Incidental Mutation 'R1303:Or51a24'
ID 158475
Institutional Source Beutler Lab
Gene Symbol Or51a24
Ensembl Gene ENSMUSG00000051340
Gene Name olfactory receptor family 51 subfamily A member 24
Synonyms GA_x6K02T2PBJ9-6819097-6818150, MOR13-5, Olfr645
MMRRC Submission 039369-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R1303 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 103733338-103734285 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 103733948 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 113 (E113G)
Ref Sequence ENSEMBL: ENSMUSP00000062821 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057104] [ENSMUST00000138055]
AlphaFold Q7TRQ1
Predicted Effect probably damaging
Transcript: ENSMUST00000057104
AA Change: E113G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062821
Gene: ENSMUSG00000051340
AA Change: E113G

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 5.4e-113 PFAM
Pfam:7TM_GPCR_Srsx 37 256 8e-8 PFAM
Pfam:7tm_1 43 295 5.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.0%
  • 20x: 88.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 11 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankfy1 A G 11: 72,640,897 (GRCm39) probably null Het
Fubp3 T A 2: 31,490,532 (GRCm39) L212H probably damaging Het
Hecw2 G T 1: 54,079,552 (GRCm39) Q34K probably benign Het
Ifnlr1 T C 4: 135,431,528 (GRCm39) I239T possibly damaging Het
Kcnh1 T C 1: 191,959,010 (GRCm39) L188P probably damaging Het
Nbl1 A G 4: 138,812,778 (GRCm39) S52P probably benign Het
Psd4 T C 2: 24,285,030 (GRCm39) V298A probably benign Het
Spata31h1 T C 10: 82,120,390 (GRCm39) T237A possibly damaging Het
Trim46 T A 3: 89,149,515 (GRCm39) T290S probably benign Het
Trpc2 T C 7: 101,737,368 (GRCm39) S387P probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Other mutations in Or51a24
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1488:Or51a24 UTSW 7 103,733,859 (GRCm39) missense probably benign
R1556:Or51a24 UTSW 7 103,733,468 (GRCm39) missense probably benign
R2158:Or51a24 UTSW 7 103,734,033 (GRCm39) missense probably benign
R2987:Or51a24 UTSW 7 103,734,077 (GRCm39) missense probably benign 0.01
R4437:Or51a24 UTSW 7 103,734,128 (GRCm39) missense possibly damaging 0.88
R4773:Or51a24 UTSW 7 103,733,502 (GRCm39) missense probably damaging 1.00
R5285:Or51a24 UTSW 7 103,733,340 (GRCm39) makesense probably null
R5396:Or51a24 UTSW 7 103,734,098 (GRCm39) missense probably benign 0.08
R5516:Or51a24 UTSW 7 103,733,444 (GRCm39) missense possibly damaging 0.53
R5761:Or51a24 UTSW 7 103,733,376 (GRCm39) missense probably benign 0.01
R5793:Or51a24 UTSW 7 103,734,237 (GRCm39) missense probably benign 0.10
R5960:Or51a24 UTSW 7 103,733,560 (GRCm39) missense probably damaging 1.00
R6242:Or51a24 UTSW 7 103,733,771 (GRCm39) missense possibly damaging 0.82
R6676:Or51a24 UTSW 7 103,733,661 (GRCm39) missense probably benign 0.02
R6975:Or51a24 UTSW 7 103,734,002 (GRCm39) missense probably benign
R8202:Or51a24 UTSW 7 103,734,198 (GRCm39) missense probably benign 0.20
R9402:Or51a24 UTSW 7 103,733,610 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCAACACGATGGACAACCCATAGTG -3'
(R):5'- GATCAATGCCTCTCAGGTTCCCAG -3'

Sequencing Primer
(F):5'- TGTCCACATGTAGACAGTAAGC -3'
(R):5'- TCTTACAGGCTTTCCAGGAATG -3'
Posted On 2014-02-18