Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02158:Or8b101'

282294

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or8b101

Ensembl Gene

ENSMUSG00000095527

Gene Name

olfactory receptor family 8 subfamily B member 101

Synonyms

Olfr888, GA_x6K02T2PVTD-31787920-31788864, MOR162-4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

IGL02158

Quality Score

Status

Chromosome

Chromosomal Location

38019984-38020928 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 38020425 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 148 (M148V)

Ref Sequence

ENSEMBL: ENSMUSP00000074713 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075228] [ENSMUST00000211851]

AlphaFold

Q9EQA5

Predicted Effect

probably benign
Transcript: ENSMUST00000075228
AA Change: M148V

PolyPhen 2 Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000074713
Gene: ENSMUSG00000095527
AA Change: M148V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	36	311	8.8e-49	PFAM
Pfam:7tm_1	46	293	3.9e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000211851
AA Change: M143V

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	A	T	9: 57,163,902 (GRCm39)		probably null	Het
Abca2	A	G	2: 25,337,891 (GRCm39)		probably benign	Het
Abcb11	A	T	2: 69,130,269 (GRCm39)	S262R	probably damaging	Het
Abhd12	T	A	2: 150,690,341 (GRCm39)	Q118L	probably benign	Het
Adam1a	A	T	5: 121,657,034 (GRCm39)	L753*	probably null	Het
Ahctf1	A	T	1: 179,607,217 (GRCm39)	I699N	possibly damaging	Het
Arl11	C	A	14: 61,548,487 (GRCm39)	A99E	probably damaging	Het
Atp5po	G	A	16: 91,727,289 (GRCm39)	R16W	probably damaging	Het
AW551984	T	C	9: 39,510,621 (GRCm39)	H238R	probably null	Het
Bpifb9a	C	A	2: 154,108,733 (GRCm39)		probably benign	Het
Carhsp1	A	G	16: 8,481,577 (GRCm39)		probably benign	Het
Ccdc33	T	C	9: 57,937,702 (GRCm39)	D623G	probably damaging	Het
Chd6	C	A	2: 160,868,212 (GRCm39)	R378L	possibly damaging	Het
Chn2	T	C	6: 54,277,230 (GRCm39)		probably benign	Het
Clgn	T	G	8: 84,149,765 (GRCm39)	I422S	probably damaging	Het
Col15a1	T	A	4: 47,300,606 (GRCm39)		probably null	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cyp2c39	T	C	19: 39,556,574 (GRCm39)	I470T	probably benign	Het
Dcaf11	T	A	14: 55,801,980 (GRCm39)		probably null	Het
Dnah1	G	T	14: 31,022,924 (GRCm39)	T1071K	probably benign	Het
Dnah2	T	A	11: 69,348,949 (GRCm39)	M2513L	probably benign	Het
Dqx1	A	G	6: 83,035,891 (GRCm39)		probably benign	Het
Gm1587	T	C	14: 78,036,282 (GRCm39)	E8G	unknown	Het
Hydin	T	C	8: 111,336,598 (GRCm39)	I5125T	possibly damaging	Het
Ighv5-9	G	T	12: 113,625,563 (GRCm39)	P60Q	probably damaging	Het
Itga7	T	G	10: 128,789,651 (GRCm39)	L993R	possibly damaging	Het
Itpr3	A	G	17: 27,317,416 (GRCm39)	N857S	probably damaging	Het
Krt23	C	T	11: 99,383,490 (GRCm39)		probably benign	Het
Lrp1	T	C	10: 127,390,140 (GRCm39)	N3093S	probably benign	Het
Mms22l	T	C	4: 24,505,349 (GRCm39)	F203S	probably damaging	Het
Morn5	A	G	2: 35,947,088 (GRCm39)	D122G	probably damaging	Het
Mpp2	G	T	11: 101,954,088 (GRCm39)	L220I	probably benign	Het
Mrgpra6	A	T	7: 46,835,700 (GRCm39)	Y240*	probably null	Het
Mtmr12	T	C	15: 12,238,016 (GRCm39)	I165T	probably damaging	Het
Mylk2	C	A	2: 152,761,077 (GRCm39)	N428K	probably damaging	Het
Nfil3	A	G	13: 53,122,188 (GRCm39)	Y239H	probably damaging	Het
Notch1	A	G	2: 26,350,351 (GRCm39)	L2263P	probably damaging	Het
Or2g7	T	A	17: 38,378,158 (GRCm39)	I32N	probably damaging	Het
P3h3	A	T	6: 124,830,055 (GRCm39)	Y387N	probably damaging	Het
Pdcd6ip	A	T	9: 113,509,121 (GRCm39)	Y324*	probably null	Het
Plcb2	C	A	2: 118,541,844 (GRCm39)	R922L	probably benign	Het
Pml	T	C	9: 58,154,286 (GRCm39)	T196A	probably benign	Het
Ppp2r1b	C	A	9: 50,772,909 (GRCm39)	Q65K	probably benign	Het
Ric8a	A	G	7: 140,442,270 (GRCm39)	T507A	probably benign	Het
Sec16a	A	G	2: 26,306,644 (GRCm39)		probably null	Het
Slc46a3	G	T	5: 147,823,044 (GRCm39)	T266N	probably damaging	Het
Smg1	A	G	7: 117,812,169 (GRCm39)	S41P	possibly damaging	Het
Snrnp200	T	A	2: 127,079,403 (GRCm39)	N1837K	probably benign	Het
Sptan1	A	G	2: 29,920,336 (GRCm39)	T2318A	probably damaging	Het
St7l	C	T	3: 104,782,148 (GRCm39)	T175I	possibly damaging	Het
Tmc7	G	A	7: 118,137,434 (GRCm39)	R703C	probably damaging	Het
Urah	A	G	7: 140,416,799 (GRCm39)		probably benign	Het
Vmn1r42	A	T	6: 89,822,296 (GRCm39)	I91N	probably damaging	Het
Yy1	T	A	12: 108,780,525 (GRCm39)		probably benign	Het

