Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02124:Fcrlb'

280750

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fcrlb

Ensembl Gene

ENSMUSG00000070524

Gene Name

Fc receptor-like B

Synonyms

Fcry, FcRL2, FREB2, mFCRL2, FREB-2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02124

Quality Score

Status

Chromosome

Chromosomal Location

170734842-170740510 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 170734927 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Valine at position 400 (E400V)

Ref Sequence

ENSEMBL: ENSMUSP00000091895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094337]

AlphaFold

Q5DRQ8

Predicted Effect

probably benign
Transcript: ENSMUST00000094337
AA Change: E400V

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000091895
Gene: ENSMUSG00000070524
AA Change: E400V

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
IG_like	29	101	1.17e1	SMART
IG	109	191	9.34e-4	SMART
Blast:IG_like	209	281	2e-38	BLAST
low complexity region	290	306	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit an enhanced antibody response to a T-dependent antigen. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810024B03Rik	T	C	2: 127,028,654 (GRCm39)	R182G	possibly damaging	Het
Casd1	A	T	6: 4,624,142 (GRCm39)	I312F	probably benign	Het
Cdc27	T	C	11: 104,413,557 (GRCm39)	T395A	probably damaging	Het
Cep152	A	G	2: 125,405,381 (GRCm39)	I1717T	probably benign	Het
Ces1f	A	T	8: 93,992,488 (GRCm39)	V321E	possibly damaging	Het
Chrnb3	T	C	8: 27,886,832 (GRCm39)		probably benign	Het
Col14a1	T	A	15: 55,327,099 (GRCm39)	F1416L	unknown	Het
Cplx4	T	C	18: 66,103,123 (GRCm39)		probably benign	Het
Cubn	A	T	2: 13,386,648 (GRCm39)	I1539N	probably damaging	Het
Dapk1	A	G	13: 60,878,696 (GRCm39)	T562A	probably benign	Het
Dnmt1	C	A	9: 20,819,845 (GRCm39)	V1433F	probably damaging	Het
Dytn	A	G	1: 63,680,251 (GRCm39)	L436P	probably damaging	Het
Evpl	T	C	11: 116,117,841 (GRCm39)	I783V	probably benign	Het
Fat4	T	A	3: 38,942,553 (GRCm39)	V482E	probably damaging	Het
Folh1	T	C	7: 86,374,626 (GRCm39)	D656G	probably damaging	Het
Frem3	A	C	8: 81,339,723 (GRCm39)	D672A	probably damaging	Het
G3bp2	A	G	5: 92,221,106 (GRCm39)	M3T	possibly damaging	Het
Gm973	C	T	1: 59,621,632 (GRCm39)	Q26*	probably null	Het
Hsp90b1	T	C	10: 86,541,222 (GRCm39)		probably benign	Het
Hspg2	G	A	4: 137,246,125 (GRCm39)		probably null	Het
Lpin3	T	C	2: 160,737,753 (GRCm39)		probably null	Het
Mtss2	G	A	8: 111,464,256 (GRCm39)	R295Q	probably damaging	Het
Muc5b	G	T	7: 141,409,369 (GRCm39)	W1151L	unknown	Het
Myo3a	A	G	2: 22,467,538 (GRCm39)	Y264C	probably benign	Het
Or4c123	A	G	2: 89,127,407 (GRCm39)	V69A	probably benign	Het
Or55b3	T	C	7: 102,126,742 (GRCm39)	T112A	possibly damaging	Het
Or5p60	T	A	7: 107,724,249 (GRCm39)	I74L	probably benign	Het
Pecam1	C	T	11: 106,581,807 (GRCm39)	G380S	probably damaging	Het
Phf21a	C	T	2: 92,179,767 (GRCm39)	T345I	probably damaging	Het
Polg	G	A	7: 79,109,485 (GRCm39)	S444L	probably damaging	Het
Prickle1	A	G	15: 93,401,027 (GRCm39)	Y486H	probably damaging	Het
Scg5	G	A	2: 113,622,382 (GRCm39)		probably benign	Het
Septin5	G	T	16: 18,443,579 (GRCm39)	D123E	probably damaging	Het
Skint6	G	A	4: 112,944,993 (GRCm39)	T483I	probably benign	Het
Tep1	A	T	14: 51,091,581 (GRCm39)		probably benign	Het
Tepsin	T	C	11: 119,982,547 (GRCm39)	R440G	probably benign	Het
Tmem214	G	A	5: 31,030,090 (GRCm39)	A296T	probably benign	Het
Trpm4	A	T	7: 44,959,947 (GRCm39)	V649E	probably damaging	Het
Usf3	C	A	16: 44,040,019 (GRCm39)	Q1500K	possibly damaging	Het
Vmn1r231	T	C	17: 21,110,568 (GRCm39)	S116G	probably damaging	Het
Vmn1r45	T	A	6: 89,910,035 (GRCm39)	I312L	probably benign	Het

Other mutations in Fcrlb

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Fcrlb	APN	1	170,736,393 (GRCm39)	missense	possibly damaging	0.81
IGL02142:Fcrlb	APN	1	170,736,248 (GRCm39)	missense	probably damaging	1.00
IGL02385:Fcrlb	APN	1	170,735,168 (GRCm39)	missense	probably damaging	0.99
R0928:Fcrlb	UTSW	1	170,735,509 (GRCm39)	missense	possibly damaging	0.87
R1460:Fcrlb	UTSW	1	170,739,853 (GRCm39)	splice site	probably benign
R1735:Fcrlb	UTSW	1	170,734,901 (GRCm39)	missense	probably benign
R1806:Fcrlb	UTSW	1	170,735,096 (GRCm39)	missense	probably benign	0.01
R2078:Fcrlb	UTSW	1	170,735,650 (GRCm39)	missense	probably damaging	1.00
R3806:Fcrlb	UTSW	1	170,735,183 (GRCm39)	missense	probably benign	0.00
R4570:Fcrlb	UTSW	1	170,740,189 (GRCm39)	critical splice donor site	probably null
R5457:Fcrlb	UTSW	1	170,739,726 (GRCm39)	missense	probably damaging	0.99
R5854:Fcrlb	UTSW	1	170,735,530 (GRCm39)	missense	probably damaging	1.00
R6233:Fcrlb	UTSW	1	170,736,458 (GRCm39)	missense	probably damaging	1.00
R7502:Fcrlb	UTSW	1	170,736,210 (GRCm39)	missense	probably damaging	0.98
R7579:Fcrlb	UTSW	1	170,735,416 (GRCm39)	splice site	probably null
R7879:Fcrlb	UTSW	1	170,736,365 (GRCm39)	missense	probably damaging	1.00
R8287:Fcrlb	UTSW	1	170,739,653 (GRCm39)	missense	probably damaging	1.00
R8696:Fcrlb	UTSW	1	170,739,648 (GRCm39)	missense	probably damaging	1.00
R8957:Fcrlb	UTSW	1	170,735,536 (GRCm39)	missense	probably benign	0.28
R9036:Fcrlb	UTSW	1	170,734,938 (GRCm39)	missense	probably benign
R9629:Fcrlb	UTSW	1	170,739,735 (GRCm39)	missense	probably benign	0.13
R9706:Fcrlb	UTSW	1	170,735,474 (GRCm39)	missense	possibly damaging	0.86

Posted On

2015-04-16