Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02402:Nrg4'

291937

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nrg4

Ensembl Gene

ENSMUSG00000032311

Gene Name

neuregulin 4

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02402

Quality Score

Status

Chromosome

Chromosomal Location

55127506-55190937 bp(-) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

G to A at 55135198 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000130929 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034859] [ENSMUST00000130158] [ENSMUST00000135531] [ENSMUST00000137675] [ENSMUST00000140375] [ENSMUST00000145784] [ENSMUST00000164721] [ENSMUST00000153970] [ENSMUST00000146201]

AlphaFold

Q9WTX4

Predicted Effect

probably benign
Transcript: ENSMUST00000034859

SMART Domains

Protein: ENSMUSP00000034859
Gene: ENSMUSG00000032309

Domain	Start	End	E-Value	Type
Pfam:F-box	22	66	1.7e-6	PFAM
FIST_C	231	365	2.61e-6	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126368

Predicted Effect

probably benign
Transcript: ENSMUST00000130158

SMART Domains

Protein: ENSMUSP00000115247
Gene: ENSMUSG00000032311

Domain	Start	End	E-Value	Type
EGF	8	46	4.78e-3	SMART
transmembrane domain	61	83	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000135531

Predicted Effect

probably benign
Transcript: ENSMUST00000137675

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139261

Predicted Effect

probably benign
Transcript: ENSMUST00000140375

SMART Domains

Protein: ENSMUSP00000117341
Gene: ENSMUSG00000032309

Domain	Start	End	E-Value	Type
Pfam:F-box	21	66	3e-8	PFAM
Pfam:F-box-like	26	66	4.5e-8	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144939

Predicted Effect

probably benign
Transcript: ENSMUST00000145784

SMART Domains

Protein: ENSMUSP00000115851
Gene: ENSMUSG00000032311

Domain	Start	End	E-Value	Type
Blast:EGF	8	35	9e-13	BLAST
SCOP:d1jl9a_	9	35	6e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000164721

SMART Domains

Protein: ENSMUSP00000130929
Gene: ENSMUSG00000032311

Domain	Start	End	E-Value	Type
EGF	8	46	4.78e-3	SMART
transmembrane domain	61	83	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000153970

