Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01988:Zdhhc7'

182007

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zdhhc7

Ensembl Gene

ENSMUSG00000031823

Gene Name

zinc finger, DHHC domain containing 7

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

IGL01988

Quality Score

Status

Chromosome

Chromosomal Location

120807834-120828211 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 120809329 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 293 (R293G)

Ref Sequence

ENSEMBL: ENSMUSP00000034280 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034280] [ENSMUST00000127664]

AlphaFold

Q91WU6

Predicted Effect

probably benign
Transcript: ENSMUST00000034280
AA Change: R293G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000034280
Gene: ENSMUSG00000031823
AA Change: R293G

Domain	Start	End	E-Value	Type
low complexity region	25	31	N/A	INTRINSIC
transmembrane domain	39	61	N/A	INTRINSIC
transmembrane domain	76	98	N/A	INTRINSIC
Pfam:zf-DHHC	129	258	9.8e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124044

Predicted Effect

probably benign
Transcript: ENSMUST00000127664

SMART Domains

Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

Domain	Start	End	E-Value	Type
Pfam:Glycos_transf_2	104	287	7.4e-31	PFAM
Pfam:Glyco_transf_7C	261	331	4.9e-8	PFAM
RICIN	406	531	9.28e-27	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141886

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150444

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9330159F19Rik	T	A	10: 29,101,107 (GRCm39)	S493R	probably benign	Het
Abca17	T	C	17: 24,553,229 (GRCm39)	N161D	probably damaging	Het
Ace2	C	A	X: 162,946,988 (GRCm39)	N290K	possibly damaging	Het
Adam26a	G	A	8: 44,022,207 (GRCm39)	P428S	possibly damaging	Het
Adgrv1	T	C	13: 81,705,428 (GRCm39)	R1461G	probably damaging	Het
Arhgef10l	T	C	4: 140,305,672 (GRCm39)		probably benign	Het
Bicc1	A	G	10: 70,792,006 (GRCm39)	V334A	probably damaging	Het
C8a	T	C	4: 104,683,891 (GRCm39)	Y408C	probably damaging	Het
Col24a1	T	C	3: 145,229,922 (GRCm39)		probably null	Het
Copa	T	A	1: 171,945,831 (GRCm39)	N931K	probably benign	Het
Cr1l	A	G	1: 194,799,858 (GRCm39)	M272T	probably damaging	Het
Dcaf12	T	C	4: 41,298,299 (GRCm39)	N283S	probably benign	Het
Dnttip2	T	A	3: 122,069,944 (GRCm39)	S386R	probably benign	Het
Fbll1	G	T	11: 35,688,728 (GRCm39)	D178E	probably benign	Het
Fgd6	A	G	10: 93,910,197 (GRCm39)		probably benign	Het
Fyn	T	A	10: 39,409,917 (GRCm39)	L408*	probably null	Het
Gkn2	T	C	6: 87,356,257 (GRCm39)	V176A	probably benign	Het
Gm10764	G	A	10: 87,126,953 (GRCm39)	C120Y	unknown	Het
Gpr19	A	T	6: 134,846,247 (GRCm39)	F442I	probably damaging	Het
Herc1	A	G	9: 66,395,357 (GRCm39)		probably benign	Het
Il7	A	G	3: 7,669,126 (GRCm39)	Y37H	possibly damaging	Het
Kcnj3	G	A	2: 55,327,243 (GRCm39)	D11N	probably benign	Het
Kif1c	A	G	11: 70,595,762 (GRCm39)	D156G	probably damaging	Het
Lrch1	T	C	14: 75,032,813 (GRCm39)		probably benign	Het
Nedd1	G	T	10: 92,550,021 (GRCm39)	T88K	probably benign	Het
Nlrc3	T	G	16: 3,771,803 (GRCm39)	S875R	probably benign	Het
Optc	A	G	1: 133,834,667 (GRCm39)		probably null	Het
Or4a78	T	A	2: 89,497,424 (GRCm39)	I269F	probably benign	Het
Pcdh17	T	A	14: 84,684,062 (GRCm39)	D176E	probably damaging	Het
Pde1b	A	G	15: 103,433,283 (GRCm39)		probably null	Het
Phf11a	A	T	14: 59,514,807 (GRCm39)	D291E	probably damaging	Het
Slc30a8	A	T	15: 52,198,601 (GRCm39)	I349L	probably benign	Het
Spty2d1	T	A	7: 46,647,358 (GRCm39)	S524C	probably damaging	Het
Syndig1	T	C	2: 149,845,090 (GRCm39)		probably benign	Het
Syvn1	G	A	19: 6,102,437 (GRCm39)	A502T	probably benign	Het
Tenm2	A	G	11: 35,918,078 (GRCm39)	L1894P	probably damaging	Het
Tmem176a	T	A	6: 48,819,554 (GRCm39)	V11E	possibly damaging	Het
Tpr	G	T	1: 150,302,750 (GRCm39)		probably null	Het
Txnrd2	T	C	16: 18,274,768 (GRCm39)		probably benign	Het
Ubqln3	G	A	7: 103,792,089 (GRCm39)		probably benign	Het
Vmn1r6	C	T	6: 56,979,650 (GRCm39)	T82I	probably damaging	Het
Wdfy4	C	T	14: 32,798,437 (GRCm39)	E1990K	possibly damaging	Het
Zeb1	T	A	18: 5,759,037 (GRCm39)	L148*	probably null	Het

Other mutations in Zdhhc7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01757:Zdhhc7	APN	8	120,814,662 (GRCm39)	missense	probably benign
IGL03407:Zdhhc7	APN	8	120,812,131 (GRCm39)	missense	probably damaging	0.98
R0362:Zdhhc7	UTSW	8	120,813,386 (GRCm39)	missense	probably null	0.32
R0588:Zdhhc7	UTSW	8	120,810,106 (GRCm39)	intron	probably benign
R0629:Zdhhc7	UTSW	8	120,814,785 (GRCm39)	missense	possibly damaging	0.60
R1224:Zdhhc7	UTSW	8	120,809,311 (GRCm39)	missense	probably benign
R1317:Zdhhc7	UTSW	8	120,811,639 (GRCm39)	missense	probably benign	0.04
R1796:Zdhhc7	UTSW	8	120,812,157 (GRCm39)	missense	probably benign	0.04
R5891:Zdhhc7	UTSW	8	120,811,639 (GRCm39)	missense	probably benign	0.04
R6495:Zdhhc7	UTSW	8	120,813,395 (GRCm39)	missense	probably benign	0.19
R6711:Zdhhc7	UTSW	8	120,810,066 (GRCm39)	missense	probably benign	0.04
R6833:Zdhhc7	UTSW	8	120,811,663 (GRCm39)	missense	probably damaging	1.00
R7083:Zdhhc7	UTSW	8	120,812,166 (GRCm39)	missense	probably damaging	1.00
R7743:Zdhhc7	UTSW	8	120,813,467 (GRCm39)	missense	possibly damaging	0.49
R9368:Zdhhc7	UTSW	8	120,814,494 (GRCm39)	missense	probably damaging	1.00
R9401:Zdhhc7	UTSW	8	120,813,425 (GRCm39)	missense	probably benign	0.44

Posted On

2014-05-07