Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02011:Gbp10'

183358

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gbp10

Ensembl Gene

ENSMUSG00000105096

Gene Name

guanylate-binding protein 10

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL02011

Quality Score

Status

Chromosome

Chromosomal Location

105363565-105387399 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 105368967 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Tryptophan at position 291 (G291W)

Ref Sequence

ENSEMBL: ENSMUSP00000069042 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050011] [ENSMUST00000065588]

AlphaFold

Q000W5

Predicted Effect

probably benign
Transcript: ENSMUST00000050011

SMART Domains

Protein: ENSMUSP00000062528
Gene: ENSMUSG00000079362

Domain	Start	End	E-Value	Type
Pfam:GBP	16	279	7.6e-118	PFAM
Pfam:GBP_C	281	575	2.1e-117	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000065588
AA Change: G291W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000069042
Gene: ENSMUSG00000105096
AA Change: G291W

Domain	Start	End	E-Value	Type
Pfam:GBP	16	279	5e-115	PFAM
Pfam:GBP_C	281	575	3.6e-117	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196634

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap5m1	T	A	14: 49,318,592 (GRCm39)		probably benign	Het
Arg1	T	C	10: 24,792,275 (GRCm39)	T215A	probably benign	Het
Arhgap15	A	T	2: 43,670,767 (GRCm39)	K50N	probably damaging	Het
Ctdsp1	C	T	1: 74,433,175 (GRCm39)		probably benign	Het
Cwc22	A	T	2: 77,751,366 (GRCm39)	D363E	possibly damaging	Het
Drd2	G	T	9: 49,318,258 (GRCm39)	C400F	probably damaging	Het
Eef1akmt1	A	T	14: 57,795,555 (GRCm39)	Y65N	probably damaging	Het
Lrit1	T	A	14: 36,784,280 (GRCm39)	V536E	probably damaging	Het
Or4d1	C	A	11: 87,805,708 (GRCm39)	W8L	probably benign	Het
Or52ab4	G	T	7: 102,988,056 (GRCm39)	R265L	probably damaging	Het
Or9s15	T	A	1: 92,524,621 (GRCm39)	Y127N	probably damaging	Het
Pcdh12	C	T	18: 38,414,473 (GRCm39)	G884D	probably damaging	Het
Pih1d1	G	T	7: 44,806,156 (GRCm39)	A31S	probably damaging	Het
Plcxd2	T	C	16: 45,785,454 (GRCm39)	D317G	probably damaging	Het
Prkaca	T	C	8: 84,717,565 (GRCm39)	F231S	probably damaging	Het
Raet1d	T	A	10: 22,247,473 (GRCm39)	I183K	probably damaging	Het
Scaper	A	G	9: 55,487,606 (GRCm39)	F752S	probably damaging	Het
Shisa9	C	T	16: 12,062,502 (GRCm39)	T241I	possibly damaging	Het
Taar9	C	T	10: 23,984,477 (GRCm39)	R319H	possibly damaging	Het
Unkl	T	A	17: 25,437,565 (GRCm39)	V365E	probably damaging	Het
Usp34	C	T	11: 23,421,554 (GRCm39)	S3077F	probably damaging	Het
Vps16	A	G	2: 130,283,399 (GRCm39)	I566V	probably benign	Het
Vrk2	T	A	11: 26,421,717 (GRCm39)	T414S	probably benign	Het
Xpnpep1	A	T	19: 52,990,896 (GRCm39)		probably benign	Het
Zfp804a	A	G	2: 82,087,035 (GRCm39)	Q288R	probably damaging	Het

Other mutations in Gbp10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01470:Gbp10	APN	5	105,368,980 (GRCm39)	splice site	probably benign
IGL01680:Gbp10	APN	5	105,372,137 (GRCm39)	splice site	probably null
IGL01809:Gbp10	APN	5	105,365,225 (GRCm39)	missense	probably benign
IGL01845:Gbp10	APN	5	105,367,815 (GRCm39)	splice site	probably null
IGL02063:Gbp10	APN	5	105,383,906 (GRCm39)	missense	possibly damaging	0.95
IGL02533:Gbp10	APN	5	105,367,901 (GRCm39)	missense	probably damaging	1.00
IGL02612:Gbp10	APN	5	105,366,368 (GRCm39)	missense	possibly damaging	0.88
R0349:Gbp10	UTSW	5	105,368,942 (GRCm39)	missense	possibly damaging	0.60
R0462:Gbp10	UTSW	5	105,366,390 (GRCm39)	missense	possibly damaging	0.67
R0535:Gbp10	UTSW	5	105,368,877 (GRCm39)	missense	possibly damaging	0.95
R1223:Gbp10	UTSW	5	105,366,867 (GRCm39)	missense	probably damaging	1.00
R1704:Gbp10	UTSW	5	105,372,217 (GRCm39)	missense	probably damaging	1.00
R1792:Gbp10	UTSW	5	105,372,166 (GRCm39)	missense	probably damaging	1.00
R3738:Gbp10	UTSW	5	105,372,324 (GRCm39)	missense	possibly damaging	0.84
R3739:Gbp10	UTSW	5	105,372,324 (GRCm39)	missense	possibly damaging	0.84
R4035:Gbp10	UTSW	5	105,372,324 (GRCm39)	missense	possibly damaging	0.84
R4421:Gbp10	UTSW	5	105,372,517 (GRCm39)	splice site	probably null
R5207:Gbp10	UTSW	5	105,372,575 (GRCm39)	missense	probably benign	0.05
R5338:Gbp10	UTSW	5	105,372,166 (GRCm39)	missense	probably damaging	1.00
R6010:Gbp10	UTSW	5	105,372,205 (GRCm39)	missense	probably damaging	1.00
R6045:Gbp10	UTSW	5	105,366,269 (GRCm39)	missense	probably damaging	0.98
R6156:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R6285:Gbp10	UTSW	5	105,366,326 (GRCm39)	missense	probably damaging	1.00
R6525:Gbp10	UTSW	5	105,383,950 (GRCm39)	missense	probably benign	0.01
R6908:Gbp10	UTSW	5	105,368,898 (GRCm39)	missense	probably damaging	0.97
R7339:Gbp10	UTSW	5	105,367,964 (GRCm39)	missense	possibly damaging	0.77
R7396:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7397:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7399:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7554:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7555:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7574:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7575:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7576:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7577:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7578:Gbp10	UTSW	5	105,384,015 (GRCm39)	start gained	probably benign
R7975:Gbp10	UTSW	5	105,368,967 (GRCm39)	missense	probably benign	0.20
R8293:Gbp10	UTSW	5	105,372,235 (GRCm39)	missense	probably damaging	1.00
R8708:Gbp10	UTSW	5	105,368,831 (GRCm39)	missense	probably damaging	1.00
R9002:Gbp10	UTSW	5	105,369,847 (GRCm39)	missense	probably benign	0.00
R9086:Gbp10	UTSW	5	105,366,369 (GRCm39)	missense	probably benign	0.00
R9149:Gbp10	UTSW	5	105,366,861 (GRCm39)	missense	probably damaging	0.98
R9402:Gbp10	UTSW	5	105,381,863 (GRCm39)	missense	possibly damaging	0.82
R9582:Gbp10	UTSW	5	105,372,256 (GRCm39)	missense	probably benign	0.05

Posted On

2014-05-07