Predicted Effect

probably benign
Transcript: ENSMUST00000146201

SMART Domains

Protein: ENSMUSP00000117106
Gene: ENSMUSG00000032309

Domain	Start	End	E-Value	Type
FIST_C	128	262	2.61e-6	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
PHENOTYPE: A gene trap insertion into an intron of this gene results in no obvious phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	G	13: 81,707,543 (GRCm39)	F568L	probably benign	Het
AW112010	T	A	19: 11,025,741 (GRCm39)		noncoding transcript	Het
Bbs4	A	T	9: 59,237,729 (GRCm39)	L205H	probably benign	Het
Bmal2	T	C	6: 146,711,266 (GRCm39)	V90A	possibly damaging	Het
C2cd2l	T	C	9: 44,227,878 (GRCm39)	K121R	probably benign	Het
Car14	A	G	3: 95,806,870 (GRCm39)	V198A	possibly damaging	Het
Cd22	G	T	7: 30,576,955 (GRCm39)	H117Q	possibly damaging	Het
Celf1	T	A	2: 90,829,068 (GRCm39)	I45N	probably damaging	Het
Cluh	T	C	11: 74,547,997 (GRCm39)	S103P	probably damaging	Het
Cyp39a1	T	A	17: 44,002,613 (GRCm39)	L276Q	probably benign	Het
Ddx27	T	G	2: 166,857,245 (GRCm39)		probably benign	Het
Defb4	A	T	8: 19,251,279 (GRCm39)	I49F	possibly damaging	Het
Dock8	C	A	19: 25,055,509 (GRCm39)	T157K	probably benign	Het
Dpp6	T	C	5: 27,839,541 (GRCm39)	V352A	probably damaging	Het
Elmo2	C	T	2: 165,139,312 (GRCm39)	E412K	probably damaging	Het
Eme1	G	A	11: 94,541,733 (GRCm39)	P30S	possibly damaging	Het
Espnl	G	T	1: 91,272,535 (GRCm39)	A632S	probably benign	Het
Gfod1	C	A	13: 43,354,211 (GRCm39)	A255S	probably benign	Het
Helz2	T	A	2: 180,872,704 (GRCm39)	K2432M	probably damaging	Het
Idua	T	C	5: 108,827,657 (GRCm39)	L157P	probably damaging	Het
Ifi207	T	A	1: 173,555,159 (GRCm39)	D848V	probably damaging	Het
Jag1	C	T	2: 136,927,858 (GRCm39)	S851N	possibly damaging	Het
Kat6b	T	A	14: 21,681,415 (GRCm39)	F571I	probably damaging	Het
Lrrc74b	G	A	16: 17,376,028 (GRCm39)		probably benign	Het
Mst1r	A	G	9: 107,794,026 (GRCm39)	K1160E	probably damaging	Het
Muc19	C	A	15: 91,778,192 (GRCm39)		noncoding transcript	Het
Ociad1	T	C	5: 73,458,037 (GRCm39)	I12T	possibly damaging	Het
Or1o3	A	G	17: 37,574,111 (GRCm39)	V148A	possibly damaging	Het
Pold3	A	G	7: 99,749,618 (GRCm39)		probably benign	Het
Psmd5	T	C	2: 34,747,784 (GRCm39)	E291G	probably damaging	Het
Ptpn23	A	G	9: 110,222,781 (GRCm39)	V92A	possibly damaging	Het
Rab44	T	A	17: 29,359,490 (GRCm39)	H559Q	probably benign	Het
Rbm6	T	C	9: 107,730,051 (GRCm39)	D199G	probably damaging	Het
Rps18-ps3	C	T	8: 107,989,754 (GRCm39)		noncoding transcript	Het
Septin10	T	C	10: 59,006,758 (GRCm39)	T93A	probably benign	Het
Slmap	T	C	14: 26,184,865 (GRCm39)	T111A	probably damaging	Het
Spata25	C	T	2: 164,670,377 (GRCm39)	M1I	probably null	Het
Spink5	T	A	18: 44,100,171 (GRCm39)	C63S	probably damaging	Het
Sycp3	T	C	10: 88,302,425 (GRCm39)		probably benign	Het
Tarbp1	A	G	8: 127,177,567 (GRCm39)		probably benign	Het
Thbs2	A	T	17: 14,891,716 (GRCm39)	N940K	probably benign	Het
Tmem106b	A	T	6: 13,081,600 (GRCm39)	Q169L	possibly damaging	Het
Trpm6	G	T	19: 18,764,120 (GRCm39)	C242F	probably benign	Het
Ush2a	T	A	1: 187,999,305 (GRCm39)	M205K	probably benign	Het
Utp18	A	C	11: 93,774,617 (GRCm39)		probably benign	Het

Other mutations in Nrg4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1840:Nrg4	UTSW	9	55,189,890 (GRCm39)	start gained	probably benign
R4524:Nrg4	UTSW	9	55,135,186 (GRCm39)	utr 3 prime	probably benign
R4824:Nrg4	UTSW	9	55,156,405 (GRCm39)	intron	probably benign
R4877:Nrg4	UTSW	9	55,166,679 (GRCm39)	missense	probably benign	0.00
R5057:Nrg4	UTSW	9	55,189,880 (GRCm39)	utr 5 prime	probably benign
R6004:Nrg4	UTSW	9	55,166,667 (GRCm39)	missense	possibly damaging	0.66
R6053:Nrg4	UTSW	9	55,143,774 (GRCm39)	missense	probably benign	0.34
R6254:Nrg4	UTSW	9	55,143,796 (GRCm39)	missense	possibly damaging	0.53
R7158:Nrg4	UTSW	9	55,149,384 (GRCm39)	missense	probably damaging	0.99
R9393:Nrg4	UTSW	9	55,149,420 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16