Incidental Mutation 'R1013:Il10rb'
ID 95912
Institutional Source Beutler Lab
Gene Symbol Il10rb
Ensembl Gene ENSMUSG00000022969
Gene Name interleukin 10 receptor, beta
Synonyms 6620401D04Rik, D21S58h, Il10r2, CRF2-4, D16H21S58, Crfb4
MMRRC Submission 039117-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1013 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 91203166-91222718 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 91211581 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 140 (N140D)
Ref Sequence ENSEMBL: ENSMUSP00000023691 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023691] [ENSMUST00000156133]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000023691
AA Change: N140D

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000023691
Gene: ENSMUSG00000022969
AA Change: N140D

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
FN3 23 100 4.6e-2 SMART
FN3 114 204 7.1e-3 SMART
transmembrane domain 228 250 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137612
Predicted Effect probably benign
Transcript: ENSMUST00000144215
SMART Domains Protein: ENSMUSP00000120485
Gene: ENSMUSG00000022969

DomainStartEndE-ValueType
Pfam:Tissue_fac 7 65 1.7e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152729
Predicted Effect probably benign
Transcript: ENSMUST00000156133
SMART Domains Protein: ENSMUSP00000120227
Gene: ENSMUSG00000022969

DomainStartEndE-ValueType
low complexity region 39 48 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000160764
AA Change: N226D
SMART Domains Protein: ENSMUSP00000123997
Gene: ENSMUSG00000093701
AA Change: N226D

DomainStartEndE-ValueType
FN3 2 92 5.1e1 SMART
FN3 110 187 9.09e0 SMART
FN3 201 291 1.39e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161517
SMART Domains Protein: ENSMUSP00000125579
Gene: ENSMUSG00000093701

DomainStartEndE-ValueType
Pfam:Interfer-bind 1 100 7.5e-20 PFAM
Meta Mutation Damage Score 0.0784 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.4%
Validation Efficiency 98% (39/40)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
PHENOTYPE: Most mice homozygous for a knock-out allele develop moderate to severe colitis without small intestinal involvement and splenomegaly with a hyperproliferative splenic red pulp. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700056E22Rik C T 1: 183,765,702 (GRCm39) S119N probably benign Het
4930527J03Rik ACCC ACC 1: 178,276,503 (GRCm38) noncoding transcript Het
Bclaf1 T A 10: 20,207,822 (GRCm39) probably benign Het
Bicdl2 A G 17: 23,884,377 (GRCm39) probably benign Het
C8a T C 4: 104,685,236 (GRCm39) I336V probably benign Het
Calcr A T 6: 3,692,621 (GRCm39) V374D probably damaging Het
Col28a1 A G 6: 7,999,452 (GRCm39) probably benign Het
Cuedc1 C T 11: 88,078,853 (GRCm39) A327V possibly damaging Het
Cul2 C A 18: 3,425,535 (GRCm39) Y378* probably null Het
Dnaaf10 A G 11: 17,178,183 (GRCm39) K226E probably damaging Het
Flt4 C T 11: 49,527,166 (GRCm39) probably benign Het
Gm8369 TG TGNG 19: 11,489,147 (GRCm39) probably null Het
Hivep1 A G 13: 42,310,438 (GRCm39) R893G probably damaging Het
Itga4 A G 2: 79,150,847 (GRCm39) M818V probably benign Het
Kyat3 T C 3: 142,432,007 (GRCm39) I245T probably damaging Het
Lck C T 4: 129,451,920 (GRCm39) C20Y probably damaging Het
Mcm6 T G 1: 128,276,778 (GRCm39) S271R probably benign Het
Megf10 A G 18: 57,394,291 (GRCm39) I472V probably benign Het
Mroh2a T C 1: 88,162,334 (GRCm39) probably null Het
Mrpl11 T C 19: 5,013,651 (GRCm39) I144T possibly damaging Het
Or2t26 G A 11: 49,039,977 (GRCm39) V298M probably damaging Het
Or8k25 G A 2: 86,244,319 (GRCm39) P26S possibly damaging Het
Pcdhb17 A G 18: 37,619,020 (GRCm39) D270G probably damaging Het
Plg G A 17: 12,597,608 (GRCm39) probably benign Het
Ppp3cb T A 14: 20,574,072 (GRCm39) E255D probably benign Het
Psenen A G 7: 30,261,802 (GRCm39) F38S possibly damaging Het
Rims4 C T 2: 163,705,849 (GRCm39) V262M possibly damaging Het
Sorl1 T C 9: 41,913,855 (GRCm39) N1358S probably benign Het
Trim3 G A 7: 105,267,102 (GRCm39) P426S probably benign Het
Ttc28 T C 5: 111,424,831 (GRCm39) M1552T probably benign Het
Unc13c T C 9: 73,840,614 (GRCm39) D79G probably benign Het
Zcchc14 A G 8: 122,333,664 (GRCm39) probably benign Het
Zfp354a T C 11: 50,951,677 (GRCm39) probably benign Het
Zfp729a T C 13: 67,767,626 (GRCm39) I868V probably benign Het
Other mutations in Il10rb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Il10rb APN 16 91,203,227 (GRCm39) missense probably benign 0.11
R0393:Il10rb UTSW 16 91,208,898 (GRCm39) missense probably benign 0.13
R1444:Il10rb UTSW 16 91,218,675 (GRCm39) splice site probably null
R2449:Il10rb UTSW 16 91,208,791 (GRCm39) missense probably benign
R4425:Il10rb UTSW 16 91,204,603 (GRCm39) missense possibly damaging 0.93
R4779:Il10rb UTSW 16 91,211,545 (GRCm39) missense possibly damaging 0.54
R6051:Il10rb UTSW 16 91,218,752 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- AGCATGGTGATGGTGACATGCC -3'
(R):5'- TTACCAAACTGAGCGGAGAGCAC -3'

Sequencing Primer
(F):5'- caggaagatcgaaagtttgagg -3'
(R):5'- GAGCACAATACTCATGTCAGATG -3'
Posted On 2014-01-05