Mutagenetix > Incidental Mutation

Incidental Mutation 'R6891:Dmxl2'

537221

Institutional Source

Beutler Lab

Gene Symbol

Dmxl2

Ensembl Gene

ENSMUSG00000041268

Gene Name

Dmx-like 2

Synonyms

E130119P06Rik, 6430411K14Rik

MMRRC Submission

044985-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6891 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

54272442-54408910 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 54387664 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 58 (I58T)

Ref Sequence

ENSEMBL: ENSMUSP00000113705 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000118163] [ENSMUST00000118600]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000118163
AA Change: I58T

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000113705
Gene: ENSMUSG00000041268
AA Change: I58T

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
Pfam:Rav1p_C	1430	1903	1.5e-71	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2472	2490	N/A	INTRINSIC
low complexity region	2635	2649	N/A	INTRINSIC
low complexity region	2744	2766	N/A	INTRINSIC
WD40	2774	2809	5.73e0	SMART
WD40	2813	2852	8.88e0	SMART
WD40	2859	2901	2.67e-1	SMART
WD40	2907	2946	2.57e-2	SMART
WD40	2949	2988	3.61e-6	SMART
WD40	3001	3039	8.25e0	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000118600
AA Change: I58T

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000113693
Gene: ENSMUSG00000041268
AA Change: I58T

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
low complexity region	1426	1436	N/A	INTRINSIC
Pfam:Rav1p_C	1447	1903	4.2e-68	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2471	2489	N/A	INTRINSIC
low complexity region	2722	2744	N/A	INTRINSIC
WD40	2752	2787	5.73e0	SMART
WD40	2791	2830	8.88e0	SMART
WD40	2837	2879	2.67e-1	SMART
WD40	2885	2924	2.57e-2	SMART
WD40	2927	2966	3.61e-6	SMART
WD40	2979	3017	8.25e0	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.0%

Validation Efficiency

97% (72/74)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete prenatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(2) Gene trapped(2)

