Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01626:Fut7'

92779

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fut7

Ensembl Gene

ENSMUSG00000036587

Gene Name

fucosyltransferase 7

Synonyms

FTVII, Fuc-TVII, FucT-VII

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.196) question?

Stock #

IGL01626

Quality Score

Status

Chromosome

Chromosomal Location

25313279-25316386 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 25315343 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 153 (Y153*)

Ref Sequence

ENSEMBL: ENSMUSP00000109917 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041654] [ENSMUST00000100320] [ENSMUST00000102919] [ENSMUST00000114278] [ENSMUST00000134259]

AlphaFold

Q11131

Predicted Effect

probably null
Transcript: ENSMUST00000041654
AA Change: Y153*

SMART Domains

Protein: ENSMUSP00000039985
Gene: ENSMUSG00000036587
AA Change: Y153*

Domain	Start	End	E-Value	Type
Pfam:Glyco_transf_10	10	341	5.1e-122	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000100320
AA Change: Y200*

SMART Domains

Protein: ENSMUSP00000097895
Gene: ENSMUSG00000036587
AA Change: Y200*

Domain	Start	End	E-Value	Type
transmembrane domain	59	81	N/A	INTRINSIC
Pfam:Glyco_tran_10_N	91	201	8.8e-37	PFAM
Pfam:Glyco_transf_10	216	387	6.5e-58	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000102919

SMART Domains

Protein: ENSMUSP00000099983
Gene: ENSMUSG00000026944

Domain	Start	End	E-Value	Type
transmembrane domain	21	40	N/A	INTRINSIC
low complexity region	119	130	N/A	INTRINSIC
low complexity region	220	237	N/A	INTRINSIC
coiled coil region	271	296	N/A	INTRINSIC
low complexity region	309	346	N/A	INTRINSIC
Pfam:ABC2_membrane_3	493	911	9.7e-18	PFAM
AAA	1015	1197	9.22e-7	SMART
low complexity region	1364	1376	N/A	INTRINSIC
low complexity region	1589	1607	N/A	INTRINSIC
Pfam:ABC2_membrane_3	1696	2008	2.3e-44	PFAM
AAA	2079	2264	1.12e-5	SMART
low complexity region	2375	2394	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000114278
AA Change: Y153*

SMART Domains

Protein: ENSMUSP00000109917
Gene: ENSMUSG00000036587
AA Change: Y153*

Domain	Start	End	E-Value	Type
Pfam:Glyco_transf_10	10	341	5.1e-122	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000134259

SMART Domains

Protein: ENSMUSP00000123526
Gene: ENSMUSG00000036587

Domain	Start	End	E-Value	Type
Pfam:Glyco_transf_10	9	104	2.3e-16	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142156

Meta Mutation Damage Score

0.9755

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene are superficially normal. However, abnormalities are found in immune cell function and lymph node morphology. Redeuced tumor metastasis is also seen. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl2	A	G	3: 59,926,595 (GRCm39)	D188G	probably damaging	Het
Aoc1	A	G	6: 48,883,465 (GRCm39)	Y447C	probably damaging	Het
Brd1	A	T	15: 88,585,090 (GRCm39)	L915M	probably damaging	Het
Cacna2d3	T	A	14: 28,665,564 (GRCm39)	E152D	possibly damaging	Het
Dnase2b	A	G	3: 146,290,371 (GRCm39)		probably null	Het
Ecpas	G	A	4: 58,832,814 (GRCm39)		probably benign	Het
Fat4	T	C	3: 39,005,181 (GRCm39)	V1860A	probably damaging	Het
Fbxl5	C	A	5: 43,916,047 (GRCm39)	G455V	probably benign	Het
Fpr-rs4	G	A	17: 18,242,493 (GRCm39)	V167M	probably damaging	Het
Gnptab	A	G	10: 88,273,357 (GRCm39)	T1045A	probably damaging	Het
Gucy1a1	T	A	3: 82,015,926 (GRCm39)	D354V	probably damaging	Het
Gucy2e	A	G	11: 69,123,681 (GRCm39)	V406A	possibly damaging	Het
Herc2	T	C	7: 55,734,890 (GRCm39)	F160S	probably benign	Het
Ice2	T	G	9: 69,314,614 (GRCm39)	V42G	probably benign	Het
L3mbtl4	A	G	17: 68,937,197 (GRCm39)	Y406C	probably damaging	Het
Lepr	C	T	4: 101,590,731 (GRCm39)	T103I	probably benign	Het
Ly75	T	A	2: 60,131,359 (GRCm39)	M1589L	probably benign	Het
Map4k3	A	G	17: 80,913,238 (GRCm39)	V644A	probably damaging	Het
Micall1	A	G	15: 79,014,712 (GRCm39)	D696G	possibly damaging	Het
Muc4	T	C	16: 32,555,220 (GRCm39)	V8A	possibly damaging	Het
Myo1h	A	G	5: 114,453,027 (GRCm39)	D9G	probably damaging	Het
Nop14	T	A	5: 34,806,689 (GRCm39)	K472*	probably null	Het
Npat	T	A	9: 53,467,871 (GRCm39)	D275E	possibly damaging	Het
Nt5c1b	A	G	12: 10,424,798 (GRCm39)	T115A	probably benign	Het
Or2d3c	A	T	7: 106,526,627 (GRCm39)	I13N	probably benign	Het
Or6n1	A	G	1: 173,917,122 (GRCm39)	N172S	probably damaging	Het
Pnpla7	T	A	2: 24,940,905 (GRCm39)	S1086T	possibly damaging	Het
Pold1	C	T	7: 44,182,796 (GRCm39)		probably null	Het
Ppfia1	A	G	7: 144,035,456 (GRCm39)	F1165L	probably benign	Het
Prlr	T	A	15: 10,328,804 (GRCm39)	D426E	probably benign	Het
Ptgs2	G	A	1: 149,979,478 (GRCm39)	R231H	probably damaging	Het
Rorc	A	G	3: 94,296,094 (GRCm39)	D91G	probably damaging	Het
Scaper	C	T	9: 55,819,335 (GRCm39)	V127M	possibly damaging	Het
Sema3g	A	T	14: 30,943,684 (GRCm39)	Y188F	probably damaging	Het
Slc45a3	G	T	1: 131,906,725 (GRCm39)	A400S	possibly damaging	Het
Slc9b2	C	A	3: 135,042,156 (GRCm39)	H478Q	probably benign	Het
Spg11	T	A	2: 121,891,452 (GRCm39)	H1973L	probably damaging	Het
Srgap3	A	G	6: 112,750,609 (GRCm39)	Y359H	probably damaging	Het
Stx16	T	G	2: 173,935,813 (GRCm39)	I248S	probably damaging	Het
Sytl3	A	G	17: 7,002,839 (GRCm39)	R287G	probably damaging	Het
Tiam1	T	C	16: 89,609,856 (GRCm39)	T82A	probably damaging	Het
Trpm1	T	C	7: 63,918,637 (GRCm39)	L659P	probably damaging	Het
Ttc13	G	A	8: 125,400,477 (GRCm39)		probably benign	Het
Unc80	T	C	1: 66,590,213 (GRCm39)		probably null	Het
Vldlr	G	T	19: 27,221,173 (GRCm39)	R613L	probably damaging	Het
Wdr77	C	T	3: 105,867,002 (GRCm39)	R35*	probably null	Het
Zc3h14	T	G	12: 98,745,445 (GRCm39)	I478R	possibly damaging	Het
Zfp366	A	G	13: 99,364,920 (GRCm39)	H27R	probably damaging	Het

Other mutations in Fut7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02483:Fut7	APN	2	25,313,888 (GRCm39)	missense	possibly damaging	0.47
IGL02967:Fut7	APN	2	25,315,155 (GRCm39)	missense	probably damaging	1.00
IGL03180:Fut7	APN	2	25,315,465 (GRCm39)	missense	possibly damaging	0.79
R1524:Fut7	UTSW	2	25,315,159 (GRCm39)	missense	probably damaging	1.00
R1968:Fut7	UTSW	2	25,315,738 (GRCm39)	missense	probably benign	0.16
R2115:Fut7	UTSW	2	25,315,343 (GRCm39)	nonsense	probably null
R2900:Fut7	UTSW	2	25,313,923 (GRCm39)	missense	probably benign
R4448:Fut7	UTSW	2	25,314,951 (GRCm39)	missense	probably benign	0.06
R7019:Fut7	UTSW	2	25,315,792 (GRCm39)	missense	probably benign	0.00
R9222:Fut7	UTSW	2	25,315,191 (GRCm39)	missense	possibly damaging	0.81
R9349:Fut7	UTSW	2	25,314,993 (GRCm39)	missense	possibly damaging	0.73
R9648:Fut7	UTSW	2	25,315,336 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09