Incidental Mutation 'IGL02590:Il15'
ID 299688
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il15
Ensembl Gene ENSMUSG00000031712
Gene Name interleukin 15
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02590
Quality Score
Status
Chromosome 8
Chromosomal Location 83058261-83129851 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 83069912 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 51 (I51V)
Ref Sequence ENSEMBL: ENSMUSP00000148256 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034148] [ENSMUST00000209363] [ENSMUST00000209573] [ENSMUST00000210094] [ENSMUST00000211565]
AlphaFold P48346
Predicted Effect probably benign
Transcript: ENSMUST00000034148
AA Change: I51V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000034148
Gene: ENSMUSG00000031712
AA Change: I51V

DomainStartEndE-ValueType
Pfam:IL15 33 160 8.6e-53 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209363
AA Change: I51V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000209573
AA Change: I51V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209687
Predicted Effect probably benign
Transcript: ENSMUST00000210094
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210885
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211282
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211722
Predicted Effect probably benign
Transcript: ENSMUST00000211565
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. [provided by RefSeq, Aug 2016]
PHENOTYPE: Mice homozygous for disruptions of this gene have normal life spans but display a variety of immune system abnormalities and maternal placental defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl3 A G 4: 144,184,404 (GRCm39) F118S probably damaging Het
Adam5 T G 8: 25,234,151 (GRCm39) probably benign Het
Bok T C 1: 93,614,397 (GRCm39) probably benign Het
C1s1 C T 6: 124,508,235 (GRCm39) V585I possibly damaging Het
Chd2 C T 7: 73,102,948 (GRCm39) V1346I probably benign Het
Cyb5a A T 18: 84,889,732 (GRCm39) T54S probably benign Het
Dnah7b A T 1: 46,162,937 (GRCm39) T428S probably benign Het
Efhc1 T C 1: 21,037,608 (GRCm39) Y262H probably damaging Het
Fyb2 A T 4: 104,836,250 (GRCm39) I404F probably damaging Het
Glra2 T C X: 164,037,222 (GRCm39) N237S probably benign Het
Gypc A G 18: 32,663,060 (GRCm39) *96R probably null Het
Itgb2 T C 10: 77,395,347 (GRCm39) C483R probably damaging Het
Kdr C T 5: 76,096,983 (GRCm39) D1272N probably benign Het
Kif14 C A 1: 136,423,742 (GRCm39) T969K probably benign Het
Klhl42 T C 6: 146,993,810 (GRCm39) S261P probably damaging Het
Lrp1 C A 10: 127,388,660 (GRCm39) G3263V probably damaging Het
Mid1 A G X: 168,710,019 (GRCm39) E5G probably damaging Het
Mmrn2 T A 14: 34,121,224 (GRCm39) L698* probably null Het
Myh14 T G 7: 44,273,503 (GRCm39) Q1393P probably damaging Het
Ncoa7 C T 10: 30,570,159 (GRCm39) E267K probably damaging Het
Obox5 T C 7: 15,491,517 (GRCm39) I19T possibly damaging Het
Or13a20 A G 7: 140,232,305 (GRCm39) probably null Het
Or8k22 A G 2: 86,163,344 (GRCm39) S119P possibly damaging Het
Pcnx1 A G 12: 82,041,752 (GRCm39) Y2128C probably damaging Het
Plcb1 A G 2: 135,136,784 (GRCm39) D293G probably benign Het
Prpf4b T C 13: 35,072,129 (GRCm39) probably benign Het
Psapl1 A T 5: 36,362,397 (GRCm39) T330S probably benign Het
Rap1gap A G 4: 137,447,611 (GRCm39) T453A probably damaging Het
Ric1 T A 19: 29,544,881 (GRCm39) probably benign Het
Robo1 A G 16: 72,840,020 (GRCm39) E1590G probably benign Het
Sorl1 C T 9: 41,957,857 (GRCm39) V596I probably benign Het
Tlr12 A G 4: 128,511,182 (GRCm39) I356T probably benign Het
Trav8d-2 T C 14: 53,279,906 (GRCm39) S8P possibly damaging Het
Tyms C A 5: 30,269,149 (GRCm39) V75L probably benign Het
Vmn1r230 T A 17: 21,067,172 (GRCm39) S120R probably damaging Het
Vmn2r84 T A 10: 130,227,356 (GRCm39) probably benign Het
Wdr27 C T 17: 15,138,041 (GRCm39) A388T possibly damaging Het
Other mutations in Il15
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0306:Il15 UTSW 8 83,061,083 (GRCm39) splice site probably benign
R0638:Il15 UTSW 8 83,069,890 (GRCm39) missense probably damaging 0.99
R0685:Il15 UTSW 8 83,064,188 (GRCm39) splice site probably benign
R3012:Il15 UTSW 8 83,071,049 (GRCm39) missense probably damaging 1.00
R7089:Il15 UTSW 8 83,064,204 (GRCm39) missense probably damaging 0.98
R9499:Il15 UTSW 8 83,061,177 (GRCm39) missense probably benign 0.00
R9551:Il15 UTSW 8 83,061,177 (GRCm39) missense probably benign 0.00
R9552:Il15 UTSW 8 83,061,177 (GRCm39) missense probably benign 0.00
R9674:Il15 UTSW 8 83,069,938 (GRCm39) missense probably damaging 0.98
R9679:Il15 UTSW 8 83,071,094 (GRCm39) missense probably benign 0.05
R9720:Il15 UTSW 8 83,058,608 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16