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actl11	C	T	9: 107,806,346 (GRCm39)	A223V	probably benign	Het
Agbl5	G	T	5: 31,052,522 (GRCm39)	R61L	probably damaging	Het
Agmat	A	T	4: 141,483,192 (GRCm39)	T209S	probably benign	Het
Ankrd34a	G	A	3: 96,505,335 (GRCm39)	V180I	probably benign	Het
Anks1	C	T	17: 28,276,398 (GRCm39)	T1047M	probably damaging	Het
Arhgap21	T	A	2: 20,855,142 (GRCm39)	I1407F	probably damaging	Het
Armc1	C	A	3: 19,189,205 (GRCm39)	C183F	probably damaging	Het
Atg13	A	G	2: 91,516,136 (GRCm39)	M196T	probably benign	Het
AU040320	G	T	4: 126,740,231 (GRCm39)	S864I	possibly damaging	Het
Btn2a2	T	C	13: 23,667,014 (GRCm39)	D197G	probably benign	Het
Carmil1	A	G	13: 24,325,706 (GRCm39)	I208T	probably benign	Het
Cbs	T	A	17: 31,841,431 (GRCm39)	R263S	probably damaging	Het
Ccdc7a	C	A	8: 129,753,119 (GRCm39)	R204L	probably damaging	Het
Cdhr1	A	T	14: 36,819,334 (GRCm39)		probably null	Het
Cers4	G	A	8: 4,573,731 (GRCm39)	R378Q	probably damaging	Het
Chst1	T	G	2: 92,444,088 (GRCm39)	L187V	probably benign	Het
Clec4e	A	T	6: 123,260,565 (GRCm39)	N164K	probably damaging	Het
Cln3	T	A	7: 126,181,975 (GRCm39)	D29V	possibly damaging	Het
Crybg2	A	G	4: 133,809,148 (GRCm39)	S187G	probably benign	Het
Ddx1	A	T	12: 13,286,096 (GRCm39)	N285K	probably benign	Het
Dock4	A	G	12: 40,829,135 (GRCm39)	Y1007C	probably damaging	Het
Eral1	C	T	11: 77,966,559 (GRCm39)	V234I	possibly damaging	Het
Fads2b	C	A	2: 85,319,149 (GRCm39)	M384I	possibly damaging	Het
Fads2b	T	G	2: 85,319,157 (GRCm39)	T382P	probably damaging	Het
Fam161b	A	G	12: 84,401,554 (GRCm39)	F400S	probably damaging	Het
Fmnl3	T	C	15: 99,223,754 (GRCm39)	D314G	probably damaging	Het
Foxred2	A	T	15: 77,839,909 (GRCm39)	L127Q	probably damaging	Het
Gjd2	G	A	2: 113,843,575 (GRCm39)	A14V	possibly damaging	Het
Gon4l	A	G	3: 88,766,173 (GRCm39)		probably null	Het
Gpr151	T	A	18: 42,711,985 (GRCm39)	D231V	probably benign	Het
Gzf1	A	T	2: 148,526,689 (GRCm39)	K387*	probably null	Het
Hfm1	T	A	5: 107,065,240 (GRCm39)	K146N	possibly damaging	Het
Hgf	G	A	5: 16,809,920 (GRCm39)		probably null	Het
Isoc2b	A	G	7: 4,854,487 (GRCm39)	S15P	probably damaging	Het
Itga5	A	G	15: 103,265,970 (GRCm39)	S126P	probably damaging	Het
Kat6b	A	G	14: 21,719,104 (GRCm39)	D1152G	probably benign	Het
Kcna4	C	T	2: 107,126,652 (GRCm39)	S462F	probably damaging	Het
Kif24	A	T	4: 41,394,168 (GRCm39)	C902S	probably benign	Het
Lama2	A	T	10: 27,204,068 (GRCm39)	C523*	probably null	Het
Lama2	G	C	10: 27,204,078 (GRCm39)	S520*	probably null	Het
Ltf	T	C	9: 110,854,181 (GRCm39)	V332A	probably benign	Het
Mapkap1	T	C	2: 34,453,153 (GRCm39)	F349L	probably damaging	Het
Mdm1	A	G	10: 117,983,937 (GRCm39)	N188D	probably benign	Het
Mfn1	T	C	3: 32,631,252 (GRCm39)	S730P	possibly damaging	Het
Mrgprd	T	A	7: 144,876,087 (GRCm39)	D319E	probably benign	Het
Mrps9	C	A	1: 42,944,573 (GRCm39)	L364I	probably damaging	Het
Myo1h	C	T	5: 114,487,673 (GRCm39)	R626C	probably damaging	Het
Nme3	T	C	17: 25,115,829 (GRCm39)	S61P	probably benign	Het
Or2g1	A	G	17: 38,106,395 (GRCm39)	Q20R	probably benign	Het
Or52e18	A	G	7: 104,609,192 (GRCm39)	I249T	probably damaging	Het
Pald1	A	G	10: 61,184,311 (GRCm39)		probably null	Het
Papola	A	T	12: 105,775,950 (GRCm39)		probably benign	Het
Peg10	GAT	GATCAT	6: 4,756,449 (GRCm39)		probably benign	Het
Plch1	T	C	3: 63,605,504 (GRCm39)	T1458A	probably benign	Het
Polr3e	A	G	7: 120,543,873 (GRCm39)	Q659R	probably damaging	Het
Pramel38	C	A	5: 94,365,978 (GRCm39)	P32Q	probably damaging	Het
Shoc2	T	C	19: 53,976,548 (GRCm39)	V146A	probably benign	Het
Slc15a1	T	C	14: 121,713,442 (GRCm39)	T362A	probably benign	Het
Smpd3	A	G	8: 106,991,300 (GRCm39)	Y418H	probably damaging	Het
Sorcs1	A	T	19: 50,213,557 (GRCm39)	C723*	probably null	Het
Supt7l	T	A	5: 31,680,365 (GRCm39)	N16Y	probably damaging	Het
Syngr2	T	C	11: 117,703,499 (GRCm39)	V105A	probably damaging	Het
Thrb	T	A	14: 17,981,899 (GRCm38)	V8E	probably benign	Het
Tlx1	A	T	19: 45,139,757 (GRCm39)	I135F	probably damaging	Het
Tnfaip3	A	G	10: 18,887,417 (GRCm39)	I36T	probably damaging	Het
Troap	A	G	15: 98,980,569 (GRCm39)	Y583C	possibly damaging	Het
Usp17lb	T	C	7: 104,490,307 (GRCm39)	K207E	probably benign	Het
Vmn2r10	C	T	5: 109,149,845 (GRCm39)	V400M	probably damaging	Het
Wdr49	A	T	3: 75,240,590 (GRCm39)		probably null	Het
Wdr64	G	T	1: 175,533,634 (GRCm39)	W90L	probably damaging	Het
Yme1l1	A	G	2: 23,085,401 (GRCm39)	E662G	probably damaging	Het
Zfp334	C	T	2: 165,224,644 (GRCm39)	V68I	probably benign	Het

