Incidental Mutation 'R7264:Adora3'
ID 564794
Institutional Source Beutler Lab
Gene Symbol Adora3
Ensembl Gene ENSMUSG00000000562
Gene Name adenosine A3 receptor
Synonyms A3R, 1700001D09Rik, 4930578J19Rik, AA3R, ARA3, A3AR, Gpcr 2
MMRRC Submission 045354-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R7264 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 105811737-105816244 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 105812141 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 9 (T9K)
Ref Sequence ENSEMBL: ENSMUSP00000000574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000574] [ENSMUST00000010279] [ENSMUST00000164730] [ENSMUST00000196748] [ENSMUST00000200482]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000000574
AA Change: T9K

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000000574
Gene: ENSMUSG00000000562
AA Change: T9K

DomainStartEndE-ValueType
Pfam:7tm_4 21 301 3.5e-12 PFAM
Pfam:7TM_GPCR_Srsx 24 298 5e-12 PFAM
Pfam:7tm_1 30 283 2.8e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000010279
SMART Domains Protein: ENSMUSP00000010279
Gene: ENSMUSG00000074344

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
IG 20 115 3.94e0 SMART
transmembrane domain 151 173 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164730
SMART Domains Protein: ENSMUSP00000126710
Gene: ENSMUSG00000000562

DomainStartEndE-ValueType
Pfam:7tm_1 1 137 6.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000196748
AA Change: T9K

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000143674
Gene: ENSMUSG00000074344
AA Change: T9K

DomainStartEndE-ValueType
Pfam:7tm_4 21 131 7.3e-9 PFAM
Pfam:7TM_GPCR_Srsx 24 123 1.3e-7 PFAM
Pfam:7tm_1 30 129 2.9e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000200482
SMART Domains Protein: ENSMUSP00000142695
Gene: ENSMUSG00000074344

