Incidental Mutation 'R6944:Rnf123'
| ID |
540780 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rnf123
|
| Ensembl Gene |
ENSMUSG00000041528 |
| Gene Name |
ring finger protein 123 |
| Synonyms |
KPC1 |
| MMRRC Submission |
045058-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.171)
|
| Stock # |
R6944 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
107928869-107957183 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 107940822 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 679
(L679P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125745
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047746]
[ENSMUST00000160249]
[ENSMUST00000160649]
[ENSMUST00000162355]
[ENSMUST00000162753]
[ENSMUST00000178267]
|
| AlphaFold |
Q5XPI3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047746
AA Change: L679P
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000040803
Gene: ENSMUSG00000041528
AA Change: L679P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159306
|
| SMART Domains |
Protein: ENSMUSP00000125695
Gene: ENSMUSG00000041528
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
172 |
192 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160249
AA Change: L673P
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000124548
Gene: ENSMUSG00000041528
AA Change: L673P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160649
AA Change: L673P
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000125495
Gene: ENSMUSG00000041528
AA Change: L673P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162355
AA Change: L679P
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000125745
Gene: ENSMUSG00000041528
AA Change: L679P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1047 |
1067 |
N/A |
INTRINSIC |
|
low complexity region
|
1242 |
1251 |
N/A |
INTRINSIC |
|
RING
|
1260 |
1297 |
5.27e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000162753
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000178267
AA Change: L673P
PolyPhen 2
Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000136953
Gene: ENSMUSG00000041528
AA Change: L673P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
104 |
115 |
N/A |
INTRINSIC |
|
SPRY
|
132 |
253 |
1.52e-28 |
SMART |
|
low complexity region
|
471 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
518 |
N/A |
INTRINSIC |
|
coiled coil region
|
1041 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1236 |
1245 |
N/A |
INTRINSIC |
|
RING
|
1254 |
1291 |
5.27e-4 |
SMART |
|
| Meta Mutation Damage Score |
0.0949 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.2%
|
| Validation Efficiency |
97% (75/77) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1b |
T |
G |
5: 8,863,693 (GRCm39) |
V216G |
probably damaging |
Het |
| Abcb5 |
T |
C |
12: 118,875,265 (GRCm39) |
R636G |
probably benign |
Het |
| Ago1 |
G |
T |
4: 126,354,215 (GRCm39) |
F198L |
possibly damaging |
Het |
| Ankrd42 |
C |
T |
7: 92,268,755 (GRCm39) |
|
probably null |
Het |
| Anxa11 |
T |
A |
14: 25,875,176 (GRCm39) |
F274I |
probably damaging |
Het |
| Ascc1 |
T |
C |
10: 59,849,475 (GRCm39) |
L122P |
probably damaging |
Het |
| Bptf |
T |
C |
11: 106,971,649 (GRCm39) |
S953G |
probably damaging |
Het |
| Chml |
T |
A |
1: 175,515,727 (GRCm39) |
N65Y |
probably damaging |
Het |
| Clcc1 |
A |
G |
3: 108,578,284 (GRCm39) |
K262E |
probably damaging |
Het |
| Clhc1 |
T |
G |
11: 29,519,346 (GRCm39) |
D384E |
probably damaging |
Het |
| Cnot2 |
G |
A |
10: 116,373,128 (GRCm39) |
|
probably benign |
Het |
| Cntnap1 |
T |
C |
11: 101,073,730 (GRCm39) |
V627A |
probably damaging |
Het |
| Col6a4 |
A |
G |
9: 105,949,370 (GRCm39) |
V755A |
probably damaging |
Het |
| Cyp4f18 |
T |
A |
8: 72,743,738 (GRCm39) |
I406F |
probably benign |
Het |
| Dclre1a |
T |
C |
19: 56,533,451 (GRCm39) |
E381G |
possibly damaging |
Het |
| Dnah1 |
A |
G |
14: 30,990,861 (GRCm39) |
Y3153H |
probably damaging |
Het |
| Dnah8 |
C |
A |