Other mutations in Dmxl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Dmxl2	APN	9	54,308,988 (GRCm39)	missense	probably benign
IGL00226:Dmxl2	APN	9	54,323,277 (GRCm39)	missense	probably damaging	1.00
IGL00419:Dmxl2	APN	9	54,313,951 (GRCm39)	missense	probably damaging	0.96
IGL00551:Dmxl2	APN	9	54,358,122 (GRCm39)	missense	probably damaging	1.00
IGL00765:Dmxl2	APN	9	54,322,706 (GRCm39)	unclassified	probably benign
IGL00852:Dmxl2	APN	9	54,330,597 (GRCm39)	nonsense	probably null
IGL00857:Dmxl2	APN	9	54,283,604 (GRCm39)	missense	probably benign	0.32
IGL00952:Dmxl2	APN	9	54,324,166 (GRCm39)	missense	probably damaging	0.99
IGL01139:Dmxl2	APN	9	54,366,248 (GRCm39)	missense	probably damaging	1.00
IGL01346:Dmxl2	APN	9	54,322,759 (GRCm39)	missense	probably damaging	1.00
IGL01538:Dmxl2	APN	9	54,352,660 (GRCm39)	splice site	probably benign
IGL01645:Dmxl2	APN	9	54,286,017 (GRCm39)	missense	possibly damaging	0.93
IGL02096:Dmxl2	APN	9	54,308,349 (GRCm39)	missense	possibly damaging	0.89
IGL02104:Dmxl2	APN	9	54,311,299 (GRCm39)	nonsense	probably null
IGL02145:Dmxl2	APN	9	54,281,981 (GRCm39)	missense	probably benign	0.29
IGL02210:Dmxl2	APN	9	54,311,333 (GRCm39)	missense	probably damaging	1.00
IGL02238:Dmxl2	APN	9	54,352,717 (GRCm39)	missense	probably damaging	1.00
IGL02255:Dmxl2	APN	9	54,301,052 (GRCm39)	missense	probably benign	0.06
IGL02364:Dmxl2	APN	9	54,301,127 (GRCm39)	missense	probably benign	0.02
IGL02423:Dmxl2	APN	9	54,301,032 (GRCm39)	missense	possibly damaging	0.89
IGL02440:Dmxl2	APN	9	54,313,899 (GRCm39)	missense	probably damaging	0.98
IGL02546:Dmxl2	APN	9	54,273,698 (GRCm39)	utr 3 prime	probably benign
IGL02668:Dmxl2	APN	9	54,324,229 (GRCm39)	missense	probably damaging	1.00
IGL03229:Dmxl2	APN	9	54,311,456 (GRCm39)	missense	probably damaging	1.00
IGL03244:Dmxl2	APN	9	54,323,655 (GRCm39)	missense	probably damaging	1.00
IGL03277:Dmxl2	APN	9	54,311,504 (GRCm39)	missense	probably damaging	1.00
IGL03399:Dmxl2	APN	9	54,353,956 (GRCm39)	missense	probably damaging	1.00
BB003:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
BB013:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
I2288:Dmxl2	UTSW	9	54,309,077 (GRCm39)	missense	probably damaging	1.00
P0014:Dmxl2	UTSW	9	54,309,048 (GRCm39)	missense	probably damaging	1.00
R0411:Dmxl2	UTSW	9	54,286,223 (GRCm39)	missense	probably damaging	1.00
R0422:Dmxl2	UTSW	9	54,307,224 (GRCm39)	critical splice donor site	probably null
R0432:Dmxl2	UTSW	9	54,324,235 (GRCm39)	missense	probably benign	0.01
R0436:Dmxl2	UTSW	9	54,291,034 (GRCm39)	missense	probably damaging	1.00
R0538:Dmxl2	UTSW	9	54,301,120 (GRCm39)	missense	probably benign	0.06
R0603:Dmxl2	UTSW	9	54,313,190 (GRCm39)	missense	possibly damaging	0.95
R0605:Dmxl2	UTSW	9	54,327,229 (GRCm39)	missense	probably benign	0.01
