Incidental Mutation 'IGL01678:Klrb1a'
ID103721
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Klrb1a
Ensembl Gene ENSMUSG00000030361
Gene Namekiller cell lectin-like receptor subfamily B member 1A
SynonymsLy55a, Nkrp1-a, NKR-P1A
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01678
Quality Score
Status
Chromosome6
Chromosomal Location128609227-128623533 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 128618448 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145519 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032512] [ENSMUST00000171306] [ENSMUST00000203150] [ENSMUST00000203275] [ENSMUST00000204819]
Predicted Effect probably benign
Transcript: ENSMUST00000032512
SMART Domains Protein: ENSMUSP00000032512
Gene: ENSMUSG00000030361

DomainStartEndE-ValueType
transmembrane domain 45 67 N/A INTRINSIC
CLECT 100 217 1.52e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000171306
SMART Domains Protein: ENSMUSP00000132390
Gene: ENSMUSG00000030361

DomainStartEndE-ValueType
CLECT 67 184 1.52e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000203150
SMART Domains Protein: ENSMUSP00000144707
Gene: ENSMUSG00000030361

DomainStartEndE-ValueType
transmembrane domain 51 73 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000203275
SMART Domains Protein: ENSMUSP00000145086
Gene: ENSMUSG00000030361

DomainStartEndE-ValueType
transmembrane domain 39 61 N/A INTRINSIC
CLECT 88 205 7.6e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000204819
SMART Domains Protein: ENSMUSP00000145519
Gene: ENSMUSG00000030361

DomainStartEndE-ValueType
transmembrane domain 45 67 N/A INTRINSIC
CLECT 97 214 7.6e-27 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 T A 16: 14,405,019 M186K probably null Het
Adamts3 T C 5: 89,707,856 N385S probably damaging Het
Adamts6 T C 13: 104,313,688 V299A probably damaging Het
Angel1 T C 12: 86,717,026 E500G probably benign Het
Car9 T C 4: 43,512,941 probably benign Het
Colec11 A G 12: 28,594,868 F209S probably damaging Het
Dock10 A G 1: 80,543,352 Y1179H probably damaging Het
Ece1 T A 4: 137,962,733 W697R probably damaging Het
Eml2 T A 7: 19,186,122 M117K probably benign Het
Flii G T 11: 60,716,846 probably benign Het
Frmpd1 T A 4: 45,243,717 D63E probably damaging Het
Ftmt A T 18: 52,332,134 H174L probably damaging Het
Gm438 A T 4: 144,777,873 M236K probably benign Het
Gm960 T A 19: 4,672,165 I76L possibly damaging Het
Gpr37l1 A G 1: 135,167,053 V151A probably damaging Het
Inppl1 T C 7: 101,832,596 T180A probably benign Het
Klhdc4 T C 8: 121,796,938 D513G possibly damaging Het
Nit1 A G 1: 171,342,694 V270A probably damaging Het
Olfr774 A C 10: 129,238,668 D173A possibly damaging Het
Phox2b T A 5: 67,098,919 Y8F probably damaging Het
Psg20 T A 7: 18,680,870 S364C probably damaging Het
Rab38 T A 7: 88,430,532 V44E probably damaging Het
Rapgef4 T C 2: 72,242,225 probably benign Het
Ror1 C T 4: 100,425,968 P410L possibly damaging Het
Rptn A G 3: 93,396,811 N484D probably benign Het
Sirpb1a G T 3: 15,411,310 S142R probably damaging Het
Smox G A 2: 131,512,059 R17H possibly damaging Het
Trpm7 A T 2: 126,816,799 C1146S probably damaging Het
Upf3a C T 8: 13,791,930 A155V probably benign Het
Vmn1r212 A T 13: 22,883,911 V84D probably damaging Het
Vmn2r40 T C 7: 8,920,106 N419D probably damaging Het
Wdr92 T C 11: 17,232,790 V317A probably benign Het
Zfp143 C A 7: 110,080,351 probably benign Het
Zmat4 T A 8: 23,902,048 C7S probably damaging Het
Other mutations in Klrb1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01308:Klrb1a APN 6 128618045 splice site probably benign
IGL01976:Klrb1a APN 6 128618109 missense probably benign 0.36
R0387:Klrb1a UTSW 6 128609734 missense possibly damaging 0.79
R1348:Klrb1a UTSW 6 128609834 missense possibly damaging 0.79
R3709:Klrb1a UTSW 6 128618503 missense probably benign 0.00
R5253:Klrb1a UTSW 6 128619163 missense probably benign 0.00
R5541:Klrb1a UTSW 6 128609736 missense probably benign 0.01
R5630:Klrb1a UTSW 6 128618610 missense probably benign 0.01
R5913:Klrb1a UTSW 6 128618509 missense probably damaging 0.99
R6248:Klrb1a UTSW 6 128619174 missense probably damaging 1.00
R7248:Klrb1a UTSW 6 128609734 missense possibly damaging 0.52
Z1176:Klrb1a UTSW 6 128618585 frame shift probably null
Posted On2014-01-21