
G |
T |
4: 58,104,536 (GRCm39) |
T1229K |
possibly damaging |
Het |
| Tanc1 |
T |
A |
2: 59,669,305 (GRCm39) |
|
probably null |
Het |
| Tmem232 |
T |
C |
17: 65,737,800 (GRCm39) |
Y420C |
probably damaging |
Het |
| Tubd1 |
A |
T |
11: 86,448,619 (GRCm39) |
M311L |
probably benign |
Het |
| Tulp3 |
G |
A |
6: 128,332,703 (GRCm39) |
|
probably null |
Het |
| Usp42 |
T |
C |
5: 143,702,942 (GRCm39) |
T560A |
possibly damaging |
Het |
| Vmn1r170 |
A |
T |
7: 23,305,934 (GRCm39) |
Y112F |
probably damaging |
Het |
| Vmn2r4 |
A |
T |
3: 64,322,699 (GRCm39) |
C7S |
probably benign |
Het |
| Wrn |
A |
G |
8: 33,774,682 (GRCm39) |
M652T |
probably benign |
Het |
| Wsb1 |
G |
A |
11: 79,139,336 (GRCm39) |
P120L |
possibly damaging |
Het |
| Zfp142 |
T |
C |
1: 74,609,667 (GRCm39) |
E1376G |
probably damaging |
Het |
| Zfp709 |
TCGACG |
TCG |
8: 72,644,552 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Patj |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Patj
|
APN |
4 |
98,353,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00095:Patj
|
APN |
4 |
98,423,799 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL00517:Patj
|
APN |
4 |
98,329,308 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL00802:Patj
|
APN |
4 |
98,312,643 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01064:Patj
|
APN |
4 |
98,385,210 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01110:Patj
|
APN |
4 |
98,301,261 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01407:Patj
|
APN |
4 |
98,301,287 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01821:Patj
|
APN |
4 |
98,344,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Patj
|
APN |
4 |
98,480,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02494:Patj
|
APN |
4 |
98,592,224 (GRCm39) |
splice site |
probably benign |
|
|
IGL02803:Patj
|
APN |
4 |
98,314,301 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02931:Patj
|
APN |
4 |
98,299,410 (GRCm39) |
splice site |
probably benign |
|
|
IGL03017:Patj
|
APN |
4 |
98,353,264 (GRCm39) |
splice site |
probably benign |
|
|
IGL03115:Patj
|
APN |
4 |
98,332,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03209:Patj
|
APN |
4 |
98,353,377 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL03377:Patj
|
APN |
4 |
98,353,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D4186:Patj
|
UTSW |
4 |
98,526,999 (GRCm39) |
missense |
probably benign |
0.17 |
|
PIT4531001:Patj
|
UTSW |
4 |
98,329,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0136:Patj
|
UTSW |
4 |
98,555,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0294:Patj
|
UTSW |
4 |
98,385,285 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0376:Patj
|
UTSW |
4 |
98,457,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0463:Patj
|
UTSW |
4 |
98,562,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0465:Patj
|
UTSW |
4 |
98,423,744 (GRCm39) |
splice site |
probably null |
|
|
R0466:Patj
|
UTSW |
4 |
98,576,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0544:Patj
|
UTSW |
4 |
98,457,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Patj
|
UTSW |
4 |
98,569,472 (GRCm39) |
splice site |
probably benign |
|
|
R0657:Patj
|
UTSW |
4 |
98,555,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1281:Patj
|
UTSW |
4 |
98,304,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1393:Patj
|
UTSW |
4 |
98,312,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1480:Patj
|
UTSW |
4 |
98,357,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Patj
|
UTSW |
4 |
98,301,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1728:Patj
|
UTSW |
4 |
98,320,017 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1729:Patj
|
UTSW |
4 |
98,320,017 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1797:Patj
|
UTSW |
4 |
98,575,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1818:Patj
|
UTSW |
4 |
98,511,885 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1835:Patj
|
UTSW |
4 |
98,379,827 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1880:Patj
|
UTSW |
4 |
98,385,477 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2009:Patj
|
UTSW |
4 |
98,344,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2090:Patj
|
UTSW |
4 |
98,325,560 (GRCm39) |
unclassified |
probably benign |
|
|
R2120:Patj
|
UTSW |
4 |
98,344,462 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2180:Patj
|
UTSW |
4 |
98,411,739 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2655:Patj
|
UTSW |
4 |
98,325,687 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R3156:Patj
|
UTSW |
4 |
98,562,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3749:Patj
|
UTSW |
4 |
98,357,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3767:Patj
|
UTSW |
4 |
98,569,456 (GRCm39) |
nonsense |
probably null |
|
|
R3913:Patj
|
UTSW |
4 |
98,457,338 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3917:Patj
|
UTSW |
4 |
98,480,245 (GRCm39) |
nonsense |
probably null |
|
|
R3918:Patj
|
UTSW |
4 |
98,344,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4299:Patj
|
UTSW |
4 |
98,565,558 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4355:Patj
|
UTSW |
4 |
98,538,691 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4471:Patj