R0625:Dmxl2	UTSW	9	54,289,986 (GRCm39)	missense	probably benign
R0626:Dmxl2	UTSW	9	54,323,838 (GRCm39)	missense	probably damaging	1.00
R0736:Dmxl2	UTSW	9	54,286,101 (GRCm39)	missense	probably damaging	0.99
R0847:Dmxl2	UTSW	9	54,313,112 (GRCm39)	missense	probably damaging	1.00
R0855:Dmxl2	UTSW	9	54,273,724 (GRCm39)	missense	probably benign	0.03
R0962:Dmxl2	UTSW	9	54,353,696 (GRCm39)	missense	probably damaging	0.99
R1015:Dmxl2	UTSW	9	54,275,049 (GRCm39)	missense	probably benign	0.32
R1084:Dmxl2	UTSW	9	54,323,717 (GRCm39)	missense	probably damaging	1.00
R1328:Dmxl2	UTSW	9	54,303,533 (GRCm39)	missense	probably benign	0.12
R1401:Dmxl2	UTSW	9	54,322,712 (GRCm39)	critical splice donor site	probably null
R1503:Dmxl2	UTSW	9	54,354,272 (GRCm39)	nonsense	probably null
R1609:Dmxl2	UTSW	9	54,316,547 (GRCm39)	missense	possibly damaging	0.90
R1613:Dmxl2	UTSW	9	54,289,311 (GRCm39)	missense	probably benign
R1660:Dmxl2	UTSW	9	54,358,314 (GRCm39)	missense	possibly damaging	0.68
R1712:Dmxl2	UTSW	9	54,308,769 (GRCm39)	missense	probably benign	0.00
R1772:Dmxl2	UTSW	9	54,330,508 (GRCm39)	splice site	probably benign
R1832:Dmxl2	UTSW	9	54,368,233 (GRCm39)	missense	probably damaging	0.97
R1922:Dmxl2	UTSW	9	54,308,807 (GRCm39)	missense	probably benign
R2104:Dmxl2	UTSW	9	54,322,848 (GRCm39)	missense	probably damaging	1.00
R2109:Dmxl2	UTSW	9	54,301,097 (GRCm39)	missense	probably benign	0.06
R2145:Dmxl2	UTSW	9	54,323,194 (GRCm39)	missense	probably damaging	1.00
R2199:Dmxl2	UTSW	9	54,283,527 (GRCm39)	missense	probably benign	0.35
R2352:Dmxl2	UTSW	9	54,301,146 (GRCm39)	missense	probably damaging	1.00
R2516:Dmxl2	UTSW	9	54,307,378 (GRCm39)	missense	probably damaging	1.00
R2981:Dmxl2	UTSW	9	54,300,986 (GRCm39)	missense	probably damaging	1.00
R3430:Dmxl2	UTSW	9	54,384,745 (GRCm39)	missense	possibly damaging	0.94
R3625:Dmxl2	UTSW	9	54,300,927 (GRCm39)	missense	probably benign	0.23
R3725:Dmxl2	UTSW	9	54,301,053 (GRCm39)	missense	probably damaging	1.00
R3787:Dmxl2	UTSW	9	54,277,162 (GRCm39)	missense	probably damaging	1.00
R4002:Dmxl2	UTSW	9	54,381,116 (GRCm39)	splice site	probably benign
R4004:Dmxl2	UTSW	9	54,353,674 (GRCm39)	missense	probably benign	0.04
R4005:Dmxl2	UTSW	9	54,353,674 (GRCm39)	missense	probably benign	0.04
R4012:Dmxl2	UTSW	9	54,286,297 (GRCm39)	splice site	probably null
R4014:Dmxl2	UTSW	9	54,285,993 (GRCm39)	splice site	probably null
R4115:Dmxl2	UTSW	9	54,354,272 (GRCm39)	nonsense	probably null
R4232:Dmxl2	UTSW	9	54,327,193 (GRCm39)	missense	possibly damaging	0.89
R4388:Dmxl2	UTSW	9	54,303,551 (GRCm39)	missense	probably damaging	1.00
R4513:Dmxl2	UTSW	9	54,327,168 (GRCm39)	missense	probably null	0.17
R4552:Dmxl2	UTSW	9	54,359,047 (GRCm39)	missense	probably damaging	1.00
