Incidental Mutation 'R7000:Abcb1a'
| ID |
544459 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Abcb1a
|
| Ensembl Gene |
ENSMUSG00000040584 |
| Gene Name |
ATP-binding cassette, sub-family B member 1A |
| Synonyms |
Evi32, multiple drug resistant 1a, Pgp, MDR3, Pgy-3, Mdr1a, P-glycoprotein, P-gp, Pgy3, mdr-3 |
| MMRRC Submission |
045105-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R7000 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
8710077-8798575 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 8752823 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 525
(A525T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000041204
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047753]
|
| AlphaFold |
P21447 |
| PDB Structure |
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [X-RAY DIFFRACTION]
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [X-RAY DIFFRACTION]
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [X-RAY DIFFRACTION]
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain [X-RAY DIFFRACTION]
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain [X-RAY DIFFRACTION]
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain [X-RAY DIFFRACTION]
Structure of Mouse P-Glycoprotein [X-RAY DIFFRACTION]
Corrected Structure of Mouse P-glycoprotein [X-RAY DIFFRACTION]
Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR [X-RAY DIFFRACTION]
Corrected Structure of Mouse P-glycoprotein bound to QZ59-SSS [X-RAY DIFFRACTION]
>> 5 additional structures at PDB <<
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047753
AA Change: A525T
PolyPhen 2
Score 0.193 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000041204
Gene: ENSMUSG00000040584
AA Change: A525T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
30 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
50 |
339 |
8.3e-97 |
PFAM |
|
AAA
|
415 |
607 |
1.22e-20 |
SMART |
|
Pfam:ABC_membrane
|
707 |
982 |
4.8e-79 |
PFAM |
|
AAA
|
1058 |
1246 |
8.85e-18 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine. Mice with a null allele develop spontanous colitis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc6 |
A |
G |
7: 45,654,946 (GRCm39) |
I515T |
possibly damaging |
Het |
| Abi1 |
G |
A |
2: 22,832,053 (GRCm39) |
A420V |
probably damaging |
Het |
| Abtb2 |
A |
T |
2: 103,542,787 (GRCm39) |
I887F |
possibly damaging |
Het |
| Acap3 |
G |
A |
4: 155,988,306 (GRCm39) |
G602S |
possibly damaging |
Het |
| Auts2 |
T |
A |
5: 131,469,056 (GRCm39) |
T754S |
probably benign |
Het |
| AW551984 |
T |
C |
9: 39,512,085 (GRCm39) |
R12G |
probably benign |
Het |
| Bcan |
G |
A |
3: 87,895,686 (GRCm39) |
R817* |
probably null |
Het |
| Bmp10 |
A |
G |
6: 87,411,175 (GRCm39) |
T323A |
probably benign |
Het |
| Bpnt1 |
T |
C |
1: 185,082,053 (GRCm39) |
L165P |
probably damaging |
Het |
| Casz1 |
G |
A |
4: 149,013,693 (GRCm39) |
A86T |
probably damaging |
Het |
| Ccn3 |
A |
T |
15: 54,615,743 (GRCm39) |
T303S |
probably damaging |
Het |
| Cd1d2 |
T |
C |
3: 86,895,080 (GRCm39) |
F189L |
probably benign |
Het |
| Cep72 |
A |
G |
13: 74,206,444 (GRCm39) |
M126T |
probably damaging |
Het |
| Cep85l |
T |
A |
10: 53,174,295 (GRCm39) |
T483S |
probably damaging |
Het |
| Cfi |
C |
A |
3: 129,666,522 (GRCm39) |
T415K |
probably damaging |
Het |
| Chrna7 |
A |
G |
7: 62,755,787 (GRCm39) |
L253S |
probably damaging |
Het |
| Col4a4 |
T |
C |
1: 82,475,051 (GRCm39) |
H596R |
unknown |
Het |
| Cplx3 |
G |
C |
9: 57,523,231 (GRCm39) |
Q109E |
probably benign |
Het |
| Cyp2j8 |
A |
T |
4: 96,335,588 (GRCm39) |
M402K |
probably benign |
Het |
| Cyp3a16 |
T |
A |
5: 145,399,980 (GRCm39) |
|
probably null |
Het |
| Dhdh |
T |
C |
7: 45,124,698 (GRCm39) |
K332E |
possibly damaging |
Het |
| Dnah11 |
C |
A |
12: 117,981,396 (GRCm39) |
C2590F |
probably damaging |
Het |
| Dnah17 |
T |
C |
11: 117,916,528 (GRCm39) |
|
probably null |
Het |
| Dtx1 |
A |
G |
5: 120,833,148 (GRCm39) |
Y97H |
probably damaging |
Het |
| Duxf1 |
T |
C |
10: 58,058,814 (GRCm39) |
T647A |
