Incidental Mutation 'R6647:Or5d36'
ID 526108
Institutional Source Beutler Lab
Gene Symbol Or5d36
Ensembl Gene ENSMUSG00000075137
Gene Name olfactory receptor family 5 subfamily D member 36
Synonyms Olfr1163, MOR174-8, GA_x6K02T2Q125-49563265-49562315
MMRRC Submission 044768-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R6647 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87900709-87901751 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87901053 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 224 (F224L)
Ref Sequence ENSEMBL: ENSMUSP00000149399 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099835] [ENSMUST00000215268]
AlphaFold Q8VFR4
Predicted Effect probably benign
Transcript: ENSMUST00000099835
AA Change: F224L

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000097423
Gene: ENSMUSG00000075137
AA Change: F224L

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 1.2e-44 PFAM
Pfam:7tm_1 43 292 2.3e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215268
AA Change: F224L

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.6%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl T C 3: 116,544,060 (GRCm39) T1416A probably damaging Het
Atp7b A G 8: 22,518,494 (GRCm39) S103P probably damaging Het
Ces1h A C 8: 94,078,654 (GRCm39) *563G probably null Het
Cfap157 G T 2: 32,669,086 (GRCm39) A339E probably benign Het
Crebbp C T 16: 3,937,670 (GRCm39) A698T possibly damaging Het
Cyp2b13 A G 7: 25,785,324 (GRCm39) H231R possibly damaging Het
Ddx31 A T 2: 28,765,750 (GRCm39) T483S probably damaging Het
Defa25 A T 8: 21,575,201 (GRCm39) D60V possibly damaging Het
Dnah5 G A 15: 28,403,633 (GRCm39) A3453T probably benign Het
Dnah6 A T 6: 73,115,743 (GRCm39) F1500I probably damaging Het
Eprs1 C T 1: 185,146,621 (GRCm39) A1217V probably damaging Het
Ermp1 T C 19: 29,604,335 (GRCm39) Y481C probably benign Het
Fmn2 T A 1: 174,420,670 (GRCm39) N635K unknown Het
Fras1 A G 5: 96,883,061 (GRCm39) D2531G probably damaging Het
Frat1 C T 19: 41,819,264 (GRCm39) Q220* probably null Het
Gcc2 T A 10: 58,123,103 (GRCm39) probably null Het
Gm3285 T C 10: 77,698,447 (GRCm39) probably benign Het
Gm9857 T C 3: 108,847,379 (GRCm39) probably benign Het
Grin2b C A 6: 135,710,108 (GRCm39) W1146L probably damaging Het
Hells T A 19: 38,919,948 (GRCm39) L33I probably benign Het
Ift81 T A 5: 122,748,229 (GRCm39) R54* probably null Het
Ints12 G A 3: 132,802,639 (GRCm39) R41Q possibly damaging Het
Katnal2 C T 18: 77,067,733 (GRCm39) E403K probably benign Het
Kcnk1 A G 8: 126,722,199 (GRCm39) M1V probably null Het
Kdm5a A G 6: 120,389,422 (GRCm39) T950A probably benign Het
Kdr G A 5: 76,113,549 (GRCm39) A773V probably damaging Het
Lats1 G C 10: 7,573,271 (GRCm39) M118I possibly damaging Het
Mug1 A G 6: 121,817,200 (GRCm39) I90V probably benign Het
Nid2 A G 14: 19,852,484 (GRCm39) D1064G probably benign Het
Nkx2-4 A T 2: 146,926,187 (GRCm39) I225N possibly damaging Het
Nlrp4e A G 7: 23,020,740 (GRCm39) D409G probably benign Het