R4609:Dmxl2	UTSW	9	54,353,796 (GRCm39)	missense	probably damaging	1.00
R4625:Dmxl2	UTSW	9	54,311,404 (GRCm39)	missense	possibly damaging	0.55
R4694:Dmxl2	UTSW	9	54,354,189 (GRCm39)	missense	probably benign	0.04
R4711:Dmxl2	UTSW	9	54,358,208 (GRCm39)	missense	probably benign	0.37
R4715:Dmxl2	UTSW	9	54,353,689 (GRCm39)	splice site	probably null
R4746:Dmxl2	UTSW	9	54,359,080 (GRCm39)	missense	probably benign	0.04
R4789:Dmxl2	UTSW	9	54,287,099 (GRCm39)	missense	probably benign	0.30
R4825:Dmxl2	UTSW	9	54,311,325 (GRCm39)	missense	probably benign	0.01
R4911:Dmxl2	UTSW	9	54,318,937 (GRCm39)	missense	probably damaging	1.00
R4995:Dmxl2	UTSW	9	54,408,725 (GRCm39)	utr 5 prime	probably benign
R5026:Dmxl2	UTSW	9	54,323,960 (GRCm39)	missense	probably damaging	1.00
R5118:Dmxl2	UTSW	9	54,368,271 (GRCm39)	missense	probably damaging	1.00
R5174:Dmxl2	UTSW	9	54,352,768 (GRCm39)	splice site	probably null
R5288:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5373:Dmxl2	UTSW	9	54,276,473 (GRCm39)	intron	probably benign
R5374:Dmxl2	UTSW	9	54,276,473 (GRCm39)	intron	probably benign
R5385:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5386:Dmxl2	UTSW	9	54,286,041 (GRCm39)	missense	probably benign
R5418:Dmxl2	UTSW	9	54,281,935 (GRCm39)	critical splice donor site	probably null
R5540:Dmxl2	UTSW	9	54,301,141 (GRCm39)	missense	probably benign	0.21
R5568:Dmxl2	UTSW	9	54,330,643 (GRCm39)	splice site	probably null
R5733:Dmxl2	UTSW	9	54,283,550 (GRCm39)	missense	possibly damaging	0.64
R5758:Dmxl2	UTSW	9	54,380,248 (GRCm39)	missense	probably benign	0.28
R5759:Dmxl2	UTSW	9	54,282,792 (GRCm39)	missense	probably damaging	1.00
R5893:Dmxl2	UTSW	9	54,294,704 (GRCm39)	missense	possibly damaging	0.64
R6030:Dmxl2	UTSW	9	54,300,957 (GRCm39)	missense	probably benign	0.18
R6030:Dmxl2	UTSW	9	54,300,957 (GRCm39)	missense	probably benign	0.18
R6041:Dmxl2	UTSW	9	54,324,037 (GRCm39)	missense	probably damaging	1.00
R6174:Dmxl2	UTSW	9	54,301,011 (GRCm39)	missense	probably damaging	1.00
R6278:Dmxl2	UTSW	9	54,323,046 (GRCm39)	missense	probably damaging	1.00
R6307:Dmxl2	UTSW	9	54,289,990 (GRCm39)	missense	possibly damaging	0.68
R6349:Dmxl2	UTSW	9	54,327,193 (GRCm39)	missense	possibly damaging	0.89
R6404:Dmxl2	UTSW	9	54,282,820 (GRCm39)	missense	probably damaging	1.00
R6516:Dmxl2	UTSW	9	54,323,960 (GRCm39)	missense	probably damaging	1.00
R6712:Dmxl2	UTSW	9	54,318,908 (GRCm39)	missense	probably damaging	1.00
R6747:Dmxl2	UTSW	9	54,323,372 (GRCm39)	missense	probably damaging	1.00
R6769:Dmxl2	UTSW	9	54,323,808 (GRCm39)	missense	probably damaging	1.00
R6771:Dmxl2	UTSW	9	54,323,808 (GRCm39)	missense	probably damaging	1.00
R6800:Dmxl2	UTSW	9	54,316,467 (GRCm39)	missense	probably damaging	1.00
R6920:Dmxl2	UTSW	9	54,379,496 (GRCm39)	missense	probably damaging	1.00