possibly damaging |
Het |
| Elf1 |
A |
G |
14: 79,808,208 (GRCm39) |
D183G |
probably damaging |
Het |
| Esyt3 |
A |
C |
9: 99,204,206 (GRCm39) |
L94R |
probably damaging |
Het |
| Exoc3 |
A |
G |
13: 74,330,285 (GRCm39) |
Y521H |
probably benign |
Het |
| F5 |
C |
T |
1: 164,007,075 (GRCm39) |
T293M |
probably damaging |
Het |
| Fam118b |
A |
T |
9: 35,146,560 (GRCm39) |
H102Q |
probably damaging |
Het |
| Flad1 |
T |
C |
3: 89,309,549 (GRCm39) |
|
probably benign |
Het |
| Flrt3 |
G |
A |
2: 140,502,804 (GRCm39) |
R275* |
probably null |
Het |
| Fndc7 |
G |
A |
3: 108,783,964 (GRCm39) |
A215V |
probably benign |
Het |
| Fscn1 |
T |
A |
5: 142,946,382 (GRCm39) |
V60E |
probably damaging |
Het |
| Gm17175 |
A |
T |
14: 51,811,418 (GRCm39) |
M1K |
probably null |
Het |
| Gpatch2l |
G |
A |
12: 86,290,958 (GRCm39) |
R47H |
probably damaging |
Het |
| Gprc6a |
T |
C |
10: 51,491,143 (GRCm39) |
S694G |
probably benign |
Het |
| Iglon5 |
A |
T |
7: 43,126,254 (GRCm39) |
|
probably null |
Het |
| Iqch |
T |
C |
9: 63,361,892 (GRCm39) |
T874A |
probably benign |
Het |
| Lamc2 |
T |
A |
1: 153,041,873 (GRCm39) |
H87L |
possibly damaging |
Het |
| Ldlrad1 |
T |
A |
4: 107,066,777 (GRCm39) |
D37E |
probably benign |
Het |
| Loxhd1 |
T |
C |
18: 77,460,129 (GRCm39) |
|
probably null |
Het |
| Lxn |
T |
G |
3: 67,369,704 (GRCm39) |
E60D |
probably benign |
Het |
| Man2b2 |
A |
G |
5: 36,979,213 (GRCm39) |
W276R |
probably damaging |
Het |
| Mast1 |
T |
C |
8: 85,655,598 (GRCm39) |
Y182C |
probably damaging |
Het |
| Mroh8 |
C |
T |
2: 157,058,897 (GRCm39) |
R923Q |
probably benign |
Het |
| Obscn |
A |
G |
11: 59,026,864 (GRCm39) |
L113P |
probably damaging |
Het |
| Ocln |
C |
T |
13: 100,671,470 (GRCm39) |
|
probably null |
Het |
| Oog2 |
A |
T |
4: 143,921,897 (GRCm39) |
Q269L |
probably damaging |
Het |
| Or52e8 |
G |
A |
7: 104,624,338 (GRCm39) |
P285S |
probably damaging |
Het |
| Or5b113 |
A |
G |
19: 13,341,987 (GRCm39) |
|
probably benign |
Het |
| Osbpl3 |
A |
G |
6: 50,274,137 (GRCm39) |
S826P |
probably damaging |
Het |
| Otogl |
T |
C |
10: 107,615,692 (GRCm39) |
N1869S |
probably benign |
Het |
| Pamr1 |
G |
A |
2: 102,441,968 (GRCm39) |
D186N |
probably damaging |
Het |
| Pcdhga8 |
T |
A |
18: 37,859,946 (GRCm39) |
I334K |
probably benign |
Het |
| Pde7b |
A |
G |
10: 20,319,038 (GRCm39) |
S95P |
probably damaging |
Het |
| Pik3cg |
A |
T |
12: 32,242,128 (GRCm39) |
V994E |
probably damaging |
Het |
| Pkp1 |
T |
C |
1: 135,817,692 (GRCm39) |
M148V |
probably benign |
Het |
| Plbd1 |
T |
G |
6: 136,589,836 (GRCm39) |
K461Q |
probably benign |
Het |
| Pmfbp1 |
A |
G |
8: 110,257,221 (GRCm39) |
E594G |
possibly damaging |
Het |
| Pold3 |
A |
T |
7: 99,755,865 (GRCm39) |
H60Q |
probably damaging |
Het |
| Polr3gl |
C |
T |
3: 96,487,783 (GRCm39) |
R52Q |
possibly damaging |
Het |
| Ptgds |
A |
G |
2: 25,357,828 (GRCm39) |
|
probably null |
Het |
| Scarb2 |
T |
C |
5: 92,601,934 (GRCm39) |
D320G |
probably benign |
Het |
| Sdk2 |
T |
C |
11: 113,693,995 (GRCm39) |
Y1812C |
probably damaging |
Het |
| Skint8 |
C |
A |
4: 111,794,222 (GRCm39) |
T204N |
probably benign |
Het |
| Slc23a2 |
T |
C |
2: 131,936,123 (GRCm39) |
Q49R |
possibly damaging |
Het |
| Slc26a7 |
T |
C |
4: 14,552,476 (GRCm39) |
Q227R |
probably benign |
Het |
| Sntn |
C |
T |
14: 13,679,108 (GRCm38) |
T94I |
probably damaging |
Het |
| Spem2 |
C |
T |
11: 69,708,582 (GRCm39) |
G128S |
probably benign |
Het |
| Supt16 |
A |
T |
14: 52,408,907 (GRCm39) |
S822R |
probably damaging |
Het |
| Syn3 |
T |
C |
10: 85,916,116 (GRCm39) |
Y290C |
probably damaging |
Het |
| Tdrd6 |
C |
G |
17: 43,938,599 (GRCm39) |
E816D |
probably benign |
Het |
| Tln1 |
A |
T |
4: 43,556,302 (GRCm39) |
M72K |
probably damaging |
Het |
| Tlnrd1 |
A |
G |
7: 83,531,987 (GRCm39) |
V148A |
probably damaging |
Het |
| Trim24 |
C |
A |
6: 37,935,613 (GRCm39) |
T832K |
probably benign |
Het |
| Ubr4 |
C |
T |
4: 139,141,715 (GRCm39) |
A1267V |
probably damaging |
Het |
| Usp17lb |
A |
T |
7: 104,490,492 (GRCm39) |