DomainStartEndE-ValueType
low complexity region 3 13 N/A INTRINSIC
IG 20 115 1.6e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. This gene shares its 3' terminal exon with a transcript variant from overlapping GeneID:69296, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene are phenotypically indistinguishable from wild-type mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankib1 T A 5: 3,805,739 (GRCm39) N176I probably damaging Het
Ankle2 G A 5: 110,385,689 (GRCm39) G346D probably damaging Het
Anks1b T A 10: 90,348,732 (GRCm39) M800K probably benign Het
Arhgef16 C T 4: 154,365,387 (GRCm39) G576D probably damaging Het
C2cd2 C A 16: 97,677,419 (GRCm39) probably null Het
Cacna1c T C 6: 118,579,156 (GRCm39) N1847S Het
Camta1 A G 4: 151,537,856 (GRCm39) I108T probably damaging Het
Catsper4 TTCTC TTC 4: 133,954,423 (GRCm39) probably null Het
Cep192 A G 18: 67,953,426 (GRCm39) Y481C probably damaging Het
Cep250 A G 2: 155,821,071 (GRCm39) E887G probably damaging Het
Clcn1 C A 6: 42,275,772 (GRCm39) A298D probably damaging Het
Col11a1 A G 3: 113,979,248 (GRCm39) N1305S unknown Het
Depdc5 T C 5: 33,125,089 (GRCm39) V1155A probably benign Het
Dnah1 A T 14: 30,991,851 (GRCm39) D3050E probably benign Het
Dnah7a T C 1: 53,557,973 (GRCm39) D2147G probably benign Het
Fbxl4 T C 4: 22,386,145 (GRCm39) Y251H possibly damaging Het
Gm19410 A G 8: 36,252,920 (GRCm39) M622V probably benign Het
Gm3402 T A 5: 146,451,472 (GRCm39) M110K probably damaging Het
Gm8257 T A 14: 44,893,817 (GRCm39) E82D probably damaging Het
Gne T A 4: 44,042,175 (GRCm39) I498F probably damaging Het
Grep1 A G 17: 23,931,308 (GRCm39) S200P not run Het
Gstcd C T 3: 132,790,540 (GRCm39) V76I probably benign Het
Hgs G T 11: 120,365,139 (GRCm39) V176L probably benign Het
Hrob T A 11: 102,146,422 (GRCm39) C233S probably benign Het
Igbp1b T C 6: 138,635,108 (GRCm39) N112S possibly damaging Het
Itga11 A T 9: 62,653,190 (GRCm39) T355S probably benign Het
Lama1 A T 17: 68,050,292 (GRCm39) H301L Het
Lhx9 T C 1: 138,760,489 (GRCm39) D296G probably damaging Het
Lrp1 C T 10: 127,427,962 (GRCm39) G537D probably damaging Het
Mroh2b A G 15: 4,950,844 (GRCm39) I581V possibly damaging Het
Mrps36 A G 13: 100,875,707 (GRCm39) S36P probably benign Het
Or52z13 T A 7: 103,246,955 (GRCm39) I144N probably damaging Het
Plcb4 A T 2: 135,807,000 (GRCm39) N547I probably benign Het
Plch2 T A 4: 155,083,424 (GRCm39) M505L probably damaging Het
Prg4 T A 1: 150,329,818 (GRCm39) N154Y not run Het
Rev1 A T 1: 38,124,682 (GRCm39) V420D probably damaging Het
Rin3 A G 12: 102,356,374 (GRCm39) I972V probably benign Het
Rtel1 T C 2: 180,993,654 (GRCm39) L775P not run Het
Scarf2 G T 16: 17,621,154 (GRCm39) C274F possibly damaging Het
Serinc2 C T 4: 130,152,052 (GRCm39) V271I probably benign Het
Slpi C A 2: 164,198,322 (GRCm39) probably benign Het
Spopfm1 C T 3: 94,173,045 (GRCm39) H14Y possibly damaging Het
Stxbp6 T C 12: 44,948,782 (GRCm39) D109G probably damaging Het
Tmem74 G A 15: 43,730,864 (GRCm39) L60F probably benign Het
Trhde C T 10: 114,636,776 (GRCm39) G144S possibly damaging Het
Trrap T C 5: 144,751,333 (GRCm39) S1610P probably benign Het
Ttc33 C T 15: 5,246,718 (GRCm39) Q175* probably null Het
Usp34 A G 11: 23,283,566 (GRCm39) T106A probably benign Het
Vmn1r204 A G 13: 22,741,167 (GRCm39) D266G probably benign Het
Wdfy3 C A 5: 102,003,389 (GRCm39) A2905S probably benign Het
Wfs1 A G 5: 37,125,190 (GRCm39) L567P probably damaging Het
Zfp42 T C 8: 43,749,312 (GRCm39) E63G probably damaging Het
Zfp957 A G 14: 79,451,080 (GRCm39) F240L probably damaging Het
Zgrf1 A T 3: 127,357,218 (GRCm39) M815L probably benign Het
Other mutations in Adora3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02565:Adora3 APN 3 105,815,128 (GRCm39) missense probably benign 0.02
IGL03210:Adora3 APN 3 105,815,176 (GRCm39) missense probably benign 0.01
R1885:Adora3 UTSW 3 105,812,152 (GRCm39) missense possibly damaging 0.80
R1886:Adora3 UTSW 3 105,812,152 (GRCm39) missense possibly damaging 0.80
R1887:Adora3 UTSW 3 105,812,152 (GRCm39) missense possibly damaging 0.80
R3434:Adora3 UTSW 3 105,812,231 (GRCm39) missense probably benign 0.11
R4864:Adora3 UTSW 3 105,815,131 (GRCm39) missense probably damaging 1.00
R5328:Adora3 UTSW 3 105,814,619 (GRCm39) missense probably benign 0.00
R5746:Adora3 UTSW 3 105,815,126 (GRCm39) missense possibly damaging 0.49
R6322:Adora3 UTSW 3 105,814,760 (GRCm39) missense probably benign 0.10
R6432:Adora3 UTSW 3 105,814,991 (GRCm39) nonsense probably null
R7772:Adora3 UTSW 3 105,815,039 (GRCm39) missense probably benign
R9020:Adora3 UTSW 3 105,815,141 (GRCm39) missense probably damaging 1.00
R9350:Adora3 UTSW 3 105,814,613 (GRCm39) missense possibly damaging 0.80
Z1177:Adora3 UTSW 3 105,815,101 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGCCCTTTCTGAGAAGAG -3'
(R):5'- AATGGCCAAAGGTGTGACC -3'

Sequencing Primer
(F):5'- TCTAAGAGAGAGTCATACCGGAAG -3'
(R):5'- GTGACCAGCACCCCAACG -3'
Posted On 2019-06-26