17: 31,013,633 (GRCm39) |
D3791E |
probably benign |
Het |
| Dnah9 |
T |
C |
11: 65,975,975 (GRCm39) |
E1358G |
possibly damaging |
Het |
| Eef1g |
G |
A |
19: 8,945,656 (GRCm39) |
R30H |
probably benign |
Het |
| Egln3 |
A |
T |
12: 54,230,738 (GRCm39) |
I181N |
probably benign |
Het |
| Entpd6 |
A |
G |
2: 150,605,519 (GRCm39) |
T250A |
probably damaging |
Het |
| Epb41l5 |
C |
T |
1: 119,536,859 (GRCm39) |
R344Q |
probably damaging |
Het |
| Fam20b |
T |
C |
1: 156,515,091 (GRCm39) |
D258G |
probably benign |
Het |
| Fbxw18 |
A |
T |
9: 109,531,655 (GRCm39) |
D21E |
probably damaging |
Het |
| Fbxw21 |
T |
C |
9: 108,986,603 (GRCm39) |
E92G |
probably damaging |
Het |
| Fzd6 |
T |
A |
15: 38,889,212 (GRCm39) |
M110K |
possibly damaging |
Het |
| Golgb1 |
C |
T |
16: 36,732,475 (GRCm39) |
P574L |
probably benign |
Het |
| Gpr153 |
A |
G |
4: 152,363,820 (GRCm39) |
E80G |
probably damaging |
Het |
| Gvin2 |
G |
A |
7: 105,551,187 (GRCm39) |
Q622* |
probably null |
Het |
| Kcnt1 |
T |
C |
2: 25,767,840 (GRCm39) |
|
probably benign |
Het |
| Kcnt2 |
T |
G |
1: 140,511,803 (GRCm39) |
V962G |
probably benign |
Het |
| Malt1 |
T |
C |
18: 65,570,991 (GRCm39) |
V109A |
probably benign |
Het |
| Marchf7 |
A |
G |
2: 60,064,587 (GRCm39) |
I288V |
probably benign |
Het |
| Mief1 |
C |
T |
15: 80,133,644 (GRCm39) |
R234C |
probably damaging |
Het |
| Morc3 |
A |
G |
16: 93,667,460 (GRCm39) |
S613G |
probably benign |
Het |
| Myt1 |
A |
G |
2: 181,439,387 (GRCm39) |
E345G |
possibly damaging |
Het |
| Napb |
T |
C |
2: 148,548,889 (GRCm39) |
T133A |
probably benign |
Het |
| Nwd1 |
T |
C |
8: 73,380,162 (GRCm39) |
V16A |
possibly damaging |
Het |
| Oas1f |
G |
A |
5: 120,986,247 (GRCm39) |
E67K |
probably benign |
Het |
| Obscn |
T |
C |
11: 58,929,756 (GRCm39) |
K5153R |
probably damaging |
Het |
| Or2w3b |
T |
A |
11: 58,623,068 (GRCm39) |
S308C |
possibly damaging |
Het |
| Or5a3 |
G |
T |
19: 12,400,628 (GRCm39) |
M318I |
probably benign |
Het |
| Or5g26 |
C |
T |
2: 85,494,195 (GRCm39) |
M194I |
probably benign |
Het |
| Or6d12 |
T |
C |
6: 116,492,791 (GRCm39) |
F18L |
possibly damaging |
Het |
| Pdcd2 |
T |
C |
17: 15,745,632 (GRCm39) |
N185S |
possibly damaging |
Het |
| Pgap1 |
A |
T |
1: 54,569,320 (GRCm39) |
W349R |
probably damaging |
Het |
| Prpf39 |
T |
A |
12: 65,089,454 (GRCm39) |
V64E |
probably benign |
Het |
| Ptpn13 |
T |
A |
5: 103,624,857 (GRCm39) |
W54R |
probably null |
Het |
| Rbms3 |
G |
T |
9: 116,939,173 (GRCm39) |
P29Q |
probably damaging |
Het |
| Samd4 |
T |
A |
14: 47,254,092 (GRCm39) |
D84E |
possibly damaging |
Het |
| Scarf1 |
T |
C |
11: 75,413,032 (GRCm39) |
V426A |
probably benign |
Het |
| Slc12a1 |
A |
G |
2: 125,002,454 (GRCm39) |
N145D |
probably damaging |
Het |
| Slc2a6 |
A |
T |
2: 26,916,076 (GRCm39) |
M99K |
probably damaging |
Het |
| Slc34a2 |
A |
T |
5: 53,222,225 (GRCm39) |
I306L |
probably benign |
Het |
| Slx4ip |
A |
G |
2: 136,910,195 (GRCm39) |
K397E |
probably damaging |
Het |
| Smr3a |
C |
T |
5: 88,155,949 (GRCm39) |
|
probably benign |
Het |
| Spata31h1 |
A |
C |
10: 82,132,056 (GRCm39) |
I318R |
probably benign |
Het |
| Spef2 |
T |
C |
15: 9,592,835 (GRCm39) |
E1502G |
probably damaging |
Het |
| Sri |
A |
T |
5: 8,113,365 (GRCm39) |
T119S |
probably benign |
Het |
| Synrg |
T |
A |
11: 83,915,912 (GRCm39) |
L1085H |
probably damaging |
Het |
| Taf7 |
A |
T |
18: 37,775,910 (GRCm39) |
L219H |
probably damaging |
Het |
| Tmco3 |
T |
A |
8: 13,353,729 (GRCm39) |
V347E |
probably damaging |
Het |
| Tmem8b |
A |
T |
4: 43,674,465 (GRCm39) |
I250F |
probably damaging |
Het |
| Tom1l2 |
A |
G |
11: 60,139,817 (GRCm39) |
V239A |
probably damaging |
Het |
| Trpm1 |
T |
A |
7: 63,893,181 (GRCm39) |
M1011K |
probably damaging |
Het |
| Tspan9 |
A |
T |
6: 127,942,769 (GRCm39) |
Y153N |
probably benign |
Het |
| Ttll11 |
T |
C |
2: 35,642,306 (GRCm39) |
H675R |
probably benign |
Het |
| Unc50 |
C |
T |
1: 37,471,743 (GRCm39) |