M145K |
probably damaging |
Het |
| Vmn1r178 |
T |
A |
7: 23,593,762 (GRCm39) |
M270K |
probably benign |
Het |
| Vmn2r70 |
A |
T |
7: 85,208,819 (GRCm39) |
C553S |
probably damaging |
Het |
| Vps37c |
G |
T |
19: 10,687,693 (GRCm39) |
E51D |
probably damaging |
Het |
| Zfp62 |
T |
G |
11: 49,107,206 (GRCm39) |
Y432* |
probably null |
Het |
|
| Other mutations in Abcb1a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00704:Abcb1a
|
APN |
5 |
8,736,257 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00898:Abcb1a
|
APN |
5 |
8,783,690 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01064:Abcb1a
|
APN |
5 |
8,782,388 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01118:Abcb1a
|
APN |
5 |
8,724,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01150:Abcb1a
|
APN |
5 |
8,752,550 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01584:Abcb1a
|
APN |
5 |
8,748,637 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01654:Abcb1a
|
APN |
5 |
8,765,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01820:Abcb1a
|
APN |
5 |
8,765,896 (GRCm39) |
splice site |
probably benign |
|
|
IGL02499:Abcb1a
|
APN |
5 |
8,776,807 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02711:Abcb1a
|
APN |
5 |
8,773,245 (GRCm39) |
splice site |
probably null |
|
|
IGL02954:Abcb1a
|
APN |
5 |
8,782,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03018:Abcb1a
|
APN |
5 |
8,752,451 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03119:Abcb1a
|
APN |
5 |
8,764,887 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03292:Abcb1a
|
APN |
5 |
8,765,827 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03338:Abcb1a
|
APN |
5 |
8,744,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0418:Abcb1a
|
UTSW |
5 |
8,763,281 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0559:Abcb1a
|
UTSW |
5 |
8,748,535 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0595:Abcb1a
|
UTSW |
5 |
8,790,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0599:Abcb1a
|
UTSW |
5 |
8,748,539 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0811:Abcb1a
|
UTSW |
5 |
8,763,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0812:Abcb1a
|
UTSW |
5 |
8,763,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0894:Abcb1a
|
UTSW |
5 |
8,724,856 (GRCm39) |
splice site |
probably benign |
|
|
R0948:Abcb1a
|
UTSW |
5 |
8,790,621 (GRCm39) |
splice site |
probably null |
|
|
R1292:Abcb1a
|
UTSW |
5 |
8,763,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1318:Abcb1a
|
UTSW |
5 |
8,751,621 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1459:Abcb1a
|
UTSW |
5 |
8,752,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1489:Abcb1a
|
UTSW |
5 |
8,736,300 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1514:Abcb1a
|
UTSW |
5 |
8,724,791 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2100:Abcb1a
|
UTSW |
5 |
8,763,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2409:Abcb1a
|
UTSW |
5 |
8,788,747 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2844:Abcb1a
|
UTSW |
5 |
8,736,164 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3709:Abcb1a
|
UTSW |
5 |
8,788,738 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3755:Abcb1a
|
UTSW |
5 |
8,797,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4193:Abcb1a
|
UTSW |
5 |
8,765,068 (GRCm39) |
splice site |
probably null |
|
|
R4401:Abcb1a
|
UTSW |
5 |
8,752,390 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4463:Abcb1a
|
UTSW |
5 |
8,769,981 (GRCm39) |
splice site |
probably benign |
|
|
R4539:Abcb1a
|
UTSW |
5 |
8,765,793 (GRCm39) |
missense |
probably benign |
|
|
R4635:Abcb1a
|
UTSW |
5 |
8,764,927 (GRCm39) |
missense |
probably benign |
|
|
R4740:Abcb1a
|
UTSW |
5 |
8,752,280 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4757:Abcb1a
|
UTSW |
5 |
8,787,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4764:Abcb1a
|
UTSW |
5 |
8,765,732 (GRCm39) |
splice site |
probably null |
|
|
R4792:Abcb1a
|
UTSW |
5 |
8,796,657 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4829:Abcb1a
