Incidental Mutation 'IGL00478:Zfp770'
| ID |
7083 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp770
|
| Ensembl Gene |
ENSMUSG00000040321 |
| Gene Name |
zinc finger protein 770 |
| Synonyms |
6430601A21Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.233)
|
| Stock # |
IGL00478
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
114023937-114031945 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 114027946 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 41
(E41G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052194
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000050668]
|
| AlphaFold |
Q8BIQ8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000050668
AA Change: E41G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000052194
Gene: ENSMUSG00000040321
AA Change: E41G
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
31 |
53 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
59 |
81 |
4.11e-2 |
SMART |
|
ZnF_C2H2
|
85 |
107 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
164 |
186 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
192 |
214 |
3.58e-2 |
SMART |
|
ZnF_C2H2
|
220 |
242 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
298 |
318 |
1.93e2 |
SMART |
|
low complexity region
|
341 |
354 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
485 |
507 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
513 |
535 |
1.82e-3 |
SMART |
|
low complexity region
|
576 |
595 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
640 |
662 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
668 |
690 |
7.37e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123562
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
All alleles(4) : Targeted(3) Gene trapped(1)
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aars1 |
A |
G |
8: 111,774,604 (GRCm39) |
T578A |
possibly damaging |
Het |
| Ablim1 |
C |
T |
19: 57,056,618 (GRCm39) |
A359T |
probably damaging |
Het |
| Akap9 |
G |
A |
5: 4,096,639 (GRCm39) |
V2505M |
probably damaging |
Het |
| Alpk2 |
A |
T |
18: 65,440,297 (GRCm39) |
C365* |
probably null |
Het |
| C920021L13Rik |
A |
T |
3: 95,794,797 (GRCm39) |
|
probably benign |
Het |
| Chd3 |
A |
T |
11: 69,247,888 (GRCm39) |
V905E |
probably damaging |
Het |
| Cntrl |
T |
C |
2: 35,050,613 (GRCm39) |
V1529A |
probably damaging |
Het |
| Coro2a |
T |
C |
4: 46,540,455 (GRCm39) |
D488G |
probably benign |
Het |
| Dpf1 |
G |
T |
7: 29,015,981 (GRCm39) |
|
probably benign |
Het |
| Fga |
T |
A |
3: 82,935,951 (GRCm39) |
D59E |
probably benign |
Het |
| Ggh |
T |
A |
4: 20,057,965 (GRCm39) |
H175Q |
probably benign |
Het |
| Glyat |
T |
C |
19: 12,625,497 (GRCm39) |
|
probably benign |
Het |
| Gpr137c |
T |
C |
14: 45,516,202 (GRCm39) |
V312A |
probably damaging |
Het |
| Myt1 |
T |
C |
2: 181,442,908 (GRCm39) |
S466P |
probably damaging |
Het |
| Nlrp5 |
A |
T |
7: 23,141,213 (GRCm39) |
D1078V |
probably damaging |
Het |
| Rad17 |
T |
C |
13: 100,769,782 (GRCm39) |
D259G |
probably damaging |
Het |
| Rpp14 |
G |
A |
14: 8,083,934 (GRCm38) |
G30E |
possibly damaging |
Het |
| Uspl1 |
A |
T |
5: 149,152,024 (GRCm39) |
T1075S |
possibly damaging |
Het |
| Vash1 |
T |
A |
12: 86,727,042 (GRCm39) |
I94N |
possibly damaging |
Het |
|
| Other mutations in Zfp770 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Zfp770
|
APN |
2 |
114,026,413 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01539:Zfp770
|
APN |
2 |
114,027,574 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01778:Zfp770
|
APN |
2 |
114,026,719 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02596:Zfp770
|
APN |
2 |
114,026,308 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03227:Zfp770
|
APN |
2 |
114,027,570 (GRCm39) |
nonsense |
probably null |
|
|
R0057:Zfp770
|
UTSW |
2 |
114,027,713 (GRCm39) |
nonsense |
probably null |
|
|
R0057:Zfp770
|
UTSW |
2 |
114,027,713 (GRCm39) |
nonsense |
probably null |
|
|
R1081:Zfp770
|
UTSW |
2 |
114,027,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1446:Zfp770
|
UTSW |
2 |
114,027,514 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4477:Zfp770
|
UTSW |
2 |
114,027,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4597:Zfp770
|
UTSW |
2 |
114,027,251 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4964:Zfp770
|
UTSW |
2 |
114,027,868 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4966:Zfp770
|
UTSW |
2 |
114,027,868 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5259:Zfp770
|
UTSW |
2 |
114,027,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5440:Zfp770
|
UTSW |
2 |
114,026,596 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5910:Zfp770
|
UTSW |
2 |
114,026,713 (GRCm39) |
nonsense |
probably null |
|
|
R5941:Zfp770
|
UTSW |
2 |
114,028,027 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6074:Zfp770
|
UTSW |
2 |
114,026,870 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6341:Zfp770
|
UTSW |
2 |
114,027,240 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7181:Zfp770
|
UTSW |
2 |
114,027,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7288:Zfp770
|
UTSW |
2 |
114,026,142 (GRCm39) |
nonsense |
probably null |
|
|
R7935:Zfp770
|
UTSW |
2 |
114,027,305 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8119:Zfp770
|
UTSW |
2 |
114,027,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8304:Zfp770
|
UTSW |
2 |
114,027,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9356:Zfp770
|
UTSW |
2 |
114,026,917 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9657:Zfp770
|
UTSW |
2 |
114,027,766 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9663:Zfp770
|
UTSW |
2 |
114,026,949 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2012-04-20 |
Incidental Mutation