T131M |
probably damaging |
Het |
| Vgf |
T |
A |
5: 137,061,206 (GRCm39) |
I456N |
probably damaging |
Het |
| Vmn1r223 |
A |
G |
13: 23,433,483 (GRCm39) |
I26V |
unknown |
Het |
| Vmn1r39 |
T |
C |
6: 66,782,205 (GRCm39) |
M1V |
probably null |
Het |
| Vmn2r111 |
T |
C |
17: 22,778,032 (GRCm39) |
N549S |
possibly damaging |
Het |
| Vmn2r14 |
T |
C |
5: 109,363,925 (GRCm39) |
T664A |
probably benign |
Het |
| Vmn2r14 |
G |
A |
5: 109,364,140 (GRCm39) |
T592I |
probably benign |
Het |
| Vmn2r96 |
T |
A |
17: 18,817,891 (GRCm39) |
F489L |
probably benign |
Het |
| Vmn2r-ps158 |
T |
C |
7: 42,697,393 (GRCm39) |
F817L |
possibly damaging |
Het |
|
| Other mutations in Rnf123 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00950:Rnf123
|
APN |
9 |
107,944,594 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01358:Rnf123
|
APN |
9 |
107,946,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01464:Rnf123
|
APN |
9 |
107,929,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01637:Rnf123
|
APN |
9 |
107,935,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01669:Rnf123
|
APN |
9 |
107,935,555 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01905:Rnf123
|
APN |
9 |
107,948,569 (GRCm39) |
splice site |
probably benign |
|
|
IGL02070:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02072:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02073:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02074:Rnf123
|
APN |
9 |
107,944,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02079:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02080:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02231:Rnf123
|
APN |
9 |
107,943,598 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02281:Rnf123
|
APN |
9 |
107,948,651 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02336:Rnf123
|
APN |
9 |
107,939,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02543:Rnf123
|
APN |
9 |
107,943,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02565:Rnf123
|
APN |
9 |
107,929,411 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02571:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02572:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02574:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02586:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02589:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02600:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02601:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02602:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02603:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02609:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02628:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02629:Rnf123
|
APN |
9 |
107,947,988 (GRCm39) |
splice site |
probably benign |
|
|
IGL02629:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02630:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02631:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02632:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02650:Rnf123
|
APN |
9 |
107,946,947 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL02690:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02691:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02692:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02693:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02713:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02736:Rnf123
|
APN |
9 |
107,945,501 (GRCm39) |
nonsense |
probably null |
|
|
IGL02929:Rnf123
|
APN |
9 |
107,946,275 (GRCm39) |
missense |
probably benign |
|
|
R1175:Rnf123
|
UTSW |
9 |
107,954,572 (GRCm39) |
missense |
probably benign |
|
|
R1465:Rnf123
|
UTSW |
9 |
107,948,665 (GRCm39) |
splice site |
probably benign |
|
|
R1502:Rnf123
|
UTSW |
9 |
107,945,709 (GRCm39) |
splice site |
probably null |
|
|
R1682:Rnf123
|
UTSW |
9 |
107,954,597 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1817:Rnf123