|
UTSW |
5 |
8,773,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4935:Abcb1a
|
UTSW |
5 |
8,787,773 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5140:Abcb1a
|
UTSW |
5 |
8,752,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5181:Abcb1a
|
UTSW |
5 |
8,764,937 (GRCm39) |
missense |
probably benign |
|
|
R5355:Abcb1a
|
UTSW |
5 |
8,776,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5406:Abcb1a
|
UTSW |
5 |
8,752,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5496:Abcb1a
|
UTSW |
5 |
8,724,818 (GRCm39) |
missense |
probably benign |
|
|
R5557:Abcb1a
|
UTSW |
5 |
8,764,949 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5572:Abcb1a
|
UTSW |
5 |
8,765,108 (GRCm39) |
splice site |
probably null |
|
|
R5702:Abcb1a
|
UTSW |
5 |
8,787,752 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5753:Abcb1a
|
UTSW |
5 |
8,773,160 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5769:Abcb1a
|
UTSW |
5 |
8,733,426 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5895:Abcb1a
|
UTSW |
5 |
8,752,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6536:Abcb1a
|
UTSW |
5 |
8,769,030 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6555:Abcb1a
|
UTSW |
5 |
8,752,468 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6798:Abcb1a
|
UTSW |
5 |
8,782,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6875:Abcb1a
|
UTSW |
5 |
8,751,628 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7102:Abcb1a
|
UTSW |
5 |
8,744,072 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7172:Abcb1a
|
UTSW |
5 |
8,752,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7313:Abcb1a
|
UTSW |
5 |
8,773,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7513:Abcb1a
|
UTSW |
5 |
8,765,771 (GRCm39) |
nonsense |
probably null |
|
|
R7718:Abcb1a
|
UTSW |
5 |
8,765,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7816:Abcb1a
|
UTSW |
5 |
8,736,132 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7829:Abcb1a
|
UTSW |
5 |
8,748,623 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7943:Abcb1a
|
UTSW |
5 |
8,736,222 (GRCm39) |
missense |
probably benign |
|
|
R8040:Abcb1a
|
UTSW |
5 |
8,765,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8086:Abcb1a
|
UTSW |
5 |
8,724,833 (GRCm39) |
missense |
probably benign |
|
|
R8271:Abcb1a
|
UTSW |
5 |
8,736,212 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8367:Abcb1a
|
UTSW |
5 |
8,736,221 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8520:Abcb1a
|
UTSW |
5 |
8,735,346 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8680:Abcb1a
|
UTSW |
5 |
8,735,371 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8820:Abcb1a
|
UTSW |
5 |
8,773,204 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8996:Abcb1a
|
UTSW |
5 |
8,769,069 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9114:Abcb1a
|
UTSW |
5 |
8,788,702 (GRCm39) |
nonsense |
probably null |
|
|
R9127:Abcb1a
|
UTSW |
5 |
8,724,707 (GRCm39) |
missense |
probably benign |
|
|
R9187:Abcb1a
|
UTSW |
5 |
8,765,016 (GRCm39) |
missense |
probably benign |
|
|
R9294:Abcb1a
|
UTSW |
5 |
8,736,171 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9459:Abcb1a
|
UTSW |
5 |
8,735,414 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9581:Abcb1a
|
UTSW |
5 |
8,790,428 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9617:Abcb1a
|
UTSW |
5 |
8,797,353 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9676:Abcb1a
|
UTSW |
5 |
8,714,548 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9682:Abcb1a
|
UTSW |
5 |
8,752,507 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9790:Abcb1a
|
UTSW |
5 |
8,748,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9791:Abcb1a
|
UTSW |
5 |
8,748,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Abcb1a
|
UTSW |
5 |
8,796,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCTGAGGTAGAACAAGTGCC -3'
(R):5'- TGGTAACAGGTGATACAAGCTATC -3'
Sequencing Primer
(F):5'- CAAGTGCCTTAGCTGGGAAATCC -3'
(R):5'- CTTTCTGTATCCAGGGCT -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation