Incidental Mutation 'IGL01626:Or6n1'
ID 92707
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6n1
Ensembl Gene ENSMUSG00000049528
Gene Name olfactory receptor family 6 subfamily N member 1
Synonyms Olfr429, GA_x6K02T2P20D-21090094-21089156, MOR105-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # IGL01626
Quality Score
Status
Chromosome 1
Chromosomal Location 173916604-173917546 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 173917122 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 172 (N172S)
Ref Sequence ENSEMBL: ENSMUSP00000149257 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060693] [ENSMUST00000216346]
AlphaFold Q7TRW1
Predicted Effect probably damaging
Transcript: ENSMUST00000060693
AA Change: N172S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051323
Gene: ENSMUSG00000049528
AA Change: N172S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-65 PFAM
Pfam:7tm_1 41 290 1.3e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000193320
AA Change: N172S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142323
Gene: ENSMUSG00000049528
AA Change: N172S

DomainStartEndE-ValueType
low complexity region 25 40 N/A INTRINSIC
Pfam:7tm_1 41 290 8.9e-31 PFAM
Pfam:7tm_4 139 283 6.7e-43 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216346
AA Change: N172S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2 A G 3: 59,926,595 (GRCm39) D188G probably damaging Het
Aoc1 A G 6: 48,883,465 (GRCm39) Y447C probably damaging Het
Brd1 A T 15: 88,585,090 (GRCm39) L915M probably damaging Het
Cacna2d3 T A 14: 28,665,564 (GRCm39) E152D possibly damaging Het
Dnase2b A G 3: 146,290,371 (GRCm39) probably null Het
Ecpas G A 4: 58,832,814 (GRCm39) probably benign Het
Fat4 T C 3: 39,005,181 (GRCm39) V1860A probably damaging Het
Fbxl5 C A 5: 43,916,047 (GRCm39) G455V probably benign Het
Fpr-rs4 G A 17: 18,242,493 (GRCm39) V167M probably damaging Het
Fut7 C A 2: 25,315,343 (GRCm39) Y153* probably null Het
Gnptab A G 10: 88,273,357 (GRCm39) T1045A probably damaging Het
Gucy1a1 T A 3: 82,015,926 (GRCm39) D354V probably damaging Het
Gucy2e A G 11: 69,123,681 (GRCm39) V406A possibly damaging Het
Herc2 T C 7: 55,734,890 (GRCm39) F160S probably benign Het
Ice2 T G 9: 69,314,614 (GRCm39) V42G probably benign Het
L3mbtl4 A G 17: 68,937,197 (GRCm39) Y406C probably damaging Het
Lepr C T 4: 101,590,731 (GRCm39) T103I probably benign Het
Ly75 T A 2: 60,131,359 (GRCm39) M1589L probably benign Het
Map4k3 A G 17: 80,913,238 (GRCm39) V644A probably damaging Het
Micall1 A G 15: 79,014,712 (GRCm39) D696G possibly damaging Het
Muc4 T C 16: 32,555,220 (GRCm39) V8A possibly damaging Het
Myo1h A G 5: 114,453,027 (GRCm39) D9G probably damaging Het
Nop14 T A 5: 34,806,689 (GRCm39) K472* probably null Het
Npat T A 9: 53,467,871 (GRCm39) D275E possibly damaging Het
Nt5c1b A G 12: 10,424,798 (GRCm39) T115A probably benign Het
Or2d3c A T 7: 106,526,627 (GRCm39) I13N probably benign Het
Pnpla7 T A 2: 24,940,905 (GRCm39) S1086T possibly damaging Het
Pold1 C T 7: 44,182,796 (GRCm39) probably null Het
Ppfia1 A G 7: 144,035,456 (GRCm39) F1165L probably benign Het
Prlr T A 15: 10,328,804 (GRCm39) D426E probably benign Het
Ptgs2 G A 1: 149,979,478 (GRCm39) R231H probably damaging Het
Rorc A G 3: 94,296,094 (GRCm39) D91G probably damaging Het
Scaper C T 9: 55,819,335 (GRCm39) V127M possibly damaging Het
Sema3g A T 14: 30,943,684 (GRCm39) Y188F probably damaging Het
Slc45a3 G T 1: 131,906,725 (GRCm39) A400S possibly damaging Het
Slc9b2 C A 3: 135,042,156 (GRCm39) H478Q probably benign Het
Spg11 T A 2: 121,891,452 (GRCm39) H1973L probably damaging Het
Srgap3 A G 6: 112,750,609 (GRCm39) Y359H probably damaging Het
Stx16 T G 2: 173,935,813 (GRCm39) I248S probably damaging Het
Sytl3 A G 17: 7,002,839 (GRCm39) R287G probably damaging Het
Tiam1 T C 16: 89,609,856 (GRCm39) T82A probably damaging Het
Trpm1 T C 7: 63,918,637 (GRCm39) L659P probably damaging Het
Ttc13 G A 8: 125,400,477 (GRCm39) probably benign Het
Unc80 T C 1: 66,590,213 (GRCm39) probably null Het
Vldlr G T 19: 27,221,173 (GRCm39) R613L probably damaging Het
Wdr77 C T 3: 105,867,002 (GRCm39) R35* probably null Het
Zc3h14 T G 12: 98,745,445 (GRCm39) I478R possibly damaging Het
Zfp366 A G 13: 99,364,920 (GRCm39) H27R probably damaging Het
Other mutations in Or6n1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01868:Or6n1 APN 1 173,916,936 (GRCm39) missense possibly damaging 0.83
IGL01972:Or6n1 APN 1 173,916,987 (GRCm39) missense probably damaging 0.99
IGL02412:Or6n1 APN 1 173,916,809 (GRCm39) missense probably benign 0.00
IGL02628:Or6n1 APN 1 173,916,756 (GRCm39) missense probably benign
IGL02861:Or6n1 APN 1 173,916,602 (GRCm39) utr 5 prime probably benign
IGL03404:Or6n1 APN 1 173,917,464 (GRCm39) missense probably damaging 1.00
R0267:Or6n1 UTSW 1 173,916,732 (GRCm39) missense probably damaging 1.00
R0357:Or6n1 UTSW 1 173,916,675 (GRCm39) missense possibly damaging 0.71
R1499:Or6n1 UTSW 1 173,916,813 (GRCm39) nonsense probably null
R2051:Or6n1 UTSW 1 173,916,785 (GRCm39) missense possibly damaging 0.95
R4706:Or6n1 UTSW 1 173,917,268 (GRCm39) missense probably damaging 1.00
R4820:Or6n1 UTSW 1 173,916,742 (GRCm39) missense possibly damaging 0.95
R5439:Or6n1 UTSW 1 173,917,541 (GRCm39) missense probably benign 0.01
R5538:Or6n1 UTSW 1 173,917,544 (GRCm39) makesense probably null
R5907:Or6n1 UTSW 1 173,916,785 (GRCm39) missense probably benign 0.08
R6932:Or6n1 UTSW 1 173,917,316 (GRCm39) missense probably damaging 0.96
R7808:Or6n1 UTSW 1 173,917,417 (GRCm39) nonsense probably null
R8040:Or6n1 UTSW 1 173,916,723 (GRCm39) missense possibly damaging 0.68
R8467:Or6n1 UTSW 1 173,917,007 (GRCm39) missense probably benign 0.00
R9124:Or6n1 UTSW 1 173,917,341 (GRCm39) missense probably damaging 1.00
R9797:Or6n1 UTSW 1 173,917,356 (GRCm39) missense possibly damaging 0.65
Posted On 2013-12-09