Incidental Mutation 'IGL00951:Olfr186'
ID29173
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr186
Ensembl Gene ENSMUSG00000047960
Gene Nameolfactory receptor 186
SynonymsGA_x54KRFPKG5P-55257214-55256285, MOR183-9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.069) question?
Stock #IGL00951
Quality Score
Status
Chromosome16
Chromosomal Location59025797-59030291 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 59027853 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 18 (T18I)
Ref Sequence ENSEMBL: ENSMUSP00000150366 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062380] [ENSMUST00000206463] [ENSMUST00000216415]
Predicted Effect probably benign
Transcript: ENSMUST00000062380
AA Change: T18I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000056448
Gene: ENSMUSG00000047960
AA Change: T18I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.4e-49 PFAM
Pfam:7tm_1 41 290 7e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205894
Predicted Effect probably benign
Transcript: ENSMUST00000206463
AA Change: T18I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000216415
AA Change: T18I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armc8 C A 9: 99,505,704 R388L probably benign Het
Bcan T C 3: 87,994,174 E407G probably damaging Het
Brms1l A G 12: 55,866,049 I276V possibly damaging Het
Brpf1 C A 6: 113,322,553 D1182E probably damaging Het
Clpb A G 7: 101,751,260 M268V probably benign Het
Cpne8 A T 15: 90,601,893 probably benign Het
Ddx25 A T 9: 35,552,835 probably null Het
Dgki A G 6: 37,000,159 M672T probably damaging Het
Fhdc1 T C 3: 84,464,313 T112A possibly damaging Het
Galnt7 A T 8: 57,583,824 M177K probably damaging Het
Gucy1a1 T C 3: 82,111,191 D113G probably benign Het
Hp T C 8: 109,577,497 D24G possibly damaging Het
Jak2 A G 19: 29,299,583 R847G probably damaging Het
Lama2 A T 10: 27,030,285 D2391E probably benign Het
Mpzl1 A G 1: 165,605,822 F87L probably damaging Het
Ms4a4d A T 19: 11,554,921 I144F probably benign Het
Olfr152 A T 2: 87,782,539 I2F probably benign Het
Olfr191 A C 16: 59,086,393 L30R possibly damaging Het
Olfr214 G A 6: 116,557,066 V214I probably benign Het
Olfr818 A G 10: 129,945,712 S2P probably damaging Het
Prr16 A G 18: 51,303,339 R297G probably damaging Het
Ralgps1 A C 2: 33,273,602 L148V probably damaging Het
Rara A G 11: 98,968,166 D150G probably benign Het
Rb1 A T 14: 73,322,072 V64D probably damaging Het
Ros1 A G 10: 52,143,252 Y742H probably damaging Het
Rpl7a A G 2: 26,912,429 D160G possibly damaging Het
Sdccag8 A G 1: 176,878,002 M461V possibly damaging Het
Tagln T A 9: 45,930,872 N141I probably benign Het
Tas2r137 A T 6: 40,491,979 R248* probably null Het
Ube2j2 C T 4: 155,946,377 probably benign Het
Ulk1 A G 5: 110,792,404 C384R possibly damaging Het
Ush2a A T 1: 188,263,465 E144D probably benign Het
Vkorc1l1 C T 5: 129,982,267 T144I probably benign Het
Zfp235 T C 7: 24,137,080 F17S probably damaging Het
Other mutations in Olfr186
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00969:Olfr186 APN 16 59027631 missense possibly damaging 0.48
IGL01102:Olfr186 APN 16 59027829 missense probably benign 0.03
IGL01348:Olfr186 APN 16 59027794 missense probably damaging 1.00
IGL01399:Olfr186 APN 16 59027266 missense probably benign 0.05
IGL02088:Olfr186 APN 16 59027052 missense probably damaging 1.00
R0047:Olfr186 UTSW 16 59027224 missense probably benign 0.00
R0479:Olfr186 UTSW 16 59027128 missense possibly damaging 0.64
R0866:Olfr186 UTSW 16 59027428 missense probably benign
R0926:Olfr186 UTSW 16 59027688 missense possibly damaging 0.80
R1760:Olfr186 UTSW 16 59026987 missense probably benign 0.01
R1955:Olfr186 UTSW 16 59027411 missense probably damaging 0.99
R2085:Olfr186 UTSW 16 59027869 missense probably benign 0.02
R2118:Olfr186 UTSW 16 59027815 missense possibly damaging 0.78
R4156:Olfr186 UTSW 16 59027568 missense probably damaging 1.00
R4287:Olfr186 UTSW 16 59027613 missense probably benign 0.00
R4783:Olfr186 UTSW 16 59027897 missense probably benign
R4885:Olfr186 UTSW 16 59027155 missense probably damaging 1.00
R4947:Olfr186 UTSW 16 59027445 missense probably damaging 0.98
R4965:Olfr186 UTSW 16 59027333 missense probably damaging 1.00
R6314:Olfr186 UTSW 16 59027457 missense probably benign 0.18
R7624:Olfr186 UTSW 16 59027019 missense possibly damaging 0.80
R7683:Olfr186 UTSW 16 59027106 missense probably benign
Posted On2013-04-17