Incidental Mutation 'IGL01678:Olfr774'
ID103695
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr774
Ensembl Gene ENSMUSG00000096229
Gene Nameolfactory receptor 774
SynonymsMOR111-2, MOR111-11, GA_x6K02T2PULF-10924432-10925370
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock #IGL01678
Quality Score
Status
Chromosome10
Chromosomal Location129236204-129239403 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 129238668 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Alanine at position 173 (D173A)
Ref Sequence ENSEMBL: ENSMUSP00000145042 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097164] [ENSMUST00000203248]
Predicted Effect possibly damaging
Transcript: ENSMUST00000097164
AA Change: D173A

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000131609
Gene: ENSMUSG00000096229
AA Change: D173A

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 6e-49 PFAM
Pfam:7tm_1 39 288 2.2e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000203248
AA Change: D173A

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000145042
Gene: ENSMUSG00000096229
AA Change: D173A

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 6e-49 PFAM
Pfam:7tm_1 39 288 2.2e-18 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 T A 16: 14,405,019 M186K probably null Het
Adamts3 T C 5: 89,707,856 N385S probably damaging Het
Adamts6 T C 13: 104,313,688 V299A probably damaging Het
Angel1 T C 12: 86,717,026 E500G probably benign Het
Car9 T C 4: 43,512,941 probably benign Het
Colec11 A G 12: 28,594,868 F209S probably damaging Het
Dock10 A G 1: 80,543,352 Y1179H probably damaging Het
Ece1 T A 4: 137,962,733 W697R probably damaging Het
Eml2 T A 7: 19,186,122 M117K probably benign Het
Flii G T 11: 60,716,846 probably benign Het
Frmpd1 T A 4: 45,243,717 D63E probably damaging Het
Ftmt A T 18: 52,332,134 H174L probably damaging Het
Gm438 A T 4: 144,777,873 M236K probably benign Het
Gm960 T A 19: 4,672,165 I76L possibly damaging Het
Gpr37l1 A G 1: 135,167,053 V151A probably damaging Het
Inppl1 T C 7: 101,832,596 T180A probably benign Het
Klhdc4 T C 8: 121,796,938 D513G possibly damaging Het
Klrb1a A G 6: 128,618,448 probably benign Het
Nit1 A G 1: 171,342,694 V270A probably damaging Het
Phox2b T A 5: 67,098,919 Y8F probably damaging Het
Psg20 T A 7: 18,680,870 S364C probably damaging Het
Rab38 T A 7: 88,430,532 V44E probably damaging Het
Rapgef4 T C 2: 72,242,225 probably benign Het
Ror1 C T 4: 100,425,968 P410L possibly damaging Het
Rptn A G 3: 93,396,811 N484D probably benign Het
Sirpb1a G T 3: 15,411,310 S142R probably damaging Het
Smox G A 2: 131,512,059 R17H possibly damaging Het
Trpm7 A T 2: 126,816,799 C1146S probably damaging Het
Upf3a C T 8: 13,791,930 A155V probably benign Het
Vmn1r212 A T 13: 22,883,911 V84D probably damaging Het
Vmn2r40 T C 7: 8,920,106 N419D probably damaging Het
Wdr92 T C 11: 17,232,790 V317A probably benign Het
Zfp143 C A 7: 110,080,351 probably benign Het
Zmat4 T A 8: 23,902,048 C7S probably damaging Het
Other mutations in Olfr774
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01308:Olfr774 APN 10 129238607 missense probably benign 0.00
IGL01627:Olfr774 APN 10 129238269 missense probably damaging 1.00
IGL01759:Olfr774 APN 10 129239072 missense probably benign 0.13
IGL03261:Olfr774 APN 10 129238403 missense possibly damaging 0.72
R1996:Olfr774 UTSW 10 129238429 missense possibly damaging 0.89
R2103:Olfr774 UTSW 10 129238499 missense probably damaging 0.99
R2104:Olfr774 UTSW 10 129238499 missense probably damaging 0.99
R2330:Olfr774 UTSW 10 129239039 nonsense probably null
R3977:Olfr774 UTSW 10 129238508 missense probably damaging 1.00
R4544:Olfr774 UTSW 10 129238158 missense probably damaging 0.96
R6058:Olfr774 UTSW 10 129238460 missense probably damaging 0.97
Posted On2014-01-21