Incidental Mutation 'IGL02214:Morn1'
ID284796
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Morn1
Ensembl Gene ENSMUSG00000029049
Gene NameMORN repeat containing 1
Synonyms2900057D20Rik, 4930417P05Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02214
Quality Score
Status
Chromosome4
Chromosomal Location155086577-155145505 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 155092319 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Tyrosine at position 100 (H100Y)
Ref Sequence ENSEMBL: ENSMUSP00000123207 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030915] [ENSMUST00000127457] [ENSMUST00000132367] [ENSMUST00000155775]
Predicted Effect possibly damaging
Transcript: ENSMUST00000030915
AA Change: H137Y

PolyPhen 2 Score 0.921 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000030915
Gene: ENSMUSG00000029049
AA Change: H137Y

DomainStartEndE-ValueType
Pfam:MORN 23 35 1.4e-3 PFAM
MORN 37 58 4.11e-6 SMART
MORN 60 81 2.41e-1 SMART
MORN 84 105 1.43e-1 SMART
MORN 107 128 8.05e0 SMART
MORN 130 151 2.06e-6 SMART
MORN 153 174 7.56e-5 SMART
MORN 176 197 1.2e0 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000127457
AA Change: H137Y

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000116690
Gene: ENSMUSG00000029049
AA Change: H137Y

DomainStartEndE-ValueType
Pfam:MORN 23 35 5.5e-4 PFAM
MORN 37 58 4.11e-6 SMART
MORN 60 81 2.41e-1 SMART
MORN 84 105 1.43e-1 SMART
MORN 107 128 8.05e0 SMART
MORN 130 151 2.06e-6 SMART
MORN 153 174 7.56e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129180
Predicted Effect possibly damaging
Transcript: ENSMUST00000132367
AA Change: H137Y

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000116794
Gene: ENSMUSG00000029049
AA Change: H137Y

DomainStartEndE-ValueType
Pfam:MORN 23 35 6.8e-4 PFAM
MORN 37 58 4.11e-6 SMART
MORN 60 81 2.41e-1 SMART
MORN 84 105 1.43e-1 SMART
MORN 107 128 8.05e0 SMART
MORN 130 151 2.06e-6 SMART
MORN 153 174 7.56e-5 SMART
MORN 176 197 1.2e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155375
Predicted Effect probably damaging
Transcript: ENSMUST00000155775
AA Change: H100Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000123207
Gene: ENSMUSG00000029049
AA Change: H100Y

DomainStartEndE-ValueType
Pfam:MORN 23 35 2.7e-4 PFAM
MORN 37 58 4.11e-6 SMART
MORN 60 81 2.41e-1 SMART
MORN 93 114 2.06e-6 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430097D07Rik T C 2: 32,574,724 probably benign Het
A330008L17Rik T A 8: 99,421,758 noncoding transcript Het
A930004D18Rik A G 2: 18,027,256 L17P unknown Het
Abca14 A T 7: 120,294,175 M1283L probably benign Het
Adarb1 A T 10: 77,322,301 V104E probably damaging Het
Ano1 T A 7: 144,655,708 N252Y possibly damaging Het
Atp6v0a1 A G 11: 101,039,840 S498G probably benign Het
Bdp1 A G 13: 100,041,535 V1942A probably benign Het
Carf T A 1: 60,148,081 D579E probably damaging Het
Cltc A T 11: 86,732,586 S200R probably benign Het
Cpeb1 T C 7: 81,372,057 S113G possibly damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Ehd3 T A 17: 73,820,546 L158H probably damaging Het
Etfa C A 9: 55,464,811 G289W probably damaging Het
Fndc3c1 G A X: 106,425,829 T1029I probably benign Het
Gipr C A 7: 19,157,546 G402V possibly damaging Het
Gm5724 T A 6: 141,723,185 D507V possibly damaging Het
Hacd1 C T 2: 14,026,947 V242M probably damaging Het
Hecw1 A G 13: 14,300,393 L520P probably damaging Het
Ibtk A T 9: 85,714,179 probably benign Het
Igkv16-104 A C 6: 68,425,794 I24L probably benign Het
Kcnh8 A T 17: 52,877,911 Y407F possibly damaging Het
Mansc1 C T 6: 134,610,360 V285M probably benign Het
Mindy4 A G 6: 55,216,651 R110G possibly damaging Het
Naip6 A T 13: 100,316,059 S165T probably damaging Het
Olfr1110 T G 2: 87,135,505 K272T probably damaging Het
Olfr538 A T 7: 140,574,557 R135* probably null Het
Prx G T 7: 27,518,912 R946M probably damaging Het
Ptchd1 A G X: 155,573,710 V833A possibly damaging Het
Rgl2 A G 17: 33,935,189 D481G probably benign Het
Serpinb3a A G 1: 107,048,488 probably null Het
Shtn1 T C 19: 58,999,886 probably benign Het
Sult1b1 C T 5: 87,535,090 probably benign Het
Tbl3 T C 17: 24,704,132 probably benign Het
Trappc9 C T 15: 73,012,882 W416* probably null Het
Ubr4 G A 4: 139,461,827 probably null Het
Ubr4 T C 4: 139,428,583 Y2240H possibly damaging Het
Vmn2r76 A C 7: 86,229,930 F387L probably benign Het
Vps8 G A 16: 21,517,285 C729Y probably damaging Het
Other mutations in Morn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00471:Morn1 APN 4 155092328 missense possibly damaging 0.81
IGL01143:Morn1 APN 4 155092304 missense probably damaging 1.00
IGL03112:Morn1 APN 4 155093144 missense probably damaging 1.00
R0091:Morn1 UTSW 4 155145172 missense probably damaging 1.00
R0573:Morn1 UTSW 4 155111016 missense possibly damaging 0.87
R0639:Morn1 UTSW 4 155089503 missense possibly damaging 0.92
R0918:Morn1 UTSW 4 155087471 missense probably damaging 1.00
R2041:Morn1 UTSW 4 155090942 missense probably damaging 1.00
R2360:Morn1 UTSW 4 155092313 missense probably damaging 0.98
R5831:Morn1 UTSW 4 155101276 missense probably benign 0.02
R6897:Morn1 UTSW 4 155086655 missense probably benign 0.06
Posted On2015-04-16