R6979:Dmxl2	UTSW	9	54,358,163 (GRCm39)	missense	possibly damaging	0.49
R7147:Dmxl2	UTSW	9	54,324,013 (GRCm39)	missense	probably benign	0.06
R7327:Dmxl2	UTSW	9	54,308,869 (GRCm39)	missense	probably damaging	1.00
R7462:Dmxl2	UTSW	9	54,273,916 (GRCm39)	splice site	probably null
R7526:Dmxl2	UTSW	9	54,308,241 (GRCm39)	missense	possibly damaging	0.47
R7569:Dmxl2	UTSW	9	54,323,271 (GRCm39)	missense	possibly damaging	0.51
R7622:Dmxl2	UTSW	9	54,379,502 (GRCm39)	missense	probably damaging	0.99
R7638:Dmxl2	UTSW	9	54,365,078 (GRCm39)	missense	unknown
R7703:Dmxl2	UTSW	9	54,368,370 (GRCm39)	missense	probably benign	0.01
R7768:Dmxl2	UTSW	9	54,288,223 (GRCm39)	missense	probably damaging	1.00
R7926:Dmxl2	UTSW	9	54,335,326 (GRCm39)	missense	probably benign	0.01
R7969:Dmxl2	UTSW	9	54,354,165 (GRCm39)	missense	possibly damaging	0.85
R8007:Dmxl2	UTSW	9	54,290,975 (GRCm39)	nonsense	probably null
R8200:Dmxl2	UTSW	9	54,387,630 (GRCm39)	missense	probably benign
R8311:Dmxl2	UTSW	9	54,354,217 (GRCm39)	missense	probably benign	0.00
R8320:Dmxl2	UTSW	9	54,291,043 (GRCm39)	missense	probably benign
R8377:Dmxl2	UTSW	9	54,286,032 (GRCm39)	missense	probably damaging	1.00
R8400:Dmxl2	UTSW	9	54,291,037 (GRCm39)	missense	probably benign	0.03
R8509:Dmxl2	UTSW	9	54,335,341 (GRCm39)	nonsense	probably null
R8698:Dmxl2	UTSW	9	54,281,953 (GRCm39)	missense	probably benign	0.10
R8768:Dmxl2	UTSW	9	54,301,105 (GRCm39)	missense	possibly damaging	0.83
R8770:Dmxl2	UTSW	9	54,311,298 (GRCm39)	missense	probably benign	0.01
R8799:Dmxl2	UTSW	9	54,327,027 (GRCm39)	critical splice donor site	probably null
R8840:Dmxl2	UTSW	9	54,309,139 (GRCm39)	missense	possibly damaging	0.58
R8898:Dmxl2	UTSW	9	54,308,941 (GRCm39)	missense	probably benign	0.01
R8954:Dmxl2	UTSW	9	54,381,156 (GRCm39)	missense	probably benign	0.04
R9083:Dmxl2	UTSW	9	54,316,548 (GRCm39)	missense	probably benign	0.29
R9114:Dmxl2	UTSW	9	54,307,321 (GRCm39)	missense
R9115:Dmxl2	UTSW	9	54,309,011 (GRCm39)	missense	probably benign
R9263:Dmxl2	UTSW	9	54,358,945 (GRCm39)	missense	probably benign	0.01
R9272:Dmxl2	UTSW	9	54,311,404 (GRCm39)	missense	possibly damaging	0.55
R9577:Dmxl2	UTSW	9	54,323,664 (GRCm39)	missense	unknown
R9673:Dmxl2	UTSW	9	54,294,840 (GRCm39)	missense	probably damaging	1.00
R9722:Dmxl2	UTSW	9	54,323,892 (GRCm39)	missense	probably benign	0.00
R9726:Dmxl2	UTSW	9	54,322,996 (GRCm39)	missense	probably benign	0.09
R9797:Dmxl2	UTSW	9	54,358,187 (GRCm39)	missense	probably benign	0.00
X0064:Dmxl2	UTSW	9	54,308,997 (GRCm39)	missense	probably benign
Z1177:Dmxl2	UTSW	9	54,289,318 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- CCCTTTCAACATGGCATGTC -3'
(R):5'- TGAATGATAATGCGTGGAATGC -3'

Sequencing Primer
(F):5'- GCATGTCCACTGGGAGAACTATC -3'
(R):5'- GTCCTAGCTCTGTAGACCAGACTAG -3'

Posted On

2018-10-18