Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01779:Ifna16'

153879

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna16

Ensembl Gene

ENSMUSG00000078355

Gene Name

interferon alpha 16

Synonyms

Gm13280, Ifna6t

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01779

Quality Score

Status

Chromosome

Chromosomal Location

88594524-88595093 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 88594882 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 71 (I71N)

Ref Sequence

ENSEMBL: ENSMUSP00000100779 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105148]

AlphaFold

Q810G1

Predicted Effect

probably damaging
Transcript: ENSMUST00000105148
AA Change: I71N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000100779
Gene: ENSMUSG00000078355
AA Change: I71N

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	2.69e-66	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl3	A	T	5: 81,535,717 (GRCm39)	I119F	probably damaging	Het
Akt1	C	T	12: 112,623,603 (GRCm39)	G286R	probably damaging	Het
Apof	A	G	10: 128,105,346 (GRCm39)	I167V	probably benign	Het
Arhgap15	A	G	2: 43,955,057 (GRCm39)	E220G	possibly damaging	Het
Clca3a2	T	A	3: 144,525,139 (GRCm39)	Y31F	possibly damaging	Het
Clmn	T	C	12: 104,748,399 (GRCm39)	I383V	probably benign	Het
Cntnap5b	A	G	1: 99,895,064 (GRCm39)	D112G	probably damaging	Het
Col8a1	A	T	16: 57,448,726 (GRCm39)	H261Q	unknown	Het
Csmd3	A	T	15: 47,721,290 (GRCm39)	V1551D	probably benign	Het
Ddx60	G	A	8: 62,470,857 (GRCm39)	V1450M	possibly damaging	Het
Ethe1	A	T	7: 24,294,434 (GRCm39)	H79L	probably damaging	Het
Fhdc1	G	A	3: 84,352,042 (GRCm39)	A1061V	possibly damaging	Het
Gm11110	C	T	17: 57,409,087 (GRCm39)		probably benign	Het
Hs1bp3	C	T	12: 8,391,945 (GRCm39)	T349I	probably benign	Het
Il18bp	A	G	7: 101,666,002 (GRCm39)	Y59H	possibly damaging	Het
Kcnt1	T	A	2: 25,790,979 (GRCm39)	I511N	probably damaging	Het
Mlph	A	G	1: 90,870,672 (GRCm39)	M528V	probably benign	Het
Or52d1	A	G	7: 103,755,840 (GRCm39)	D118G	probably damaging	Het
Pprc1	T	A	19: 46,050,641 (GRCm39)	I52N	probably damaging	Het
Rfx1	T	A	8: 84,819,291 (GRCm39)		probably benign	Het
Rnf17	A	T	14: 56,699,520 (GRCm39)	I553F	probably benign	Het
Scaper	A	T	9: 55,799,524 (GRCm39)	H180Q	probably benign	Het
Slc26a4	C	T	12: 31,578,853 (GRCm39)		probably benign	Het
Slc30a10	A	T	1: 185,196,376 (GRCm39)	Q346L	possibly damaging	Het
Stambpl1	A	T	19: 34,217,427 (GRCm39)	H422L	possibly damaging	Het
Trim67	G	A	8: 125,554,860 (GRCm39)	G701R	probably damaging	Het
Vipr1	T	C	9: 121,493,696 (GRCm39)	F249S	probably damaging	Het
Vmn2r117	G	T	17: 23,696,215 (GRCm39)	D397E	probably benign	Het

Other mutations in Ifna16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01085:Ifna16	APN	4	88,594,969 (GRCm39)	missense	probably benign
IGL02717:Ifna16	APN	4	88,594,777 (GRCm39)	missense	possibly damaging	0.95
IGL03226:Ifna16	APN	4	88,594,741 (GRCm39)	missense	probably benign	0.18
R0040:Ifna16	UTSW	4	88,594,867 (GRCm39)	missense	probably benign	0.35
R0040:Ifna16	UTSW	4	88,594,867 (GRCm39)	missense	probably benign	0.35
R1514:Ifna16	UTSW	4	88,594,979 (GRCm39)	missense	possibly damaging	0.84
R2341:Ifna16	UTSW	4	88,594,565 (GRCm39)	missense	probably damaging	1.00
R4877:Ifna16	UTSW	4	88,594,681 (GRCm39)	missense	probably benign	0.00
R8989:Ifna16	UTSW	4	88,594,912 (GRCm39)	missense	probably damaging	1.00
R9619:Ifna16	UTSW	4	88,594,762 (GRCm39)	missense	probably benign	0.30
R9648:Ifna16	UTSW	4	88,595,060 (GRCm39)	missense	probably benign	0.18
R9688:Ifna16	UTSW	4	88,594,874 (GRCm39)	nonsense	probably null
R9743:Ifna16	UTSW	4	88,594,930 (GRCm39)	missense	probably damaging	1.00
Z1088:Ifna16	UTSW	4	88,594,615 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-02-04