Incidental Mutation 'IGL02325:Cuedc1'
ID288447
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cuedc1
Ensembl Gene ENSMUSG00000018378
Gene NameCUE domain containing 1
SynonymsC330016O16Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02325
Quality Score
Status
Chromosome11
Chromosomal Location88098058-88194140 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 88170173 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Valine at position 114 (E114V)
Ref Sequence ENSEMBL: ENSMUSP00000018522 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018522] [ENSMUST00000154812]
Predicted Effect probably null
Transcript: ENSMUST00000018522
AA Change: E114V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000018522
Gene: ENSMUSG00000018378
AA Change: E114V

DomainStartEndE-ValueType
low complexity region 6 33 N/A INTRINSIC
CUE 50 92 6.55e-15 SMART
low complexity region 94 110 N/A INTRINSIC
low complexity region 121 136 N/A INTRINSIC
low complexity region 207 222 N/A INTRINSIC
low complexity region 331 340 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133149
Predicted Effect probably damaging
Transcript: ENSMUST00000154812
AA Change: E114V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000120867
Gene: ENSMUSG00000018378
AA Change: E114V

DomainStartEndE-ValueType
low complexity region 6 33 N/A INTRINSIC
CUE 50 92 6.55e-15 SMART
low complexity region 94 110 N/A INTRINSIC
low complexity region 121 136 N/A INTRINSIC
low complexity region 207 222 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acads A T 5: 115,111,954 I233N probably damaging Het
Agtpbp1 C T 13: 59,500,489 G393S probably benign Het
Ahctf1 T C 1: 179,776,015 D822G probably benign Het
Alpk1 T C 3: 127,679,903 N817S probably benign Het
Aoah G A 13: 20,917,125 E272K probably damaging Het
Aoc1 A G 6: 48,905,895 D235G possibly damaging Het
Ccdc186 G T 19: 56,813,356 Q110K probably benign Het
Celsr2 G T 3: 108,412,871 T875K probably damaging Het
Chdh T C 14: 30,032,825 V264A probably benign Het
Col15a1 A G 4: 47,289,364 T854A probably damaging Het
Ddx23 A T 15: 98,647,193 D677E possibly damaging Het
Ddx24 A G 12: 103,416,266 V640A probably damaging Het
Ddx25 T C 9: 35,554,508 probably benign Het
Ddx43 T C 9: 78,402,490 probably benign Het
Diaph1 T C 18: 37,853,600 K1111E probably damaging Het
Dnah9 T C 11: 65,834,217 D4370G probably damaging Het
Eef1e1 A T 13: 38,656,036 probably benign Het
Egfem1 T C 3: 29,151,917 I101T probably benign Het
Gpr142 G T 11: 114,806,121 L164F probably damaging Het
Gtf2h5 T A 17: 6,080,831 probably null Het
Hap1 T A 11: 100,354,364 probably null Het
Hemgn T G 4: 46,396,085 I384L probably benign Het
Ints3 A T 3: 90,404,042 H419Q probably damaging Het
Itgb2 T C 10: 77,547,192 L132P probably damaging Het
Krtap29-1 C T 11: 99,978,333 V241M probably damaging Het
Lrguk A G 6: 34,129,179 E713G probably benign Het
Lrrk2 G T 15: 91,726,308 probably null Het
Nlrp14 A G 7: 107,182,316 D240G possibly damaging Het
Olfr1113 G T 2: 87,213,506 G205W probably damaging Het
Omt2b A T 9: 78,328,572 T60S possibly damaging Het
Pcdhb2 A G 18: 37,296,680 N569D possibly damaging Het
Plcd3 G A 11: 103,080,621 R66* probably null Het
Polr1a G A 6: 71,920,657 R212Q probably benign Het
Pou3f2 A T 4: 22,487,020 L371Q probably damaging Het
Rnf207 A T 4: 152,311,780 I509N probably damaging Het
Sema5a T G 15: 32,686,831 S1030A possibly damaging Het
Shank1 C A 7: 44,327,080 S534* probably null Het
Sntg2 T C 12: 30,195,543 T495A probably benign Het
Spem2 A T 11: 69,816,963 V392D probably benign Het
Srrm2 T A 17: 23,810,479 probably benign Het
Tbc1d8 A T 1: 39,394,240 F287Y probably damaging Het
Tgfbi A G 13: 56,631,230 D422G probably benign Het
Tppp G A 13: 74,021,176 A12T probably benign Het
Usp46 C T 5: 74,037,028 probably null Het
Zdhhc12 C T 2: 30,091,436 V205I probably damaging Het
Other mutations in Cuedc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Cuedc1 APN 11 88183254 missense possibly damaging 0.56
IGL02103:Cuedc1 APN 11 88188799 missense probably damaging 0.99
IGL03001:Cuedc1 APN 11 88182489 missense probably benign 0.02
IGL03245:Cuedc1 APN 11 88177262 splice site probably benign
R0242:Cuedc1 UTSW 11 88184621 splice site probably benign
R0511:Cuedc1 UTSW 11 88183405 missense probably damaging 1.00
R1013:Cuedc1 UTSW 11 88188027 missense possibly damaging 0.68
R1382:Cuedc1 UTSW 11 88177363 missense probably benign 0.08
R2004:Cuedc1 UTSW 11 88177390 missense probably damaging 1.00
R5320:Cuedc1 UTSW 11 88177310 missense probably damaging 1.00
R5381:Cuedc1 UTSW 11 88187986 splice site probably null
R5782:Cuedc1 UTSW 11 88170032 missense probably damaging 1.00
R6282:Cuedc1 UTSW 11 88183402 missense probably damaging 1.00
R6918:Cuedc1 UTSW 11 88187073 missense probably benign 0.00
R7329:Cuedc1 UTSW 11 88169866 missense unknown
R7985:Cuedc1 UTSW 11 88182516 missense probably benign 0.16
R8289:Cuedc1 UTSW 11 88182555 missense probably benign
Posted On2015-04-16