Other mutations in Or8b101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01384:Or8b101	APN	9	38,020,858 (GRCm39)	missense	probably damaging	1.00
IGL02713:Or8b101	APN	9	38,020,623 (GRCm39)	missense	probably damaging	0.99
BB007:Or8b101	UTSW	9	38,020,264 (GRCm39)	missense	possibly damaging	0.60
BB017:Or8b101	UTSW	9	38,020,264 (GRCm39)	missense	possibly damaging	0.60
R0007:Or8b101	UTSW	9	38,020,390 (GRCm39)	missense	possibly damaging	0.94
R0125:Or8b101	UTSW	9	38,020,815 (GRCm39)	missense	probably benign	0.03
R0310:Or8b101	UTSW	9	38,020,782 (GRCm39)	missense	possibly damaging	0.54
R1671:Or8b101	UTSW	9	38,020,428 (GRCm39)	missense	probably benign
R3687:Or8b101	UTSW	9	38,020,177 (GRCm39)	missense	probably damaging	1.00
R3704:Or8b101	UTSW	9	38,020,299 (GRCm39)	missense	possibly damaging	0.95
R3708:Or8b101	UTSW	9	38,020,740 (GRCm39)	missense	probably damaging	0.99
R3824:Or8b101	UTSW	9	38,020,134 (GRCm39)	missense	possibly damaging	0.71
R3825:Or8b101	UTSW	9	38,020,134 (GRCm39)	missense	possibly damaging	0.71
R4254:Or8b101	UTSW	9	38,020,546 (GRCm39)	missense	probably damaging	1.00
R4828:Or8b101	UTSW	9	38,020,036 (GRCm39)	missense	probably damaging	0.98
R7265:Or8b101	UTSW	9	38,020,227 (GRCm39)	missense	possibly damaging	0.78
R7918:Or8b101	UTSW	9	38,020,103 (GRCm39)	nonsense	probably null
R7930:Or8b101	UTSW	9	38,020,264 (GRCm39)	missense	possibly damaging	0.60
R8062:Or8b101	UTSW	9	38,020,213 (GRCm39)	missense	probably damaging	1.00
R8355:Or8b101	UTSW	9	38,020,258 (GRCm39)	missense	probably benign	0.00
R9213:Or8b101	UTSW	9	38,020,426 (GRCm39)	missense	possibly damaging	0.69
R9250:Or8b101	UTSW	9	38,020,718 (GRCm39)	nonsense	probably null
Z1088:Or8b101	UTSW	9	38,020,882 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16