|
UTSW |
9 |
107,940,125 (GRCm39) |
missense |
probably benign |
0.41 |
|
R1855:Rnf123
|
UTSW |
9 |
107,938,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2394:Rnf123
|
UTSW |
9 |
107,940,735 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2483:Rnf123
|
UTSW |
9 |
107,940,720 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3896:Rnf123
|
UTSW |
9 |
107,946,302 (GRCm39) |
splice site |
probably benign |
|
|
R3940:Rnf123
|
UTSW |
9 |
107,941,234 (GRCm39) |
splice site |
probably benign |
|
|
R4206:Rnf123
|
UTSW |
9 |
107,941,162 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4641:Rnf123
|
UTSW |
9 |
107,935,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Rnf123
|
UTSW |
9 |
107,929,638 (GRCm39) |
splice site |
probably null |
|
|
R4767:Rnf123
|
UTSW |
9 |
107,929,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Rnf123
|
UTSW |
9 |
107,933,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Rnf123
|
UTSW |
9 |
107,940,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5274:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5275:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5276:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5294:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5295:Rnf123
|
UTSW |
9 |
107,941,202 (GRCm39) |
frame shift |
probably null |
|
|
R5394:Rnf123
|
UTSW |
9 |
107,947,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5717:Rnf123
|
UTSW |
9 |
107,944,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6186:Rnf123
|
UTSW |
9 |
107,947,157 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6449:Rnf123
|
UTSW |
9 |
107,933,252 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6502:Rnf123
|
UTSW |
9 |
107,945,531 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7003:Rnf123
|
UTSW |
9 |
107,940,882 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7088:Rnf123
|
UTSW |
9 |
107,935,735 (GRCm39) |
missense |
probably null |
1.00 |
|
R7092:Rnf123
|
UTSW |
9 |
107,945,799 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7100:Rnf123
|
UTSW |
9 |
107,933,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Rnf123
|
UTSW |
9 |
107,946,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Rnf123
|
UTSW |
9 |
107,947,607 (GRCm39) |
splice site |
probably null |
|
|
R7468:Rnf123
|
UTSW |
9 |
107,946,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7517:Rnf123
|
UTSW |
9 |
107,947,473 (GRCm39) |
nonsense |
probably null |
|
|
R7577:Rnf123
|
UTSW |
9 |
107,947,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8296:Rnf123
|
UTSW |
9 |
107,940,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Rnf123
|
UTSW |
9 |
107,945,706 (GRCm39) |
missense |
probably benign |
0.26 |
|
R8754:Rnf123
|
UTSW |
9 |
107,948,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Rnf123
|
UTSW |
9 |
107,946,272 (GRCm39) |
missense |
probably benign |
|
|
R9052:Rnf123
|
UTSW |
9 |
107,936,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9156:Rnf123
|
UTSW |
9 |
107,940,227 (GRCm39) |
splice site |
probably benign |
|
|
R9170:Rnf123
|
UTSW |
9 |
107,948,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9332:Rnf123
|
UTSW |
9 |
107,944,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9385:Rnf123
|
UTSW |
9 |
107,929,467 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9394:Rnf123
|
UTSW |
9 |
107,942,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9432:Rnf123
|
UTSW |
9 |
107,937,008 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9717:Rnf123
|
UTSW |
9 |
107,954,963 (GRCm39) |
missense |
probably benign |
0.43 |
|
Z1176:Rnf123
|
UTSW |
9 |
107,940,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Rnf123
|
UTSW |
9 |
107,935,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTAAGGGGTTGCACACAGC -3'
(R):5'- TTCTCTCCGTGTAGGCAAGG -3'
Sequencing Primer
(F):5'- ACAGCAGACGGTCCCTTAG -3'
(R):5'- CTTCTCACTGGGGGAGCATG -3'
|
| Posted On |
2018-11-28 |
Incidental Mutation