|
UTSW |
4 |
98,423,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4762:Patj
|
UTSW |
4 |
98,293,807 (GRCm39) |
nonsense |
probably null |
|
|
R4877:Patj
|
UTSW |
4 |
98,457,295 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4945:Patj
|
UTSW |
4 |
98,383,301 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5274:Patj
|
UTSW |
4 |
98,407,218 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5343:Patj
|
UTSW |
4 |
98,564,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5554:Patj
|
UTSW |
4 |
98,342,633 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5688:Patj
|
UTSW |
4 |
98,409,047 (GRCm39) |
nonsense |
probably null |
|
|
R5880:Patj
|
UTSW |
4 |
98,299,382 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5972:Patj
|
UTSW |
4 |
98,457,290 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6149:Patj
|
UTSW |
4 |
98,312,562 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6265:Patj
|
UTSW |
4 |
98,357,804 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6350:Patj
|
UTSW |
4 |
98,293,855 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6363:Patj
|
UTSW |
4 |
98,320,097 (GRCm39) |
missense |
probably benign |
0.25 |
|
R6434:Patj
|
UTSW |
4 |
98,379,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6496:Patj
|
UTSW |
4 |
98,304,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6896:Patj
|
UTSW |
4 |
98,314,287 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7039:Patj
|
UTSW |
4 |
98,457,315 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7040:Patj
|
UTSW |
4 |
98,329,317 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7052:Patj
|
UTSW |
4 |
98,565,497 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7066:Patj
|
UTSW |
4 |
98,301,434 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7236:Patj
|
UTSW |
4 |
98,299,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7242:Patj
|
UTSW |
4 |
98,480,170 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7260:Patj
|
UTSW |
4 |
98,304,970 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7412:Patj
|
UTSW |
4 |
98,299,376 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7493:Patj
|
UTSW |
4 |
98,383,298 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7570:Patj
|
UTSW |
4 |
98,312,737 (GRCm39) |
splice site |
probably null |
|
|
R7571:Patj
|
UTSW |
4 |
98,457,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7626:Patj
|
UTSW |
4 |
98,435,224 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7658:Patj
|
UTSW |
4 |
98,576,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7664:Patj
|
UTSW |
4 |
98,385,187 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7669:Patj
|
UTSW |
4 |
98,407,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7796:Patj
|
UTSW |
4 |
98,435,220 (GRCm39) |
start codon destroyed |
probably benign |
0.05 |
|
R7870:Patj
|
UTSW |
4 |
98,312,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7883:Patj
|
UTSW |
4 |
98,499,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7948:Patj
|
UTSW |
4 |
98,312,547 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8050:Patj
|
UTSW |
4 |
98,427,201 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8183:Patj
|
UTSW |
4 |
98,562,466 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8239:Patj
|
UTSW |
4 |
98,570,308 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8483:Patj
|
UTSW |
4 |
98,312,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8546:Patj
|
UTSW |
4 |
98,325,634 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8746:Patj
|
UTSW |
4 |
98,394,067 (GRCm39) |
intron |
probably benign |
|
|
R8844:Patj
|
UTSW |
4 |
98,480,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8905:Patj
|
UTSW |
4 |
98,385,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8912:Patj
|
UTSW |
4 |
98,385,565 (GRCm39) |
missense |
|
|
|
R8959:Patj
|
UTSW |
4 |
98,480,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9083:Patj
|
UTSW |
4 |
98,401,871 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9173:Patj
|
UTSW |
4 |
98,526,958 (GRCm39) |
missense |
probably benign |
|
|
R9206:Patj
|
UTSW |
4 |
98,427,310 (GRCm39) |
missense |
unknown |
|
|
R9208:Patj
|
UTSW |
4 |
98,427,310 (GRCm39) |
missense |
unknown |
|
|
R9347:Patj
|
UTSW |
4 |
98,576,484 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9560:Patj
|
UTSW |
4 |
98,570,289 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9609:Patj
|
UTSW |
4 |
98,576,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9617:Patj
|
UTSW |
4 |
98,393,991 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9658:Patj
|
UTSW |
4 |
98,353,377 (GRCm39) |
missense |
probably null |
1.00 |
|
R9756:Patj
|
UTSW |
4 |
98,565,535 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Patj
|
UTSW |
4 |
98,564,555 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Patj
|
UTSW |
4 |
98,499,367 (GRCm39) |
missense |
probably benign |
0.11 |
|
Z1177:Patj
|
UTSW |
4 |
98,385,411 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTTCCTGTGCTGGGAATC -3'
(R):5'- CTGTATTACCCAGTAAGCTGTTGG -3'
Sequencing Primer
(F):5'- CCTGTGCTGGGAATCTTAGG -3'
(R):5'- GCCTGGCATTAGTGACATTGTCAATC -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation