Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02214:Morn1'

284796

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Morn1

Ensembl Gene

ENSMUSG00000029049

Gene Name

MORN repeat containing 1

Synonyms

4930417P05Rik, 2900057D20Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02214

Quality Score

Status

Chromosome

Chromosomal Location

155171034-155229962 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 155176776 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Tyrosine at position 100 (H100Y)

Ref Sequence

ENSEMBL: ENSMUSP00000123207 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030915] [ENSMUST00000127457] [ENSMUST00000132367] [ENSMUST00000155775]

AlphaFold

A2RTS7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000030915
AA Change: H137Y

PolyPhen 2 Score 0.921 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000030915
Gene: ENSMUSG00000029049
AA Change: H137Y

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	1.4e-3	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	84	105	1.43e-1	SMART
MORN	107	128	8.05e0	SMART
MORN	130	151	2.06e-6	SMART
MORN	153	174	7.56e-5	SMART
MORN	176	197	1.2e0	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000127457
AA Change: H137Y

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000116690
Gene: ENSMUSG00000029049
AA Change: H137Y

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	5.5e-4	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	84	105	1.43e-1	SMART
MORN	107	128	8.05e0	SMART
MORN	130	151	2.06e-6	SMART
MORN	153	174	7.56e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129180

Predicted Effect

possibly damaging
Transcript: ENSMUST00000132367
AA Change: H137Y

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000116794
Gene: ENSMUSG00000029049
AA Change: H137Y

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	6.8e-4	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	84	105	1.43e-1	SMART
MORN	107	128	8.05e0	SMART
MORN	130	151	2.06e-6	SMART
MORN	153	174	7.56e-5	SMART
MORN	176	197	1.2e0	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155375

Predicted Effect

probably damaging
Transcript: ENSMUST00000155775
AA Change: H100Y

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000123207
Gene: ENSMUSG00000029049
AA Change: H100Y

Domain	Start	End	E-Value	Type
Pfam:MORN	23	35	2.7e-4	PFAM
MORN	37	58	4.11e-6	SMART
MORN	60	81	2.41e-1	SMART
MORN	93	114	2.06e-6	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9430097D07Rik	T	C	2: 32,464,736 (GRCm39)		probably benign	Het
A330008L17Rik	T	A	8: 100,148,390 (GRCm39)		noncoding transcript	Het
A930004D18Rik	A	G	2: 18,032,067 (GRCm39)	L17P	unknown	Het
Abca14	A	T	7: 119,893,398 (GRCm39)	M1283L	probably benign	Het
Adarb1	A	T	10: 77,158,135 (GRCm39)	V104E	probably damaging	Het
Ano1	T	A	7: 144,209,445 (GRCm39)	N252Y	possibly damaging	Het
Atp6v0a1	A	G	11: 100,930,666 (GRCm39)	S498G	probably benign	Het
Bdp1	A	G	13: 100,178,043 (GRCm39)	V1942A	probably benign	Het
Carf	T	A	1: 60,187,240 (GRCm39)	D579E	probably damaging	Het
Cltc	A	T	11: 86,623,412 (GRCm39)	S200R	probably benign	Het
Cpeb1	T	C	7: 81,021,805 (GRCm39)	S113G	possibly damaging	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Ehd3	T	A	17: 74,127,541 (GRCm39)	L158H	probably damaging	Het
Etfa	C	A	9: 55,372,095 (GRCm39)	G289W	probably damaging	Het
Fndc3c1	G	A	X: 105,469,435 (GRCm39)	T1029I	probably benign	Het
Gipr	C	A	7: 18,891,471 (GRCm39)	G402V	possibly damaging	Het
Hacd1	C	T	2: 14,031,758 (GRCm39)	V242M	probably damaging	Het
Hecw1	A	G	13: 14,474,978 (GRCm39)	L520P	probably damaging	Het
Ibtk	A	T	9: 85,596,232 (GRCm39)		probably benign	Het
Igkv16-104	A	C	6: 68,402,778 (GRCm39)	I24L	probably benign	Het
Kcnh8	A	T	17: 53,184,939 (GRCm39)	Y407F	possibly damaging	Het
Mansc1	C	T	6: 134,587,323 (GRCm39)	V285M	probably benign	Het
Mindy4	A	G	6: 55,193,636 (GRCm39)	R110G	possibly damaging	Het
Naip6	A	T	13: 100,452,567 (GRCm39)	S165T	probably damaging	Het
Or13a24	A	T	7: 140,154,470 (GRCm39)	R135*	probably null	Het
Or5aq1	T	G	2: 86,965,849 (GRCm39)	K272T	probably damaging	Het
Prx	G	T	7: 27,218,337 (GRCm39)	R946M	probably damaging	Het
Ptchd1	A	G	X: 154,356,706 (GRCm39)	V833A	possibly damaging	Het
Rgl2	A	G	17: 34,154,163 (GRCm39)	D481G	probably benign	Het
Serpinb3a	A	G	1: 106,976,218 (GRCm39)		probably null	Het
Shtn1	T	C	19: 58,988,318 (GRCm39)		probably benign	Het
Slco1a7	T	A	6: 141,668,911 (GRCm39)	D507V	possibly damaging	Het
Sult1b1	C	T	5: 87,682,949 (GRCm39)		probably benign	Het
Tbl3	T	C	17: 24,923,106 (GRCm39)		probably benign	Het
Trappc9	C	T	15: 72,884,731 (GRCm39)	W416*	probably null	Het
Ubr4	T	C	4: 139,155,894 (GRCm39)	Y2240H	possibly damaging	Het
Ubr4	G	A	4: 139,189,138 (GRCm39)		probably null	Het
Vmn2r76	A	C	7: 85,879,138 (GRCm39)	F387L	probably benign	Het
Vps8	G	A	16: 21,336,035 (GRCm39)	C729Y	probably damaging	Het

Other mutations in Morn1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00471:Morn1	APN	4	155,176,785 (GRCm39)	missense	possibly damaging	0.81
IGL01143:Morn1	APN	4	155,176,761 (GRCm39)	missense	probably damaging	1.00
IGL03112:Morn1	APN	4	155,177,601 (GRCm39)	missense	probably damaging	1.00
R0091:Morn1	UTSW	4	155,229,629 (GRCm39)	missense	probably damaging	1.00
R0573:Morn1	UTSW	4	155,195,473 (GRCm39)	missense	possibly damaging	0.87
R0639:Morn1	UTSW	4	155,173,960 (GRCm39)	missense	possibly damaging	0.92
R0918:Morn1	UTSW	4	155,171,928 (GRCm39)	missense	probably damaging	1.00
R2041:Morn1	UTSW	4	155,175,399 (GRCm39)	missense	probably damaging	1.00
R2360:Morn1	UTSW	4	155,176,770 (GRCm39)	missense	probably damaging	0.98
R5831:Morn1	UTSW	4	155,185,733 (GRCm39)	missense	probably benign	0.02
R6897:Morn1	UTSW	4	155,171,112 (GRCm39)	missense	probably benign	0.06
R8178:Morn1	UTSW	4	155,213,160 (GRCm39)	missense	probably benign	0.00
R8505:Morn1	UTSW	4	155,177,792 (GRCm39)	missense	unknown

Posted On

2015-04-16