Ogfod2 G C 5: 124,252,866 (GRCm39) R292P possibly damaging Het
Oprk1 C T 1: 5,672,507 (GRCm39) P215S probably damaging Het
Or6c35 T A 10: 129,169,033 (GRCm39) C94* probably null Het
Or7g27 T A 9: 19,249,925 (GRCm39) H56Q possibly damaging Het
Or8g21 T C 9: 38,906,210 (GRCm39) I174V possibly damaging Het
Pcdhb16 A G 18: 37,612,225 (GRCm39) K395R possibly damaging Het
Ptprg C A 14: 11,962,714 (GRCm38) P171T probably damaging Het
Pycard T C 7: 127,592,741 (GRCm39) T29A probably benign Het
Rap1gap2 G A 11: 74,298,754 (GRCm39) A452V probably benign Het
Rasgrf1 C G 9: 89,892,516 (GRCm39) T1072S probably benign Het
Rc3h2 G A 2: 37,272,956 (GRCm39) R707* probably null Het
Rsf1 G A 7: 97,229,117 (GRCm39) probably benign Het
Senp7 T C 16: 55,993,618 (GRCm39) I767T probably damaging Het
Setd7 A G 3: 51,450,183 (GRCm39) V81A probably benign Het
Shisal2a A G 4: 108,225,224 (GRCm39) S113P probably benign Het
Shkbp1 A G 7: 27,041,800 (GRCm39) S685P probably benign Het
Snrnp200 A G 2: 127,068,372 (GRCm39) E904G probably damaging Het
Spata22 T A 11: 73,245,526 (GRCm39) probably null Het
Spata31e2 T A 1: 26,721,659 (GRCm39) N1174Y probably damaging Het
Tas2r138 G T 6: 40,589,733 (GRCm39) T171K possibly damaging Het
Tor1aip1 T C 1: 155,893,999 (GRCm39) D77G possibly damaging Het
Vav3 A T 3: 109,434,732 (GRCm39) H421L probably benign Het
Vmn1r43 A G 6: 89,846,841 (GRCm39) L215P probably damaging Het
Vmn2r100 T A 17: 19,742,785 (GRCm39) S386R probably benign Het
Xpa T A 4: 46,183,089 (GRCm39) R233S probably benign Het
Other mutations in Or5d36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Or5d36 APN 2 87,901,468 (GRCm39) missense possibly damaging 0.56
IGL01472:Or5d36 APN 2 87,901,322 (GRCm39) missense possibly damaging 0.56
IGL02111:Or5d36 APN 2 87,901,571 (GRCm39) missense probably benign 0.22
R1274:Or5d36 UTSW 2 87,900,939 (GRCm39) missense probably damaging 1.00
R1938:Or5d36 UTSW 2 87,901,300 (GRCm39) missense probably damaging 1.00
R2012:Or5d36 UTSW 2 87,901,063 (GRCm39) missense probably benign 0.03
R3056:Or5d36 UTSW 2 87,901,583 (GRCm39) missense probably benign
R4127:Or5d36 UTSW 2 87,901,579 (GRCm39) missense probably benign 0.00
R4748:Or5d36 UTSW 2 87,900,956 (GRCm39) missense probably benign 0.44
R4749:Or5d36 UTSW 2 87,900,956 (GRCm39) missense probably benign 0.44
R4769:Or5d36 UTSW 2 87,901,073 (GRCm39) missense probably benign 0.25
R7111:Or5d36 UTSW 2 87,901,000 (GRCm39) missense probably damaging 1.00
R7168:Or5d36 UTSW 2 87,900,921 (GRCm39) missense probably benign 0.37
R8222:Or5d36 UTSW 2 87,901,381 (GRCm39) missense probably benign 0.00
R8869:Or5d36 UTSW 2 87,901,753 (GRCm39) critical splice acceptor site probably null
R9043:Or5d36 UTSW 2 87,900,983 (GRCm39) missense possibly damaging 0.94
R9205:Or5d36 UTSW 2 87,900,778 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- ACTGCATAAAAGACCGAGGC -3'
(R):5'- ACTGGGTCATATATCTGGAGTACC -3'

Sequencing Primer
(F):5'- CTGCATAAAAGACCGAGGCTACTTTG -3'
(R):5'- GAAACATTGATTCTCCTTTGCTATGC -3'
Posted On 2018-06-22