Incidental Mutation 'IGL01779:Ifna16'
ID 153879
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifna16
Ensembl Gene ENSMUSG00000078355
Gene Name interferon alpha 16
Synonyms Gm13280, Ifna6t
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.049) question?
Stock # IGL01779
Quality Score
Status
Chromosome 4
Chromosomal Location 88675915-88676924 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 88676645 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 71 (I71N)
Ref Sequence ENSEMBL: ENSMUSP00000100779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105148]
AlphaFold Q810G1
Predicted Effect probably damaging
Transcript: ENSMUST00000105148
AA Change: I71N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000100779
Gene: ENSMUSG00000078355
AA Change: I71N

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 2.69e-66 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl3 A T 5: 81,387,870 I119F probably damaging Het
Akt1 C T 12: 112,657,169 G286R probably damaging Het
Apof A G 10: 128,269,477 I167V probably benign Het
Arhgap15 A G 2: 44,065,045 E220G possibly damaging Het
Clca3a2 T A 3: 144,819,378 Y31F possibly damaging Het
Clmn T C 12: 104,782,140 I383V probably benign Het
Cntnap5b A G 1: 99,967,339 D112G probably damaging Het
Col8a1 A T 16: 57,628,363 H261Q unknown Het
Csmd3 A T 15: 47,857,894 V1551D probably benign Het
Ddx60 G A 8: 62,017,823 V1450M possibly damaging Het
Ethe1 A T 7: 24,595,009 H79L probably damaging Het
Fhdc1 G A 3: 84,444,735 A1061V possibly damaging Het
Gm11110 C T 17: 57,102,087 probably benign Het
Hs1bp3 C T 12: 8,341,945 T349I probably benign Het
Il18bp A G 7: 102,016,795 Y59H possibly damaging Het
Kcnt1 T A 2: 25,900,967 I511N probably damaging Het
Mlph A G 1: 90,942,950 M528V probably benign Het
Olfr646 A G 7: 104,106,633 D118G probably damaging Het
Pprc1 T A 19: 46,062,202 I52N probably damaging Het
Rfx1 T A 8: 84,092,662 probably benign Het
Rnf17 A T 14: 56,462,063 I553F probably benign Het
Scaper A T 9: 55,892,240 H180Q probably benign Het
Slc26a4 C T 12: 31,528,854 probably benign Het
Slc30a10 A T 1: 185,464,179 Q346L possibly damaging Het
Stambpl1 A T 19: 34,240,027 H422L possibly damaging Het
Trim67 G A 8: 124,828,121 G701R probably damaging Het
Vipr1 T C 9: 121,664,630 F249S probably damaging Het
Vmn2r117 G T 17: 23,477,241 D397E probably benign Het
Other mutations in Ifna16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01085:Ifna16 APN 4 88676732 missense probably benign
IGL02717:Ifna16 APN 4 88676540 missense possibly damaging 0.95
IGL03226:Ifna16 APN 4 88676504 missense probably benign 0.18
R0040:Ifna16 UTSW 4 88676630 missense probably benign 0.35
R0040:Ifna16 UTSW 4 88676630 missense probably benign 0.35
R1514:Ifna16 UTSW 4 88676742 missense possibly damaging 0.84
R2341:Ifna16 UTSW 4 88676328 missense probably damaging 1.00
R4877:Ifna16 UTSW 4 88676444 missense probably benign 0.00
R8989:Ifna16 UTSW 4 88676675 missense probably damaging 1.00
R9619:Ifna16 UTSW 4 88676525 missense probably benign 0.30
R9648:Ifna16 UTSW 4 88676823 missense probably benign 0.18
R9688:Ifna16 UTSW 4 88676637 nonsense probably null
R9743:Ifna16 UTSW 4 88676693 missense probably damaging 1.00
Z1088:Ifna16 UTSW 4 88676378 missense probably damaging 1.00
Posted On 2014-02-04